Stein DJ, Palk AC, Kendler KS (2021) What is a mental disorder? An exemplar-focused approach. Psychol Med 51:894–901. https://doi.org/10.1017/S0033291721001185

Article  PubMed  PubMed Central  Google Scholar 

McCutcheon RA, Reis Marques T, Howes OD (2020) Schizophrenia-an overview. JAMA Psychiatr 77:201–210. https://doi.org/10.1001/jamapsychiatry.2019.3360

Article  Google Scholar 

Greenwood TA (2020) Creativity and bipolar disorder: a shared genetic vulnerability. Annu Rev Clin Psychol 16:239–264. https://doi.org/10.1146/annurev-clinpsy-050718-095449

Article  PubMed  Google Scholar 

Carvalho AF, Firth J, Vieta E (2020) Bipolar disorder. N Engl J Med 383:58–66. https://doi.org/10.1056/NEJMra1906193

Article  PubMed  CAS  Google Scholar 

Radley J, Grant C, Barlow J, Johns L (2021) Parenting interventions for people with schizophrenia or related serious mental illness. Cochrane Database Syst Rev. https://doi.org/10.1002/14651858.CD013536.pub2

Article  PubMed  PubMed Central  Google Scholar 

Jauhar S, Johnstone M, McKenna PJ (2022) Schizophrenia. Lancet 399:473–486. https://doi.org/10.1016/S0140-6736(21)01730-X

Article  PubMed  CAS  Google Scholar 

Solmi M, Seitidis G, Mavridis D, Correll CU, Dragioti E, Guimond S et al (2023) Incidence, prevalence, and global burden of schizophrenia - data, with critical appraisal, from the Global Burden of Disease (GBD) 2019. Mol Psychiatry 28:5319–5327. https://doi.org/10.1038/s41380-023-02138-4

Article  PubMed  Google Scholar 

Adelborg K, Sundbøll J, Videbech P, Grove EL (2017) The risk of thromboembolism in users of antidepressants and antipsychotics. Adv Exp Med Biol 906:351–361. https://doi.org/10.1007/5584_2016_125

Article  PubMed  CAS  Google Scholar 

Tritschler T, Kraaijpoel N, Le Gal G, Wells PS (2018) Venous thromboembolism: advances in diagnosis and treatment. JAMA 320:1583–1594. https://doi.org/10.1001/jama.2018.14346

Article  PubMed  Google Scholar 

Potere N, Mahé I, Angchaisuksiri P, Cesarman-Maus G, Tan CW, Rashid A et al (2024) Unmet needs and barriers in venous thromboembolism education and awareness among people living with cancer: a global survey. J Thromb Haemost 22:1973–1983. https://doi.org/10.1016/j.jtha.2024.03.019

Article  PubMed  Google Scholar 

Lin C-E, Chung C-H, Chen L-F, Chien W-C (2019) Increased risk for venous thromboembolism among patients with concurrent depressive, bipolar, and schizophrenic disorders. Gen Hosp Psychiatry 61:34–40. https://doi.org/10.1016/j.genhosppsych.2019.10.003

Article  PubMed  Google Scholar 

Smith ML, Farkas DK, Sumner JA, Valdimarsdóttir U, Lash TL, Sørensen HT et al (2021) Unspecified stress disorders and risk of arterial and venous thromboembolic disease in the Danish population. J Affect Disord 282:712–716. https://doi.org/10.1016/j.jad.2020.12.180

Article  PubMed  Google Scholar 

Ward J, Le N-Q, Suryakant S, Brody JA, Amouyel P, Boland A et al (2023) Polygenic risk of major depressive disorder as a risk factor for venous thromboembolism. Blood Adv 7:5341–5350. https://doi.org/10.1182/bloodadvances.2023010562

