Understanding predictors of medication adherence and treatment outcomes among TB patients in the Western Region, Ghana: strategies for strengthening TB control efforts

WHO. Tuberculosis [Internet]. 2023 [cited 2025 Mar 28]. Available from: https://www.who.int/news-room/fact-sheets/detail/tuberculosis

Centre for Disease Control [CDC]. Tuberculosis: Causes and How It Spreads [Internet]. 2023 [cited 2025 Mar 28]. Available from: https://www.cdc.gov/tb/causes/index.html

Nasir BB, Muhammed OS, Tamiru MT, Chelkeba L. Assessing the impact of COVID-19 on tuberculosis detection and treatment in healthcare facilities across Addis Ababa, Ethiopia: A comprehensive mixed-method, multi-center study. PLoS One [Internet]. 2024 Oct 1 [cited 2025 Sep 11];19(10):e0311408. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0311408

Yang H, Ruan X, Li W, Xiong J, Zheng Y. Global, regional, and national burden of tuberculosis and attributable risk factors for 204 countries and territories, 1990–2021: a systematic analysis for the Global Burden of Diseases 2021 study. BMC Public Health. 2024;24(1):3111. https://doi.org/10.1186/s12889-024-20664-w.

Article  PubMed  PubMed Central  Google Scholar 

Al-Worafi YM. Infectious Disease Causes and Risk Factors in Developing Countries: Adults. Handb Med Heal Sci Dev Ctries [Internet]. 2024 [cited 2025 Mar 28];1–23. Available from: https://link.springer.com/referenceworkentry/https://doi.org/10.1007/978-3-030-74786-2_328-1

Scott GY, Aborode AT, Adesola RO, Benson K, Omulepu I, Ajayi OO et al. Diagnostic innovations for tuberculosis in sub-Saharan Africa. Discov public Heal [Internet]. 2025 Dec 1 [cited 2025 Sep 12];22(1):1–24. Available from: https://link.springer.com/article/https://doi.org/10.1186/s12982-025-00593-8

Torpey K, Agyei-Nkansah A, Ogyiri L, Forson A, Lartey M, Ampofo W et al. Management of TB/HIV co-infection: the state of the evidence. Ghana Med J [Internet]. 2020 Sep 1 [cited 2025 Mar 28];54(3):186. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC8042796/

Atake EH. Health system productivity in sub-Saharan Africa: tuberculosis control in high burden countries. Cost Eff Resour Alloc. 2023;21(1):1–11. https://doi.org/10.1186/s12962-023-00485-1.

Article  Google Scholar 

Appiah MA, Arthur JA, Gborgblorvor D, Asampong E, Kye-Duodu G, Kamau EM et al. Barriers to tuberculosis treatment adherence in high-burden tuberculosis settings in Ashanti region, Ghana: a qualitative study from patient’s perspective. BMC Public Health [Internet]. 2023 Dec 1 [cited 2025 Jul 19];23(1):1–12. Available from: https://bmcpublichealth.biomedcentral.com/articles/https://doi.org/10.1186/s12889-023-16259-6

Zegeye A, Dessie G, Wagnew F, Gebrie A, Islam SMS, Tesfaye B et al. Prevalence and determinants of anti-tuberculosis treatment non-adherence in Ethiopia: A systematic review and meta-analysis. PLoS One [Internet]. 2019 Jan 1 [cited 2025 Mar 28];14(1). Available from: https://pubmed.ncbi.nlm.nih.gov/30629684/

Ardila Lailatul B, Retno I, Sulistiawati S. The role of social support on treatment adherence in Tb patients: a systematic review. Nurse Heal J Keperawatan [Internet]. 2020 Dec 27 [cited 2025 Mar 28];9(2):201–10. Available from: https://ejournal-kertacendekia.id/index.php/nhjk/article/view/186

Noguchi Memorial Institute. Tuberculosis - The Noguchi Memorial Institute for Medical Research [Internet]. 2025 [cited 2025 Mar 28]. Available from: https://noguchi.ug.edu.gh/main-research/tuberculosis/

Gyimah FT, Dako-Gyeke P. Perspectives on TB patients’ care and support: A qualitative study conducted in Accra Metropolis, Ghana. Global Health [Internet]. 2019 Mar 5 [cited 2025 Mar 28];15(1):1–9. Available from: https://link.springer.com/articles/https://doi.org/10.1186/s12992-019-0459-9

Yakubu S, Cecilia E. Tuberculosis treatment adherence in Ghana: patients’ perspectives of barriers and enablers to treatment. An Int J Nurs Midwifery [Internet]. 2017 [cited 2025 Mar 28]; Available from: http://ir.ucc.edu.gh:8080/xmlui/bitstream/handle/123456789/8148/Awareness and knowledge of gestational diabetes mellitus among pregnant women at the Tema General Hospital%2 C Ghana.pdf?sequence = 1&isAllowed = y#page = 19.

