Krainc D, Martin WJ, Casey B, Jensen FE, Tishkoff S, Potter WZ, Hyman SE (2023) Shifting the trajectory of therapeutic development for neurological and psychiatric disorders. Sci Transl Med 15(720):eadg4775. https://doi.org/10.1126/scitranslmed.adg4775

Article  PubMed  Google Scholar 

Nikolova VL, Smith MRB, Hall LJ, Cleare AJ, Stone JM, Young AH (2021) Perturbations in gut microbiota composition in psychiatric disorders: a review and Meta-analysis. JAMA Psychiatry 78(12):1343–1354. https://doi.org/10.1001/jamapsychiatry.2021.2573

Article  PubMed  Google Scholar 

Bonnechère B, Amin N, van Duijn C (2022) What are the key gut microbiota involved in neurological diseases? A systematic review. Int J Mol Sci 23(22):13665. https://doi.org/10.3390/ijms232213665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Halverson T, Alagiakrishnan K (2020) Gut microbes in neurocognitive and mental health disorders. Ann Med 52(8):423–443. https://doi.org/10.1080/07853890.2020.1808239

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tae H, Kim TS (2024) The effect of prebiotic and probiotic food consumption on anxiety severity: a nationwide study in Korea. Front Nutr 11:1385518. https://doi.org/10.3389/fnut.2024.1385518

Article  PubMed  PubMed Central  Google Scholar 

Ligezka AN, Sonmez AI, Corral-Frias MP, Golebiowski R, Lynch B, Croarkin PE, Romanowicz M (2021) A systematic review of Microbiome changes and impact of probiotic supplementation in children and adolescents with neuropsychiatric disorders. Prog Neuropsychopharmacol Biol Psychiatry 108:110187. https://doi.org/10.1016/j.pnpbp.2020.110187

Article  PubMed  Google Scholar 

Yang C, Sun J, Li L, Zheng J, Wang C, Zhao Y, Yun D, Jia M, Wu Z, Liang H, Li W, Hu T, Guo R, Xiao L, Zou Y, Liu Z (2025) Synbiotics of Lactobacillus suilingensis and inulin alleviates cognitive impairment via regulating gut microbiota indole-3-lactic acid metabolism in female AD mice. Alzheimers Dement 21(7):e70406. https://doi.org/10.1002/alz.70406

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zandifar A, Badrfam R, Mohammaditabar M, Kargar B, Goodarzi S, Hajialigol A, Ketabforoush S, Heidari A, Fathi H, Shafiee A, Pourjafar H (2025) The effect of prebiotics and probiotics on levels of depression, anxiety, and cognitive function: a meta-analysis of randomized clinical trials. Brain Behav 15(3):e70401. https://doi.org/10.1002/brb3.70401

Article  PubMed  PubMed Central  Google Scholar 

Xiao-Hang Q, Si-Yue C, Hui-Dong T (2024) Multi-strain probiotics ameliorate Alzheimer’s-like cognitive impairment and pathological changes through the AKT/GSK-3β pathway in senescence-accelerated mouse prone 8 mice. Brain Behav Immun 119:14–27. https://doi.org/10.1016/j.bbi.2024.03.031

Article  CAS  PubMed  Google Scholar 

Asad A, Kirk M, Zhu S, Dong X, Gao M (2025) Effects of prebiotics and probiotics on symptoms of depression and anxiety in clinically diagnosed samples: systematic review and meta-analysis of randomized controlled trials. Nutr Rev 83(7):e1504–e1520. https://doi.org/10.1093/nutrit/nuae177

Article  PubMed  Google Scholar 

Wiegers C, Veerman MA, Brummer RJ, Larsen OFA (2022) Reviewing the state of the Art of probiotics as clinical modalities for brain-gut-microbiota axis associated disorders. Front Microbiol 13:1053958. https://doi.org/10.3389/fmicb.2022.1053958

Article  PubMed  PubMed Central  Google Scholar 

Nikolova VL, Cleare AJ, Young AH, Stone JM (2023) Acceptability, Tolerability, and estimates of putative treatment effects of probiotics as adjunctive treatment in patients with depression: a randomized clinical trial. JAMA Psychiatry 80(8):842–847. https://doi.org/10.1001/jamapsychiatry.2023.1817

Article  PubMed  PubMed Central  Google Scholar 

Taghizadeh Ghassab F, Shamlou Mahmoudi F, Taheri Tinjani R, Emami Meibodi A, Zali MR, Yadegar A (2024) Probiotics and the microbiota-gut-brain axis in neurodegeneration: beneficial effects and mechanistic insights. Life Sci 350:122748. https://doi.org/10.1016/j.lfs.2024.122748

