Arnett DK, Blumenthal RS, Albert MA, et al. 2019 ACC/AHA guideline on the primary prevention of cardiovascular disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation. 2019;140(11):e596-646.

PubMed  PubMed Central  Google Scholar 

Visseren FLJ, Mach F, Smulders YM, et al. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227–337.

Article  PubMed  Google Scholar 

Vrints C, Andreotti F, Koskinas KC, et al. 2024 ESC guidelines for the management of chronic coronary syndromes. Eur Heart J. 2024;45(36):3415–537.

Article  CAS  PubMed  Google Scholar 

Writing Committee Members, Virani SS, Newby LK, et al. 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA guideline for the management of patients with chronic coronary disease: a report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2023;82(9):833–955.

Global Cardiovascular Risk Consortium, Magnussen C, Ojeda FM, et al. Global effect of modifiable risk factors on cardiovascular disease and mortality. N Engl J Med. 2023;389(14):1273–85.

Article  Google Scholar 

Bowry AD, Shrank WH, Lee JL, Stedman M, Choudhry NK. A systematic review of adherence to cardiovascular medications in resource-limited settings. J Gen Intern Med. 2011;26(12):1479–91.

Article  PubMed  PubMed Central  Google Scholar 

Chowdhury R, Khan H, Heydon E, et al. Adherence to cardiovascular therapy: a meta-analysis of prevalence and clinical consequences. Eur Heart J. 2013;34(38):2940–8.

Article  CAS  PubMed  Google Scholar 

Aminde LN, Agbor VN, Fongwen NT, et al. High burden and trend in nonadherence to blood pressure-lowering medications: meta-analysis of data from over 34 000 adults with hypertension in sub-Saharan Africa. J Am Heart Assoc. 2025. https://doi.org/10.1161/JAHA.124.037555.

Article  PubMed  PubMed Central  Google Scholar 

World Health Organization. Adherence to long-term therapies: evidence for action. 2003. https://iris.who.int/bitstream/handle/10665/42682/9241545992.pdf?sequence=1&isAllowed=y. Accessed 3 Feb 2025.

Vrijens B, De Geest S, Hughes DA, et al. A new taxonomy for describing and defining adherence to medications. Br J Clin Pharmacol. 2012;73(5):691–705.

Article  PubMed  PubMed Central  Google Scholar 

de Oliveira CJ, Lin J, Pearson SA, Buckley NA, Schaffer AL, Falster MO. Persistence and adherence to cardiovascular medicines in Australia. J Am Heart Assoc. 2023;12(13):e030264.

Article  Google Scholar 

Bissonnette JM. Adherence: a concept analysis. J Adv Nurs. 2008;63(6):634–43.

Article  PubMed  Google Scholar 

Dobrowolski P, Prejbisz A, Szyndler A, et al. Physician-patient partnership—can it help increase adherence to the therapeutic recommendations in cardiovascular disease? Position statement of the Polish Society of Hypertension and Working Group on Cardiovascular Pharmacotherapy, Polish Cardiac Society endorsed by patient advocacy groups (1) WE Patients Foundation, (2) The Institute for Patients’ Rights and Health Education, (3) The National Association of Patients with Heart and Vascular Conditions “EcoHeart/EcoSerce.” Arterial Hyper. 2024;28:50–70.

Article  Google Scholar 

Sacristan JA. Patient-centered medicine and patient-oriented research: improving health outcomes for individual patients. BMC Med Inform Decis Mak. 2013;13:6.

Article  PubMed  PubMed Central  Google Scholar 

Schade DS, Godasi BN, Duro T, Eaton RP. The importance of setting treatment goals for cardiovascular disease. World J Cardiovasc Dis. 2024;14:10–5.

Article  Google Scholar 

Rosano G, George M, Kaski J-C, et al. Abstract 16624: patients’ perspectives on the impact and management of angina—preliminary results of the PACT-ANGINA international survey. Circulation. 2023;148(Suppl_1):A16624.

Article  Google Scholar 

Kardas P, Lewek P, Matyjaszczyk M. Determinants of patient adherence: a review of systematic reviews. Front Pharmacol. 2013;4:91.

Article  PubMed  PubMed Central  Google Scholar 

Burnier M, Egan BM. Adherence in hypertension. Circ Res. 2019;124(7):1124–40.

