Awathale SN, Waghade AM, Kawade HM, Jadhav G, Choudhary AG, Sagarkar S, Sakharkar AJ, Subhedar NK, Kokare DM (2022) Neuroplastic changes in the superior colliculus and hippocampus in self-rewarding paradigm: importance of visual cues. Mol Neurobiol 59:890–915. https://doi.org/10.1007/s12035-021-02597-2

Article  PubMed  CAS  Google Scholar 

Awathale SN, Shirasath KR, More BR, Pardeshi GN, Goyal SN, Nakhate KT (2025) Naringenin prevents ethanol-induced reward behavior in adolescent rats through inhibition of TRPM3-dependent inflammation in the pVTA. J Nutr Biochem 110078. https://doi.org/10.1016/j.jnutbio.2025.110078

Bharne AP, Borkar CD, Bodakuntla S, Lahiri M, Subhedar NK, Kokare DM (2016) Pro-cognitive action of CART is mediated via ERK in the hippocampus. Hippocampus 26:1313–1327. https://doi.org/10.1002/hipo.22608

Article  PubMed  CAS  Google Scholar 

Bliuc D, Tran T, Adachi JD, Atkins GJ, Berger C, van den Bergh J, Cappai R, Eisman JA, van Geel T, Geusens P, Goltzman D, Hanley DA, Josse R, Kaiser S, Kovacs CS, Langsetmo L, Prior JC, Nguyen TV, Solomon LB, Stapledon C, Center JR, Group, F. the C.M.O.S. (CaMos) R. (2021) Cognitive decline is associated with an accelerated rate of bone loss and increased fracture risk in women: a prospective study from the Canadian Multicentre Osteoporosis Study. J Bone Miner Res 36:2106–2115. https://doi.org/10.1002/jbmr.4402

Article  PubMed  Google Scholar 

Bodet C, La VD, Epifano F, Grenier D (2008) Naringenin has anti-inflammatory properties in macrophage and ex vivo human whole‐blood models. J Periodontal Res 43:400–407. https://doi.org/10.1111/j.1600-0765.2007.01055.x

Article  PubMed  CAS  Google Scholar 

Bonvini S, Arshad M, Wortley MA, Adcock JJ, Dubuis E, Kosmidou K, Maher SA, Shala F, Vriens J, Voets T, Birrell MA, Belvisi MG (2016) TRPM3: A regulator of airway sensory nerves and respiratory reflexes. Eur Respir J 48. https://doi.org/10.1183/13993003.congress-2016.PA5070

Briceno Silva G, Arvelaez Pascucci J, Karim H, Kaur G, Lerma O, Mann R, Gnanasekaran AK, Garcia ST, K.D (2024) Influence of the onset of menopause on the risk of developing alzheimer’s disease.https://doi.org/10.7759/cureus.69124. Cureus

Burglen L, Van Hoeymissen E, Qebibo L, Barth M, Belnap N, Boschann F, Depienne C, De Clercq K, Douglas AG, Fitzgerald MP, Foulds N, Garel C, Helbig I, Held K, Horn D, Janssen A, Kaindl AM, Narayanan V, Prager C, Rupin-Mas M, Afenjar A, Zhao S, Ramaekers VT, Ruggiero SM, Thomas S, Valence S, Van Maldergem L, Rohacs T, Rodriguez D, Dyment D, Voets T, Vriens J (2023) Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders. Elife 12:e81032. https://doi.org/10.7554/eLife.81032

Article  PubMed  PubMed Central  CAS  Google Scholar 

Chaudhari AK, Shirasath KR, Goyal SN, Nakhate KT, Awathale SN (2025) A novel biting rod model for assessing aggressive behavior in restraint-stressed rats: role of 5-HT3 receptor and NF-κB-kynurenine pathways. Physiol Behav 115091. https://doi.org/10.1016/j.physbeh.2025.115091

Dallner C, Woods AG, Deller T, Kirsch M, Hofmann H-D (2002) CNTF and CNTF receptor alpha are constitutively expressed by astrocytes in the mouse brain. Glia 37:374–378

Article  PubMed  Google Scholar 

Dandekar MP, Nakhate KT, Kokare DM, Subhedar NK (2012) Involvement of CART in estradiol-induced anorexia. Physiol Behav 105:460–469. https://doi.org/10.1016/j.physbeh.2011.09.001

Article  PubMed  CAS  Google Scholar 

Deore R, Ansari R, Awathale SN, Shelke M, Badwaik HR, Goyal SN, Nakhate KT (2024) Lycopene alleviates BCG-induced depressive phenotypes in mice by disrupting 5-HT3 receptor–IDO1 interplay in the brain. Eur J Pharmacol 977:176707. https://doi.org/10.1016/j.ejphar.2024.176707

Dudhabhate BB, Awathale SN, Choudhary AG, Subhedar NK, Kokare DM (2024) Deep brain stimulation targeted at lateral hypothalamus-medial forebrain bundle reverses depressive-like symptoms and related cognitive deficits in rat: role of serotoninergic system. Neuroscience 556:96–113. https://doi.org/10.1016/j.neuroscience.2024.07.052

Article  PubMed  CAS  Google Scholar 

Emran TB, Islam F, Nath N, Sutradhar H, Das R, Mitra S, Alshahrani MM, Alhasaniah AH, Sharma R (2022) Naringin and naringenin polyphenols in neurological diseases: understandings from a therapeutic viewpoint. Life 13:99. https://doi.org/10.3390/life13010099

Article  PubMed  PubMed Central  CAS  Google Scholar 

Frye CA, Duffy CK, Walf AA (2007) Estrogens and progestins enhance spatial learning of intact and ovariectomized rats in the object placement task. Neurobiol Learn Mem 88:208. https://doi.org/10.1016/j.nlm.2007.04.003