WHO. Adherence to long-term therapies: evidence for action. Geneva; 2003.

Lemma Tirore L, Ersido T, Beyene Handiso T, Shiferaw Areba A. Non-adherence to anti-tuberculosis treatment and associated factors among TB patients in public health facilities of Hossana town, Southern Ethiopia, 2022. Front Med. 2024;11:1360351.

Article  Google Scholar 

Kamarul Zaman MF, Nik Husain NR, Sidek MY, Abu Bakar Z. Determinants of unfavourable treatment outcomes of drug-resistant tuberculosis cases in Malaysia: a case–control study. BMJ Open [Internet]. 2025 Feb 1 [cited 2025 Mar 28];15(2):e093391. Available from: https://bmjopen.bmj.com/content/15/2/e093391

Rosenstock IM. Historical origins of the health belief model. Heal Educ Behav [Internet]. 1974;2(4):328–35. https://doi.org/10.1177/109019817400200403.

Article  Google Scholar 

Bandura A. Social Foundations of Thought and Action: A Social Cognitive Theory. Prentice Hall [Internet]. 1986 [cited 2025 Mar 15];16(1):20002. Available from: https://search.worldcat.org/title/783975129

Grigoryan Z, McPherson R, Harutyunyan T, Truzyan N, Sahakyan S. Factors Influencing Treatment Adherence Among Drug-Sensitive Tuberculosis (DS-TB) Patients in Armenia: A Qualitative Study. Patient Prefer Adherence [Internet]. 2022 Sep 1 [cited 2025 Jul 19];16:2399–408. Available from: https://www.dovepress.com/factors-influencing-treatment-adherence-among-drug-sensitive-tuberculo-peer-reviewed-fulltext-article-PPA

Berhan A, Almaw A, Solomon Y, Legese B, Damtie S, Erkihun M et al. Tuberculosis Treatment Outcome and Associated Factors Among Tuberculosis Patients Linked to Tuberculosis Treatment Clinics in Ethiopia, 2023: A Multi-Center Retrospective Study. Infect Drug Resist [Internet]. 2023 [cited 2025 Mar 28];16:3367. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10239251/

Puplampu P, Kyeremateng I, Asafu-Adjaye O, Asare AA, Agyabeng K, Sarkodee R et al. Evaluation of treatment outcomes among adult patients diagnosed with tuberculosis in Ghana: A 10 year retrospective review. IJID Reg [Internet]. 2023 Mar 1 [cited 2025 Mar 29];10:9. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC10687693/

Opito R, Kwenya K, Ssentongo SM, Kizito M, Alwedo S, Bakashaba B et al. Treatment success rate and associated factors among drug susceptible tuberculosis individuals in St. Kizito Hospital, Matany, Napak district, Karamoja region. A retrospective study. PLoS One [Internet]. 2024 May 1 [cited 2025 Jul 19];19(5):e0300916. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0300916

Effia Kwesimintsim MHD. Effia Kwesimintsim municipal annual report 2023. Kwesimintsim; 2024.

Zenbaba D, Bonsa M, Sahiledengle B. Trends of unsuccessful treatment outcomes and associated factors among tuberculosis patients in public hospitals of Bale Zone, Southeast Ethiopia: A 5-year retrospective study. Heliyon [Internet]. 2021 Sep 1 [cited 2025 Mar 28];7(9). Available from: https://www.cell.com/action/showFullText?pii=S2405844021020855

National TB Control Programme. STOP TB Strategies [Internet]. 2025 [cited 2025 Mar 29]. Available from: http://www.tbghana.gov.gh/strategies.php

WHO. SDG Target 3.3 Communicable diseases [Internet]. 2025 [cited 2025 Mar 28]. Available from: https://www.who.int/data/gho/data/themes/topics/sdg-target-3_3-communicable-diseases

Vandenbroucke JP, von Elm E, Altman DG, Gøtzsche PC, Mulrow CD, Pocock SJ, et al. Strengthening the reporting of observational studies in epidemiology (STROBE): explanation and elaboration. Int J Surg. 2014;12(12):1500–24.

