Piber, D. et al. Sleep disturbance and activation of cellular and transcriptional mechanisms of inflammation in older adults. Brain Behav. Immun. 106, 67–75 (2022).
Article CAS PubMed Google Scholar
Leproult, R., Holmback, U. & Van Cauter, E. Circadian misalignment augments markers of insulin resistance and inflammation, independently of sleep loss. Diabetes 63, 1860–1869 (2014).
Article CAS PubMed PubMed Central Google Scholar
Copinschi, G., Leproult, R. & Spiegel, K. The important role of sleep in metabolism. Front. Horm. Res. 42, 59–72 (2014).
Irwin, M. R., Olmstead, R. & Carroll, J. E. Sleep disturbance, sleep duration, and inflammation: a systematic review and meta-analysis of cohort studies and experimental sleep deprivation. Biol. Psychiatry 80, 40–52 (2016).
Grandner, M. A. & Fernandez, F. X. The translational neuroscience of sleep: a contextual framework. Science 374, 568–573 (2021).
Article CAS PubMed PubMed Central Google Scholar
Cappuccio, F. P., Cooper, D., D’Elia, L., Strazzullo, P. & Miller, M. A. Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur. Heart J. 32, 1484–1492 (2011).
Scheer, F. A., Hilton, M. F., Mantzoros, C. S. & Shea, S. A. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc. Natl Acad. Sci. USA 106, 4453–4458 (2009).
Article CAS PubMed PubMed Central Google Scholar
Aziz, M. et al. Association of subjective and objective sleep duration as well as sleep quality with non-invasive markers of sub-clinical cardiovascular disease (CVD): a systematic review. J. Atheroscler. Thromb. 24, 208–226 (2017).
Article PubMed PubMed Central Google Scholar
Xiao, Q., Full, K. M., Rutter, M. K. & Lipworth, L. Long-term trajectories of sleep duration are associated with incident diabetes in middle-to-older-aged Black and White Americans. Diabetologia https://doi.org/10.1007/s00125-024-06202-8 (2024).
Article PubMed PubMed Central Google Scholar
Chaput, J. P. et al. The role of insufficient sleep and circadian misalignment in obesity. Nat. Rev. Endocrinol. 19, 82–97 (2023).
Article CAS PubMed Google Scholar
Potter, G. D. et al. Circadian rhythm and sleep disruption: causes, metabolic consequences, and countermeasures. Endocr. Rev. 37, 584–608 (2016).
Article CAS PubMed PubMed Central Google Scholar
Tsao, C. W. et al. Heart disease and stroke statistics–2023 update: a report from the american heart association. Circulation 147, e93–e621 (2023).
Article PubMed PubMed Central Google Scholar
Caraballo, C. et al. Evaluation of temporal trends in racial and ethnic disparities in sleep duration among US adults, 2004–2018. JAMA Netw. Open 5, e226385 (2022).
Article PubMed PubMed Central Google Scholar
Tubbs, A. S. et al. Racial/ethnic minorities have greater declines in sleep duration with higher risk of cardiometabolic disease: an analysis of the U.S. National health interview survey. Sleep Epidemiol. 2, 100022 (2022).
Article PubMed PubMed Central Google Scholar
Johnson, D. A., Jackson, C. L., Williams, N. J. & Alcantara, C. Are sleep patterns influenced by race/ethnicity - a marker of relative advantage or disadvantage? Evidence to date. Nat. Sci. Sleep. 11, 79–95 (2019).
Article PubMed PubMed Central Google Scholar
Tan, S. C. W. et al. Global burden of cardiovascular diseases and its risk factors, 1990–2021: a systematic analysis for the global burden of disease study 2021. QJM https://doi.org/10.1093/qjmed/hcaf022 (2025).
Lim, D. C. et al. The need to promote sleep health in public health agendas across the globe. Lancet Public Health 8, e820–e826 (2023).
