Spontaneous Coronary Artery Dissection: Advances in Understanding and Management in Women

Saw J, Starovoytov A, Humphries K, Sheth T, So D, Minhas K, et al. Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes. Eur Heart J. 2019;40:1188–97. https://doi.org/10.1093/eurheartj/ehz007.

Article  PubMed  PubMed Central  Google Scholar 

Lettieri C, Zavalloni D, Rossini R, Morici N, Ettori F, Leonzi O, et al. Management and long-term prognosis of spontaneous coronary artery dissection. Am J Cardiol. 2015;116:66–73. https://doi.org/10.1016/j.amjcard.2015.03.039.

Article  PubMed  Google Scholar 

Luong C, Starovoytov A, Heydari M, Sedlak T, Aymong E, Saw J. Clinical presentation of patients with spontaneous coronary artery dissection. Catheter Cardiovasc Interv. 2017;89:1149–54. https://doi.org/10.1002/ccd.26977.

Article  PubMed  Google Scholar 

Hayes SN, Tweet MS, Adlam D, Kim ESH, Gulati R, Price JE, et al. Spontaneous coronary artery dissection: JACC state-of-the-art review. J Am Coll Cardiol. 2020;76:961–84. https://doi.org/10.1016/j.jacc.2020.05.084.

Article  PubMed  Google Scholar 

Prasad M, Tweet MS, Hayes SN, Leng S, Liang JJ, Eleid MF, et al. Prevalence of extracoronary vascular abnormalities and fibromuscular dysplasia in patients with spontaneous coronary artery dissection. Am J Cardiol. 2015;115:1672–7. https://doi.org/10.1016/j.amjcard.2015.03.011.

Article  PubMed  Google Scholar 

Bcharah H, Bcharah G, Nabi HA, Dreher L, Ibrahim R, Abdelnabi M, et al. Extracoronary arterial pathologies in patients with spontaneous coronary artery dissection. Am J Cardiol. 2025;258:151–7. https://doi.org/10.1016/j.amjcard.2025.08.042.

Article  PubMed  Google Scholar 

Saw J, Starovoytov A, Aymong E, Inohara T, Alfadhel M, McAlister C, et al. Canadian spontaneous coronary artery dissection cohort study: 3-year outcomes. J Am Coll Cardiol. 2022;80:1585–97. https://doi.org/10.1016/j.jacc.2022.08.759.

Article  PubMed  Google Scholar 

Saw J, Ricci D, Starovoytov A, Fox R, Buller CE. Spontaneous coronary artery dissection: prevalence of predisposing conditions including fibromuscular dysplasia in a tertiary center cohort. JACC Cardiovasc Interv. 2013;6:44–52. https://doi.org/10.1016/j.jcin.2012.08.017.

Article  PubMed  Google Scholar 

Rayner-Hartley E, Verma T, Starovoytov A, Aymong E, Nicolau S, Saw J. Catheter-based angiography versus CT angiography for the diagnosis of extracoronary fibromuscular dysplasia in patients with spontaneous coronary artery dissection. Cardiovasc Diagn Ther. 2021;11:142–5. https://doi.org/10.21037/cdt-20-71.

Article  PubMed  PubMed Central  Google Scholar 

Benson JC, Lehman VT, Verdoorn JT, Shlapak DP, Hayes SN, Tweet MS. Prevalence of cervical artery abnormalities on CTA in patients with spontaneous coronary artery dissection: fibromuscular dysplasia, dissection, aneurysm, and tortuosity. AJNR Am J Neuroradiol. 2021;42:1497–502. https://doi.org/10.3174/ajnr.A7151.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tweet MS, Pellikka PA, Gulati R, Gochanour BR, Barrett-O’Keefe Z, Raphael CE, et al. Coronary artery tortuosity and spontaneous coronary artery dissection: association with echocardiography and global longitudinal strain, fibromuscular dysplasia, and outcomes. J Am Soc Echocardiogr. 2024;37:518–29. https://doi.org/10.1016/j.echo.2024.02.013.

Article  PubMed  PubMed Central  Google Scholar 

McNair PW, Parker A, Taylor A, Battle R, Norton P, Sharma AM. Spontaneous coronary artery dissection and its association with fibromuscular dysplasia and other vascular abnormalities. Am J Cardiol. 2020;125:34–9. https://doi.org/10.1016/j.amjcard.2019.09.043.

Article  PubMed  Google Scholar 

Goel K, Tweet M, Olson TM, Maleszewski JJ, Gulati R, Hayes SN. Familial spontaneous coronary artery dissection: evidence for genetic susceptibility. JAMA Intern Med. 2015;175:821–6. https://doi.org/10.1001/jamainternmed.2014.8307.

