Asok A, Leroy F, Rayman JB, Kandel ER (2019) Molecular mechanisms of the memory trace. Trends Neurosci 42:14–22. https://doi.org/10.1016/j.tins.2018.10.005
Article CAS PubMed Google Scholar
Bailey CH, Kandel ER, Harris KM (2015) Structural components of synaptic plasticity and memory consolidation. Cold Spring Harb Perspect Biol 7:a021758. https://doi.org/10.1101/cshperspect.a021758
Article PubMed PubMed Central Google Scholar
Bolz S, Kaempf N, Puchkov D et al (2023) Synaptotagmin 1-triggered lipid signaling facilitates coupling of exo- and endocytosis. Neuron 111(3765–3774):e3767. https://doi.org/10.1016/j.neuron.2023.08.016
Bourke LT, Knight RA, Latchman DS, Stephanou A, McCormick J (2013) Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy. JAKSTAT 2:e25666. https://doi.org/10.4161/jkst.25666
Article PubMed PubMed Central Google Scholar
Chen S, Ye J, Chen X et al (2018) Valproic acid attenuates traumatic spinal cord injury-induced inflammation via STAT1 and NF-kappaB pathway dependent of HDAC3. J Neuroinflammation 15:150. https://doi.org/10.1186/s12974-018-1193-6
Article CAS PubMed PubMed Central Google Scholar
Clark DN, Brown SV, Xu L et al (2025) Prolonged STAT1 signaling in neurons causes hyperactive behavior. Brain Behav Immun 124:1–8. https://doi.org/10.1016/j.bbi.2024.11.018
Article CAS PubMed Google Scholar
Darnell JE Jr, Kerr IM, Stark GR (1994) Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264:1415–1421. https://doi.org/10.1126/science.8197455
Article CAS PubMed Google Scholar
Durbin JE, Hackenmiller R, Simon MC, Levy DE (1996) Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84:443–450. https://doi.org/10.1016/s0092-8674(00)81289-1
Article CAS PubMed Google Scholar
Enkler L, Szentgyorgyi V, Pennauer M et al (2023) Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis. Nat Cell Biol 25:1157–1172. https://doi.org/10.1038/s41556-023-01180-2
Article CAS PubMed PubMed Central Google Scholar
Hao X, Ou M, Zhang D et al (2020) The effects of general anesthetics on synaptic transmission. Curr Neuropharmacol 18:936–965. https://doi.org/10.2174/1570159X18666200227125854
Article CAS PubMed PubMed Central Google Scholar
Hebert-Chatelain E, Desprez T, Serrat R et al (2016) A cannabinoid link between mitochondria and memory. Nature 539:555–559. https://doi.org/10.1038/nature20127
Article CAS PubMed Google Scholar
Hong S, Beja-Glasser VF, Nfonoyim BM et al (2016) Complement and microglia mediate early synapse loss in Alzheimer mouse models. Science 352:712–716. https://doi.org/10.1126/science.aad8373
Article CAS PubMed PubMed Central Google Scholar
Hong X, Huang L, Lei F, Li T, Luo Y, Zeng M, Wang Z (2025) The role and pathogenesis of tau protein in Alzheimer’s disease. Biomolecules. https://doi.org/10.3390/biom15060824
Article PubMed PubMed Central Google Scholar
Jung JH, Wang Y, Mocle AJ, Zhang T, Kohler S, Frankland PW, Josselyn SA (2023) Examining the engram encoding specificity hypothesis in mice. Neuron 111(1830–1845):e1835. https://doi.org/10.1016/j.neuron.2023.03.007
Kandhaya-Pillai R, Yang X, Tchkonia T, Martin GM, Kirkland JL, Oshima J (2022) TNF-alpha/IFN-gamma synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1. Aging Cell 21:e13646. https://doi.org/10.1111/acel.13646
Article CAS PubMed PubMed Central Google Scholar
Kreutzfeldt M, Bergthaler A, Fernandez M et al (2013) Neuroprotective intervention by interferon-gamma blockade prevents CD8+ T cell-mediated dendrite and synapse loss. J Exp Med 210:2087–2103. https://doi.org/10.1084/jem.20122143
Article CAS PubMed PubMed Central Google Scholar
Levy DE, Darnell JE Jr (2002) Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol 3:651–662. https://doi.org/10.1038/nrm909
Article CAS PubMed Google Scholar
Li J, Zhou Y, Du G, Qin X, Gao L (2019a) Integration of transcriptomics and network analysis deciphers the mechanisms of baicalein in improving learning and memory impairment in senescence-accelerated mouse prone 8 (SAMP8). Eur J Pharmacol 865:172789. https://doi.org/10.1016/j.ejphar.2019.172789
Article CAS PubMed Google Scholar
Li XG, Hong XY, Wang YL et al (2019b) Tau accumulation triggers STAT1-dependent memory deficits by suppressing NMDA receptor expression. EMBO Rep. https://doi.org/10.15252/embr.201847202
Article PubMed PubMed Central Google Scholar
Li T, Li X, Huang X et al (2022) Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5xFAD mice. Neuropharmacology 204:108899. https://doi.org/10.1016/j.neuropharm.2021.108899
Article CAS PubMed Google Scholar
Li YJ, Zhang C, Martincuks A, Herrmann A, Yu H (2023) STAT proteins in cancer: orchestration of metabolism. Nat Rev Cancer 23:115–134. https://doi.org/10.1038/s41568-022-00537-3
Article CAS PubMed Google Scholar
Li C, Cai Y, Chen Y et al (2024) ABCG2 shields against epilepsy, relieves oxidative stress and apoptosis via inhibiting the ISGylation of STAT1 and mTOR. Redox Biol 75:103262. https://doi.org/10.1016/j.redox.2024.103262
Article CAS PubMed PubMed Central Google Scholar
Li X, Xu Y, Li T, Xiong B, Yang X, Feng Y (2025) Downregulation of STAT1 improved learning and memory impairments in aging mice. Neurosci Lett 850:138155. https://doi.org/10.1016/j.neulet.2025.138155
Article CAS PubMed Google Scholar
Liu F, Tian N, Zhang HQ et al (2020) GSK-3beta activation accelerates early-stage consumption of hippocampal neurogenesis in senescent mice. Theranostics 10:9674–9685. https://doi.org/10.7150/thno.43829
Article CAS PubMed PubMed Central Google Scholar
Liu H, Zhang Z, Zang C et al (2021) GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation. J Ethnopharmacol 267:113491. https://doi.org/10.1016/j.jep.2020.113491
Article CAS PubMed Google Scholar
Lopez-Otin C, Blasco MA, Partridge L, Serrano M, Kroemer G (2023) Hallmarks of aging: an expanding universe. Cell 186:243–278. https://doi.org/10.1016/j.cell.2022.11.001
Article CAS PubMed Google Scholar
Ma D, Huang R, Guo K et al (2021) Cornel iridoid glycoside protects against STAT1-dependent synapse and memory deficits by increasing N-methyl-D-aspartate receptor expression in a tau transgenic mice. Front Aging Neurosci 13:671206. https://doi.org/10.3389/fnagi.2021.671206
Article CAS PubMed PubMed Central Google Scholar
Magee JC, Grienberger C (2020) Synaptic plasticity forms and functions. Annu Rev Neurosci 43:95–117. https://doi.org/10.1146/annurev-neuro-090919-022842
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