Article PubMed PubMed Central Google Scholar
Smith, B. W. et al. The brief resilience scale: assessing the ability to bounce back. Int. J. Behav. Med. 15, 194–200 (2008).
National Institutes of Health. Trans-NIH Resilience Working Group (NIH). ods.od.nih.gov https://ods.od.nih.gov/Research/resilience.aspx (2024).
Taylor, H. A. et al. Scientific opportunities in resilience research for cardiovascular health and wellness. Report from a National Heart, Lung, and Blood Institute workshop. FASEB J. 36, e22639 (2022).
Article CAS PubMed Google Scholar
Guida, J. L. et al. Integrating sleep health into resilience research. Stress Health 39, 22–27 (2023).
Javaheri, S. et al. Sleep apnea: types, mechanisms, and clinical cardiovascular consequences. J. Am. Coll. Cardiol. 69, 841–858 (2017).
Article PubMed PubMed Central Google Scholar
National Heart, Lung, and Blood Institute. NHLBI workshop on sleep and circadian rhythms in cardiovascular resilience (NHLBI). videocast.nih.gov https://videocast.nih.gov/watch=54632 (2024).
Southwick, S. M., Bonanno, G. A., Masten, A. S., Panter-Brick, C. & Yehuda, R. Resilience definitions, theory, and challenges: interdisciplinary perspectives. Eur. J. Psychotraumatol. https://doi.org/10.3402/ejpt.v5.25338 (2014).
Brown, L., Cohen, B., Costello, R., Brazhnik, O. & Galis, Z. Conceptualizing a resilience research framework at the National Institutes of Health. Stress Health 39, 4–9 (2023).
Sartor, F. et al. Circadian clock and hypoxia. Circ. Res. 134, 618–634 (2024).
Article CAS PubMed Google Scholar
Lloyd-Jones, D. M. et al. Defining and setting national goals for cardiovascular health promotion and disease reduction: the American Heart Association’s strategic impact goal through 2020 and beyond. Circulation 121, 586–613 (2010).
Lloyd-Jones, D. M. et al. Life’s Essential 8: updating and enhancing the American Heart Association’s construct of cardiovascular health: a presidential advisory from the American Heart Association. Circulation 146, e18–e43 (2022).
Article PubMed PubMed Central Google Scholar
Sun, J. et al. Association of the American Heart Association’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality: prospective cohort study. BMC Med. 21, 116 (2023).
Article CAS PubMed PubMed Central Google Scholar
Yi, J., Wang, L., Guo, X. & Ren, X. Association of Life’s Essential 8 with all-cause and cardiovascular mortality among US adults: a prospective cohort study from the NHANES 2005–2014. Nutr. Metab. Cardiovasc. Dis. 33, 1134–1143 (2023).
Herraiz-Adillo, A. et al. Life’s Essential 8 in relation to self-rated health and health-related quality of life in a large population-based sample: the SCAPIS project. Qual. Life Res. 33, 1003–1014 (2024).
Article PubMed PubMed Central Google Scholar
Vanhoutte, P. M., Shimokawa, H., Feletou, M. & Tang, E. H. Endothelial dysfunction and vascular disease—a 30th anniversary update. Acta Physiol. 219, 22–96 (2017).
Gao, Y. & Galis, Z. S. Exploring the role of endothelial cell resilience in cardiovascular health and disease. Arterioscler. Thromb. Vasc. Biol. 41, 179–185 (2021).
Article CAS PubMed Google Scholar
Baeyens, N. et al. Vascular remodeling is governed by a VEGFR3-dependent fluid shear stress set point. eLife 4, e04645 (2015).
Article PubMed PubMed Central Google Scholar
Astone, M., Oberkersch, R. E., Tosi, G., Biscontin, A. & Santoro, M. M. The circadian protein BMAL1 supports endothelial cell cycle during angiogenesis. Cardiovasc. Res. 119, 1952–1968 (2023).
Comments (0)