Climate Change, Air Pollution and the Global Obesity Syndemic: a Review of Current Evidence

WHO Facts, available online at: http://www.who.int./health-topics/obesity. (assessed on August 31, 2025).

GBD. Adult BMI Collaborators 2025 Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet. 2021;405(10481):813–38. https://doi.org/10.1016/S0140-6736(25)00355-1.

Article  Google Scholar 

Spyrou N, Vallianou N, Kadillari J, Dalamaga M. The interplay of obesity, gut microbiome and diet in the immune check point inhibitors therapy era. Semin Cancer Biol. 2021;73:356–76. https://doi.org/10.1016/j.semcancer.2021.05.008.

Article  PubMed  CAS  Google Scholar 

Marouga A, Dalamaga M, Kastania AN, Kroupis C, Lagiou M, Saounatsou K, et al. Circulating resistin is a significant predictor of mortality independently from cardiovascular comorbidities in elderly, non-diabetic subjects with chronic kidney disease. Biomarkers. 2016;21(1):73–9. https://doi.org/10.3109/1354750X.2015.1118536.

Article  PubMed  CAS  Google Scholar 

Dalamaga M, Karmaniolas K, Nikolaidou A, Chamberland J, Hsi A, Dionyssiou-Asteriou A, et al. Adiponectin and resistin are associated with risk for myelodysplastic syndrome, independently from the insulin-like growth factor-I (IGF-I) system. Eur J Cancer. 2008;44(12):1744–53. https://doi.org/10.1016/j.ejca.2008.04.015.

Article  PubMed  CAS  Google Scholar 

Pavlidou A, Dalamaga M, Kroupis C, Konstantoudakis G, Belimezi M, Athanasas G, et al. Survivin isoforms and clinicopathological characteristics in colorectal adenocarcinomas using real-time qPCR. World J Gastroenterol. 2011;17(12):1614–21. https://doi.org/10.3748/wjg.v17.i12.1614.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dalamaga M, Karmaniolas K, Matekovits A, Migdalis I, Papadavid E. Cutaneous manifestations in relation to immunologic parameters in a cohort of primary myelodysplastic syndrome patients. J Eur Acad Dermatol Venereol. 2008;22(5):543–8. https://doi.org/10.1111/j.1468-3083.2007.02520.x.

Article  PubMed  CAS  Google Scholar 

Dalamaga M, Karmaniolas K, Papadavid E, Pelekanos N, Sotiropoulos G, Lekka A. Hyperresistinemia is associated with postmenopausal breast cancer. Menopause. 2013;20(8):845–51. https://doi.org/10.1097/GME.0b013e31827f06dc.

Article  PubMed  Google Scholar 

Dalamaga M, Karmaniolas K, Chamberland J, Nikolaidou A, Lekka A, Dionyssiou-Asteriou A, et al. Higher fetuin-A, lower adiponectin and free leptin levels mediate effects of excess body weight on insulin resistance and risk for myelodysplastic syndrome. Metabolism. 2013;62(12):1830–9. https://doi.org/10.1016/j.metabol.2013.09.007.

Article  PubMed  CAS  Google Scholar 

Tsilingiris D, Vallianou NG, Karampela I, Dalamaga M. Vaccine induced thrombotic thrombocytopenia: The shady chapter of a success story. Metabol Open. 2021;11:100101. https://doi.org/10.1016/j.metop.2021.100101.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vallianou NG, Kounatidis D, Psallida S, Vythoulkas-Biotis N, Adamou A, Zachariadou T, et al. NAFLD/MASLD and the gut-liver axis: from pathogenesis to treatment options. Metabolites. 2024;14(7):366. https://doi.org/10.3390/metabo14070366.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Cypess AM. Reassessing human adipose tissue. N Engl J Med. 2022;386(8):768–79. https://doi.org/10.1056/NEJMra2032804.

Article  PubMed  CAS  Google Scholar 

Loos RJF. Genetic causes of obesity: mapping a path forward. Trends Mol Med. 2025;31(4):319–25. https://doi.org/10.1016/j.molmed.2025.02.002.

