Adhikari A, Topiwala MA, Gordon JA (2010) Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety. Neuron 65:257–269. https://doi.org/10.1016/j.neuron.2009.12.002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aisa B, Tordera R, Lasheras B, Del Río J, Ramírez MJ (2007) Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats. Psychoneuroendocrinology 32:256–266. https://doi.org/10.1016/j.psyneuen.2006.12.013

Article  CAS  PubMed  Google Scholar 

Andersen SL, Tomada A, Vincow ES, Valente E, Polcari A, Teicher MH (2008) Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development. J Neuropsychiatry Clin Neurosci 20(3):292–301

Article  PubMed  PubMed Central  Google Scholar 

Bagot RC, Parise EM, Peña CJ, Zhang HX, Maze I, Chaudhury D, Persaud B, Cachope R, Bolaños-Guzmán CA, Cheer J, Deisseroth K, Han MH, Nestler EJ (2015) Ventral hippocampal afferents to the nucleus accumbens regulate susceptibility to depression. Nat Commun. https://doi.org/10.1038/ncomms8062

Article  PubMed  PubMed Central  Google Scholar 

Bannerman DM, Grubb M, Deacon RMJ, Yee BK, Feldon J, Rawlins JNP (2003) Ventral hippocampal lesions affect anxiety but not spatial learning. Behav Brain Res 139(1–2):197–213

Article  CAS  PubMed  Google Scholar 

Banqueri M, Méndez M, Gómez-Lázaro E, Arias JL (2019) Early life stress by repeated maternal separation induces long-term neuroinflammatory response in glial cells of male rats. Stress 22(5):563–570

Article  CAS  PubMed  Google Scholar 

Belzung C, Lemoine M (2011) Criteria of validity for animal models of psychiatric disorders: focus on anxiety disorders and depression. Biol Mood Anxiety Disord 1:9. https://doi.org/10.1186/2045-5380-1-9

Article  PubMed  PubMed Central  Google Scholar 

Bertollo AG, Grolli RE, Plissari ME, Gasparin VA, Quevedo J, Réus GZ, Ignácio ZM (2020) Stress and serum cortisol levels in major depressive disorder: a cross-sectional study. AIMS Neurosci 7(4):459

Article  PubMed  PubMed Central  Google Scholar 

Betz A (2025) Criteria for ex vivo classification of microglial phenotypes. Created in BioRender. https://BioRender.com/k14y577

Betz A (2025a) Graphical and Experimental timeline. Created in BioRender. https://BioRender.com/t19s794

Betz A (2025b) Microglial activation in the nucleus accumbens (NAc) of maternally separated rats. Created in BioRender. https://BioRender.com/k39r656

Boldrini M, Galfalvy H, Dwork AJ, Rosoklija GB, Trencevska-Ivanovska I, Pavlovski G, Mann JJ (2019) Resilience is associated with larger dentate gyrus, while suicide decedents with major depressive disorder have fewer granule neurons. Biol Psychiatry 85(10):850–862

Article  PubMed  PubMed Central  Google Scholar 

Butovsky O, Ziv Y, Schwartz A, Landa G, Talpalar AE, Pluchino S, Martino G, Schwartz M (2006) Microglia activated by IL-4 or IFN-γ differentially induce neurogenesis and oligodendrogenesis from adult stem/progenitor cells. Mol Cell Neurosci 31:149–160. https://doi.org/10.1016/j.mcn.2005.10.006

Article  CAS  PubMed  Google Scholar 

Chamak B, Morandi V, Mallat M (1994) Brain macrophages stimulate neurite growth and regeneration by secreting thrombospondin. J Neurosci Res 38:221–233. https://doi.org/10.1002/jnr.490380213

Article  CAS  PubMed  Google Scholar 

Chen Y, Dube CM, Rice CJ, Baram TZ (2008) Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci 28:2903–2911. https://doi.org/10.1523/JNEUROSCI.0225-08.2008

