Han N, Peng X, Zhang T, Qiang Y, Li X, Zhang W. Rapid turnover and short-term blooms of Escherichia coli in the human gut. J Bacteriol. 2024;206(1):e0023923. https://doi.org/10.1128/jb.00239-23.
Article CAS PubMed Google Scholar
Martinson JNV, Walk ST. Escherichia coli residency in the gut of healthy human adults. EcoSalPlus. 2020;9(1). https://doi.org/10.1128/ecosalplus.ESP-0003-2020.
Hacker J, Blum-Oehler G. In appreciation of Theodor Escherich. Nat Rev Microbiol. 2007;5:902. https://doi.org/10.1038/nrmicro1810.
Fan S, Jiang S, Luo L, et al. Antibiotic-Resistant Escherichia coli strains isolated from captive giant pandas: A reservoir of antibiotic resistance genes and Virulence-Associated genes. Vet Sci. 2022;9(12):705. https://doi.org/10.3390/vetsci9120705.
Article PubMed PubMed Central Google Scholar
Riley LW. Distinguishing pathovars from nonpathovars: Escherichia coli. Microbiol Spectr. 2020;8(4). https://doi.org/10.1128/microbiolspec.AME-0014-2020.
Kathayat D, Lokesh D, Ranjit S, Rajashekara G. Avian pathogenic Escherichia coli (APEC): an overview of virulence and pathogenesis factors, zoonotic potential, and control strategies. Pathogens. 2021;10(4):467. https://doi.org/10.3390/pathogens10040467.
Article CAS PubMed PubMed Central Google Scholar
Sarowska J, Futoma-Koloch B, Jama-Kmiecik A, et al. Virulence factors, prevalence and potential transmission of extraintestinal pathogenic Escherichia coli isolated from different sources: recent reports. Gut Pathog. 2019;11:10. https://doi.org/10.1186/s13099-019-0290-0.
Article PubMed PubMed Central Google Scholar
Manges AR, Geum HM, Guo A, Edens TJ, Fibke CD, Pitout JDD. Global Extraintestinal Pathogenic Escherichia coli (ExPEC) Lineages. Clin Microbiol Rev. 2019;32(3):e00135–18. https://doi.org/10.1128/CMR.00135-18
Terlizzi ME, Gribaudo G, Maffei ME. UroPathogenic Escherichia coli (UPEC) Infections: Virulence Factors, Bladder Responses, Antibiotic, and Non-antibiotic Antimicrobial Strategies. Front Microbiol. 2017;8:1566. https://doi.org/10.3389/fmicb.2017.01566
Zhou Y, Zhou Z, Zheng L, et al. Urinary Tract Infections Caused by Uropathogenic Escherichia coli: Mechanisms of Infection and Treatment Options. Int J Mol Sci. 2023;24(13):10537. https://doi.org/10.3390/ijms241310537
Rosen DA, Hooton TM, Stamm WE, Humphrey PA, Hultgren SJ. Detection of intracellular bacterial communities in human urinary tract infection. PLoS Med. 2007;4(12):e329. https://doi.org/10.1371/journal.pmed.0040329.
Article PubMed PubMed Central Google Scholar
Schwan WR, Lee JL, Lenard FA, Matthews BT, Beck MT. Osmolarity and pH growth conditions regulate Fim gene transcription and type 1 Pilus expression in uropathogenic Escherichia coli. Infect Immun. 2002;70(3):1391–402. https://doi.org/10.1128/IAI.70.3.1391-1402.2002.
Article CAS PubMed PubMed Central Google Scholar
Stærk K, Grønnemose RB, Nielsen TK, et al. Escherichia coli type-1 fimbriae are critical to overcome initial bottlenecks of infection upon low-dose inoculation in a Porcine model of cystitis. Microbiol (Reading). 2021;167(10):001101. https://doi.org/10.1099/mic.0.001101.
Wright KJ, Seed PC, Hultgren SJ. Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. Cell Microbiol. 2007;9(9):2230–41. https://doi.org/10.1111/j.1462-5822.2007.00952.x.
Article CAS PubMed Google Scholar
Wu XR, Sun TT, Medina JJ. In vitro binding of type 1-fimbriated Escherichia coli to uroplakins Ia and ib: relation to urinary tract infections. Proc Natl Acad Sci U S A. 1996;93(18):9630–5. https://doi.org/10.1073/pnas.93.18.9630.
Article CAS PubMed PubMed Central Google Scholar
Bessaiah H, Anamalé C, Sung J, Dozois CM. What flips the switch?? Signals and stress regulating extraintestinal pathogenic Escherichia coli type 1 fimbriae (Pili). Microorganisms. 2021;10(1):5. https://doi.org/10.3390/microorganisms10010005.
