FLNA, a disulfidptosis-related gene, modulates tumor immunity and progression in colorectal cancer

Siegel RL, Giaquinto AN, Jemal A. Cancer statistics, 2024. CA Cancer J Clin. 2024;74(1):12–49. https://doi.org/10.3322/caac.21820.

Article  PubMed  Google Scholar 

Sonkin D, Thomas A, Teicher BA. Cancer treatments: past, present, and future. Cancer Genet. 2024. https://doi.org/10.1016/j.cancergen.2024.06.002.

Article  PubMed  Google Scholar 

Raphael M, Karanicolas P. Regional therapy for colorectal cancer liver metastases: which modality and when? J Clin Oncol. 2022;40(24):2806–17. https://doi.org/10.1200/jco.21.02505.

Article  CAS  PubMed  Google Scholar 

Ciardiello F, Ciardiello D, Martini G, Napolitano S, Tabernero J, Cervantes A. Clinical management of metastatic colorectal cancer in the era of precision medicine. CA: A Cancer J Clin. 2022;72(4):372–401. https://doi.org/10.3322/caac.21728.

Article  Google Scholar 

Jin Z, Sinicrope FA. Mismatch repair-deficient colorectal cancer: building on checkpoint blockade. J Clin Oncol. 2022;40(24):2735–50. https://doi.org/10.1200/JCO.21.02691.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Splendiani E, Besharat ZM, Covre A, Maio M, Di Giacomo AM, Ferretti E. Immunotherapy in melanoma: Can we predict response to treatment with circulating biomarkers? Pharmacol Ther. 2024;256: 108613. https://doi.org/10.1016/j.pharmthera.2024.108613.

Article  CAS  PubMed  Google Scholar 

Ramapriyan R, Vykunta VS, Vandecandelaere G, Richardson LG, Sun J, Curry WT, et al. Altered cancer metabolism and implications for next-generation CAR T-cell therapies. Pharmacol Therapeut. 2024. https://doi.org/10.1016/j.pharmthera.2024.108667.

Article  Google Scholar 

Yu X, Zhai X, Wu J, Feng Q, Hu C, Zhu L, et al. Evolving perspectives regarding the role of the PD-1/PD-L1 pathway in gastric cancer immunotherapy. Biochimica et Biophysica Acta (BBa)- Mol Basis Dis. 2024;1870(1):166881. https://doi.org/10.1016/j.bbadis.2023.166881.

Article  CAS  Google Scholar 

Niu L, Wang Q, Feng F, Yang W, Xie Z, Zheng G, et al. Small extracellular vesicles-mediated cellular interactions between tumor cells and tumor-associated macrophages: Implication for immunotherapy. Biochimica et Biophysica Acta (BBA)- Mol Basis of Dis. 2024;1870(2):166917. https://doi.org/10.1016/j.bbadis.2023.166917.

Article  CAS  Google Scholar 

Schmitt M, Greten F. The inflammatory pathogenesis of colorectal cancer. Nat Rev Immunol. 2021;21(10):653–67. https://doi.org/10.1038/s41577-021-00534-x.

Article  CAS  PubMed  Google Scholar 

Ratovomanana T, Nicolle R, Cohen R, Diehl A, Siret A, Letourneur Q, et al. Prediction of response to immune checkpoint blockade in patients with metastatic colorectal cancer with microsatellite instability. Ann Oncol. 2023;34(8):703–13. https://doi.org/10.1016/j.annonc.2023.05.010.

Article  CAS  PubMed  Google Scholar 

Yuan J, Ofengeim D. A guide to cell death pathways. Nat Rev Mol Cell Biol. 2023. https://doi.org/10.1038/s41580-023-00689-6.

Article  PubMed  Google Scholar 

Shen S, Shao Y, Li C. Different types of cell death and their shift in shaping disease. Cell Death Discov. 2023;9(1):284. https://doi.org/10.1038/s41420-023-01581-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pentimalli F, Grelli S, Di Daniele N, Melino G, Amelio I. Cell death pathologies: targeting death pathways and the immune system for cancer therapy. Genes Immun. 2019;20(7):539–54. https://doi.org/10.1038/s41435-018-0052-x.

