Silva, C.F.M., Guerrinha, A.P.D.d.M.S., Carvalho, S., Pinto, D.C.G.A., and Silva, A.M.S., 1,3,5-Triazine: A promising molecular scaffold for novel agents for the treatment of Alzheimer’s disease, Int. J. Mol. Sci., 2025, vol. 26, no. 3, p. 882. https://doi.org/10.3390/ijms26030882

Article  CAS  PubMed  PubMed Central  Google Scholar 

Weixin, Y.A.N., Zhao, Y., and He, J., Anti‑breast cancer activity of selected 1,3,5‑triazines via modulation of EGFR‑TK, Mol. Med. Rep., 2018, vol. 18, no. 5, pp. 4175–4184. https://doi.org/10.3892/mmr.2018.9426

Article  CAS  Google Scholar 

Srivastava, J.K., Pillai, G.G., Bhat, H.R., and Verma, A., Design and discovery of novel monastrol-1,3,5-triazines as potent anti-breast cancer agent via attenuating Epidermal Growth Factor Receptor tyrosine kinase, Sci. Rep., 2017, vol. 7, p. 5851. https://doi.org/10.1038/s41598-017-05934-5

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, B., A systematic review on antitumor agents with 1,3,5-triazines, Med. Chem. (Henderson, NV, U. S.), 2015, vol. 5, no. 3, pp. 131–148. https://doi.org/10.4172/2161-0444.1000255

Article  CAS  Google Scholar 

Liu, B., A systematic review on antitumor agents with 1,3,5-triazines, Med. Chem. (Henderson, NV, U. S.), 2015, vol. 5, no. 3, pp. 131–148. https://doi.org/10.4172/2161-0444.1000255

Article  CAS  Google Scholar 

Lim, H.Y. and Dolzhenko, A.V., 1,3,5-Triazine as a promising scaffold in the development of therapeutic agents against breast cancer, Eur. J. Med. Chem., 2024, vol. 276, p. 116680. https://doi.org/10.1016/j.ejmech.2024.116680

Article  CAS  PubMed  Google Scholar 

Mikolaichuk, O.V., Sharoyko, V.V., Popova, E.A., et al., A new tetrazole-containing 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine derivative: Synthesis, interaction with DNA, and antitumor activity, Russ. Chem. Bull., 2022, vol. 71, pp. 1050–1056.

Marchesi, F., Turriziani, M., Tortorelli, G., Avvisati, G., Torino, F., and De Vecchis, L., Triazene compounds: Mechanism of action and related DNA repair systems, Pharmacol. Res., 2007, vol. 56, no. 4, pp. 275–287. https://doi.org/10.1016/j.phrs.2007.08.003

Article  CAS  PubMed  Google Scholar 

Andrés, C.M.C., de la Lastra, J.M.P., Juan, C.A., Plou, F.J., and Pérez-Lebeña, E., Chemical insights into oxidative and nitrative modifications of DNA, Int. J. Mol. Sci., 2023, vol. 24, no. 20, p. 15240. https://doi.org/10.3390/ijms242015240

Article  CAS  PubMed  PubMed Central  Google Scholar 

Juvekar, A., Burga, L.N., Hu, H., et al., Combining a PI3K inhibitor with a PARP inhibitor provides an effective therapy for BRCA1-related breast cancer, Cancer Discovery, 2012, vol. 2, no. 11, pp. 1048–1063. https://doi.org/10.1158/2159-8290.CD-11-0336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, J., Li, H., He, G., et al., Discovery of novel dual poly(ADP-ribose)polymerase and phosphoinositide 3-kinase inhibitors as a promising strategy for cancer therapy, J. Med. Chem., 2020, vol. 63, no. 1, pp. 122–139. https://doi.org/10.1021/acs.jmedchem.9b00622

Article  CAS  PubMed  Google Scholar 

Dai, Q. et al., Antitumor activity of s-triazine derivatives: A systematic review, Molecules, 2023, vol. 28, no. 11, p. 4278. https://doi.org/10.3390/molecules28114278

Article  CAS  PubMed  PubMed Central  Google Scholar 

Protas, A.V. et al., Aziridine-functionalized 1,3,5-triazine derivatives as promising anticancer agents: Synthesis, DFT study, DNA binding investigations and in vitro cytotoxic activity, J. Heterocycl. Chem., 2024, vol. 61, no. 11, pp. 1801–1806. https://doi.org/10.1002/jhet.4908

Article  CAS  Google Scholar 

Belyaeva, O.A. et al., Targeted delivery of domestic anticancer drugs from the group of aziridine triazines (literature review), Rev. Clin. Pharmacol. Drug Ther., 2024, vol. 22, no. 2, pp. 131–144. https://doi.org/10.17816/RCF625968

Article  Google Scholar 

Molchanov, O.E. et al., Patent RU2825828C1, 2024.