Article  CAS  PubMed  Google Scholar 

Loh JS, Mak WQ, Tan LKS, Ng CX, Chan HH, Yeow SH, Foo JB, Ong YS, How CW, Khaw KY (2024) Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. Signal Transduct Target Ther 9(1):37. https://doi.org/10.1038/s41392-024-01743-1

Article  PubMed  PubMed Central  Google Scholar 

Toader C, Dobrin N, Costea D, Glavan LA, Covache-Busuioc RA, Dumitrascu DI, Bratu BG, Costin HP, Ciurea AV (2024) Mind, mood and microbiota-gut-brain axis in psychiatric disorders. Int J Mol 25(6):3340. https://doi.org/10.3390/ijms25063340

Article  CAS  Google Scholar 

Gao K, Mu CL, Farzi A, Zhu WY (2020) Tryptophan metabolism: a link between the gut microbiota and brain. Adv Nutr 11(3):709–723. https://doi.org/10.1093/advances/nmz127

Article  PubMed  Google Scholar 

Agus A, Planchais J, Sokol H (2018) Gut microbiota regulation of tryptophan metabolism in health and disease. Cell Host Microbe 23(6):716–724. https://doi.org/10.1016/j.chom.2018.05.003

Article  CAS  PubMed  Google Scholar 

Gheorghe CE, Martin JA, Manriquez FV, Dinan TG, Cryan JF, Clarke G (2019) Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis. Curr Opin Pharmacol 48:137–145. https://doi.org/10.1016/j.coph.2019.08.004

Article  CAS  PubMed  Google Scholar 

Davies NM, Holmes MV, Davey Smith G (2018) Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians. BMJ 362:k601. https://doi.org/10.1136/bmj.k601

Article  PubMed  PubMed Central  Google Scholar 

Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, Beaumont M, Van Treuren W, Knight R, Bell JT, Spector TD, Clark AG, Ley RE (2014) Human genetics shape the gut microbiome. Cell 159(4):789–799. https://doi.org/10.1016/j.cell.2014.09.053

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hall AB, Tolonen AC, Xavier RJ (2017) Human genetic variation and the gut microbiome in disease. Nat Rev Genet 18(11):690–699. https://doi.org/10.1038/nrg.2017.63

Article  CAS  PubMed  Google Scholar 

Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT, Timpson NJ, Dimou N, Langenberg C, Golub RM, Loder EW, Gallo V, Tybjaerg-Hansen A, Davey Smith G, Egger M, Richards JB (2021) Strengthening the reporting of observational studies in epidemiology using Mendelian randomization: the STROBE-MR statement. JAMA 326(16):1614–1621. https://doi.org/10.1001/jama.2021.18236

Article  PubMed  Google Scholar 

Cryan JF, O’Riordan KJ, Cowan CSM, Sandhu KV, Bastiaanssen TFS, Boehme M, Codagnone MG, Cussotto S, Fulling C, Golubeva AV, Guzzetta KE, Jaggar M, Long-Smith CM, Lyte JM, Martin JA, Molinero-Perez A, Moloney G, Morelli E, Morillas E, O’Connor R et al (2019) The microbiota-gut-brain axis. Physiol Rev 99(4):1877–2013. https://doi.org/10.1152/physrev.00018.2018

Article  CAS  PubMed  Google Scholar 

Chen Y, Xu J, Chen Y (2021) Regulation of neurotransmitters by the gut microbiota and effects on cognition in neurological disorders. Nutrients 13(6):2099. https://doi.org/10.3390/nu13062099

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L, Huh JR, Shah K (2022) Microbiota and the gut-brain-axis: implications for new therapeutic design in the CNS. EBioMedicine 77:103908. https://doi.org/10.1016/j.ebiom.2022.103908

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morais LH, Schreiber HL, Mazmanian SK (2021) The gut microbiota-brain axis in behaviour and brain disorders. Nat Rev Microbiol 19(4):241–255. https://doi.org/10.1038/s41579-020-00460-0

Article  CAS  PubMed  Google Scholar 

Kurilshikov A, Medina-Gomez C, Bacigalupe R, Radjabzadeh D, Wang J, Demirkan A, Le Roy CI, Raygoza Garay JA, Finnicum CT, Liu X, Zhernakova DV, Bonder MJ, Hansen TH, Frost F, Rühlemann MC, Turpin W, Moon JY, Kim HN, Lüll K, Barkan E et al (2021) Large-scale association analyses identify host factors influencing human gut Microbiome composition. Nat Genet 53(2):156–165. https://doi.org/10.1038/s41588-020-00763-1

Article