Article  CAS  PubMed  Google Scholar 

Liu X, Nie L, Zhang Y, Yan Y, Wang C, Colic M, et al. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol. 2023;25(3):404–14. https://doi.org/10.1038/s41556-023-01091-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng P, Zhou C, Ding Y, Duan S. Disulfidptosis: a new target for metabolic cancer therapy. J Exper Clin Cancer Res. 2023;42(1):103. https://doi.org/10.1186/s13046-023-02675-4.

Article  Google Scholar 

Liu H, Tang T. Pan-cancer genetic analysis of disulfidptosis-related gene set. Cancer Genet. 2023;278:91–103. https://doi.org/10.1016/j.cancergen.2023.10.001.

Article  CAS  PubMed  Google Scholar 

Liu H. Expression and potential immune involvement of cuproptosis in kidney renal clear cell carcinoma. Cancer Genet. 2023;274:21–5. https://doi.org/10.1016/j.cancergen.2023.03.002.

Article  CAS  PubMed  Google Scholar 

Liu H. Pan-cancer profiles of the cuproptosis gene set. Am J Cancer Res. 2022;12(8):4074. https://doi.org/10.21203/rs.3.rs-1716214/v1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, et al. SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nat Commun. 2023;14(1):3673. https://doi.org/10.1038/s41467-023-39401-9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Olszewski K, Zhang Y, Lim EW, Shi J, Zhang X, et al. Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer. Nat Cell Biol. 2020;22(4):476–86. https://doi.org/10.1038/s41556-020-0496-x.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu X, Zhang Y, Zhuang L, Olszewski K, Gan B. NADPH debt drives redox bankruptcy: SLC7A11/xCT-mediated cystine uptake as a double-edged sword in cellular redox regulation. Genes & diseases. 2021;8(6):731–45. https://doi.org/10.1016/j.gendis.2020.11.010.

Article  CAS  Google Scholar 

Li T, Fan J, Wang B, Traugh N, Chen Q, Liu JS, et al. TIMER: A web server for comprehensive analysis of tumor-infiltrating immune cells. Cancer Res. 2017;77(21):e108–10. https://doi.org/10.1158/0008-5472.Can-17-0307.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B, Khodadoust MS, Liu CL, Newman AM, Alizadeh AA. Profiling tumor infiltrating immune cells with CIBERSORT. Methods Mol Biol. 2018;1711:243–59. https://doi.org/10.1007/978-1-4939-7493-1_12.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aran D, Hu Z, Butte AJ. xCell: digitally portraying the tissue cellular heterogeneity landscape. Genome Biol. 2017;18:1–14. https://doi.org/10.1186/s13059-017-1349-1.

Article  CAS  Google Scholar 

Racle J, Gfeller D. EPIC: a tool to estimate the proportions of different cell types from bulk gene expression data. Bioinform Cancer Immunotherapy: Methods Prot. 2022;2120:233–48. https://doi.org/10.1007/978-1-0716-0327-7_17.

Article  CAS  Google Scholar 

Bindea G, Mlecnik B, Tosolini M, Kirilovsky A, Waldner M, Obenauf AC, et al. Spatiotemporal dynamics of intratumoral immune cells reveal the immune landscape in human cancer. Immunity. 2013;39(4):782–95. https://doi.org/10.1016/j.immuni.2013.10.003.

Article  CAS  PubMed  Google Scholar 

Charoentong P, Finotello F, Angelova M, Mayer C, Efremova M, Rieder D, et al. Pan-cancer immunogenomic analyses reveal genotype-immunophenotype relationships and predictors of response to checkpoint blockade. Cell Rep. 2017;18(1):248–62. https://doi.org/10.1016/j.celrep.2016.12.019.

Article  CAS  PubMed  Google Scholar 

Xu L, Deng C, Pang B, Zhang X, Liu W, Liao G, et al. TIP: a web server for resolving tumor immunophenotype profiling. Can Res. 2018;78(23):6575–80. https://doi.org/10.1158/0008-5472.CAN-18-0689.

Article 

Comments (0)

No login
gif