Alijotas-Reig, J., Esteve-Valverde, E., Anunciación-Llunell, A., Marques-Soares, J., Pardos-Gea, J., and Miró-Mur, F., Pathogenesis, diagnosis and management of obstetric antiphospholipid syndrome: A comprehensive review, J. Clin. Med., 2022, vol. 11, no. 3, p. 675. https://doi.org/10.3390/jcm11030675

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vandevelde, A. and Devreese, K.M.J., Laboratory diagnosis of antiphospholipid syndrome: Insights and hindrances, J. Clin. Med., 2022, vol. 11, no. 8, p. 2164. https://doi.org/10.3390/jcm11082164

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, X., Zhu, L., Liu, H., Cai, Q., Yun, Z., Sun, F., Jia, Y., Guo, J., and Li, C., Non-criteria antiphospholipid antibodies in antiphospholipid syndrome: Diagnostic value added, Front. Immunol., 2022, vol. 13, p. 972012. https://doi.org/10.3389/fimmu.2022.972012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Beltagy, A., Trespidi, L., Gerosa, M., Ossola, M.W., Meroni, P.L., and Chighizola, C.B., Anti-phospholipid antibodies and reproductive failures, Am. J. Reprod. Immunol., 2021, vol. 85, no. 4, p. 13258. https://doi.org/10.1111/aji.13258

Article  CAS  Google Scholar 

Molhoek, J.E., de Groot, P.G., and Urbanus, R.T., The lupus anticoagulant paradox, Semin. Thromb. Hemostasis, 2018, vol. 44, no. 5, pp. 445–452.

Article  CAS  Google Scholar 

Devreese, K.M.J., Laboratory testing for non-criteria antiphospholipid antibodies: Antibodies toward the domain I of beta2-glycoprotein I (aDI), Methods Mol. Biol., 2023, vol. 2663, pp. 329–340. https://doi.org/10.1007/978-1-0716-3175-1_21

Article  CAS  PubMed  Google Scholar 

Xi, F., Cai, Y., Lv, M., Jiang, Y., Zhou, F., Chen, Y., Jiang, L., and Luo, Q., Anticardiolipin positivity is highly associated with intrauterine growth restriction in women with antiphospholipid syndrome, Clin. Appl. Thromb. Hemost., 2020, vol. 26, p. 1076029620974455. https://doi.org/10.1177/1076029620974455

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pires da Rosa, G., Bettencourt, P., Rodríguez-Pintó, I., Cervera, R., and Espinosa, G., “Non-criteria” antiphospholipid syndrome: A nomenclature proposal, Autoimmun. Rev., 2020, vol. 19, p. 102689. https://doi.org/10.1016/j.autrev.2020.102689

Article  CAS  PubMed  Google Scholar 

Pires da Rosa, G., Ferreira, E., Sousa-Pinto, B., Bettencourt, P., Espinosa, G., and Cervera, R., Patients with laboratory criteria of anti-phospholipid syndrome and “non-criteria” manifestations: A multicenter cohort, Scand. J. Rheumatol., 2023, vol. 52, no. 2, pp. 190–195. https://doi.org/10.1080/03009742.2022.2082114

Article  CAS  PubMed  Google Scholar 

Yang, X.X., Sun, Y.D., Zhao, J.L., Tian, X.P., Zeng, X.F., and Li, M.T., Clinical characteristics and pregnancy outcomes of non-criteria obstetric antiphospholipid syndrome, Zhonghua Nei Ke Za Zhi, 2021, vol. 60, no. 9, pp. 812–816. https://doi.org/10.3760/cma.j.cn112138-20210506-00329

Article  CAS  PubMed  Google Scholar 

Alijotas-Reig, J., Esteve-Valverde, E., Ferrer-Oliveras, R., Sáez-Comet, L., Lefkou, E., Mekinian, A., Belizna, C., Ruffatti, A., and Hoxha, A., Comparative study of obstetric antiphospholipid syndrome (OAPS) and non-criteria obstetric APS (NC-OAPS): Report of 1640 cases from the EUROAPS registry, Rheumatology, 2020, vol. 59, pp. 1306–1314. https://doi.org/10.1093/rheumatology/kez419

Article  CAS  PubMed  Google Scholar 

Rodriguez-Garcia, J.L., Bertolaccini, M.L., Cuadrado, M.J., Sanna, G., Ateka-Barrutia, O., and Khamashta, M.A., Clinical manifestations of antiphospholipid syndrome (APS) with and without antiphospholipid antibodies (the so-called ‘seronegative APS’), Ann. Rheum. Dis., 2012, vol. 71, no. 2, pp. 242–244. https://doi.org/10.1136/annrheumdis-2011-200614

Article  PubMed  Google Scholar 

Pignatelli, P., Ettorre, E., Menichelli, D., Pani, A., Violi, F., and Pastori, D., Seronegative antiphospholipid syndrome: Refining the value of “non-criteria” antibodies for diagnosis and clinical management, Haematologica, 2020, vol. 105, pp. 562–572. https://doi.org/10.3324/haematol.2019.221945

Article  CAS  PubMed  PubMed Central  Google Scholar 

Misasi, R., Longo, A., Recalchi, S., Caissutti, D., Riitano, G., Manganelli, V., Garofalo, T., Sorice, M., and Capozzi, A., Molecular mechanisms of “antiphospholipid antibodies” and their paradoxical role in the pathogenesis of “seronegative APS,” Int. J. Mol. Sci., 2020, vol. 21, no. 21, p. 8411. https://doi.org/10.3390/ijms21218411