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chocyk A, Dudys D, Przyborowska A, Majcher I, Maćkowiak M, Weogonekdzony K (2011) Maternal separation affects the number, proliferation and apoptosis of glia cells in the substantia nigra and ventral tegmental area of juvenile rats. Neuroscience 173:1–18. https://doi.org/10.1016/j.neuroscience.2010.11.037

Article  CAS  PubMed  Google Scholar 

Dang R, Zhou Y, Zhang Y, Liu D, Wu M, Liu A, Xie W (2022) Regulation of social memory by lateral entorhinal cortical projection to dorsal hippocampal CA2. Neurosci Bull 38(3):318–322

Article  PubMed  PubMed Central  Google Scholar 

Daniels WMU, Pietersen CY, Carstens ME, Stein DJ (2004) Maternal separation in rats leads to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor. Metab Brain Dis 19:3–14. https://doi.org/10.1023/B:MEBR.0000027412.19664.b3

Article  CAS  PubMed  Google Scholar 

Delpech JC, Wei L, Hao J, Yu X et al (2016) Early life stress perturbs the maturation of microglia in the developing hippocampus. Brain Behav Immun 57:79–93. https://doi.org/10.1016/j.bbi.2016.06.006

Article  PubMed  PubMed Central  Google Scholar 

Ding SL, Haber SN, Van Hoesen GW (2010) Stratum radiatum of CA2 is an additional target of the perforant path in humans and monkeys. NeuroReport 21:245–249. https://doi.org/10.1097/WNR.0b013e328333d690

Article  PubMed  PubMed Central  Google Scholar 

Dudek SM, Alexander GM, Farris S (2016) Rediscovering area CA2: unique properties and functions. Nat Rev Neurosci 17(2):89–102

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eluvathingal TJ, Chugani HT, Behen ME, Juhász C, Muzik O, Maqbool M, Makki M (2006) Abnormal brain connectivity in children after early severe socioemotional deprivation: a diffusion tensor imaging study. Pediatrics 117(6):2093–2100

Article  PubMed  Google Scholar 

Fanselow MS, Dong H-W (2010) Are the dorsal and ventral hippocampus functionally distinct structures? Neuron 65:7–19. https://doi.org/10.1016/j.neuron.2009.11.031

Article  CAS  PubMed  PubMed Central  Google Scholar 

Felix-Ortiz AC, Tye KM (2014) Amygdala inputs to the ventral hippocampus bidirectionally modulate social behavior. J Neurosci 34:586–595. https://doi.org/10.1523/JNEUROSCI.4257-13.2014

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ferbinteanu J, McDonald RJ (2000) Dorsal and ventral hippocampus: same or different? Psychobiology 28:314–324. https://doi.org/10.3758/bf03331990

Article  Google Scholar 

Figueiredo ÍL, Frota PB, da Cunha DG, da Silva Raposo R, Canuto KM, de Andrade GM, Oriá RB (2016) Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice. Nutrition 32(9):1019–1027

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu R, Shen Q, Xu P, Luo JJ, Tang Y (2014) Phagocytosis of microglia in the central nervous system diseases. Mol Neurobiol 49:1422–1434. https://doi.org/10.1007/s12035-013-8620-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Geier DA, Kern JK, King PG, Sykes LK, Geier MR (2012) An evaluation of the role and treatment of elevated male hormones in autism spectrum disorders. Acta Neurobiol Exp (Wars). https://doi.org/10.1126/science.1202529

Article  PubMed  Google Scholar 

Gemma C, Bachstetter AD (2013) The role of microglia in adult hippocampal neurogenesis. Front Cell Neurosci 7:1–5. https://doi.org/10.3389/fncel.2013.00229

Article  CAS  Google Scholar 

Genty J, Tetsi-Nomigni M, Anton F, Hanesch U (2017) Maternal separation stress leads to resilience against neuropathic pain in adulthood. Neurobiol Stress 8:1–40. https://doi.org/10.1016/j.jep.2010.01.056

Article  Google Scholar 

Gilman SE, Kawachi I, Fitzmaurice GM, Buka SL (2003) Family disruption in childhood and risk of adult depression. Am J Psychiatry 160:939–946. https://doi.org/10.1176/appi.ajp.160.5.939

Article  PubMed