Article  PubMed  CAS  Google Scholar 

Geladari EV, Kounatidis D, Christodoulatos GS, Psallida S, Pavlou A, Geladari CV, et al. Ultra-processed foods and metabolic dysfunction-associated steatotic liver disease (MASLD): what is the evidence so far? Nutrients. 2025;17(13):2098. https://doi.org/10.3390/nu17132098.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Anastasiou IA, Kounatidis D, Vallianou NG, Skourtis A, Dimitriou K, Tzivaki I, et al. Beneath the surface: the emerging role of ultra-processed foods in obesity-related cancer. Curr Oncol Rep. 2025;27(4):390–414. https://doi.org/10.1007/s11912-025-01654-6.

Article  PubMed  PubMed Central  Google Scholar 

Vallianou NG, Evangelopoulos A, Tzivaki I, Daskalopoulou S, Adamou A, Michalaki Zafeiri GC, et al. Ultra-processed foods and type 2 diabetes mellitus: what is the evidence so far? Biomolecules. 2025;15(2):307. https://doi.org/10.3390/biom15020307.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vallianou NG, Kounatidis D, Tzivaki I, Zafeiri GCM, Rigatou A, Daskalopoulou S, et al. Ultra-processed foods and childhood obesity: current evidence and perspectives. Curr Nutr Rep. 2025;14(1):5. https://doi.org/10.1007/s13668-024-00596-y.

Article  PubMed  Google Scholar 

Bell ML, Gasparrini A, Benjamin GC. Climate change, extreme heat, and health. N Engl J Med. 2024;390(19):1793–801. https://doi.org/10.1056/NEJMra2210769.

Article  PubMed  Google Scholar 

Hannan FM, Leow MKS, Lee JKW, Kovats S, Elajnaf T, Kennedy SH, et al. Endocrine effects of heat exposure and relevance to climate change. Nat Rev Endocrinol. 2024;20(11):673–84. https://doi.org/10.1038/s41574-024-01017-4.

Article  PubMed  Google Scholar 

Koch CA, Sharda P, Patel J, Gubbi S, Bansal R, Bartel MJ. Climate change and obesity. Horm Metab Res. 2021;53(9):575–87. https://doi.org/10.1055/a-1533-2861.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Minos D, Butzlaff I, Demmler KM, Rischke R. Economic growth, climate change, and obesity. Curr Obes Rep. 2016;5(4):441–8. https://doi.org/10.1007/s13679-016-0234-7.

Article  PubMed  Google Scholar 

Rhim N, Lee S, Choi KH. Adverse health effects of climate change and air pollution in people with disabilities: a systematic review. Epidemiol Health. 2024;46:e2024080. https://doi.org/10.4178/epih.e2024080.

Article  PubMed  PubMed Central  Google Scholar 

Stojchevski R, Chandrasekaran P, Hadzi-Petrushev N, Mladenov M, Avtanski D. Adipose tissue dysfunction related to climate change and air pollution: understanding the metabolic consequences. Int J Mol Sci. 2024;25(14):7849. https://doi.org/10.3390/ijms25147849.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kutlu L. Greenhouse gas emission efficiencies of world countries. Int J Environ Res Public Health. 2020;17(23):8771. https://doi.org/10.3390/ijerph17238771.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kutlu L, Wang R. Greenhouse gas emission inefficiency spillover effects in European countries. Int J Environ Res Public Health. 2021;18(9):4479. https://doi.org/10.3390/ijerph18094479.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Singaravadivelan A, Sachin PB, Harikumar S, Vijayakumar P, Vindhya MV, Farhana FMB, et al. Life cycle assessment of greenhouse gas emission from the dairy production system - review. Trop Anim Health Prod. 2023;55(5):320. https://doi.org/10.1007/s11250-023-03748-4.

Article  PubMed  CAS  Google Scholar 

Swinburn BA, Kraak VI, Allender S, Atkins VJ, Baker PI, Bogard JR, et al. The global syndemic of obesity, undernutrition, and climate change: the Lancet commission report. Lancet. 2019;393(10173):791–846. https://doi.org/10.1016/S0140-6736(18)32822-8.

Article  PubMed  Google Scholar 

Devarajan R, Prabhakaran D, Goenka S. Built environment for physical activity-an urban barometer, surveillance, and monitoring. Obes Rev. 2020;21(1):e12938. https://doi.org/10.1111/obr.12938.

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