Article CAS PubMed PubMed Central Google Scholar
Lane MC, Mobley HL. Role of P-fimbrial-mediated adherence in pyelonephritis and persistence of uropathogenic Escherichia coli (UPEC) in the mammalian kidney. Kidney Int. 2007;72(1):19–25. https://doi.org/10.1038/sj.ki.5002230.
Article CAS PubMed Google Scholar
Isidro-Coxca MI, Ortiz-Jiménez S, Puente JL. Type 1 fimbria and P pili: regulatory mechanisms of the prototypical members of the chaperone-usher fimbrial family. Arch Microbiol. 2024;206(9):373. https://doi.org/10.1007/s00203-024-04092-3.
Article CAS PubMed PubMed Central Google Scholar
Korhonen TK, Parkkinen J, Hacker J, et al. Binding of Escherichia coli S fimbriae to human kidney epithelium. Infect Immun. 1986;54(2):322–7. https://doi.org/10.1128/iai.54.2.322-327.1986.
Article CAS PubMed PubMed Central Google Scholar
Whelan S, Lucey B, Finn K. Uropathogenic Escherichia coli (UPEC)-Associated urinary tract infections: the molecular basis for challenges to effective treatment. Microorganisms. 2023;11(9):2169. https://doi.org/10.3390/microorganisms11092169.
Article CAS PubMed PubMed Central Google Scholar
Selvarangan R, Goluszko P, Singhal J, et al. Interaction of Dr adhesin with collagen type IV is a critical step in Escherichia coli renal persistence. Infect Immun. 2004;72(8):4827–35. https://doi.org/10.1128/IAI.72.8.4827-4835.2004.
Article CAS PubMed PubMed Central Google Scholar
Sen A, Kaul A, Kaul R. Estrogen receptors in human bladder cells regulate innate cytokine responses to differentially modulate uropathogenic E. coli colonization. Immunobiology. 2021;226(1):152020. https://doi.org/10.1016/j.imbio.2020.152020.
Article CAS PubMed Google Scholar
Naskar M, Parekh VP, Abraham MA, et al. α-Hemolysin promotes uropathogenic E. coli persistence in bladder epithelial cells via abrogating bacteria-harboring lysosome acidification. PLoS Pathog. 2023;19(5):e1011388. https://doi.org/10.1371/journal.ppat.1011388.
Article CAS PubMed PubMed Central Google Scholar
Smith YC, Rasmussen SB, Grande KK, Conran RM, O’Brien AD. Hemolysin of uropathogenic Escherichia coli evokes extensive shedding of the Uroepithelium and hemorrhage in bladder tissue within the first 24 hours after intraurethral inoculation of mice. Infect Immun. 2008;76(7):2978–90. https://doi.org/10.1128/IAI.00075-08.
Article CAS PubMed PubMed Central Google Scholar
Dhakal BK, Mulvey MA. The UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways. Cell Host Microbe. 2012;11(1):58–69. https://doi.org/10.1016/j.chom.2011.12.003.
Article CAS PubMed PubMed Central Google Scholar
Nipič D, Podlesek Z, Budič M, Črnigoj M, Žgur-Bertok D. Escherichia coli uropathogenic-specific protein, usp, is a bacteriocin-like genotoxin. J Infect Dis. 2013;208(10):1545–52. https://doi.org/10.1093/infdis/jit480.
Article CAS PubMed Google Scholar
Crnigoj M, Podlesek Z, Budič M, Zgur-Bertok D. The Escherichia coli uropathogenic-specific-protein-associated immunity protein 3 (Imu3) has nucleic acid -binding activity. BMC Microbiol. 2014;14:16. https://doi.org/10.1186/1471-2180-14-16.
Article CAS PubMed PubMed Central Google Scholar
Soto SM, Smithson A, Horcajada JP, Martinez JA, Mensa JP, Vila J. Implication of biofilm formation in the persistence of urinary tract infection caused by uropathogenic Escherichia coli. Clin Microbiol Infect. 2006;12(10):1034–6. https://doi.org/10.1111/j.1469-0691.2006.01543.x.
Article CAS PubMed Google Scholar
Krawczyk B, Wityk P, Laskowska A, et al. Iron uptake by Escherichia coli in urinary tract infections and Urosepsis. PLoS ONE. 2025;20(6):e0326251. https://doi.org/10.1371/journal.pone.0326251.
Article CAS PubMed PubMed Central Google Scholar
Zalewska-Pia Tek B, Pia Tek R, Olszewski M, Kur J. Identification of antigen Ag43 in uropathogenic Escherichia coli Dr + strains and defining its role in the pathogenesis of urinary tract infections. Microbiol (Reading). 2015;161(Pt 5):1034–49. https://doi.org/10.1099/mic.0.000072.
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