DeBord, D. G. et al. Use of the “Exposome” in the practice of epidemiology: a primer on -omic technologies. Am. J. Epidemiol. 184, 302–314 (2016).
Fareed, Y., Braun, D., Flasch, M., Globisch, D. & Warth, B. A broad, exposome-type evaluation of xenobiotic phase II biotransformation in human biofluids by LC-MS/MS. Exposome 2, osac008 (2022).
Singh, M., Mishra, R. C., Shah, I., Wadhwa, V. & Mor, V. Xenobiotics: sources, pathways, degradation, and risk associated with major emphasis on pharmaceutical compounds. In Xenobiotics in Urban Ecosystems: Sources, Distribution and Health Impacts (eds Singh R., Singh P., Tripathi S., Chandra K. K., Bhadouria R.) (Springer International Publishing, 2023).
Waters, M. D., Selkirk, J. K. & Olden, K. The impact of new technologies on human population studies. Mutat. Res./Rev. Mutat. Res. 544, 349–360 (2003).
Arnold, S. M. et al. The use of biomonitoring data in exposure and human health risk assessment: benzene case study. Crit. Rev. Toxicol. 43, 119–153 (2013).
CAS PubMed PubMed Central Google Scholar
Bessonneau, V., Pawliszyn, J. & Rappaport, S. M. The saliva exposome for monitoring of individuals’ health trajectories. Environ. Health Perspect. 125, 077014 (2017).
PubMed PubMed Central Google Scholar
Mueller, D. C., Piller, M., Niessner, R., Scherer, M. & Scherer, G. Untargeted metabolomic profiling in saliva of smokers and nonsmokers by a validated GC-TOF-MS Method. J. Proteome Res. 13, 1602–1613 (2014).
Heras-González, L. et al. Influence of BPA exposure, measured in saliva, on childhood weight. Front. Endocrinol.13, 1040583 (2022).
Wright, M. L., Starkweather, A. R. & York, T. P. Mechanisms of the maternal exposome and implications for health outcomes. ANS Adv. Nurs. Sci. 39, E17–E30 (2016).
PubMed PubMed Central Google Scholar
Needham, L. L. et al. Partition of environmental chemicals between maternal and fetal blood and tissues. Environ. Sci. Technol. 45, 1121–1126 (2011).
Simon, A. K., Hollander, G. A. & McMichael, A. Evolution of the immune system in humans from infancy to old age. Proc. Biol. Sci. 282, 20143085 (2015).
PubMed PubMed Central Google Scholar
Soomro, M. H. et al. Associations between the chemical exposome and pregnancy induced hypertension. Environ. Res. 237, 116838 (2023).
Wu, D.-d et al. Increased adverse pregnancy outcomes associated with stage 1 hypertension in a low-risk cohort. Hypertension 75, 772–780 (2020).
Pearson, H. Meet the human metabolome. Nature 446, 8 (2007).
Wishart, D. S. et al. HMDB 3.0-the human metabolome database in 2013. Nucleic Acids Res. 41, D801–D807 (2013).
Yoshizawa, J. M. et al. Salivary biomarkers: toward future clinical and diagnostic utilities. Clin. Microbiol. Rev. 26, 781–791 (2013).
CAS PubMed PubMed Central Google Scholar
Qiu, S. et al. Small molecule metabolites: discovery of biomarkers and therapeutic targets. Signal. Transduct. Target Ther. 8, 132 (2023).
PubMed PubMed Central Google Scholar
Bessonneau, V., Pawliszyn, J., Rappaport, S. M. The saliva exposome for monitoring of individuals’ health trajectories. Environ. Health Perspect. 125, 077014 (2017).
Su, G., Kuchinsky, A., Morris, J. H., States, D. J. & Meng, F. GLay: community structure analysis of biological networks. Bioinformatics 26, 3135–3137 (2010).
CAS PubMed PubMed Central Google Scholar
Maitre, L. et al. Multi-omics signatures of the human early life exposome. Nat. Commun. 13, 7024 (2022).
CAS PubMed PubMed Central Google Scholar
Holzman, C. et al. Maternal catecholamine levels in midpregnancy and risk of preterm delivery. Am. J. Epidemiol. 170, 1014–1024 (2009).
PubMed PubMed Central Google Scholar
Natrajan, P. G., McGarrtgle, H. H. G., Lawrence, D. M. & Lachelin, G. C. L. Plasma noradrenaline and adrenaline levels in normal pregnancy and in pregnancy-induced hypertension. BJOG: Int. J. Obstet. Gynaecol. 89, 1041–1045 (1982).
Whiting, M. J. & Doogue, M. P. Advances in biochemical screening for phaeochromocytoma using biogenic amines. Clin. Biochem. Rev. 30, 3–17 (2009).