Article  CAS  PubMed  Google Scholar 

Wu D, Lowry PB, Zhang D, Tao Y. Patient trust in physicians matters-understanding the role of a mobile patient education system and patient-physician communication in improving patient adherence behavior: field study. J Med Internet Res. 2022;24(12):e42941.

Article  PubMed  PubMed Central  Google Scholar 

Gupta N, Thiele CM, Daum JI, et al. Building patient-physician trust: a medical student perspective. Acad Med. 2020;95(7):980–3.

Article  PubMed  Google Scholar 

Lupia A, Allison DB, Jamieson KH, Heimberg J, Skipper M, Wolf SM. Trends in U.S. public confidence in science and opportunities for progress. Proc Natl Acad Sci USA. 2024;121(11):e2319488121.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pew Research Center. Public trust in scientists and views on their role in policymaking. 2024. https://www.pewresearch.org/science/2024/11/14/public-trust-in-scientists-and-views-on-their-role-in-policymaking/. Accessed 5 Feb 2025.

Cologna V, Mede NG, Berger S, et al. Trust in scientists and their role in society across 68 countries. Nat Hum Behav. 2025;9(4):713–30.

Article  PubMed  PubMed Central  Google Scholar 

Gao Q, Wang X, Lin Z, Liao Z. Internet usage time and trust in doctors: evidence from China. BMC Public Health. 2024;24(1):2891.

Article  PubMed  PubMed Central  Google Scholar 

Hyvert S, Yailian AL, Haesebaert J, et al. Association between health literacy and medication adherence in chronic diseases: a recent systematic review. Int J Clin Pharm. 2023;45(1):38–51.

Article  PubMed  Google Scholar 

Chen X, Hay JL, Waters EA, et al. Health literacy and use and trust in health information. J Health Commun. 2018;23(8):724–34.

Article  PubMed  PubMed Central  Google Scholar 

Meppelink CS, Smit EG, Fransen ML, Diviani N. “I was right about vaccination”: confirmation bias and health literacy in online health information seeking. J Health Commun. 2019;24(2):129–40.

Article  PubMed  Google Scholar 

O’Keefe-McCarthy S, McGillion MH, Victor JC, Jones J, McFetridge-Durdle J. Prodromal symptoms associated with acute coronary syndrome acute symptom presentation. Eur J Cardiovasc Nurs. 2016;15(3):e52–9.

Article  PubMed  Google Scholar 

Liljeroos T, Humphries S, Puthoopparambil SJ, Norlund F, Olsson EMG. Management of emotional distress following a myocardial infarction: a qualitative content analysis. Cogn Behav Ther. 2023;52(1):47–64.

Article  PubMed  Google Scholar 

Gulati M, Khan N, George M, et al. Ischemia with no obstructive coronary artery disease (INOCA): a patient self-report quality of life survey from INOCA international. Int J Cardiol. 2023;371:28–39.

Article  PubMed  Google Scholar 

Tran V, Vo TML, Vo QLD, et al. Behavioral factors associated with medication adherence among hypertensive patients using the theoretical domains framework. Explor Res Clin Soc Pharm. 2024;16:100510.

PubMed  PubMed Central  Google Scholar 

Rosenberg J, Lampridou S, Moores A, Garfield S, Wingfield D, Judah G. A systematic review uncovering modifiable influences on statin adherence. Patient Prefer Adherence. 2025;19:29–48.

Article  PubMed  PubMed Central  Google Scholar 

Goldstein CM, Gathright EC, Garcia S. Relationship between depression and medication adherence in cardiovascular disease: the perfect challenge for the integrated care team. Patient Prefer Adherence. 2017;11:547–59.

Article  PubMed  PubMed Central  Google Scholar 

Pantuzza LL, Ceccato M, Silveira MR, Junqueira LMR, Reis AMM. Association between medication regimen complexity and pharmacotherapy adherence: a systematic review. Eur J Clin Pharmacol. 2017;73(11):1475–89.

Article  PubMed  Google Scholar 

Ingersoll KS, Cohen J. The impact of medication regimen factors on adherence to chronic treatment: a review of literature. J Behav Med. 2008;31(3):213–24.

Article  PubMed  PubMed Central  Google Scholar 

Gupta P, Patel P, Štrauch B, et al. Risk factors for nonadherence to antihypertensive treatment. Hypertension. 2017;69(6):1113–20.

Article