Available online 5 December 2025, 152190

Point-of-care ultrasound (POCUS) is an increasingly utilized bedside imaging modality in the neonatal intensive care unit, offering procedural, diagnostic and therapeutic guidance for clinicians. This narrative review explores the key technical aspects of POCUS use in neonates and the expanding body of research supporting its use for both procedural guidance and diagnostic applications. Despite its growing potential to enhance neonatal care, widespread implementation remains challenged by lack of consensus and guidance related to training, credentialing, quality assurance and assessment of competency. A framework for curriculum development is proposed to support the integration of POCUS into neonatology practice. As its role continues to expand, addressing these challenges will be critical to optimizing the benefits of POCUS and improving neonatal outcomes.

Neonatal Intensive Care Unit

Point-of-Care Ultrasound

Randomized Controlled Trial

Peripheral Arterial Cannula

Central Venous Catheter

Umbilical Venous Catheter

Peripherally Inserted Central Catheter

continuous positive airway pressure

American Academy of Pediatrics

Respiratory Distress Syndrome, TTN, Transient Tachypnea of the Newborn

Bronchopulmonary Dysplasia

Necrotizing Enterocolitis

Intracranial Hemorrhage

© 2025 The Author(s). Published by Elsevier Inc.