Article  PubMed  Google Scholar 

Henkin S, Negrotto SM, Tweet MS, Kirmani S, Deyle DR, Gulati R, et al. Spontaneous coronary artery dissection and its association with heritable connective tissue disorders. Heart. 2016;102:876–81. https://doi.org/10.1136/heartjnl-2015-308645.

Article  PubMed  Google Scholar 

Kaadan MI, MacDonald C, Ponzini F, Duran J, Newell K, Pitler L, et al. Prospective cardiovascular genetics evaluation in spontaneous coronary artery dissection. Circulation: Genomic and Precision Medicine. 2018;11:e001933. https://doi.org/10.1161/CIRCGENETICS.117.001933.

Article  CAS  PubMed  Google Scholar 

Richer J, Hill HL, Wang Y, Yang M-L, Hunker KL, Lane J, et al. A novel recurrent COL5A1 genetic variant is associated with a dysplasia-associated arterial disease exhibiting dissections and fibromuscular dysplasia. Arterioscler Thromb Vasc Biol. 2020;40:2686–99. https://doi.org/10.1161/ATVBAHA.119.313885.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Starovoytov A, Murad AM, Hunker KL, Brunham LR, Li JZ, et al. Burden of Rare Genetic Variants in Spontaneous Coronary Artery Dissection With High-risk Features. JAMA Cardiol. 2022;7:1045–55. https://doi.org/10.1001/jamacardio.2022.2970.

Article  PubMed  PubMed Central  Google Scholar 

Adlam D, Berrandou T-E, Georges A, Nelson CP, Giannoulatou E, Henry J, et al. Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation. Nat Genet. 2023;55:964–72. https://doi.org/10.1038/s41588-023-01410-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amrani-Midoun A, Adlam D, Bouatia-Naji N. Recent advances on the genetics of spontaneous coronary artery dissection. Circ Genom Precis Med. 2021;14:e003393. https://doi.org/10.1161/CIRCGEN.121.003393.

Article  CAS  PubMed  Google Scholar 

Adlam D, Olson TM, Combaret N, Kovacic JC, Iismaa SE, Al-Hussaini A, et al. Association of the PHACTR1/EDN1 Genetic Locus With Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2019;73:58–66. https://doi.org/10.1016/j.jacc.2018.09.085.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tweet MS, Hayes SN, Codsi E, Gulati R, Rose CH, Best PJM. Spontaneous Coronary Artery Dissection Associated With Pregnancy. J Am Coll Cardiol. 2017;70:426–35. https://doi.org/10.1016/j.jacc.2017.05.055.

Article  PubMed  Google Scholar 

Sheikh AS, O′Sullivan M. Pregnancy-related spontaneous coronary artery dissection: two case reports and a comprehensive review of literature. Heart Views. 2012;13:53. https://doi.org/10.4103/1995-705X.99229.

Article  PubMed  PubMed Central  Google Scholar 

Sader MA, Celermajer DS. Endothelial function, vascular reactivity and gender differences in the cardiovascular system. Cardiovasc Res. 2002;53:597–604. https://doi.org/10.1016/S0008-6363(01)00473-4.

Article  CAS  PubMed  Google Scholar 

Koller PT, Cliffe CM, Ridley DJ. Immunosuppressive therapy for peripartum-type spontaneous coronary artery dissection: case report and review. Clin Cardiol. 1998;21:40–6. https://doi.org/10.1002/clc.4960210108.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sedlak T, Starovoytov A, Humphries K, Saw J. Coronary flow reserve in patients with prior spontaneous coronary artery dissection and recurrent angina. J Am Heart Assoc. 2020;9:e015834. https://doi.org/10.1161/JAHA.120.015834.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Saw J, Aymong E, Sedlak T, Buller CE, Starovoytov A, Ricci D, et al. Spontaneous coronary artery dissection: association with predisposing arteriopathies and precipitating stressors and cardiovascular outcomes. Circ Cardiovasc Interv. 2014;7:645–55. https://doi.org/10.1161/CIRCINTERVENTIONS.114.001760.

Article  PubMed  Google Scholar 

Saw J. Coronary angiogram classification of spontaneous coronary artery dissection. Catheter Cardiovasc Interv. 2014;84:1115–22. https://doi.org/10.1002/ccd.25293.

Article  PubMed  Google Scholar 

Offen S, Kang M, Grewal T, Fung A, Aymong E, Sheth T, et al. Safety of intracoronary imaging in patients with spontaneous coronary artery dissection. Can J Cardiol. 2024. https://doi.org/10.1016/j.cjca.2024.06.002.

Article 

Comments (0)

No login
gif