Miller FW. The increasing prevalence of autoimmunity and autoimmune diseases: an urgent call to action for improved understanding, diagnosis, treatment, and prevention. Curr Opin Immunol. 2023;80:102266. https://doi.org/10.1016/j.coi.2022.102266.

Article  CAS  PubMed  Google Scholar 

Wang L, Wang F, Gershwin ME. Human autoimmune diseases: a comprehensive update. J Intern Med. 2015;278:369–95. https://doi.org/10.1111/joim.12395.

Article  CAS  PubMed  Google Scholar 

Rosenblum MD, Remedios KA, Abbas AK. Mechanisms of human autoimmunity. J Clin Invest. 2015;125:2228–33. https://doi.org/10.1172/JCI78088.

Article  PubMed  PubMed Central  Google Scholar 

Gun SY, Lee SWL, Sieow JL, Wong SC. Targeting immune cells for cancer therapy. Redox Biol. 2019;25:101174. https://doi.org/10.1016/j.redox.2019.101174.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garrido-Trigo A, Corraliza AM, Veny M, Dotti I, Melón-Ardanaz E, Rill A, et al. Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease. Nat Commun. 2023;14:4506. https://doi.org/10.1038/s41467-023-40156-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Italiani P, Boraschi D. From monocytes to M1/M2 macrophages: phenotypical vs. functional differentiation. Front Immunol. 2014;5:514. https://doi.org/10.3389/fimmu.2014.00514.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang Z, Liu M, Chang Z, Du C, Yang Y, Zhang C, et al. Myeloid-derived growth factor promotes M2 macrophage polarization and attenuates Sjögren’s syndrome via suppression of the CX3CL1/CX3CR1 axis. Front Immunol. 2024;15:1465938. https://doi.org/10.3389/fimmu.2024.1465938.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lin J, Lin H-W, Wang Y-X, Fang Y, Jiang H-M, Li T, et al. FGF4 ameliorates the liver inflammation by reducing M1 macrophage polarization in experimental autoimmune hepatitis. J Transl Med. 2024;22:717. https://doi.org/10.1186/s12967-024-05219-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. Nat Rev Immunol. 2011;11:723–37. https://doi.org/10.1038/nri3073.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004;25:677–86. https://doi.org/10.1016/j.it.2004.09.015.

Article  CAS  PubMed  Google Scholar 

Kuo D, Ding J, Cohn IS, Zhang F, Wei K, Rao DA, et al. HBEGF + macrophages in rheumatoid arthritis induce fibroblast invasiveness. Sci Transl Med. 2019;11:eaau8587. https://doi.org/10.1126/scitranslmed.aau8587.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu X, Liu Y, Jin S, Wang M, Jiao Y, Yang B. Single-cell sequencing of immune cells from anticitrullinated peptide antibody positive and negative rheumatoid arthritis. Nat Commun. 2021;12:4977. https://doi.org/10.1038/s41467-021-25246-7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fritz D, Inamo J, Zhang F. Single-cell computational machine learning approaches to immune-mediated inflammatory disease: new tools uncover novel fibroblast and macrophage interactions driving pathogenesis. Front Immunol. 2022;13:1076700. https://doi.org/10.3389/fimmu.2022.1076700.

Article  CAS  PubMed  Google Scholar 

Saas P, Chagué C, Maraux M, Cherrier T. Toward the characterization of human pro-resolving macrophages? Front Immunol. 2020;11:593300. https://doi.org/10.3389/fimmu.2020.593300.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu Y, Jiang T, Yang X, Chen Z. Methods, mechanisms, and application prospects for enhancing extracellular vesicle uptake. Curr Med Sci. 2024;44:247–60. https://doi.org/10.1007/s11596-024-2861-7.

Article  PubMed  Google Scholar 

Liu H, Li R, Liu T, Yang L, Yin G, Xie Q. Immunomodulatory effects of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles in rheumatoid arthritis. Front Immunol. 2020;11:1912. https://doi.org/10.3389/fimmu.2020.01912.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li J, Zheng M, Shimoni O, Banks WA, Bush AI, Gamble JR, et al. Development of novel therapeutics targeting the blood-brain barrier: from barrier to carrier. Adv Sci. 2021;8:e2101090. https://doi.org/10.1002/advs.202101090.

Article  CAS  Google Scholar 

Osaid Z, Haider M, Hamoudi R, Harati R. Exosomes interactions with the blood-brain barrier: implications for cerebral disorders and therapeutics. Int J Mol Sci. 2023;24:15635. https://doi.org/10.3390/ijms242115635.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu JR, Hernandez Y, Miyasaki KF, Kwon EJ. Engineered nanomaterials that exploit blood-brain barrier dysfunction for delivery to the brain. Adv Drug Deliv Rev. 2023;197:114820. https://doi.org/10.1016/j.addr.2023.114820.

Article  CAS  PubMed  Google Scholar 

Yu X, Zhang M, Kang N, Li C, Wang Z, Ao Y, et al. Defective neutrophil-derived exosomes facilitate macrophage activation through miR-122-5p in behçet’s disease. Nat Commun. 2025;16:8186. https://doi.org/10.1038/s41467-025-63348-8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xing Y, Sun X, Dou Y, Wang M, Zhao Y, Yang Q. The immuno-modulation effect of macrophage-derived extracellular vesicles in chronic inflammatory diseases. Front Immunol. 2021;12:785728. https://doi.org/10.3389/fimmu.2021.785728.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moradi-Chaleshtori M, Bandehpour M, Soudi S, Mohammadi-Yeganeh S, Hashemi SM. In vitro and in vivo evaluation of anti-tumoral effect of M1 phenotype induction in macrophages by miR-130 and miR-33 containing exosomes. Cancer Immunol Immunother. 2021;70:1323–39. https://doi.org/10.1007/s00262-020-02762-x.

Article  CAS  PubMed  Google Scholar 

Kim H, Wang SY, Kwak G, Yang Y, Kwon IC, Kim SH. Exosome-guided phenotypic switch of M1 to M2 macrophages for cutaneous wound healing. Adv Sci. 2019;6:1900513. https://doi.org/10.1002/advs.201900513.

Article  CAS  Google Scholar 

Yuan Q, Yang M, Zheng H, Cai Y, Luo P, Wang X, et al. M2 macrophage-derived extracellular vesicles encapsulated in hyaluronic acid alleviate osteoarthritis by modulating macrophage polarization. ACS Biomater Sci Eng. 2024;10:3355–77. https://doi.org/10.1021/acsbiomaterials.3c01833.

Article  CAS  PubMed  Google Scholar 

Zhu M, Sun X, Qi X, Xia L, Wu Y. Exosomes from high glucose-treated macrophages activate macrophages andinduce inflammatory responses via NF-κB signaling pathway in vitro and in vivo. Int Immunopharmacol. 2020;84:106551. https://doi.org/10.1016/j.intimp.2020.106551.

Article  CAS  PubMed  Google Scholar 

Flynn JL, Chan J. Immunology of tuberculosis. Annu Rev Immunol. 2001;19:93–129. https://doi.org/10.1146/annurev.immunol.19.1.93.

Article  CAS  PubMed  Google Scholar 

Rhoades ER, Geisel RE, Butcher BA, McDonough S, Russell DG. Cell wall lipids from Mycobacterium bovis BCG are inflammatory when inoculated within a gel matrix: characterization of a new model of the granulomatous response to mycobacterial components. Tuberculosis. 2005;85:159–76. https://doi.org/10.1016/j.tube.2004.10.001.