Giaquinto AN, Sung H, Newman LA, Freedman RA, Smith RA, Star J, et al. Breast cancer statistics 2024. CA Cancer J Clin. 2024;74(6):477–95.
Svanoe AA, Humlevik ROC, Knutsvik G, Saele AKM, Askeland C, Ingebriktsen LM, et al. Age-related phenotypes in breast cancer: A population-based study. Int J Cancer. 2024;154(11):2014–24.
Murphy BL, Day CN, Hoskin TL, Habermann EB, Boughey JC. Adolescents and young adults with breast cancer have more aggressive disease and treatment than patients in their forties. Ann Surg Oncol. 2019;26(12):3920–30.
Brantley KD, Kirkner GJ, Hughes ME, Varella L, Suggs G, Cunningham OM, et al. The association between young age at metastatic breast cancer diagnosis and overall survival in the EMBRACE study. NPJ Breast Cancer. 2025;11(1):96.
Article CAS PubMed PubMed Central Google Scholar
Partridge AH, Pagani O, Abulkhair O, Aebi S, Amant F, Azim HA Jr., et al. First international consensus guidelines for breast cancer in young women (BCY1). Breast. 2014;23(3):209–20.
Cardoso F, Loibl S, Pagani O, Graziottin A, Panizza P, Martincich L, et al. The European society of breast cancer specialists recommendations for the management of young women with breast cancer. Eur J Cancer. 2012;48(18):3355–77.
Hou J, Li L, Wang J, Huang X, Xue J, Wu J. Young age is associated with inferior outcomes in early-stage luminal B breast cancer patients who undergo mastectomy. Future Oncol. 2023;19(10):715–26.
Article CAS PubMed Google Scholar
Chollet-Hinton L, Olshan AF, Nichols HB, Anders CK, Lund JL, Allott EH, et al. Biology and etiology of young-onset breast cancers among premenopausal African American women: results from the AMBER consortium. Cancer Epidemiol Biomarkers Prev. 2017;26(12):1722–9.
Article PubMed PubMed Central Google Scholar
Adesoye T, Babayemi O, Postlewait LM, DeSnyder SM, Sun SX, Woodward WA, et al. Inflammatory breast cancer at the extremes of age. Ann Surg Oncol. 2021;28(10):5626–34.
Johansson ALV, Andersson TM, Hsieh CC, Jirstrom K, Cnattingius S, Fredriksson I, et al. Tumor characteristics and prognosis in women with pregnancy-associated breast cancer. Int J Cancer. 2018;142(7):1343–54.
Article CAS PubMed Google Scholar
de la Haba-Rodriguez JR, Minguez P, Rojo F, Martin M, Alba E, Servitja S, et al. Gestational breast cancer: distinctive molecular and clinico-epidemiological features. J Mammary Gland Biol Neoplasia. 2024;29(1):18.
Article PubMed PubMed Central Google Scholar
Siddig A, Tengku Din T, Mohd Nafi SN, Yahya MM, Sulong S, Wan Abdul Rahman WF. The unique biology behind the early onset of breast cancer. Genes (Basel). 2021;12(3):372.
Article CAS PubMed PubMed Central Google Scholar
NCCN. Genetic/Familial High-Risk Assessment: Breast, Ovarian, Pancreatic, and Prostate: National Comprehensive Cancer Network; 2026 [Available from: https://www.nccn.org/professionals/physician_gls/pdf/genetics_bopp.pdf
Copson ER, Maishman TC, Tapper WJ, Cutress RI, Greville-Heygate S, Altman DG, et al. Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study. Lancet Oncol. 2018;19(2):169–80.
Article CAS PubMed PubMed Central Google Scholar
Luen SJ, Viale G, Nik-Zainal S, Savas P, Kammler R, Dell’Orto P, et al. Genomic characterisation of hormone receptor-positive breast cancer arising in very young women. Ann Oncol. 2023;34(4):397–409.
Article CAS PubMed Google Scholar
Ruddy KJ, Gelber S, Tamimi RM, Schapira L, Come SE, Meyer ME, et al. Breast cancer presentation and diagnostic delays in young women. Cancer. 2014;120(1):20–5.
ACS. American Cancer Society Recommendations for the Early Detection of Breast Cancer. American Cancer Society; [updated December 19, 2023. Available from: https://www.cancer.org/cancer/types/breast-cancer/screening-tests-and-early-detection/american-cancer-society-recommendations-for-the-early-detection-of-breast-cancer.html
NCCN. Breast Cancer Screening and Diagnosis: National Comprehensive Cancer Network. 2025 [Available from: https://www.nccn.org/professionals/physician_gls/pdf/breast-screening.pdf
Monticciolo DL, Newell MS, Moy L, Lee CS, Destounis SV. Breast cancer screening for women at higher-than-average risk: updated recommendations from the ACR. J Am Coll Radiol. 2023;20(9):902–14.
