Tay BQ, Wright Q, Ladwa R, Perry C, Leggatt G, Simpson F, Wells JW, Panizza BJ, Frazer IH, Cruz JLG. Evolution of cancer vaccines—challenges, achievements, and future directions. Vaccines. 2021;9(5):535.
Article CAS PubMed PubMed Central Google Scholar
Lin MJ, Svensson-Arvelund J, Lubitz GS, Marabelle A, Melero I, Brown BD, Brody JD. Cancer vaccines: the next immunotherapy frontier. Nat Cancer. 2022;3(8):911–26.
Article CAS PubMed Google Scholar
Saxena M, van der Burg SH, Melief CJM, Bhardwaj N. Therapeutic cancer vaccines. Nat Rev Cancer. 2021;21(6):360–78.
Article CAS PubMed Google Scholar
Rojas LA, Sethna Z, Soares KC, Olcese C, Pang N, Patterson E, Lihm J, Ceglia N, Guasp P, Chu A, Yu R, Chandra AK, Waters T, Ruan J, Amisaki M, Zebboudj A, Odgerel Z, Payne G, Derhovanessian E, Müller F, Rhee I, Yadav M, Dobrin A, Sadelain M, Łuksza M, Cohen N, Tang L, Basturk O, Gönen M, Katz S, Do RK, Epstein AS, Momtaz P, Park W, Sugarman R, Varghese AM, Won E, Desai A, Wei AC, D’Angelica MI, Kingham TP, Mellman I, Merghoub T, Wolchok JD, Sahin U, Türeci Ö, Greenbaum BD, Jarnagin WR, Drebin J, O’Reilly EM, Balachandran VP. Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer. Nature. 2023;618(7963):144–50.
Article CAS PubMed PubMed Central Google Scholar
Dranoff G. GM-CSF-based cancer vaccines. Immunol Rev. 2002;188:147–54.
Article CAS PubMed Google Scholar
Dranoff G, Jaffee E, Lazenby A, Golumbek P, Levitsky H, Brose K, Jackson V, Hamada H, Pardoll D, Mulligan RC. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc Natl Acad Sci U S A. 1993;90(8):3539–43.
Article CAS PubMed PubMed Central Google Scholar
Kumar A, Taghi Khani A, Sanchez Ortiz A, Swaminathan S. GM-CSF: a double-edged sword in cancer immunotherapy. Front Immunol. 2022;13:901277.
Article CAS PubMed PubMed Central Google Scholar
Clive KS, Tyler JA, Clifton GT, Holmes JP, Mittendorf EA, Ponniah S, Peoples GE. Use of GM-CSF as an adjuvant with cancer vaccines: beneficial or detrimental? Expert Rev Vaccines. 2010;9(5):519–25.
Article CAS PubMed Google Scholar
Le DT, Picozzi VJ, Ko AH, Wainberg ZA, Kindler H, Wang-Gillam A, Oberstein P, Morse MA, Zeh HJ, Weekes C, Reid T, Borazanci E, Crocenzi T, LoConte NK, Musher B, Laheru D, Murphy A, Whiting C, Nair N, Enstrom A, Ferber S, Brockstedt DG, Jaffee EM. Results from a phase IIb, randomized, multicenter study of GVAX pancreas and CRS-207 compared with chemotherapy in adults with previously treated metastatic pancreatic adenocarcinoma (ECLIPSE study). Clin Cancer Res. 2019;25(18):5493–502.
Article CAS PubMed PubMed Central Google Scholar
Soiffer RJ, Kooshesh KA, Ho V. Whole tumor cell vaccines engineered to secrete GM-CSF (GVAX). ImmunoMedicine. 2021. https://doi.org/10.1002/imed.1025.
Fernandez E, Vernet R, Charrier E, Migliorini DM, Urwyler M, Belkouch MC, Von Rohr O, Saingier V, Ancrenaz V, Grandjean N, Lafferma E, Lavalliere E, Rubin O, Villard J, Grogg JN, Mach N. 762P personalized immunotherapy with encapsulated cell technology: feasibility, safety and efficacy results from the first-in-human clinical trial in advanced relapsing solid tumors. Ann Oncol. 2022;33:S891.
Vernet R, Fernandez E, Migliorini D, Ancrenaz V, Charrier E, Belkouch MC, Von Rohr O, Urwyler M, De Vito C, Renaux J, Villard J, Rubin O, Grogg J, Mach N. A first-in-human phase I clinical study with MVX-ONCO-1, a personalized active immunotherapy, in patients with advanced solid tumors. Cancer Res Commun. 2024. https://doi.org/10.1158/2767-9764.CRC-24-0150.
