Arbelo, E. et al. 2023 ESC Guidelines for the management of cardiomyopathies. Eur. Heart J. 44, 3503–3626 (2023).

Article  CAS  PubMed  Google Scholar 

Bozkurt, B. et al. Current diagnostic and treatment strategies for specific dilated cardiomyopathies: a scientific statement from the American Heart Association. Circulation 134, e579–e646 (2016).

Article  PubMed  Google Scholar 

McNally, E. M. & Mestroni, L. Dilated cardiomyopathy: genetic determinants and mechanisms. Circ. Res. 121, 731–748 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fonarow, G. C. et al. The Acute Decompensated Heart Failure National Registry (ADHERE): opportunities to improve care of patients hospitalized with acute decompensated heart failure. Rev. Cardiovasc. Med. 4, S21–S30 (2003).

PubMed  Google Scholar 

Codd, M. B., Sugrue, D. D., Gersh, B. J. & Melton, L. J. Epidemiology of idiopathic dilated and hypertrophic cardiomyopathy. A population-based study in Olmsted County, Minnesota, 1975-1984. Circulation 80, 564–572 (1989).

Article  CAS  PubMed  Google Scholar 

Brownrigg, J. R. et al. Epidemiology of cardiomyopathies and incident heart failure in a population-based cohort study. Heart 108, 1383–1391 (2022).

Article  PubMed  Google Scholar 

Lannou, S. et al. The public health burden of cardiomyopathies: insights from a nationwide inpatient study. J. Clin. Med. 9, 920 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Ababio, Y. et al. Prevalence and clinical burden of idiopathic dilated cardiomyopathy in the United States. Am. J. Med. Open 10, 100038 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Massera, D., Sherrid, M. V., Maron, M. S., Rowin, E. J. & Maron, B. J. How common is hypertrophic cardiomyopathy… really?: disease prevalence revisited 27 years after CARDIA. Int. J. Cardiol. 382, 64–67 (2023).

Article  PubMed  Google Scholar 

Hershberger, R. E., Hedges, D. J. & Morales, A. Dilated cardiomyopathy: the complexity of a diverse genetic architecture. Nat. Rev. Cardiol. 10, 531–547 (2013).

Article  CAS  PubMed  Google Scholar 

Shah, R. A. et al. Frequency, penetrance, and variable expressivity of dilated cardiomyopathy–associated putative pathogenic gene variants in UK Biobank participants. Circulation 146, 110–124 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fry, A. et al. Comparison of sociodemographic and health-related characteristics of UK Biobank participants with those of the general population. Am. J. Epidemiol. 186, 1026–1034 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Davies, M. et al. Prevalence of left-ventricular systolic dysfunction and heart failure in the Echocardiographic Heart of England Screening study: a population based study. Lancet 358, 439–444 (2001).

Article  CAS  PubMed  Google Scholar 

Redfield, M. M. et al. Burden of systolic and diastolic ventricular dysfunction in the community: appreciating the scope of the heart failure epidemic. JAMA 289, 194 (2003).

Article  PubMed  Google Scholar 

Yeboah, J. et al. Prognosis of individuals with asymptomatic left ventricular systolic dysfunction in the multi-ethnic study of atherosclerosis (MESA). Circulation 126, 2713–2719 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Rowe, S. J., Xiang, R., Paratz, E. D., Takeuchi, F. & La Gerche, A. Left ventricular size and heart failure: a cardiac MRI assessment of 38,129 individuals from the UK Biobank. Int. J. Cardiol. 419, 132687 (2025).

Article  PubMed  Google Scholar 

McGurk, K. A. et al. The penetrance of rare variants in cardiomyopathy-associated genes: a cross-sectional approach to estimating penetrance for secondary findings. Am. J. Hum. Genet. 110, 1482–1495 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shetty, N. S. et al. Association of pathogenic/likely pathogenic genetic variants for cardiomyopathies with clinical outcomes: a multiancestry analysis in the All of Us Research Program. Circ. Genom. Precis. Med. 18, e005113 (2025).

Article  CAS  PubMed  Google Scholar 

Bergan, N. et al. Systematic review, meta-analysis, and population study to determine the biologic sex ratio in dilated cardiomyopathy. Circulation 151, 442–459 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gong, I. Y. et al. Temporal trends of women enrollment in major cardiovascular randomized clinical trials. Can. J. Cardiol. 35, 653–660 (2019).

PubMed  Google Scholar 

Halliday, B. P. et al. Sex- and age-based differences in the natural history and outcome of dilated cardiomyopathy. Eur. J. Heart Fail. 20, 1392–1400 (2018).

Article  PubMed  Google Scholar 

Owen, R. et al. Sex differences in the clinical presentation and natural history of dilated cardiomyopathy. JACC Heart Fail. 12, 352–363 (2024).

Article  CAS  PubMed  Google Scholar 

Mallabone, M. et al. Sex-based differences in the phenotypic expression and prognosis of idiopathic non-ischaemic cardiomyopathy: a cardiovascular magnetic resonance study. Eur. Heart J. Cardiovasc. Imaging 25, 804–813 (2024).

Article  PubMed  Google Scholar 

Stroeks, S. L. V. M. et al. Sex differences in prognosis of patients with genetic dilated cardiomyopathy. Circ. Heart Fail. 18, e012592 (2025).

Article  PubMed  Google Scholar 

Domínguez, F. et al. Dilated cardiomyopathy due to BLC2-associated athanogene 3 (BAG3) Mutations. J. Am. Coll. Cardiol. 72, 2471–2481 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Akhtar, M. M. et al. Clinical phenotypes and prognosis of dilated cardiomyopathy caused by truncating variants in the TTN gene. Circ. Heart Fail. 13, e006832 (2020).

Article  CAS  PubMed  Google Scholar 

Hey, T. M. et al. Pathogenic RBM20-variants are associated with a severe disease expression in male patients with dilated cardiomyopathy. Circ. Heart Fail. 12, e005700 (2019).

Article  CAS  PubMed  Google Scholar 

Gigli, M. et al. Arrhythmic risk stratification of carriers of filamin c truncating variants. JAMA Cardiol. 10, 359–369 (2025).

Article  PubMed  PubMed Central  Google Scholar 

Carrick, R. T. et al. A novel tool for arrhythmic risk stratification in desmoplakin gene variant carriers. Eur. Heart J. 45, 2968–2979 (2024).

PubMed  PubMed Central  Google Scholar 

Mangino, M. et al. Sex differences in the genetic causes of dilated cardiomyopathy. J. Am. Coll. Cardiol. 86, 400–403 (2025).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barriales-Villa, R. et al. Risk predictors in a Spanish cohort with cardiac laminopathies. The REDLAMINA registry. Rev. Esp. Cardiol. 74, 216–224 (2021).

Article  PubMed  Google Scholar 

Ahmad, K. et al. Regional variation in the association of poverty and heart failure mortality in the 3135 counties of the United States. J. Am. Heart Assoc. 8, e012422 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Towbin, J. A. et al. Incidence, causes, and outcomes of dilated cardiomyopathy in children. JAMA 296, 1867 (2006).

Article  CAS