Sharoyko, V.V. et al., Physicochemical investigation of water-soluble C60(C2NH4O2)4H4 (C60-Gly) adduct, J. Mol. Liq., 2021, vol. 344, p. 117658. https://doi.org/10.1016/j.molliq.2021.117658

Article  CAS  Google Scholar 

Topala, T., Bodoki, A., Oprean, L., and Oprean, R., Experimental techniques employed in the study of metal complexes-DNA—interactions, Farmacia, 2014, vol. 62, pp. 1049–1061.

CAS  Google Scholar 

Can, Z., Keskin, B., Üzer, A., and Apak, R., Detection of nitric oxide radical and determination of its scavenging activity by antioxidants using spectrophotometric and spectrofluorometric methods, Talanta, 2022, vol. 238, no. 1, p. 122993. https://doi.org/10.1016/j.talanta.2021.122993

Ranjbari, S., Behzadi, M., Sepehri, S. et al., Investigations of antiproliferative and antioxidant activity of β-lactam morpholino-1,3,5-triazine hybrids, Bioorg. Med. Chem., 2020, vol. 28, no. 8, p. 115408. https://doi.org/10.1016/j.bmc.2020.115408

Article  CAS  PubMed  Google Scholar 

Mikolaichuk, O.V., Protas, A.V., Popova, E.A., Mukhametshina, A.V., Ovsepyan, G.K., and Trifonov, R.E., Quantitative studies of DNA binding with trans complexes of and PdII featuring tetrazolylacetic acids and their derivatives as ligands, Russ. Chem. Bull., 2018, vol. 67, no. 7, pp. 1312–1315.

Article  CAS  Google Scholar 

Ali, I., Wani, W.A., Saleem, K., and Hsieh, M.-F., Anticancer metallodrugs of glutamic acid sulphonamides: In silico, DNA binding, hemolysis and anticancer studies, RSC Adv., 2014, vol. 4, no. 56, pp. 29629–29641. https://doi.org/10.1039/C4RA02570A

Karami, K., Alinaghi, M., Amirghofran, Z., and Lipkowski, J., Synthesis and characterization of two new trans palladium(II) complexes containing benzylamine ligand: DNA/BSA interactions, molecular docking and in vitro cytotoxic activity, Inorg. Chim. Acta, 2018, vol. 471, pp. 797–807. https://doi.org/10.1016/j.ica.2017.02.027

Article  CAS  Google Scholar 

Gałczyńska, K., Ciepluch, K., Madej, Ł., et al., Selective cytotoxicity and antifungal properties of copper(II) and cobalt(II) complexes with imidazole-4-acetate anion or 1-allylimidazole, Sci. Rep., 2019, vol. 9, p. 9777. https://doi.org/10.1038/s41598-019-46224-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cao, Y. and He, X.-w., Studies of interaction between Safranine T and double helix DNA by spectral methods, Spectrochim. Acta, Part A, 1998, vol. 54, no. 6, pp. 883–892. https://doi.org/10.1016/S1386-1425(97)00277-1

Article  Google Scholar 

Kessel, D., Luo, Y., Deng, Y., and Chang, C.K., The role of subcellular localization in initiation of apoptosis by photodynamic therapy, Photochem. Photobiol., 1997, vol. 65, no. 3, pp. 422–426. https://doi.org/10.1111/j.1751-1097.1997.tb08581.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pierce, A., McGowan, P.M., Cotter, M., et al., Comparative antiproliferative efects of iniparib and olaparib on a panel of triple-negative and non-triple-negative breast cancer cell lines, Cancer Biol. Ther., 2013, vol. 14, no. 6, pp. 537–545. https://doi.org/10.4161/cbt.24349

Article  CAS  PubMed  PubMed Central  Google Scholar 

Molla, S., Hembram, K.C., Chatterjee, S., et al., PARP inhibitor Olaparib enhances the apoptotic potentiality of curcumin by increasing the DNA damage in oral cancer cells through inhibition of BER cascade, Pathol. Oncol. Res., 2020, vol. 26, no. 4, pp. 2091–2103. https://doi.org/10.1007/s12253-019-00768-0

Article  CAS  PubMed  Google Scholar