Dendritic interaction of timescales in afterdepolarization potentials and nonmonotonic spike-adding

Abrahamsson, T., Cathala, L., Matsui, K., Shigemoto, R., & DiGregorio, D. A. (2012). Thin Dendrites of Cerebellar Interneurons Confer Sublinear Synaptic Integration and a Gradient of Short-Term Plasticity. Neuron., 73(6), 1159–1172. https://doi.org/10.1016/j.neuron.2012.01.027

Article  CAS  PubMed  Google Scholar 

Akhshi, A., Haggard, M., Marquez, M. M., Farjami, S., Chacron, M. J., & Khadra A. (2023). Decoding the relative contributions of extrinsic and intrinsic mechanisms in mediating heterogeneous spiking activities of sensory neurons in vivo using computational modeling. bioRxi. https://doi.org/10.1101/2023.01.03.521866.

Akhshi, A., Metzen, M. G., Chacron, M. J., & Khadra, A. (2025). In vivo neural activity of electrosensory pyramidal cells: Biophysical characterization and phenomenological modeling. bioRxi. https://doi.org/10.1101/2025.05.30.656684.

Alexander, R. P. D., Mitry, J., Sareen, V., Khadra, A., & Bowie, D. (2019). Cerebellar Stellate Cell Excitability Is Coordinated by Shifts in the Gating Behavior of Voltage-Gated Na+ and A-Type K+ Channels. eNeuro. 6(3), ENEURO.0126–19.2019. https://doi.org/10.1523/ENEURO.0126-19.2019.

Amir, R., Michaelis, M., & Devor, M. (2002). Burst Discharge in Primary Sensory Neurons: Triggered by Subthreshold Oscillations, Maintained by Depolarizing Afterpotentials. The Journal of Neuroscience., 22(3), 1187–1198. https://doi.org/10.1523/jneurosci.22-03-01187.2002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bezanson, J., Edelman, A., Karpinski, S., & Shah, V. B. (2017). Julia: A Fresh Approach to Numerical Computing. SIAM Rev., 59(1), 65–98. https://doi.org/10.1137/141000671

Article  Google Scholar 

Bidoret, C., Bouvier, G., Ayon, A., Szapiro, G., & Casado, M. (2015). Properties and molecular identity of NMDA receptors at synaptic and non-synaptic inputs in cerebellar molecular layer interneurons. Frontiers in Synaptic Neuroscience., 7, 1. https://doi.org/10.3389/fnsyn.2015.00001

Article  CAS  PubMed  Google Scholar 

Brunel, N., & Wang, X. J. (2001). Effects of Neuromodulation in a Cortical Network Model of Object Working Memory Dominated by Recurrent Inhibition. Journal of Computational Neuroscience., 11(1), 63–85. https://doi.org/10.1023/a:1011204814320

Article  CAS  PubMed  Google Scholar 

Burnashev, N., Zhou, Z., Neher, E., & Sakmann, B. (1995). Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. The Journal of Physiology., 485(2), 403–418. https://doi.org/10.1113/jphysiol.1995.sp020738

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burnashev, N. (1996). Calcium permeability of glutamate-gated channels in the central nervous system. Current Opinion in Neurobiology., 6(3), 311–317. https://doi.org/10.1016/s0959-4388(96)80113-9

Article  CAS  PubMed  Google Scholar 

Carannante, I., Johansson, Y., Silberberg, G., & Hellgren, K. J. (2022). Data-Driven Model of Postsynaptic Currents Mediated by NMDA or AMPA Receptors in Striatal Neurons. Frontiers in Computational Neuroscience., 16, Article 806086. https://doi.org/10.3389/fncom.2022.806086

Article  PubMed  PubMed Central  Google Scholar 

Carter, A. G., & Regehr, W. G. (2000). Prolonged Synaptic Currents and Glutamate Spillover at the Parallel Fiber to Stellate Cell Synapse. The Journal of Neuroscience., 20(12), 4423–4434. https://doi.org/10.1523/jneurosci.20-12-04423.2000

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chapin, E. M., & Andrade, R. (2000). Calcium-Independent Afterdepolarization Regulated by Serotonin in Anterior Thalamus. Journal of Neurophysiology., 83(5), 3173–3176. https://doi.org/10.1152/jn.2000.83.5.3173

Article  CAS  PubMed  Google Scholar 

Chen, S., & Yaari, Y. (2008). Spike Ca2+influx upmodulates the spike afterdepolarization and bursting via intracellular inhibition of KV7/M channels. The Journal of Physiology., 586(5), 1351–1363. https://doi.org/10.1113/jphysiol.2007.148171

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chu, Z., & Moenter, S. M. (2006). Physiologic Regulation of a Tetrodotoxin-Sensitive Sodium Influx That Mediates a Slow Afterdepolarization Potential in Gonadotropin-Releasing Hormone Neurons: Possible Implications for the Central Regulation of Fertility. The Journal of Neuroscience., 26(46), 11961–11973. https://doi.org/10.1523/jneurosci.3171-06.2006

