Alves VS, Alves-Silva HS, Orts DJB, Ribeiro-Silva L, Arcisio-Miranda M, Oliveira FA (2019) Calcium signaling in neurons and glial cells: role of Cav1 channels. Neuroscience 421:95–111
Article CAS PubMed Google Scholar
Andersen JV, Christensen SK, Westi EW, Diaz-delCastillo M, Tanila H, Schousboe A, Aldana BI, Waagepetersen HS (2021) Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer’s disease. Neurobiol Dis 148:105198. https://doi.org/10.1016/j.nbd.2020.105198
Article CAS PubMed Google Scholar
Andersen JV, Schousboe A, Verkhratsky A (2022) Astrocyte energy and neurotransmitter metabolism in Alzheimer’s disease: integration of the glutamate/GABA-glutamine cycle. Prog Neurobiol 217:102331. https://doi.org/10.1016/j.pneurobio.2022.102331
Article CAS PubMed Google Scholar
Bandyopadhyay B, Chakrabarti L, Poddar M (2008) Low protein diet consumption antagonize the age-associated change in hypothalamic GABA receptor activity. Nat Prec. https://doi.org/10.1038/npre.2008.2284.1
Bandyopadhyay BC, Swaim WD, Sarkar A, Liu X, Ambudkar IS (2012) Extracellular Ca(2+) sensing in salivary ductal cells. J Biol Chem 287(36):30305–30316
Article CAS PubMed PubMed Central Google Scholar
Chang W, Shoback D (2004) Extracellular Ca2+-sensing receptors–an overview. Cell Calcium 35(3):183–196. https://doi.org/10.1016/j.ceca.2003.10.012
Article CAS PubMed Google Scholar
Chattopadhyay N, Espinosa-Jeffrey A, Tfelt-Hansen J, Yano S, Bandyopadhyay S, Brown EM, de Vellis J (2008) Calcium receptor expression and function in oligodendrocyte commitment and lineage progression: potential impact on reduced myelin basic protein in CaR-null mice. J Neurosci Res 86:2159–2167
Article CAS PubMed Google Scholar
Chiarini A, Dal Pra I, Marconi M, Chakravarthy B, Whitfield JF, Armato U (2009) Calcium-sensing receptor (CaSR) in human brain’s pathophysiology: roles in late-onset Alzheimer’s disease (LOAD). Curr Pharm Biotechnol 10(3):317–326
Article CAS PubMed Google Scholar
Chung SD, Alavi N, Livingston D, Hiller S, Taub M (1982) Characterization of primary rabbit kidney cultures that express proximal tubule functions in a hormonally defined medium. J Cell Biol 95(1):118–126. https://doi.org/10.1083/jcb.95.1.118
Article CAS PubMed Google Scholar
Conley YP, Mukherjee A, Kammerer C et al (2009) Evidence supporting a role for the calcium-sensing receptor in Alzheimer disease. Am J Med Genet B Neuropsychiatr Genet 150B(5):703–709
Article CAS PubMed PubMed Central Google Scholar
de Juan-Sanz J, Holt GT, Schreiter ER, de Juan F, Kim DS, Ryan TA (2017) Axonal endoplasmic reticulum Ca2+ content controls release probability in CNS nerve terminals. Neuron 93(4):867-881.e6
Article PubMed PubMed Central Google Scholar
Denis C et al (2012) Probing heterotrimeric G protein activation: applications to biased ligands. Curr Pharm des 18:128–144
Article CAS PubMed PubMed Central Google Scholar
Giudice ML, Mihalik B, Dinnyés A, Kobolák J (2019) The nervous system relevance of the calcium sensing receptor in health and disease. Molecules 24(14):2546
Article PubMed PubMed Central Google Scholar
Goaillard J-M, Moubarak E, Tapia M, Tell F (2020) Diversity of axonal and dendritic contributions to neuronal output. Front Cell Neurosci 13:570
Article PubMed PubMed Central Google Scholar
Gowen M, Stroup GB, Dodds RA et al (2000) Antagonizing the parathyroid calcium receptor stimulates parathyroid hormone secretion and bone formation in osteopenic rats. J Clin Invest 105(11):1595–1604
