Takotsubo syndrome: pathophysiological insights and innovations in patient care

Lyon, A. R. et al. Current state of knowledge on Takotsubo syndrome: a position statement from the Taskforce on Takotsubo syndrome of the Heart Failure Association of the European Society of Cardiology. Eur. J. Heart Fail. 18, 8–27 (2016).

Article  PubMed  Google Scholar 

Ghadri, J. R. et al. International expert consensus document on Takotsubo syndrome (part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur. Heart J. 39, 2032–2046 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Dote, K., Sato, H., Tateishi, H., Uchida, T. & Ishihara, M. Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases [Japanese]. J. Cardiol. 21, 203–214 (1991).

CAS  PubMed  Google Scholar 

Sato, H. in Clinical Aspect of Myocardial Injury: From Ischemia to Heart Failure (eds. Kodama, K. et al.) 56–64 (Kagakuhyoronsha Publishing, 1990).

Templin, C. Clinical features and outcomes of Takotsubo (Stress) cardiomyopathy. N. Engl. J. Med. 373, 929–938 (2015).

Article  CAS  PubMed  Google Scholar 

Redfors, B. et al. Mortality in takotsubo syndrome is similar to mortality in myocardial infarction - a report from the SWEDEHEART. Int. J. Cardiol. 185, 282–289 (2015).

Article  PubMed  Google Scholar 

Hasanaginica. Wikipedia https://en.wikipedia.org/wiki/Hasanaginica (2024).

Hansen, C. & Phillips, B. ‘Wilt break my heart?’ Takotsubo syndrome and Shakespeare’s discourse of heartbreak in Antony and Cleopatra and King Lear. Shakespeare 1–24 https://doi.org/10.1080/17450918.2024.2319124 (2024)

Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 18-1986. A 44-year-old woman with substernal pain and pulmonary edema after severe emotional stress. N. Engl. J. Med. 314, 1240–1247 (1986).

Article  Google Scholar 

Dote, K. et al. Myocardial stunning due to simultaneous multivessel coronary spasms: a review of 5 cases. J. Cardiol. 21, 203–214 (1991).

CAS  PubMed  Google Scholar 

Brandspiegel, H. Z., Marinchak, R. A., Rials, S. J. & Kowey, P. R. A broken heart. Circulation 98, 1349 (1998).

Article  CAS  PubMed  Google Scholar 

Pavin, D., Le Breton, H. & Daubert, C. Human stress cardiomyopathy mimicking acute myocardial syndrome. Heart 78, 509–511 (1997).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Frank, N., Herrmann, M. J., Lauer, M. & Förster, C. Y. Exploratory review of the Takotsubo syndrome and the possible role of the psychosocial stress response and inflammaging. Biomolecules 14, 167 (2024).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haghi, D. et al. Coronary artery disease in Takotsubo cardiomyopathy. Circ. J. 71, 1092–1094 (2007).

Article  PubMed  Google Scholar 

Akashi, Y. J., Nef, H. M. & Lyon, A. R. Epidemiology and pathophysiology of Takotsubo syndrome. Nat. Rev. Cardiol. 12, 387–397 (2015).

Article  PubMed  Google Scholar 

Schweiger, V. et al. Temporal trends in Takotsubo syndrome. J. Am. Coll. Cardiol. 84, 1178–1189 (2024).

Article  PubMed  Google Scholar 

Imori, Y. et al. Ethnic comparison in takotsubo syndrome: novel insights from the international takotsubo registry. Clin. Res. Cardiol. 111, 186–196 (2022).

Article  PubMed  Google Scholar 

Ghadri, J. R. et al. Differences in the clinical profile and outcomes of typical and atypical Takotsubo syndrome: data from the international Takotsubo registry. JAMA Cardiol. 1, 335–340 (2016).

Article  PubMed  Google Scholar 

Abe, Y. et al. Assessment of clinical features in transient left ventricular apical ballooning. J. Am. Coll. Cardiol. 41, 737–742 (2003).