Miles R, Wan F, Onega TL, Lenderink-Carpenter A, O’Meara ES, Zhu W, et al. Underutilization of supplemental magnetic resonance imaging screening among patients at high breast cancer risk. J Womens Health (Larchmt). 2018;27(6):748–54.
Checka CM, Chun JE, Schnabel FR, Lee J, Toth H. The relationship of mammographic density and age: implications for breast cancer screening. AJR Am J Roentgenol. 2012;198(3):W292-5.
Bertrand KA, Scott CG, Tamimi RM, Jensen MR, Pankratz VS, Norman AD, et al. Dense and nondense mammographic area and risk of breast cancer by age and tumor characteristics. Cancer Epidemiol Biomarkers Prev. 2015;24(5):798–809.
Article PubMed PubMed Central Google Scholar
Bodewes FTH, van Asselt AA, Dorrius MD, Greuter MJW, de Bock GH. Mammographic breast density and the risk of breast cancer: a systematic review and meta-analysis. Breast. 2022;66:62–8.
Article CAS PubMed PubMed Central Google Scholar
Narayan AK, Visvanathan K, Harvey SC. Comparative effectiveness of breast MRI and mammography in screening young women with elevated risk of developing breast cancer: a retrospective cohort study. Breast Cancer Res Treat. 2016;158(3):583–9.
Chen S, Parmigiani G. Meta-analysis of BRCA1 and BRCA2 penetrance. J Clin Oncol. 2007;25(11):1329–33.
Johnson HM, Miller ME, Mitchell KB, American Society of Breast Surgeons’ Research C. Oncolactation for patients with breast cancer: executive summary from the American Society of Breast Surgeons. Ann Surg Oncol. 2025. https://doi.org/10.1245/s10434-025-17742-7.
Article PubMed PubMed Central Google Scholar
Orozco JIJ, Fancher CE, Grumley JG. ASO author reflections: breast-conserving therapy: a safe option in young patients with early-stage breast cancer. Ann Surg Oncol. 2022;29(10):6311–2.
Vila J, Gandini S, Gentilini O. Overall survival according to type of surgery in young (=40 years) early breast cancer patients: A systematic meta-analysis comparing breast-conserving surgery versus mastectomy</at. Breast. 2015;24(3):175–81.
Rajan KK, Fairhurst K, Birkbeck B, Novintan S, Wilson R, Savovic J et al. Overall survival after mastectomy versus breast-conserving surgery with adjuvant radiotherapy for early-stage breast cancer: meta-analysis. BJS Open. 2024;8(3).
de Boniface J, Szulkin R, Johansson ALV. Survival after breast conservation vs mastectomy adjusted for comorbidity and socioeconomic status: a Swedish national 6-year follow-up of 48 986 women. JAMA Surg. 2021;156(7):628–37.
Article PubMed PubMed Central Google Scholar
Yadav S, Boddicker NJ, Na J, Polley EC, Hu C, Hart SN, et al. Contralateral breast cancer risk among carriers of germline pathogenic variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2. J Clin Oncol. 2023;41(9):1703–13.
Article CAS PubMed PubMed Central Google Scholar
Grimmer L, Liederbach E, Velasco J, Pesce C, Wang CH, Yao K. Variation in contralateral prophylactic mastectomy rates according to racial groups in young women with breast cancer, 1998 to 2011: a report from the National Cancer Data Base. J Am Coll Surg. 2015;221(1):187–96.
Blondeaux E, Sonnenblick A, Agostinetto E, Bas R, Kim HJ, Franzoi MA, et al. Association between risk-reducing surgeries and survival in young BRCA carriers with breast cancer: an international cohort study. Lancet Oncol. 2025;26(6):759–70.
Article CAS PubMed Google Scholar
Rosenberg SM, Sepucha K, Ruddy KJ, Tamimi RM, Gelber S, Meyer ME, et al. Local therapy decision-making and contralateral prophylactic mastectomy in young women with early-stage breast cancer. Ann Surg Oncol. 2015;22(12):3809–15.
Article PubMed PubMed Central Google Scholar
Singh P, Agnese D, Amin M, Barrio AV, Van den Botty A, Burke E, et al. Society of surgical oncology breast disease site working group statement on contralateral mastectomy: Indications, Outcomes, and risks. Ann Surg Oncol. 2024;31(4):2212–23.
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