Article  PubMed  Google Scholar 

Limenh LW, Kasahun AE, Sendekie AK, Seid AM, Mitku ML, Fenta ET et al. Tuberculosis treatment outcomes and associated factors among tuberculosis patients treated at healthcare facilities of Motta Town, Northwest Ethiopia: a five-year retrospective study. Sci Rep [Internet]. 2024 Dec 1 [cited 2025 Jul 19];14(1):1–11. Available from: https://www.nature.com/articles/s41598-024-58080-0

Djochie RDA, Anto BP, Opare-Addo MNA, Boakye-Yiadom J. Factors influencing treatment success in drug-susceptible tuberculosis patients in Ghana: A prospective cohort study. PLOS Glob Public Heal [Internet]. 2025 Feb 21 [cited 2025 Sep 13];5(2):e0004146. Available from: https://journals.plos.org/globalpublichealth/article?id=10.1371/journal.pgph.0004146

WHO. WHO treatment outcome categories [Internet]. 2025 [cited 2025 Mar 29]. Available from: https://www.google.com/search?client=opera%20q=WHO+treatment+outcome+categories%20sourceid=opera&ie=UTF-8%20oe=UTF-8

Moon SJ, Lee WY, Hwang JS, Hong YP, Morisky DE. Accuracy of a screening tool for medication adherence: A systematic review and meta-analysis of the Morisky Medication Adherence Scale-8. PLoS One [Internet]. 2017 Nov 1 [cited 2025 Mar 29];12(11):e0187139. Available from: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0187139

Taber KS. The use of Cronbach’s alpha when developing and reporting research instruments in science education. Res Sci Educ. 2018;48(6):1273–96. https://doi.org/10.1007/s11165-016-9602-2.

Article  Google Scholar 

Agyare SA, Osei FA, Odoom SF, Mensah NK, Amanor E, Martyn-Dickens C et al. Treatment Outcomes and Associated Factors in Tuberculosis Patients at Atwima Nwabiagya District, Ashanti Region, Ghana: A Ten-Year Retrospective Study. Tuberc Res Treat [Internet]. 2021 Jan 1 [cited 2025 Jul 19];2021(1):9952806. Available from: https://doi.org/10.1155/2021/9952806

Sariem CN, Odumosu P, Dapar MP, Musa J, Ibrahim L, Aguiyi J. Tuberculosis treatment outcomes: a fifteen-year retrospective study in Jos-North and Mangu, Plateau State, North - Central Nigeria. BMC Public Health. 2020. https://doi.org/10.1186/s12889-020-09289-x.

Article  PubMed  PubMed Central  Google Scholar 

Kumar A, Harakuni S, Paranjape R, Korabu AS, Prasad JB. Factors determining successful treatment outcome among notified tuberculosis patients in Belagavi district of North Karnataka, India. Clin Epidemiol Glob Heal [Internet]. 2024 Jan 1 [cited 2025 Jul 19];25:101505. Available from: https://www.sciencedirect.com/science/article/pii/S2213398424000010

WHO. TB treatment: coverage & outcomes [Internet]. 2023 [cited 2025 Mar 29]. Available from: https://www.who.int/teams/global-programme-on-tuberculosis-and-lung-health/tb-reports/global-tuberculosis-report-2023/tb-diagnosis---treatment/tb-treatment-and-treatment-coverage

WHO- Ghana. United Against Tuberculosis: Ghana’s Private and Public Health Sectors Join Forces | WHO | Regional Office for Africa [Internet]. 2025 [cited 2025 Mar 29]. Available from: https://www.afro.who.int/countries/ghana/news/united-against-tuberculosis-ghanas-private-and-public-health-sectors-join-forces

Osei E, Amu H, Kye-Duodu G, Kwabla MP, Danso E, Binka FN et al. Impact of COVID-19 on tuberculosis and HIV health services delivery in Ghana: qualitative evidence from the perspectives of healthcare providers. BMC Health Serv Res [Internet]. 2025 Dec 1 [cited 2025 Mar 29];25(1):358. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC11892236/