Article CAS PubMed PubMed Central Google Scholar
He F, Wu CG, Gao Y et al (2024a) Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor. Nature 626(8001):1141–1148
Article CAS PubMed Google Scholar
He F, Wu CG, Gao Y, Rahman SN, Zaoralová M, Papasergi-Scott MM, Gu TJ, Robertson MJ, Seven AB, Li L, Mathiesen JM, Skiniotis G (2024b) Allosteric modulation and G-protein selectivity of the Ca2+-sensing receptor. Nature 626(8001):1141–1148
Article CAS PubMed Google Scholar
Heine M, Heck J, Ciuraszkiewicz A, Bikbaev A (2020) Dynamic compartmentalization of calcium channel signalling in neurons. Neuropharmacology 169:107556. https://doi.org/10.1016/j.neuropharm.2019.02.038
Article CAS PubMed Google Scholar
Herculano-Houzel S, Dos Santos SE (2018) You do not mess with the glia. Neuroglia 1(1):193–219
Ibeh CL, Yiu AJ, Kanaras YL et al (2019) Evidence for a regulated Ca2+ entry in proximal tubular cells and its implication in calcium stone formation. J Cell Sci 132(9):jcs225268. https://doi.org/10.1242/jcs.225268
Article CAS PubMed PubMed Central Google Scholar
Jones BL, Smith SM (2016) Calcium-Sensing receptor: a key target for extracellular calcium signaling in neurons. Front Physiol 30(7):116
Jouret F, Wu J, Hull M et al (2013) Activation of the Ca2+-sensing receptor induces deposition of tight junction components to the epithelial cell plasma membrane. J Cell Sci 126(Pt 22):5132–5142
CAS PubMed PubMed Central Google Scholar
Kim Y, Park J, Choi YK (2019) The role of astrocytes in the central nervous system focused on BK channel and heme oxygenase metabolites: a review. Antioxidants 8(5):121
Article CAS PubMed PubMed Central Google Scholar
Lu B, Zhang Q, Wang H, Wang Y, Nakayama M, Ren D (2010) Extracellular calcium controls background current and neuronal excitability via an UNC79-UNC80-NALCN cation channel complex. Neuron 68(3):488–499
Article CAS PubMed PubMed Central Google Scholar
Matejuk A, Ransohoff RM (2020) Crosstalk between astrocytes and microglia: an overview. Front Immunol 11:1416. https://doi.org/10.3389/fimmu.2020.01416
Article CAS PubMed PubMed Central Google Scholar
Mercer AJ, Rabl K, Riccardi GE, Brecha NC, Stella SL Jr, Thoreson WB (2011) Location of release sites and calcium-activated chloride channels relative to calcium channels at the photoreceptor ribbon synapse. J Neurophysiol 105(1):321–335. https://doi.org/10.1152/jn.00332.2010
Article CAS PubMed Google Scholar
Chen ZP, Zhao X, Wang S, et al (2025) GABA-dependent microglial elimination of inhibitory synapses underlies neuronal hyperexcitability in epilepsy. Nat Neurosci 28:1404-1417. https://doi.org/10.1038/s41593-025-01979-2
Mudò G, Trovato-Salinaro A, Barresi V, Belluardo N, Condorelli DF (2009) Identification of calcium sensing receptor (CaSR) mRNA-expressing cells in normal and injured rat brain. Brain Res 1298:24–36
Nakamura T, Yamashita T, Saitoh N, Takahashi T (2008) Developmental changes in calcium/calmodulin-dependent inactivation of calcium currents at the rat calyx of Held. J Physiol 586(9):2253–2261
Article CAS PubMed PubMed Central Google Scholar
Padamsey Z, Foster WJ, Emptage NJ (2019) Intracellular Ca2+ release and synaptic plasticity: a tale of many stores. Neuroscientist 25(3):208–226
Article CAS PubMed Google Scholar
Pak HJ, Riew TR, Shin YJ, Choi JH, Jin X, Lee MY (2016) Enhanced expression of the calcium-sensing receptor in reactive astrocytes following ischemic injury in vivo and in vitro. J Neurol Sci 366:102–109
Comments (0)