Article  PubMed  Google Scholar 

Bybee, K. A. et al. Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction. Ann. Intern. Med. 141, 858–865 (2004).

Article  PubMed  Google Scholar 

Thygesen, K. et al. Fourth universal definition of myocardial infarction (2018). Circulation 138, e618–e651 (2018).

Article  PubMed  Google Scholar 

Desmet, W. J. R., Adriaenssens, B. F. M. & Dens, J. A. Y. Apical ballooning of the left ventricle: first series in white patients. Heart 89, 1027–1031 (2003).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nascimento, F. O., Larrauri-Reyes, M. C., Santana, O., Pérez-Caminero, M. & Lamas, G. A. Comparison of stress cardiomyopathy in Hispanic and non-Hispanic patients. Rev. Esp. Cardiol. 66, 67–68 (2013).

Article  PubMed  Google Scholar 

Zaghlol, R., Dey, A. K., Desale, S. & Barac, A. Racial differences in Takotsubo cardiomyopathy outcomes in a large nationwide sample. Esc. Heart Fail. 7, 1056–1063 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Lyon, A. R. et al. Pathophysiology of Takotsubo syndrome: JACC state-of-the-art review. J. Am. Coll. Cardiol. 77, 902–921 (2021).

Article  CAS  PubMed  Google Scholar 

Crea, F., Iannaccone, G., La Vecchia, G. & Montone, R. A. An update on the mechanisms of Takotsubo syndrome: “at the end an acute coronary syndrome”. J. Mol. Cell. Cardiol. 191, 1–6 (2024).

Article  CAS  PubMed  Google Scholar 

Scally, C. et al. Myocardial and systemic inflammation in acute stress-induced (Takotsubo) cardiomyopathy. Circulation 139, 1581–1592 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Singh, T. et al. Takotsubo syndrome: pathophysiology, emerging concepts and clinical implications. Circulation 145, 1002–1019 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wittstein, I. S. et al. Neurohumoral features of myocardial stunning due to sudden emotional stress. N. Engl. J. Med. 352, 539–548 (2005).

Article  CAS  PubMed  Google Scholar 

Jha, S. et al. Clinical management in the Takotsubo syndrome. Expert Rev. Cardiovasc. Ther. 17, 83–93 (2019).

Article  CAS  PubMed  Google Scholar 

Ueyama, T. et al. Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by 608 indirect action on the nervous system and by direct action on the heart. Circ. J. 71, 565–573 (2007).

Article  CAS  PubMed  Google Scholar 

Ueyama, T. et al. Estrogen attenuates the emotional stress-induced cardiac responses in the animal model of Tako-tsubo (ampulla) cardiomyopathy. J. Cardiovasc. Pharmacol. 42, S117–S119 (2003).

Article  CAS  PubMed  Google Scholar 

Limongelli, G. et al. Takotsubo cardiomyopathy: do the genetics matter? Heart Fail. Clin. 9, 207–216 (2013).

Article  PubMed  Google Scholar 

Omerovic, E. et al. Pathophysiology of Takotsubo syndrome — a joint scientific statement from the heart failure association Takotsubo syndrome study group and myocardial function working group of the European society of cardiology — Part 1: overview and the central role for catecholamines and sympathetic nervous system. Eur. J. Heart Fail. 24, 257–273 (2022).

Article  CAS  PubMed  Google Scholar 

Omerovic, E. Takotsubo syndrome — scientific basis for current treatment strategies. Heart Fail. Clin. 12, 577–586 (2016).

Article  PubMed  Google Scholar 

Redfors, B., Shao, Y., Ali, A. & Omerovic, E. Are the different patterns of stress-induced (Takotsubo) cardiomyopathy explained by regional mechanical overload and demand: supply mismatch in selected ventricular regions? Med. Hypotheses 81, 954–960 (2013).

Article  PubMed 

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