Parwati NM, Bakta IM, Januraga PP, Wirawan IMA. A Health Belief Model-Based Motivational Interviewing for Medication Adherence and Treatment Success in Pulmonary Tuberculosis Patients. Int J Environ Res Public Health [Internet]. 2021 Dec 1 [cited 2025 Mar 29];18(24). Available from: https://pubmed.ncbi.nlm.nih.gov/34948846/

Charalambous S, Maraba N, Jennings L, Rabothata I, Cogill D, Mukora R et al. Treatment adherence and clinical outcomes amongst in people with drug-susceptible tuberculosis using medication monitor and differentiated care approach compared with standard of care in South Africa: a cluster randomized trial. eClinicalMedicine [Internet]. 2024 Sep 1 [cited 2025 Jul 19];75. Available from: https://www.thelancet.com/action/showFullText?pii=S2589537024003249

Bondarchuk CP, Lemon T, Medina-Marino A, Rousseau E, Sindelo S, Sibanda N, et al. Food insecurity and unemployment as mediators of the relationship between the COVID-19 pandemic and psychological well-being in young South Africans with HIV. BMC Public Health. 2024;24(1):2622. https://doi.org/10.1186/s12889-024-19966-w.

Article  PubMed  PubMed Central  Google Scholar 

Gedikli C, Miraglia M, Connolly S, Bryan M, Watson D. The relationship between unemployment and wellbeing: an updated meta-analysis of longitudinal evidence. Eur J Work Organ Psychol. 2023;32(1):128–44. https://doi.org/10.1080/1359432X.2022.2106855.

Article  Google Scholar 

Bio RB, Akweongo P, Koduah A, Adomah-Afari A. Economic burden and coping mechanisms by tuberculosis treatment supporters: a mixed method approach from Bono Region, Ghana. BMC Health Serv Res. 2024;24(1):148. https://doi.org/10.1186/s12913-024-10611-1.

Article  PubMed  PubMed Central  Google Scholar 

Nidoi J, Muttamba W, Walusimbi S, Imoko JF, Lochoro P, Ictho J, et al. Impact of socio-economic factors on Tuberculosis treatment outcomes in north-eastern Uganda: a mixed methods study. BMC Public Health. 2021;21(1):1–16. https://doi.org/10.1186/s12889-021-12056-1.

Article  Google Scholar 

WHO. Social determinants of health [Internet]. 2025 [cited 2025 Mar 29]. Available from: https://www.who.int/health-topics/social-determinants-of-health#tab=tab_1

Rania Hassan A, Mohamed Awad M. Systematic review of the impact of food provision on adherence to the tuberculosis treatment. Heal Prim Care. 2019;3(2).

Alinaitwe B, Shariff NJ, Madhavi Boddupalli B. Treatment adherence and its association with family support among pulmonary tuberculosis patients in Jinja, Eastern Uganda. Sci Rep [Internet]. 2025 Dec 1 [cited 2025 Jul 19];15(1). Available from: https://pubmed.ncbi.nlm.nih.gov/40169867/

Gebremariam RB, Wolde M, Beyene A. Determinants of adherence to anti-TB treatment and associated factors among adult TB patients in Gondar city administration, Northwest, Ethiopia: based on health belief model perspective. J Heal Popul Nutr [Internet]. 2021 Dec 1 [cited 2025 Jul 19];40(1):1–10. Available from: https://jhpn.biomedcentral.com/articles/https://doi.org/10.1186/s41043-021-00275-6

Dilas D, Flores R, Morales-García WC, Calizaya-Milla YE, Morales-García M, Sairitupa-Sanchez L et al. Social Support, Quality of Care, and Patient Adherence to Tuberculosis Treatment in Peru: The Mediating Role of Nurse Health Education. Patient Prefer Adherence [Internet]. 2023 [cited 2025 Mar 29];17:175. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC9871033/

Shinde AM. Socio-demographic factors & adherence of newly diagnosed pulmonary tuberculosis patients to the newly introduced daily regimen: A hospital survey based follow up study. Indian J Tuberc. 2024;71:S250–7.

Article  PubMed  Google Scholar 

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