Desialylated vs. Oxidized LDL: Sialidase Inhibitors as Promising Antiatherosclerotic Agents

Morin RJ, Peng SK. The role of cholesterol oxidation products in the pathogenesis of atherosclerosis. Ann Clin Lab Sci. 1989;19(4):225–37.

CAS  PubMed  Google Scholar 

Bagheri B, Khatibiyan Feyzabadi Z, Nouri A, Azadfallah A, Mahdizade Ari M, Hemmati M, et al. Atherosclerosis and Toll-Like Receptor4 (TLR4), Lectin-Like Oxidized Low-Density Lipoprotein-1 (LOX-1), and Proprotein Convertase Subtilisin/Kexin Type9 (PCSK9). Mediators Inflamm. 2024;2024:5830491.

Article  PubMed  PubMed Central  Google Scholar 

Gianopoulos I, Daskalopoulou SS. Macrophage profiling in atherosclerosis: understanding the unstable plaque. Basic Res Cardiol. 2024;119(1):35–56.

Article  PubMed  Google Scholar 

Truthe S, Klassert TE, Schmelz S, Jonigk D, Blankenfeldt W, Slevogt H. Role of Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 in inflammation and pathogen-associated interactions. J Innate Immun. 2024;16(1):105–32.

CAS  PubMed  PubMed Central  Google Scholar 

Pyrpyris N, Dimitriadis K, Beneki E, Iliakis P, Soulaidopoulos S, Tsioufis P, et al. LOX-1 receptor: a diagnostic tool and therapeutic target in atherogenesis. Curr Probl Cardiol. 2024;49(1 Pt C):102117.

Article  PubMed  Google Scholar 

Orekhov AN. We must abandon the myth: oxidized low-density lipoprotein is not a lipoprotein that plays a key role in atherogenesis. Curr Med Chem. 2024.

Sala P, Pötz S, Brunner M, Trötzmüller M, Fauland A, Triebl A, et al. Determination of oxidized phosphatidylcholines by hydrophilic interaction liquid chromatography coupled to Fourier transform mass spectrometry. Int J Mol Sci. 2015;16(4):8351–63.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tertov VV, Kaplun VV, Dvoryantsev SN, Orekhov AN. Apolipoprotein B-bound lipids as a marker for evaluation of low density lipoprotein oxidation in vivo. Biochem Biophys Res Commun. 1995;214(2):608–13.

Article  CAS  PubMed  Google Scholar 

Steinberg D. Is there a potential therapeutic role for vitamin E or other antioxidants in atherosclerosis? Curr Opin Lipidol. 2000;11(6):603–7.

Article  CAS  PubMed  Google Scholar 

Kris-Etherton PM, Lichtenstein AH, Howard BV, Steinberg D, Witztum JL, Nutrition Committee of the American Heart Association Council on Nutrition, Physical Activity, and Metabolism. Antioxidant vitamin supplements and cardiovascular disease. Circulation. 2004;110(5):637–41.

Article  CAS  PubMed  Google Scholar 

Orekhov A, Khotina V, Sukhorukov V, Sobenin I. Non-oxidative vs oxidative forms of modified low-density lipoprotein: what is more important in atherogenesis? Curr Med Chem. 2024.

Zhao Y, Xu Q, He N, Jiang M, Chen Y, Ren Z, Tang Z, Wu C. Liu, L. Non-oxidative modified low-density lipoproteins: The underappreciated risk factors for atherosclerosis. Curr Med Chem. 2023.

Chellan B, Rojas E, Zhang C, Hofmann Bowman MA. Enzyme-modified non-oxidized LDL (ELDL) induces human coronary artery smooth muscle cell transformation to a migratory and osteoblast-like phenotype. Sci Rep. 2018;8(1):11954.

Article  PubMed  PubMed Central  Google Scholar 

Hirano T, Ito Y, Saegusa H, Yoshino G. A novel and simple method for quantification of small, dense LDL. J Lipid Res. 2003;44(11):2193–201.

Article  CAS  PubMed  Google Scholar 

Packard C, Caslake M, Shepherd J. The role of small, dense low density lipoprotein (LDL): a new look. Int J Cardiol. 2000;74(Suppl 1):S17-22.

Article  PubMed  Google Scholar 

Tribble DL, Rizzo M, Chait A, Lewis DM, Blanche PJ, Krauss RM. Enhanced oxidative susceptibility and reduced antioxidant content of metabolic precursors of small, dense low-density lipoproteins. Am J Med. 2001;110(2):103–10.