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ghofrani S, Joghataei M-T, Mohseni S, Baluchnejadmojarad T, Bagheri M, Khamse S, Roghani M (2015) Naringenin improves learning and memory in an Alzheimer’s disease rat model: insights into the underlying mechanisms. Eur J Pharmacol 764:195–201. https://doi.org/10.1016/j.ejphar.2015.07.001

Article  PubMed  CAS  Google Scholar 

Hara Y, Waters EM, McEwen BS, Morrison JH (2015) Estrogen effects on cognitive and synaptic health over the lifecourse. Physiol Rev 95:785–807. https://doi.org/10.1152/physrev.00036.2014

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hassell J, Maswood S (2020) Tropisetron enhances recognition memory in ovariectomized female rats. Behav Pharmacol 31:787–791. https://doi.org/10.1097/FBP.0000000000000583

Article  PubMed  CAS  Google Scholar 

Held K, Mulier M, Ranst NV, Ge Y, Voets T, Wang YT, Vriens J (2020) TRPM3 inhibits synaptic transmission and plasticity in the hippocampus. Biophys J 118:21a. https://doi.org/10.1016/j.bpj.2019.11.297

Article  Google Scholar 

Hong DK, Kho AR, Lee SH, Kang BS, Park MK, Choi BY, Suh SW (2023) Pathophysiological roles of transient receptor potential (Trp) channels and zinc toxicity in brain disease. Int J Mol Sci 24:6665. https://doi.org/10.3390/ijms24076665

Article  PubMed  PubMed Central  CAS  Google Scholar 

Hu L-Y, Shen C-C, Hung J-H, Chen P-M, Wen C-H, Chiang Y-Y, Lu T (2016) Risk of psychiatric disorders following symptomatic menopausal transition. Medicine (Baltimore) 95:e2800. https://doi.org/10.1097/MD.0000000000002800

Article  PubMed  PubMed Central  Google Scholar 

Inoue M, Nakayama C, Noguchi H (1996) Activating mechanism of CNTF and related cytokines. Mol Neurobiol 12:195–209. https://doi.org/10.1007/BF02755588

Article  PubMed  CAS  Google Scholar 

Jia C, Brown RW, Malone HM, Burgess KC, Gill WD, Keasey MP, Hagg T (2019) Ciliary neurotrophic factor is a key sex-specific regulator of depressive-like behavior in mice. Psychoneuroendocrinology 100:96–105. https://doi.org/10.1016/j.psyneuen.2018.09.038

Article  PubMed  CAS  Google Scholar 

Jiang Y-P, Wen J-J, Zhao X-X, Gao Y-C, Ma X, Song S-Y, Jin Y, Shao T-J, Yu J, Wen C-P (2022) The flavonoid naringenin alleviates collagen-induced arthritis through curbing the migration and polarization of CD4 + T lymphocyte driven by regulating mitochondrial fission. Int J Mol Sci 24:279. https://doi.org/10.3390/ijms24010279

Article  PubMed  PubMed Central  CAS  Google Scholar 

Joshi N, Vaidya B, Sharma SS (2024) Transient receptor potential channels as an emerging target for the treatment of alzheimer’s disease: unravelling the potential of pharmacological interventions. Basic Clin Pharmacol Toxicol 135:375–400. https://doi.org/10.1111/bcpt.14073

Article  PubMed  CAS  Google Scholar 

Kamdi SP, Badwaik HR, Raval A, Ajazuddin KT (2021) Ameliorative potential of phloridzin in type 2 diabetes-induced memory deficits in rats. Eur J Pharmacol 913, 174645. https://doi.org/10.1016/j.ejphar.2021.174645

Keller ET, Pugh TD, Sun WH, Ershler WB (1996) Evaluation of ovariectomy and dehydroepiandrosterone sulfate administration on interleukin-6 levels and B16 melanoma growth in mice. AGE (Omaha) 19:75–81. https://doi.org/10.1007/BF02434086

Article  CAS  Google Scholar 

Kim S, Park TI (2013a) Naringenin: a partial agonist on estrogen receptor in T47D-KBluc breast cancer cells. Int J Clin Exp Med 6:890–899

PubMed  PubMed Central  Google Scholar 

Kim OY, Chae JS, Paik JK, Seo HS, Jang Y, Cavaillon J-M, Lee JH (2012) Effects of aging and menopause on serum interleukin-6 levels and peripheral blood mononuclear cell cytokine production in healthy Nonobese women. AGE (Omaha) 34:415–425. https://doi.org/10.1007/s11357-011-9244-2

Article  CAS  Google Scholar 

King JW, Bennett ASW, Wood HM, Baker CC, Alsaadi H, Topley M, Vanner SA, Reed DE, Lomax AE (2024) Expression and function of transient receptor potential melastatin 3 in the spinal afferent innervation of the mouse colon. Am J Physiol Gastrointest Liver Physiol 326:G176–G186. https://doi.org/10.1152/ajpgi.00230.2023

Article  PubMed  CAS  Google Scholar 

Konuri A, Bhat KMR, Rai KS, Gourishetti K, Phaneendra M (2021) Supplementation of fenugreek with choline–docosahexaenoic acid attenuates menopause induced memory loss, BDNF and dendritic arborization in ovariectomized rats. Anat Sci Int 96:197–211. https://doi.org/10.1007/s12565-020-00574-8

Article  PubMed  CAS  Google Scholar 

Lasota A, Danowska-Klonowska D (2004) Experimental osteoporosis–different methods of ovariectomy in female white rats. Rocz Akad Med Bialymst 49(Suppl 1):129–131