Acaz-Fonseca E, Avila-Rodriguez M, Garcia-Segura LM, Barreto GE (2016) Regulation of astroglia by gonadal steroid hormones under physiological and pathological conditions. Prog Neurobiol 144:5–26. https://doi.org/10.1016/j.pneurobio.2016.06.002

Article  CAS  PubMed  Google Scholar 

Aguilar-Hernández L, Alejandre R, César Morales-Medina J, Iannitti T, Flores G (2023) Cellular mechanisms in brain aging: focus on physiological and pathological aging. J Chem Neuroanat 128:102210. https://doi.org/10.1016/j.jchemneu.2022.102210

Article  CAS  PubMed  Google Scholar 

Andersen CL, Jensen JL, Ørntoft TF (2004) Normalization of real-time quantitative reverse transcription-PCR data: a model-based variance Estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets. Cancer Res 64(15):5245–5250. https://doi.org/10.1158/0008-5472.CAN-04-0496

Article  CAS  PubMed  Google Scholar 

Antunes M, Biala G (2012) The novel object recognition memory: neurobiology, test procedure, and its modifications. Cogn Process 13:93–110. https://doi.org/10.1007/s10339-011-0430-z

Article  CAS  PubMed  Google Scholar 

Arevalo MA, Santos-Galindo M, Bellini MJ, Azcoitia I, Garcia-Segura LM (2010) Actions of estrogens on glial cells: implications for neuroprotection. Biochim Biophys Acta 1800:1106–1112. https://doi.org/10.1016/j.bbagen.2009.10.002

Article  CAS  PubMed  Google Scholar 

Bagger YZ, Tankó LB, Alexandersen P, Qin G, Christiansen C, Group PS (2005) Early postmenopausal hormone therapy May prevent cognitive impairment later in life. Menopause 12(1):12–17. https://doi.org/10.1097/00042192-200512010-00005

Article  PubMed  Google Scholar 

Barnes CA (1979) Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. J Comp Physiol Psychol 93(1):74. https://doi.org/10.1037/h0077579

Article  CAS  PubMed  Google Scholar 

Bartzokis G (2004) Age-related Myelin breakdown: a developmental model of cognitive decline and alzheimer’s disease. Neurobiol Aging 25(1):5–18. https://doi.org/10.1016/j.neurobiolaging.2003.03.001

Article  CAS  PubMed  Google Scholar 

Benice T, Rizk A, Kohama S, Pfankuch T, Raber J (2006) Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity. Neuroscience 137(2):413–423. https://doi.org/10.1016/j.neuroscience.2005.08.029

Article  CAS  PubMed  Google Scholar 

Bergkvist A, Rusnakova V, Sindelka R, Garda JMA, Sjögreen B, Lindh D et al (2010) Gene expression profiling–clusters of possibilities. Methods 50(4):323–335. https://doi.org/10.1016/j.ymeth.2010.01.009

Article  CAS  PubMed  Google Scholar 

Bettio LE, Rajendran L, Gil-Mohapel J (2017) The effects of aging in the hippocampus and cognitive decline. Neurosci Biobehav Rev 79:66–86. https://doi.org/10.1016/j.neubiorev.2017.04.030

Article  PubMed  Google Scholar 

Brightwell J, Gallagher M, Colombo P (2004) Hippocampal CREB1 but not CREB2 is decreased in aged rats with Spatial memory impairments. Neurobiol Learn Mem 81(1):19–26. https://doi.org/10.1016/j.nlm.2003.08.001

Article  CAS  PubMed  Google Scholar 

Brito D, Esteves F, Rajado A, Silva N, Araújo I, Bragança J et al (2023) Assessing cognitive decline in the aging brain: lessons from rodent and human studies. Npj Aging 9(1):23. https://doi.org/10.1038/s41514-023-00120-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brooks SP, Trueman RC, Dunnett SB (2012) Assessment of motor coordination and balance in mice using the rotarod, elevated bridge, and footprint tests. Curr Protoc Mouse Biol 2(1):37–53. https://doi.org/10.1002/9780470942390.mo110165