Article  CAS  PubMed  Google Scholar 

Krauss RM, Lindgren FT, Ray RM. Interrelationships among subgroups of serum lipoproteins in normal human subjects. Clin Chim Acta. 1980;104(3):275–90.

Article  CAS  PubMed  Google Scholar 

Havel RJ, Eder HA, Bragdon JH. The distribution and chemical composition of ultracentrifugally separated lipoproteins in human serum. J Clin Invest. 1955;34(9):1345–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Williams PT, Vranizan KM, Krauss RM. Correlations of plasma lipoproteins with LDL subfractions by particle size in men and women. J Lipid Res. 1992;33:765–74.

Article  CAS  PubMed  Google Scholar 

Otvos JD, Jeyarajah EJ, Bennett DW, Krauss RM. Development of a proton nuclear magnetic resonance spectroscopic method for determining plasma lipoprotein concentrations and subspecies distributions from a single, rapid measurement. Clin Chem. 1992;38(9):1632–8.

Article  CAS  PubMed  Google Scholar 

Caulfield MP, Li S, Lee G, Blanche PJ, Salameh WA, Benner WH, Reitz RE, Krauss RM. Direct determination of lipoprotein particle sizes and concentrations by ion mobility analysis. Clin Chem. 2008;54(8):1307–16.

Article  CAS  PubMed  Google Scholar 

Musunuru K, Orho-Melander M, Caulfield MP, Li S, Salameh WA, Reitz RE, et al. Ion mobility analysis of lipoprotein subfractions identifies three independent axes of cardiovascular risk. Arterioscler Thromb Vasc Biol. 2009;29(11):1975–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Berneis KK, Krauss RM. Metabolic origins and clinical significance of LDL heterogeneity. J Lipid Res. 2002;43:1363–79.

Article  CAS  PubMed  Google Scholar 

Krauss RM, Williams PT, Lindgren FT, Wood PD. Coordinate changes in levels of human serum low and high density lipoprotein subclasses in healthy men. Arteriosclerosis. 1988;8(2):155–62.

Article  CAS  PubMed  Google Scholar 

Musunuru K, Strong A, Frank-Kamenetsky M, Lee NE, Ahfeldt T, Sachs KV, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010;466(7307):714–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

La Belle M, Krauss RM. Differences in carbohydrate content of low density lipoproteins associated with low density lipoprotein subclass patterns. J Lipid Res. 1990;31(9):1577–88.

Article  CAS  PubMed  Google Scholar 

Jaakkola O, Solakivi T, Tertov VV, Orekhov AN, Miettinen TA, Nikkari T. Characteristics of low-density lipoprotein subfractions from patients with coronary artery disease. Coron Artery Dis. 1993;4(4):379–85.

Article  CAS  PubMed  Google Scholar 

Zakiev ER, Sobenin IA, Sukhorukov VN, Myasoedova VA, Ivanova EA, Orekhov AN. Carbohydrate composition of circulating multiple-modified low-density lipoprotein. Vasc Health Risk Manag. 2016;15(1):134.

CAS  Google Scholar 

Aksenov DV, Medvedeva LA, Skalbe TA, Sobenin IA, Tertov VV, Gabbasov ZA, et al. Deglycosylation of apo B-containing lipoproteins increase their ability to aggregate and to promote intracellular cholesterol accumulation in vitro. Arch Physiol Biochem. 2008;114(5):349–56.

Article  CAS  PubMed  Google Scholar 

Tribble DL, van den Berg JJ, Motchnik PA, Ames BN, Lewis DM, Chait A, et al. Oxidative susceptibility of low density lipoprotein subfractions is related to their ubiquinol-10 and alpha-tocopherol content. Proc Natl Acad Sci U S A. 1994;91(3):1183–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Avogaro P, Cazzolato G, Bittolo-Bon G. Some questions concerning a small, more electronegative LDL circulating in human plasma. Atherosclerosis. 1991;91(1–2):163–71.

Article  CAS  PubMed  Google Scholar 

Cazzolato G, Avogaro P, Bittolo-Bon G. Characterization of a more electronegatively charged LDL subfraction by ion exchange HPLC. Free Radic Biol Med. 1991;11(3):247–53.

Article  CAS  PubMed  Google Scholar 

Schauer R, Srinivasan GV, Wipfler D, Kniep B, Schwartz-Albiez R. O-Acetylated sialic acids and their role in immune defense. Adv Exp Med Biol. 2011;705:525–48.

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