Factors Affecting Circulating Phytosterol Levels: Toward an Integrated Understanding of Atherogenicity and Atheroprotection by Dietary and Circulating Phytosterols

Sudhop T, Lütjohann D, von Bergmann K. Sterol transporters: targets of natural sterols and new lipid lowering drugs. Pharmacol Ther. 2005;105(3):333–41.

Article  PubMed  CAS  Google Scholar 

Klingberg S, Andersson H, Mulligan A, Bhaniani A, Welch A, Bingham S, et al. Food sources of plant sterols in the EPIC Norfolk population. Eur J Clin Nutr. 2007;62:695–703.

Article  PubMed  Google Scholar 

Valsta LM, Lemström A, Ovaskainen ML, Lampi AM, Toivo J, Korhonen T, et al. Estimation of plant sterol and cholesterol intake in Finland: quality of new values and their effect on intake. Br J Nutr. 2004;92(4):671–8.

Article  PubMed  CAS  Google Scholar 

Salen G, Ahrens EH Jr, Grundy SM. Metabolism of β-sitosterol in man. J Clin Invest. 1970;49(5):952–67.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Berge KE, Tian H, Graf GA, Yu L, Grishin NV, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000;290(5497):1771–5.

Article  PubMed  CAS  Google Scholar 

Lee M-H, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet. 2001;27(1):79–83.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yu L, Li-Hawkins J, Hammer RE, Berge KE, Horton JD, Cohen JC, et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest. 2002;110(5):671–80.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yu L, Hammer RE, Li-Hawkins J, von Bergmann K, Lutjohann D, Cohen JC, et al. Disruption of Abcg5 and Abcg8 in mice reveals their crucial role in biliary cholesterol secretion. Proc Natl Acad Sci USA. 2002;99(25):16237–42.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Yu L, von Bergmann K, Lutjohann D, Hobbs HH, Cohen JC. Selective sterol accumulation in ABCG5/ABCG8-deficient mice. J Lipid Res. 2004;45(2):301–7.

Article  PubMed  CAS  Google Scholar 

Graf GA, Li W-P, Gerard RD, Gelissen I, White A, Cohen JC, et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest. 2002;110(5):659–69.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Graf GA, Yu L, Li W-P, Gerard R, Tuma PL, Cohen JC, et al. ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J Biol Chem. 2003;278(48):48275–82.

Article  PubMed  CAS  Google Scholar 

Klett E, Lee M-H, Adams D, Chavin K, Patel S. Localization of ABCG5 and ABCG8 proteins in human liver, gall bladder and intestine. BMC Gastroenterol. 2004;4(1): 21.

Article  PubMed  PubMed Central  Google Scholar 

Nakano T, Inoue I, Murakoshi T. A newly integrated model for intestinal cholesterol absorption and efflux reappraises how plant sterol intake reduces circulating cholesterol levels. Nutrients. 2019;11(2):310.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Nakano T, Inoue I, Takenaka Y, Ono H, Katayama S, Awata T, et al. Ezetimibe promotes brush border membrane-to-lumen cholesterol efflux in the small intestine. PLoS One. 2016;11(3):e0152207.

Article  PubMed  PubMed Central  Google Scholar 

Miettinen TA, Klett EL, Gylling H, Isoniemi H, Patel SB. Liver transplantation in a patient with sitosterolemia and cirrhosis. Gastroenterology. 2006;130(2):542–7.

Article  PubMed  Google Scholar 

Nakano T, Inoue I, Takenaka Y, Ikegami Y, Kotani N, Shimada A, et al. Luminal plant sterol promotes brush border membrane-to-lumen cholesterol efflux in the small intestine. J Clin Biochem Nutr. 2018;63(2):102–5.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Salen G, Shefer S, Nguyen L, Ness GC, Tint GS, Shore V. Sitosterolemia. J Lipid Res. 1992;33(7):945–55.

Article  PubMed  CAS  Google Scholar 

Rocha VZ, Tada MT, Chacra APM, Miname MH, Mizuta MH. Update on sitosterolemia and atherosclerosis. Curr Atheroscler Rep. 2023;25(5):181–7.

Article  PubMed  CAS  Google Scholar 

Liu J, Chang Catherine CY, Westover Emily J, Covey Douglas F, Chang T-Y. Investigating the allosterism of acyl-CoA:cholesterol acyltransferase (ACAT) by using various sterols: in vitro and intact cell studies. Biochem J. 2005;391(2):389–97.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lin DS, Steiner RD, Merkens LS, Pappu AS, Connor WE. The effects of sterol structure upon sterol esterification. Atherosclerosis. 2010;208(1):155–60.

Article  PubMed  CAS  Google Scholar 

Salen G, Horak I, Rothkopf M, Cohen JL, Speck J, Tint GS, et al. Lethal atherosclerosis associated with abnormal plasma and tissue sterol composition in sitosterolemia with xanthomatosis. J Lipid Res. 1985;26(9):1126–33.

Article  PubMed  CAS  Google Scholar 

Sakata K, Kioka N, Ueda K, Kimura Y. The ATPase activity of ABCA1 is increased by cholesterol in the presence of anionic lipids. J Biol Chem. 2024;175(6):599–609.

Google Scholar 

Escolà-Gil JC, Quesada H, Julve J, Martín-Campos JM, Cedó L, Blanco-Vaca F. Sitosterolemia: diagnosis, investigation, and management. Curr Atheroscler Rep. 2014;16(7):424.

Article  PubMed  Google Scholar 

Makhmudova U, Schulze PC, Lütjohann D, Weingärtner O. Phytosterols and cardiovascular disease. Curr Atheroscler Rep. 2021;23(11):68.

Article  PubMed  PubMed Central  Google Scholar 

Scholz M, Horn K, Pott J, Gross A, Kleber ME, Delgado GE, et al. Genome-wide meta-analysis of phytosterols reveals five novel loci and a detrimental effect on coronary atherosclerosis. Nat Commun. 2022;13(1):143.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Helgadottir A, Thorleifsson G, Alexandersson KF, Tragante V, Thorsteinsdottir M, Eiriksson FF, et al. Genetic variability in the absorption of dietary sterols affects the risk of coronary artery disease. Eur Heart J. 2020;41(28):2618–28.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Loh WJ, Watts GF. Xenosterolemia in clinical practice: what is in a name? Curr Opin Endocrinol Diabetes Obes. 2023;30(2):123–7.

Article  PubMed  Google Scholar 

Glueck CJ, Speirs J, Tracy T, Streicher P, Illig E, Vandegrift J. Relationships of serum plant sterols (phytosterols) and cholesterol in 595 hypercholesterolemic subjects, and familial aggregation of phytosterols, cholesterol, and premature coronary heart disease in hyperphytosterolemic probands and their first-degree relatives. Metabolism. 1991;40(8):842–8.

Article  PubMed  CAS  Google Scholar 

Kritchevsky D, Chen SC. Phytosterols—health benefits and potential concerns: a review. Nutr Res. 2005;25(5):413–28.

Article  CAS  Google Scholar 

Hidaka H, Sugiura H, Nakamura T-A, Kojima H, Fujita M, Sugie N, et al. β-Sitosterolemia with generalized eruptive xanthomatosis. Endocr J. 1997;44(1):59–64.

Article  PubMed  CAS  Google Scholar 

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