Article PubMed PubMed Central Google Scholar
Mach N, Fernandez E, Vernet R, Vonrohr O, Urwyler M, Charrier E, Belkouch MC, Saingier V, Courtout F, De Vito C, Rubin O, Ancrenaz V, Grogg JN, Renaux J, Gysel K, Müller G, Brezina T, Rordorf T, Joerger M, Michielin OA. LBA46 SAKK 11/16, a phase IIa trial evaluating overall survival (OS) for recurrent/metastatic Head & neck squamous cell carcinoma (RMHNSCC) patients (pts) progressing after ≥ 1 line of systemic therapy, treated with MVX-ONCO-1, a novel, first in class cell encapsulation-based immunotherapy. Ann Oncol. 2023;34:S1286.
A’Hern RP. Sample size tables for exact single-stage phase II designs. Stat Med. 2001;20(6):859–66.
Kieser M, Wirths M, Englert S, Kunz CU, Rauch G. OneArmPhaseTwoStudy : an R package for planning, conducting, and analysing single-arm phase II studies. J Stat Soft. 2017. https://doi.org/10.18637/jss.v081.i08.
Zhang Z, Pan Q, Lu M, Zhao B. Intermediate endpoints as surrogates for outcomes in cancer immunotherapy: a systematic review and meta-analysis of phase 3 trials. EClinicalMedicine. 2023;63:102156.
Article PubMed PubMed Central Google Scholar
Hodi FS, Schmollinger JC, Soiffer RJ, Salgia R, Lynch T, Ritz J, Alyea EP, Yang J, Neuberg D, Mihm M, Dranoff G. ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction. Proc Natl Acad Sci USA. 2002;99(10):6919–24.
Article CAS PubMed PubMed Central Google Scholar
Anderson KS, Erick TK, Chen M, Daley H, Campbell M, Colson Y, Mihm M, Zakka LR, Hopper M, Barry W, Winer EP, Dranoff G, Overmoyer B. The feasibility of using an autologous GM-CSF-secreting breast cancer vaccine to induce immunity in patients with stage II–III and metastatic breast cancers. Breast Cancer Res Treat. 2022;194(1):65–78.
Article CAS PubMed PubMed Central Google Scholar
Low JL, Chong WQ, Goh BC. Is abundance of B cells the best biomarker to predict immune checkpoint inhibitor response in head and neck squamous cell cancers? Ann Oncol. 2025;36:238.
Article CAS PubMed Google Scholar
Kim SS, Shen S, Miyauchi S, Sanders PD, Franiak-Pietryga I, Mell L, Gutkind JS, Cohen EEW, Califano JA, Sharabi AB. B cells improve overall survival in HPV-associated squamous cell carcinomas and are activated by radiation and PD-1 blockade. Clin Cancer Res. 2020;26(13):3345–59.
Article CAS PubMed PubMed Central Google Scholar
Abdulla M, Traiki T, Vaali-Mohammed MA, El-Wetidy M, Alhassan N, Al-Khayal K, Zubaidi A, Al-Obeed O, Ahmad R. Targeting MUCL1 protein inhibits cell proliferation and EMT by deregulating β-catenin and increases irinotecan sensitivity in colorectal cancer. Int J Oncol. 2022;60(3):22.
Article CAS PubMed PubMed Central Google Scholar
Bhatia R, Gautam SK, Cannon A, Thompson C, Hall BR, Aithal A, Banerjee K, Jain M, Solheim JC, Kumar S, Batra SK. Cancer-associated mucins: role in immune modulation and metastasis. Cancer Metastasis Rev. 2019;38(1–2):223–36.
Article CAS PubMed PubMed Central Google Scholar
Wang Q, Li X, Ren S, Cheng N, Zhao M, Zhang Y, Li J, Cai W, Zhao C, Cao W, Zhou C. Serum levels of the cancer-testis antigen POTEE and its clinical significance in non-small-cell lung cancer. PLoS ONE. 2015;10(4):e0122792.
Article PubMed PubMed Central Google Scholar
Hasegawa K, Fujii S, Matsumoto S, Tajiri Y, Kikuchi A, Kiyoshima T. Yap signaling induces PIEZO1 to promote oral squamous cell carcinoma cell proliferation. J Pathol. 2021;253(1):80–93.
Article CAS PubMed Google Scholar
Dudka I, Thysell E, Lundquist K, Antti H, Iglesias-Gato D, Flores-Morales A, Bergh A, Wikström P, Gröbner G. Comprehensive metabolomics analysis of prostate cancer tissue in relation to tumor aggressiveness and TMPRSS2-ERG fusion status. BMC Cancer. 2020;20(1):437.
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Li N, Zheng Y, Wang A, Yu C, Song Z, Wang S, Sun Y, Zheng L, Wang G, Liu L, Yi J, Huang Y, Zhang M, Bao Y, Sun L. KIAA1217 promotes epithelial-mesenchymal transition and hepatocellular carcinoma metastasis by interacting with and activating STAT3. IJMS. 2021;23(1):104.
Article PubMed PubMed Central Google Scholar
Choy CT, Wong CH, Chan SL. Embedding of genes using cancer gene expression data: biological relevance and potential application on biomarker discovery. Front Genet. 2019;9:682.
Comments (0)