Article  PubMed  PubMed Central  CAS  Google Scholar 

Kowal C, Peyre H, Amad A, Pelissolo A, Leboyer M, Schürhoff F et al (2020) Psychotic, mood, and anxiety disorders and venous thromboembolism: a systematic review and meta-analysis. Psychosom Med 82:838–849. https://doi.org/10.1097/PSY.0000000000000863

Article  PubMed  Google Scholar 

Chow V, Reddel C, Pennings G, Scott E, Pasqualon T, Ng ACC et al (2015) Global hypercoagulability in patients with schizophrenia receiving long-term antipsychotic therapy. Schizophr Res 162:175–182. https://doi.org/10.1016/j.schres.2014.12.042

Article  PubMed  Google Scholar 

Masopust J, Malý R, Andrýs C, Vališ M, Bažant J, Hosák L (2011) Markers of thrombogenesis are activated in unmedicated patients with acute psychosis: a matched case control study. BMC Psychiatry 11:2. https://doi.org/10.1186/1471-244X-11-2

Article  PubMed  PubMed Central  Google Scholar 

Sessler DI, Imrey PB (2015) Clinical research methodology 1: study designs and methodological sources of error. Anesth Analg 121:1034–1042. https://doi.org/10.1213/ANE.0000000000000815

Article  PubMed  Google Scholar 

Sessler DI, Imrey PB (2015) Clinical research methodology 3: randomized controlled trials. Anesth Analg 121:1052–1064. https://doi.org/10.1213/ANE.0000000000000862

Article  PubMed  CAS  Google Scholar 

Kiani AK, Naureen Z, Pheby D, Henehan G, Brown R, Sieving P et al (2022) Methodology for clinical research. J Prev Med Hyg 63:E267–E278. https://doi.org/10.15167/2421-4248/jpmh2022.63.2S3.2769

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Holmes MV (2019) Meta-analysis and Mendelian randomization: a review. Res Synth Methods 10:486–496. https://doi.org/10.1002/jrsm.1346

Article  PubMed  PubMed Central  Google Scholar 

Davey Smith G, Hemani G (2014) Mendelian randomization: genetic anchors for causal inference in epidemiological studies. Hum Mol Genet 23:R89-98. https://doi.org/10.1093/hmg/ddu328

Article  PubMed  PubMed Central  CAS  Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA et al (2021) Strengthening the reporting of observational studies in epidemiology using Mendelian Randomization: the STROBE-MR statement. JAMA 326:1614. https://doi.org/10.1001/jama.2021.18236

Article  PubMed  Google Scholar 

Davies NM, Holmes MV, Davey SG (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601

Article  PubMed  PubMed Central  Google Scholar 

Papadimitriou N, Dimou N, Tsilidis KK, Banbury B, Martin RM, Lewis SJ et al (2020) Physical activity and risks of breast and colorectal cancer: a Mendelian randomisation analysis. Nat Commun 11:597. https://doi.org/10.1038/s41467-020-14389-8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Bowden J, Davey Smith G, Haycock PC, Burgess S (2016) Consistent estimation in Mendelian Randomization with some invalid instruments using a weighted median estimator. Genet Epidemiol 40:304–314. https://doi.org/10.1002/gepi.21965

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Davey Smith G, Burgess S (2015) Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression. Int J Epidemiol 44:512–525. https://doi.org/10.1093/ije/dyv080

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Butterworth A, Thompson SG (2013) Mendelian randomization analysis with multiple genetic variants using summarized data. Genet Epidemiol 37:658–665. https://doi.org/10.1002/gepi.21758

Article  PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen C-Y, Neale B, Do R (2018) Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50:693–698. https://doi.org/10.1038/s41588-018-0099-7

Article  PubMed  PubMed Central  CAS  Google Scholar 

Zhu Z, Zhang F, Hu H, Bakshi A, Robinson MR, Powell JE et al (2016) Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets. Nat Genet 48:481–487. https://doi.org/10.1038/ng.3538

Article  PubMed  CAS