Melis S, Trompet D, Chagin AS, Maes C (2025) Skeletal stem and progenitor cells in bone physiology, ageing and disease. Nat Rev Endocrinol 21:135–153
Chan CK, Seo EY, Chen JY, Lo D, McArdle A et al (2015) Identification and specification of the mouse skeletal stem cell. Cell 160:285–298
Article CAS PubMed PubMed Central Google Scholar
Zhou BO, Yue R, Murphy MM, Peyer JG, Morrison SJ (2014) Leptin-receptor-expressing mesenchymal stromal cells represent the main source of bone formed by adult bone marrow. Cell Stem Cell 15:154–168
Article CAS PubMed PubMed Central Google Scholar
Jeffery EC, Mann TLA, Pool JA, Zhao Z, Morrison SJ (2022) Bone marrow and periosteal skeletal stem/progenitor cells make distinct contributions to bone maintenance and repair. Cell Stem Cell 29:1547–61 e6
Article CAS PubMed Google Scholar
Ambrosi TH, Marecic O, Mcardle A, Sinha R, Gulati GS et al (2021) Aged skeletal stem cells generate an inflammatory degenerative niche. Nature 597:256–262
Article CAS PubMed PubMed Central Google Scholar
Liu YL, Tang XT, Shu HS, Zou W, Zhou BO (2024) Fibrous periosteum repairs bone fracture and maintains the healed bone throughout mouse adulthood. Dev Cell 59:1192–209 e6
Article CAS PubMed Google Scholar
Bianco P, Robey PG (2015) Skeletal stem cells. Development 142:1023–1027
Article CAS PubMed PubMed Central Google Scholar
Emons J, Chagin AS, Hultenby K, Zhivotovsky B, Wit JM, Karperien M, Sävendahl L (2009) Epiphyseal fusion in the human growth plate does not involve classical apoptosis. Pediatr Res 66:654–659
Yamashita A, Morioka M, Kishi H, Kimura T, Yahara Y, Okada M, Fujita K, Sawai H, Ikegawa S, Tsumaki N (2014) Statin treatment rescues FGFR3 skeletal dysplasia phenotypes. Nature 513:507–511
Article CAS PubMed Google Scholar
Liu Y, Zhou Z, Lu G, Zhang X, Shi D, Tong L, Chen D, Tuan RS, Li ZA (2025) Musculoskeletal organoids: an emerging toolkit for establishing personalized models of musculoskeletal disorders and developing regenerative therapies. Acta Biomater 200:158–186
Article CAS PubMed Google Scholar
Loh KM, Chen A, Koh PW, Deng TZ, Sinha R et al (2016) Mapping the pairwise choices leading from pluripotency to human bone, heart, and other mesoderm cell types. Cell 166:451–467
Article CAS PubMed PubMed Central Google Scholar
Tani S, Okada H, Onodera S, Chijimatsu R, Seki M, Suzuki Y, Xin X, Rowe DW, Saito T, Tanaka S, Chung U-i, Ohba S, Hojo H (2023) Stem cell-based modeling and single-cell multiomics reveal gene-regulatory mechanisms underlying human skeletal development. Cell Rep 42:112276
Article CAS PubMed Google Scholar
Xiong J, Ma R, Xie K, Shan C, Chen H, Wang Y, Liao Y, Deng Y, Ye G, Wang Y, Zhu Q, Zhang Y, Cai H, Guo W, Yin Y, Li Z (2025) Recapitulation of endochondral ossification by hPSC-derived SOX9+ sclerotomal progenitors. Nat Commun 16:2781
Article CAS PubMed PubMed Central Google Scholar
Chou DB, Frismantas V, Milton Y, David R, Pop-Damkov P et al (2020) On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nat Biomed Eng 4:394–406
Article PubMed PubMed Central Google Scholar
Galea GL, Zein MR, Allen S, Francis-West P (2021) Making and shaping endochondral and intramembranous bones. Dev Dyn 250:414–449
Article CAS PubMed Google Scholar
Tani S, Chung U-I, Ohba S, Hojo H (2020) Understanding paraxial mesoderm development and sclerotome specification for skeletal repair. Exp Mol Med 52:1166–1177
Article CAS PubMed PubMed Central Google Scholar
Neumann PE, Gest TR (2020) How many bones? Every bone in my body. Clin Anat 33:187–191
Lu F, Zhang Y (2015) Cell totipotency: molecular features, induction, and maintenance. Natl Sci Rev 2:217–225
Article CAS PubMed Google Scholar
Ambrosi TH, Longaker MT, Chan CKF (2019) A revised perspective of skeletal stem cell biology. Front Cell Dev Biol 7:189
Article PubMed PubMed Central Google Scholar
Ono N, Balani DH, Kronenberg HM (2019) Stem and progenitor cells in skeletal development. Curr Top Dev Biol. Elsevier. pp 1–24.
Matsushita Y, Ono W, Ono N (2020) Skeletal stem cells for bone development and repair: diversity matters. Curr Osteopor Rep 18:189–198
Cao Y, Buckels EJ, Matthews BG (2020) Markers for identification of postnatal skeletal stem cells in vivo. Curr Osteopor Rep 18:655–665
Cheng NK-A, Orikasa S, Ono N (2025) Growth plate skeletal stem cells and their actions within the stem cell niche. Int J Mol Sci 26:9460
Article CAS PubMed PubMed Central Google Scholar
Caplan AI (1991) Mesenchymal stem cells. J Orthop Res 9:641–650
Article CAS PubMed Google Scholar
Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR (1999) Multilineage potential of adult human mesenchymal stem cells. Science 284:143–147
Article CAS PubMed Google Scholar
Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini FC, Krause DS, Deans RJ, Keating A, Prockop DJ, Horwitz EM (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8:315–317
Article CAS PubMed Google Scholar
Han X, Liao R, Li X, Zhang C, Huo S, Qin L, Xiong Y, He T, Xiao G, Zhang T (2025) Mesenchymal stem cells in treating human diseases: molecular mechanisms and clinical studies. Signal Transduct Target Ther 10:262
Article CAS PubMed PubMed Central Google Scholar
Mizuhashi K, Ono W, Matsushita Y, Sakagami N, Takahashi A, Saunders TL, Nagasawa T, Kronenberg HM, Ono N (2018) Resting zone of the growth plate houses a unique class of skeletal stem cells. Nature 563:254–258
Article CAS PubMed PubMed Central Google Scholar
Usami Y, Gunawardena AT, Francois NB, Otsuru S, Takano H, Hirose K, Matsuoka M, Suzuki A, Huang J, Qin L, Iwamoto M, Yang W, Toyosawa S, Enomoto-Iwamoto M (2019) Possible contribution of Wnt-responsive chondroprogenitors to the postnatal murine growth plate. J Bone Miner Res 34:964–974
Article CAS PubMed Google Scholar
Newton PT, Li L, Zhou B, Schweingruber C, Hovorakova M et al (2019) A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate. Nature 567:234–238
Article CAS PubMed Google Scholar
Muruganandan S, Pierce R, Teguh DA, Perez RF, Bell N, Nguyen B, Hohl K, Snyder BD, Grinstaff MW, Alberico H, Woods D, Kong Y, Sima C, Bhagat S, Ho K, Rosen V, Gamer L, Ionescu AM (2022) A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury. Nat Commun 13:2515
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