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark, B. A., & Cull-Candy, S. G. (2002). Activity-Dependent Recruitment of Extrasynaptic NMDA Receptor Activation at an AMPA Receptor-Only Synapse. The Journal of Neuroscience., 22(11), 4428–4436. https://doi.org/10.1523/jneurosci.22-11-04428.2002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Connors, B. W., Gutnick, M. J., & Prince, D. A. (1982). Electrophysiological properties of neocortical neurons in vitro. Journal of Neurophysiology., 48(6), 1302–1320. https://doi.org/10.1152/jn.1982.48.6.1302

Article  CAS  PubMed  Google Scholar 

Dixit, V. K, & Rackauckas, C. (2022) GlobalSensitivity. jl: Performant and Parallel Global Sensitivity Analysis with Julia. Journal of Open Source Software. 7(76), 4561.

Dixit, V. K., & Rackauckas, C. (2023). Optimization.jl: A Unified Optimization Package. Zenodo. https://doi.org/10.5281/zenodo.7738525.

Doiron, B., Laing, C., Longtin, A., & Maler, L. (2002). Ghostbursting: A Novel Neuronal Burst Mechanism. Journal of Computational Neuroscience., 12(1), 5–25. https://doi.org/10.1023/a:1014921628797

Article  PubMed  Google Scholar 

Doiron, B., Noonan, L., Lemon, N., & Turner, R. W. (2003). Persistent Na+Current Modifies Burst Discharge By Regulating Conditional Backpropagation of Dendritic Spikes. Journal of Neurophysiology., 89(1), 324–337. https://doi.org/10.1152/jn.00729.2002

Article  PubMed  Google Scholar 

Dudai, A., Doron, M., Segev, I., & London, M. (2021). Synaptic Input and ACh Modulation Regulate Dendritic Ca2+Spike Duration in Pyramidal Neurons, Directly Affecting Their Somatic Output. The Journal of Neuroscience., 42(7), 1184–1195. https://doi.org/10.1523/jneurosci.1470-21.2021

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Ascenzo, M., Podda, M. V., Fellin, T., Azzena, G. B., Haydon, P., & Grassi, C. (2009). Activation of mGluR5 induces spike afterdepolarization and enhanced excitability in medium spiny neurons of the nucleus accumbens by modulating persistent Na+ currents. The Journal of Physiology., 587(13), 3233–3250. https://doi.org/10.1113/jphysiol.2009.172593

Article  CAS  PubMed  PubMed Central  Google Scholar 

van Elburg, R. A. J., & van Ooyen, A. (2010). Impact of Dendritic Size and Dendritic Topology on Burst Firing in Pyramidal Cells. PLoS Computational Biology., 6(5), Article e1000781. https://doi.org/10.1371/journal.pcbi.1000781

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans, R. C., Zhu, M., & Khaliq, Z. M. (2017). Dopamine Inhibition Differentially Controls Excitability of Substantia Nigra Dopamine Neuron Subpopulations through T-Type Calcium Channels. The Journal of Neuroscience., 37(13), 3704–3720. https://doi.org/10.1523/jneurosci.0117-17.2017

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farjami, S., Alexander, R. P. D., Bowie, D., & Khadra, A. (2020). Bursting in cerebellar stellate cells induced by pharmacological agents: Non-sequential spike adding. PLOS Computational Biology., 16(12), Article e1008463. https://doi.org/10.1371/journal.pcbi.1008463

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farjami, S., Alexander, R. P. D., Bowie, D., & Khadra, A. (2020). Switching in Cerebellar Stellate Cell Excitability in Response to a Pair of Inhibitory/Excitatory Presynaptic Inputs: A Dynamical System Perspective. Neural Computation., 32(3), 626–658. https://doi.org/10.1162/neco_a_01261

Article  PubMed  Google Scholar 

Francioni, V., & Harnett, M. T. (2022). Rethinking Single Neuron Electrical Compartmentalization: Dendritic Contributions to Network Computation in Vivo. Neuroscience., 489, 185–1. https://doi.org/10.1016/j.neuroscience.2021.05.038

Article  CAS  PubMed  Google Scholar 

Fransén, E., Alonso, A. A., & Hasselmo, M. E. (2002). Simulations of the Role of the Muscarinic-Activated Calcium-Sensitive Nonspecific Cation Current INCM in Entorhinal Neuronal Activity during Delayed Matching Tasks. The Journal of Neuroscience., 22(3), 1081–1097. https://doi.org/10.1523/jneurosci.22-03-01081.2002

Article  PubMed  PubMed Central  Google Scholar 

Golomb, D., Yue, C., & Yaari, Y. (2006). Contribution of Persistent Na+Current and M-Type K+Current to Somatic Bursting in CA1 Pyramidal Cells: Combined Experimental and Modeling Study. Journal of Neurophysiology., 96(4), 1912–1926. https://doi.org/10.1152/jn.00205.2006

Article  CAS 

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