Article  PubMed  Google Scholar 

Burke SN, Barnes CA (2006) Neural plasticity in the ageing brain. Nat Rev Neurosci 7(1):30–40. https://doi.org/10.1038/nrn1809

Article  CAS  PubMed  Google Scholar 

Butler SM (2022) The challenging future of Long-term care for older adults. JAMA Health Forum 3(5):e222133–e222133. https://doi.org/10.1001/jamahealthforum.2022.2133

Article  PubMed  Google Scholar 

Cahill-Smith S, Li JM (2014) Oxidative stress, redox signalling and endothelial dysfunction in ageing‐related neurodegenerative diseases: a role of NADPH oxidase 2. Br J Clin Pharmacol 78(3):441–453. https://doi.org/10.1111/bcp.12357

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen J (1992) Quantitative methods in psychology: A power primer. Psychol Bull 112:1155–1159.

Article  Google Scholar 

Cohen JA, Verghese J, Zwerling JL (2016) Cognition and gait in older people. Maturitas 93:73–77. https://doi.org/10.1016/j.maturitas.2016.05.005

Article  PubMed  Google Scholar 

Crespo NE (2021) Age-Related cognitive decline in female C57BL/6cenp mice 15–16 months of age. J Biomed Eng 5:1–12. https://doi.org/10.17303/jber.2021.5.101

Article  Google Scholar 

Dai J, Bercury KK, Ahrendsen JT, Macklin WB (2015) Olig1 function is required for oligodendrocyte differentiation in the mouse brain. J Neurosci 35(10):4386–4402. https://doi.org/10.1523/JNEUROSCI.4962-14.2015

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dean RL, Scozzafava J, Goas JA, Regan B, Beer B, Bartus RT III (1981) Age-related differences in behavior across the life span of the C57BL/6J mouse. Exp Aging Res 7(4):427–451. https://doi.org/10.1080/03610738108259823

Article  PubMed  Google Scholar 

del Barco DG, Montero E, Coro-Antich RM, Brown E, Suarez-Alba J, Lopez L et al (2011) Coadministration of epidermal growth factor and growth hormone releasing peptide-6 improves clinical recovery in experimental autoimmune encephalitis. Restor Neurol Neurosci 29(4):243–252. https://doi.org/10.3233/RNN-2011-0595

Article  CAS  PubMed  Google Scholar 

Della Sala S, Parra MA, Fabi K, Luzzi S, Abrahams S (2012) Short-term memory binding is impaired in AD but not in non-AD dementias. Neuropsychologia 50(5):833–840. https://doi.org/10.1016/j.neuropsychologia.2012.01.018

Article  PubMed  Google Scholar 

Dumitriu D, Rapp PR, McEwen BS, Morrison JH (2010) Estrogen and the aging brain: an elixir for the weary cortical network. Ann N Y Acad Sci 1204:104–112. https://doi.org/10.1111/j.1749-6632.2010.05529.x

Article  CAS  PubMed  PubMed Central  Google Scholar 

Engler-Chiurazzi EB, Brown CM, Povroznik JM, Simpkins JW (2017) Estrogens as neuroprotectants: estrogenic actions in the context of cognitive aging and brain injury. Prog Neurobiol 157:188–211. https://doi.org/10.1016/j.pneurobio.2015.12.008

Article  CAS  PubMed  Google Scholar 

España J, Valero J, Miñano-Molina AJ, Masgrau R, Martín E, Guardia-Laguarta C et al (2010) β-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1. J Neurosci 30(28):9402–9410. https://doi.org/10.1523/JNEUROSCI.2154-10.2010

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans WJ, Lexell J (1995) Human aging, muscle mass, and fiber type composition. J Gerontol Biol Sci Med Sci 50(SpecialIssue):11–16. https://doi.org/10.1093/gerona/50A.Special_Issue.11

Article  Google Scholar 

Fahlström A, Yu Q, Ulfhake B (2011) Behavioral changes in aging female C57BL/6 mice. Neurobiol Aging 32(10):1868–1880. https://doi.org/10.1016/j.neurobiolaging.2009.11.003

Article  PubMed