Ng M, Gakidou E, Lo J et al (2025) Global, regional, and national prevalence of adult overweight and obesity, 1990–2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021. Lancet 405:813–838. https://doi.org/10.1016/S0140-6736(25)00355-1

Article  Google Scholar 

Phelps NH, Singleton RK, Zhou B et al (2024) Worldwide trends in underweight and obesity from 1990 to 2022: a pooled analysis of 3663 population-representative studies with 222 million children, adolescents, and adults. Lancet 403:1027–1050. https://doi.org/10.1016/S0140-6736(23)02750-2

Article  Google Scholar 

Okunogbe A, Nugent R, Spencer G et al (2022) Economic impacts of overweight and obesity: current and future estimates for 161 countries. BMJ Glob Health 7:e009773. https://doi.org/10.1136/bmjgh-2022-009773

Article  PubMed  PubMed Central  Google Scholar 

Uti DE, Atangwho IJ, Omang WA et al (2025) Cytokines as key players in obesity low grade inflammation and related complications. Obes Med 54:100585. https://doi.org/10.1016/j.obmed.2025.100585

Article  Google Scholar 

Costantini S, Castello G, Colonna G (2010) Human cytokinome: a new challenge for systems biology. Bioinformation 5:166–167. https://doi.org/10.6026/97320630005166

Article  PubMed  PubMed Central  Google Scholar 

Schmidt FM, Weschenfelder J, Sander C et al (2015) Inflammatory cytokines in general and central obesity and modulating effects of physical activity. PLoS ONE 10:e0121971. https://doi.org/10.1371/journal.pone.0121971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnston BC, Kanters S, Bandayrel K et al (2014) Comparison of weight loss among named diet programs in overweight and obese adults: a meta-analysis. JAMA 312:923–933. https://doi.org/10.1001/jama.2014.10397

Article  CAS  PubMed  Google Scholar 

Drabińska N, Wiczkowski W, Piskuła MK (2021) Recent advances in the application of a ketogenic diet for obesity management. Trends Food Sci Technol 110:28–38. https://doi.org/10.1016/j.tifs.2021.01.080

Article  CAS  Google Scholar 

Jiang Z, Yin X, Wang M et al (2022) Effects of ketogenic diet on neuroinflammation in neurodegenerative diseases. Aging Dis 13:1146–1165

Article  PubMed  PubMed Central  Google Scholar 

Drabińska N (2024) Current perspective about the effect of a ketogenic diet on oxidative stress—a review. Pol J Food Nutr Sci 92–105. https://doi.org/10.31883/pjfns/185366

Barrea L, Caprio M, Watanabe M et al (2023) Could very low-calorie ketogenic diets turn off low grade inflammation in obesity? Emerging evidence. Crit Rev Food Sci Nutr 63:8320–8336. https://doi.org/10.1080/10408398.2022.2054935

Article  CAS  PubMed  Google Scholar 

Caprio M, Infante M, Moriconi E et al (2019) Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE). J Endocrinol Invest 42:1365–1386. https://doi.org/10.1007/s40618-019-01061-2

Article  CAS  PubMed  Google Scholar 

Urbanová M, Mráz M, Durovcová V et al (2017) The effect of very-low-calorie diet on mitochondrial dysfunction in subcutaneous adipose tissue and peripheral monocytes of obese subjects with type 2 diabetes mellitus. Physiol Res 66:811–822

Article  PubMed  Google Scholar 

Merra G, Gratteri S, Lorenzo ADE et al (2017) Effects of very-low-calorie diet on body composition, metabolic state, and genes expression: a randomized double-blind placebo-controlled trial. Eur Rev Med Pharmacol Sci 21:329–345. https://doi.org/10.1007/s00586-006-0076-1

Article  CAS  PubMed  Google Scholar 

Forsythe CE, Phinney SD, Fernandez ML et al (2008) Comparison of low fat and low carbohydrate diets on circulating fatty acid composition and markers of inflammation. Lipids 43:65–77. https://doi.org/10.1007/s11745-007-3132-7