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferreira, T.G., Delhommeau, F., Johanet, C., Gerotziafas, G., Bornes, M., Cohen, J., Kayem, G., Fain, O., Planche, V., and Mékinian, A., Annexin-A5 resistance and non-criteria antibodies for the diagnosis of seronegative antiphospholipid syndrome, Clin. Rheumatol., 2020, vol. 39, no. 4, pp. 1167–1171. https://doi.org/10.1007/s10067-019-04915-5

Article  PubMed  Google Scholar 

Urrego-Callejas, T., Hernández, A., Ruiz Giraldo, S., Frade-Sosa, B., Vanegas-García, A.L., Muñoz, C.H., Rua, C., Duque Botero, J., González, L.A., Vásquez, G., and Gómez-Puerta, J.A., Relevance of non-criteria antiphospholipid antibodies titers among patients with antiphospholipid syndrome and patients with systemic lupus erythematosus, Reumatol. Clin. (Engl. Ed.), 2023, vol. 19, no. 4, pp. 197–203. https://doi.org/10.1016/j.reumae.2023.01.001

Chinnaraj, M., Chen, Z., Pelc, L.A., Grese, Z., Bystranowska, D., Di Cera, E., and Pozzi, N., Structure of prothrombin in the closed form reveals new details on the mechanism of activation, Sci. Rep., 2018, vol. 8, no. 1, p. 2945. https://doi.org/10.1038/s41598-018-21304-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roselli, D., Bonifacio, M.A., Barbuti, G., Rossiello, M.R., Ranieri, P., and Mariggiò, M.A., Anti-phosphatidylserine, anti-prothrombin, and anti-annexin V autoantibodies in antiphospholipid syndrome: A real-life study, Diagnostics, 2023, vol. 13, no. 15, p. 2507. https://doi.org/10.3390/diagnostics13152507

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi, H., Zheng, H., Yin, Y.-F., Hu, Q.-Y., Teng, J.-L., Sun, Y., Liu, H.-L., Cheng, X.-B., Ye, J.-N., Su, Y.-T., Wu, X.-Y., Zhou, J.-F., Norman, G.L., Gong, H.-Y., Shi, X.-M., Peng, Y.-B., Wang, X.-F., and Yang, C.-D., Antiphosphatidylserine/prothrombin antibodies (aPS/PT) as potential diagnostic markers and risk predictors of venous thrombosis and obstetric complications in antiphospholipid syndrome, Clin. Chem. Lab. Med., 2018, vol. 56, no. 4, pp. 614–624. https://doi.org/10.1515/cclm-2017-0502

Article  CAS  PubMed  Google Scholar 

Baños, N., Castellanos, A.S., Barilaro, G., Figueras, F., Lledó, G.M., Santana, M., and Espinosa, G., Early prediction of adverse pregnancy outcome in women with systemic lupus erythematosus, antiphospholipid syndrome, or non-criteria obstetric antiphospholipid syndrome, J. Clin. Med., 2022, vol. 11, no. 22, p. 6822. https://doi.org/10.3390/jcm11226822

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodríguez, C.M., Velásquez-Berrío, M., Rúa, C., Viana, M., Abrahams, V.M., Cadavid, A.P., and Alvarez, A.M., Antiphospholipid antibodies from women with pregnancy morbidity and vascular thrombosis induce endothelial mitochondrial dysfunction, mTOR activation, and autophagy, Front. Physiol., 2021, vol. 12, p. 706743. https://doi.org/10.3389/fphys.2021.706743

Article  PubMed  PubMed Central  Google Scholar 

Katsuragawa, H., Kanzaki, H., Inoue, T., Hirano, T., Mori, T., and Rote, N.S., Monoclonal antibody against phosphatidylserine inhibits in vitro human trophoblastic hormone production and invasion, Biol. Reprod., 1997, vol. 5, no. 1, pp. 50–58. https://doi.org/10.1095/biolreprod56.1.50

Article  Google Scholar 

Di Simone, N., Meroni, P.L., de Papa, N., Raschi, E., Caliandro, D., De Carolis, C.S., Khamashta, M.A., Atsumi, T., Hughes, G.R., Balestrieri, G., Tincani, A., Casali, P., and Caruso, A., Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I, Arthritis Rheum., 2000, vol. 43, no. 1, pp. 140–150. https://doi.org/10.1002/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franklin, R.D., Effects of unfractionated and low molecular weight heparin on antiphospholipid antibody binding in vitro, Obstet. Gynecol., 2003, vol. 101, no. 3, pp. 455–462. https://doi.org/10.1016/S0029-7844(02)02520-6

Article  CAS  PubMed  Google Scholar 

Sugi, T. and McIntyre, J.A., Certain autoantibodies to phosphatidylethanolamine (aPE) recognize factor XI and prekallikrein independently or in addition to the kininogens, J. Autoimmun., 2001, vol. 17, no. 3, pp. 207–214. https://doi.org/10.1006/jaut.2001.0543

Article  CAS  PubMed  Google Scholar 

Cabrera-Marante, O., Rodríguez de Frías, E., Serrano, M., Lozano Morillo, F., Naranjo, L., Gil-Etayo, F.J., Paz-Artal, E., Pleguezuelo, D.E., and Serrano, A., The weight of IgA anti-β2glycoprotein I in the antiphospholipid syndrome pathogenesis: Closing the gap of seronegative antiphospholipid syndrome, Int. J. Mol. Sci., 2020, vol. 21, no. 23, p. 8972. https://doi.org/10.3390/ijms21238972

Article  CAS