PubMed PubMed Central Google Scholar
Lenders, J. W. M. & Eisenhofer, G. Normetanephrine and metanephrine☆. In Encyclopedia of Endocrine Diseases 2nd edn (eds Huhtaniemi, I. & Martini, L.) (Academic Press, 2017).
Tank, A. W. & Lee Wong, D. Peripheral and central effects of circulating catecholamines. Compr. Physiol. 5, 1–15 (2015).
Cyr, M. et al. Sustained elevation of extracellular dopamine causes motor dysfunction and selective degeneration of striatal GABAergic neurons. Proc. Natl. Acad. Sci. USA 100, 11035–11040 (2003).
CAS PubMed PubMed Central Google Scholar
Muncke, J. et al. Scientific challenges in the risk assessment of food contact materials. Environ. Health Perspect. 125, 095001 (2017).
PubMed PubMed Central Google Scholar
Andersson, K., Fuxe, K., Toftgård, R., Nilsen, O. G. & Eneroth, P. Gustafsson JA. Toluene-induced activation of certain hypothalamic and median eminence catecholamine nerve terminal systems of the male rat and its effects on anterior pituitary hormone secretion. Toxicol. Lett. 5, 393–398 (1980).
Riegel, A. C., Zapata, A., Shippenberg, T. S. & French, E. D. The abused inhalant toluene increases dopamine release in the nucleus accumbens by directly stimulating ventral tegmental area neurons. Neuropsychopharmacology 32, 1558–1569 (2007).
Donald, J. M., Hooper, K. & Hopenhayn-Rich, C. Reproductive and developmental toxicity of toluene: a review. Environ. Health Perspect. 94, 237–244 (1991).
CAS PubMed PubMed Central Google Scholar
Wax, P. M. Monoamine oxidase inhibitors. In Encyclopedia of Toxicology 3rd edn (eds Wexler, P) (Academic Press, 2014).
Coccini, T., Randine, G., Li, B., Manzo, L. & Costa, L. G. Effect of styrene on monoamine oxidase B activity in rat brain. J. Toxicol. Environ. Health A 56, 59–68 (1999).
Naoi, M. & Nagatsu, T. Quinoline and quninaldine as naturally occurring inhibitors specific for type A monoamine oxidase. Life Sci. 40, 1075–1082 (1987).
Skalicka-Woźniak, K., Orhan, I. E., Cordell, G. A., Nabavi, S. M. & Budzyńska, B. Implication of coumarins towards central nervous system disorders. Pharmacol. Res. 103, 188–203 (2016).
Chenu, F., Mansari, M. E. & Blier, P. Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area. Int. J. Neuropsychopharmacol. 12, 475–485 (2009).
Creeley, C. E. & Denton, L. K. Use of prescribed psychotropics during pregnancy: a systematic review of pregnancy, neonatal, and childhood outcomes. Brain Sci. 9, 235 (2019).
Onaolapo, A. Y. & Onaolapo, O. J. Food additives, food and the concept of ‘food addiction’: is stimulation of the brain reward circuit by food sufficient to trigger addiction?. Pathophysiology 25, 263–276 (2018).
Prorok, T., Jana, M., Patel, D. & Pahan, K. Cinnamic acid protects the nigrostriatum in a mouse model of Parkinson’s disease via peroxisome proliferator-activated receptorα. Neurochem. Res. 44, 751–762 (2019).
CAS PubMed PubMed Central Google Scholar
Daubner, S. C., Le, T. & Wang, S. Tyrosine hydroxylase and regulation of dopamine synthesis. Arch. Biochem. Biophys. 508, 1–12 (2011).
Rangasamy, S. B. et al. Stimulation of dopamine production by sodium benzoate, a metabolite of cinnamon and a food additive. J. Alzheimers Dis. Rep. 5, 295–310 (2021).
PubMed PubMed Central Google Scholar
Chanal, J. L., Audran, M., Sicard, M. T. & Briley, M. Brain penetration of orally administered sodium pyroglutamate. J. Pharm. Pharmacol. 40, 584–585 (1988).
Kulagina, N. V., Zigmond, M. J. & Michael, A. C. Glutamate regulates the spontaneous and evoked release of dopamine in the rat striatum. Neuroscience 102, 121–128 (2001).
Franco, R., Reyes-Resina, I. & Navarro, G. Dopamine in health and disease: much more than a neurotransmitter. Biomedicines 9, 109 (2021).
Lenders, J. W. M. Endocrine disorders in pregnancy: pheochromocytoma and pregnancy: a deceptive connection. Eur. J. Endocrinol. 166, 143–150 (2012).
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