Article  CAS  PubMed  Google Scholar 

Lorenzo PM, Sajoux I, Izquierdo AG et al (2022) Immunomodulatory effect of a very-low-calorie ketogenic diet compared with bariatric surgery and a low-calorie diet in patients with excessive body weight. Clin Nutr 41:1566–1577. https://doi.org/10.1016/j.clnu.2022.05.007

Article  CAS  PubMed  Google Scholar 

Rondanelli M, Perna S, Ilyas Z et al (2022) Effect of very low-calorie ketogenic diet in combination with omega-3 on inflammation, satiety hormones, body composition, and metabolic markers. A pilot study in class I obese subjects. Endocrine 75:129–136. https://doi.org/10.1007/s12020-021-02860-5

Article  CAS  PubMed  Google Scholar 

Alkhorayef N, Almutery FT, Rasheed Z et al (2023) Regulatory effects of ketogenic diet on the inflammatory response in obese Saudi women. J Taibah Univ Med Sci 18:1101–1107. https://doi.org/10.1016/j.jtumed.2023.03.006

Article  PubMed  PubMed Central  Google Scholar 

Kaiser A, Siddiqui MM, Bosley-Smith J et al (2024) Weight loss, pathological changes, and inflammatory effects from a short-term ketogenic diet in overweight and obese men with untreated prostate cancer on active surveillance. Nutrients 16:3716. https://doi.org/10.3390/nu16213716

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rosenbaum M, Hall KD, Guo J et al (2019) Glucose and lipid homeostasis and inflammation in humans following an isocaloric ketogenic diet. Obesity 27:971–981. https://doi.org/10.1002/oby.22468

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rondanelli M, Gasparri C, Pirola M et al (2024) Does the ketogenic diet mediate inflammation markers in obese and overweight adults? A systematic review and meta-analysis of randomized clinical trials. Nutrients 16:4002. https://doi.org/10.3390/nu16234002

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drabińska N, Romaszko J, White P (2023) The effect of isocaloric, energy-restrictive, KETOgenic diet on metabolism, inflammation, nutrition deficiencies and oxidative stress in women with overweight and obesity (KETO-MINOX): study protocol. PLoS ONE 18:e0285283. https://doi.org/10.1371/journal.pone.0285283

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stenbäck V, Leppäluoto J, Leskelä N et al (2021) Step detection and energy expenditure at different speeds by three accelerometers in a controlled environment. Sci Rep 11:20005. https://doi.org/10.1038/s41598-021-97299-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stenbäck V, Leppäluoto J, Juustila R et al (2022) Step detection accuracy and energy expenditure estimation at different speeds by three accelerometers in a controlled environment in overweight/obese subjects. J Clin Med 11:3267. https://doi.org/10.3390/jcm11123267

Article  CAS  PubMed  PubMed Central  Google Scholar 

Stenbäck V, Lehtonen I, Leppäluoto J et al (2025) Associations of step accelerations and cardiometabolic risk markers in early adulthood. Eur J Public Health 35:128–133. https://doi.org/10.1093/eurpub/ckae199

Article  PubMed  PubMed Central  Google Scholar 

Gibson AA, Seimon RV, Lee CMY et al (2015) Do ketogenic diets really suppress appetite? A systematic review and meta-analysis. Obes Rev 16:64–76. https://doi.org/10.1111/obr.12230

Article  CAS  PubMed  Google Scholar 

Ashtary-Larky D, Bagheri R, Bavi H et al (2022) Ketogenic diets, physical activity and body composition: a review. Br J Nutr 127:1898–1920. https://doi.org/10.1017/S0007114521002609

Article  CAS  PubMed  Google Scholar 

Leaf A, Rothschild JA, Sharpe TM et al (2024) International society of sports nutrition position stand: ketogenic diets. J Int Soc Sports Nutr 21. https://doi.org/10.1080/15502783.2024.2368167

Goebeler M, Gillitzer R, Kilian K et al (2001) Multiple signaling pathways regulate NF-κB–dependent transcription of the monocyte chemoattractant protein-1 gene in primary endothelial cells. Blood 97:46–55. https://doi.org/10.1182/blood.V97.1.46

Article  CAS  PubMed  Google Scholar 

Turner MD, Nedjai B, Hurst T, Pennington DJ (2014) Cytokines and chemokines: at the crossroads of cell signalling and inflammatory disease. Biochim Biophys