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Base editing and silencing of PCSK9 shows clinical promise in humans
Base editing and silencing of PCSK9 shows clinical promise in humans
Base editing therapies to silence PCSK9 have entered clinical trials, and early results show promise for a durable ‘...
Digital screening and decision-support tools in equitable preventive cardiology
Nguyen and Vinh discuss the insights from the Apple Heart Study on digital screening for atrial fibrillation and highlight...
CD8+ T cells in atherosclerosis and coronary artery disease
CD8+ T cells in atherosclerosis and coronary artery disease
Cardiovascular diseases remain a global health challenge, with >600 million cases reported annually. Atherosclerosi...
Fractional flow reserve estimated from the invasive angiogram: limitations and next steps
Fractional flow reserve (FFR) estimated from an invasive coronary angiogram produces a biased estimate, overstating the se...
Epidemiology of non-ischaemic dilated cardiomyopathy
Epidemiology of non-ischaemic dilated cardiomyopathy
Dilated cardiomyopathy, defined by left ventricular dilatation and systolic dysfunction, is a major cause of heart failure...
Engineered blood clots designed using click clotting technology can rapidly seal bleeding sites
Engineered blood clots designed using click clotting technology can rapidly seal bleeding sites
Novel engineered blood clots, generated via the rapid crosslinking of red blood cells into tough cytogels, are superior to...
Eugene Braunwald (1929–2026)
Eugene Braunwald (1929–2026)
In this Obituary, Peter Libby reflects on the life and achievements of Eugene Braunwald, celebrated as the father of moder...
The beating heart as a tumour-suppressive niche
The beating heart as a tumour-suppressive niche
The beating of the heart does more than circulate blood; its rhythmic contractions generate forces to create a biomechanic...
Rethinking the mentoring paradigm to include mentor, sponsor and advocate
In the dynamic landscape of academic medicine, there is an increased interest in refining the traditional mentoring paradi...
Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation
Arrhythmia-induced cardiomyopathy: focus on atrial fibrillation
Arrhythmias and heart failure (HF) are common causes of morbidity and premature death worldwide, and patients who present ...
Influenza vaccination reduces hospitalization and improves heart failure outcomes
Influenza vaccination reduces hospitalization and improves heart failure outcomes
Large-scale clinical trials presented at the ESC Congress 2025 support the use of high-dose vaccination for influenza to r...
Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions
Sleep and circadian rhythms in cardiovascular resilience: mechanisms, implications, and a Roadmap for research and interventions
The interaction between sleep, circadian rhythms and cardiovascular resilience is a crucial yet underexplored research are...
Resistin-like molecule-γ promotes arrhythmia and cell death after MI
In the mouse ischaemic myocardium, neutrophils promote ventricular tachycardia via the secretion of resistin-like molecule...
Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system
Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system
The miniaturization of implantable sensors and actuators, combined with advances in interactive modelling and high-resolut...
Takotsubo syndrome: pathophysiological insights and innovations in patient care
Takotsubo syndrome: pathophysiological insights and innovations in patient care
Takotsubo syndrome, also known as broken heart syndrome, was first described in Japan in the 1990s and presents as acute h...
The global cardiovascular–liver–metabolic syndemic: epidemiology, trends and challenges
The global cardiovascular–liver–metabolic syndemic: epidemiology, trends and challenges
The growing epidemics of metabolic-dysfunction-associated steatotic liver disease, type 2 diabetes mellitus, obesity and c...
Clonal expansion of CD8+ T cells in aged mice linked to pro-atherogenic phenotype
In aged mice, but not young mice, with atherosclerosis, depletion of CD8+ T cells significantly reduces atherosclerotic le...
Levothyroxine supplementation does not improve heart transplantation from brain-dead donors
The use of intravenous levothyroxine does not increase the likelihood of hearts being transplanted from haemodynamically u...
Mosaic loss of chromosome Y and cardiovascular disease
Mosaic loss of chromosome Y and cardiovascular disease
Mosaic loss of chromosome Y (mLOY) refers to the condition in male individuals in which a detectable fraction of cells los...
Anticoagulation in patients with atrial high-rate episodes
Anticoagulation in patients with atrial high-rate episodes
The risk of stroke in patients with atrial high-rate episodes (AHREs) depends on age, comorbidities and AHRE burden. Two r...
Not a spectator sport: improving participation of Black patients in cardiovascular clinical trials
Representation of Black patients in cardiovascular clinical trials remains dismally low, reflective of systemic and struct...
Author Correction: Coronary microvascular obstruction and dysfunction in patients with acute myocardial infarction
Department of Cardiology, Maria Cecilia Hospital, GVM Care & Research, Cotignola, ItalyMattia GalliDepartment of Cardi...
Base editing therapy corrects long QT syndrome in mice
Gene therapy involving adenine base editing can correct a pathogenic variant in the Scn5a gene and alleviate arrhythmia ph...
The case for eliminating racial and ethnic cardiovascular disparities in the USA
Racial and ethnic disparities in cardiovascular health in the USA result in a persistent mortality gap between white and B...
PCI for stable angina
PCI for stable angina
In the ORBITA-2 trial, percutaneous coronary intervention was associated with a lower angina symptom score compared with a...
Non-invasive ultrasound therapy for calcified aortic valve stenosis
In patients with severe calcified aortic valve stenosis, treatment with transthoracically delivered non-invasive ultrasoun...
MINT trial signals potential benefit of liberal transfusion strategy in MI with anaemia
A liberal strategy of blood transfusion might improve outcomes in patients with acute myocardial infarction and anaemia, a...
SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes
SELECT shows cardiovascular risk reduction with weight-loss drug semaglutide in people without diabetes
Treatment with the glucagon-like peptide 1 receptor agonist semaglutide, administered subcutaneously at a dose of 2.4̴...
New insights into dietary cholesterol absorption
New insights into dietary cholesterol absorption
Aster proteins are involved in the non-vesicular transport of cholesterol derived from dietary lipids in the small intesti...
Self-monitoring strategy reduces postpartum hypertension and cardiac remodelling
In women with elevated levels of blood pressure during pregnancy, the use of a physician-guided remote telemonitoring prog...
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