Tesfaye S, Boulton AJ, Dickenson AH (2013) Mechanisms and management of diabetic painful distal symmetrical polyneuropathy. Diabetes Care 36(9):2456–2465
Article CAS PubMed PubMed Central Google Scholar
Kolahdouz M et al (2021) Clavulanic acid attenuating effect on the diabetic neuropathic pain in rats. Neurochem Res 46(7):1759–1770
Article CAS PubMed Google Scholar
Widerström-Noga E (2017) Neuropathic pain and spinal cord injury: phenotypes and Pharmacological management. Drugs 77(9):967–984
Teixeira-Santos L, Albino-Teixeira A, Pinho D (2020) Neuroinflammation, oxidative stress and their interplay in neuropathic pain: focus on specialized pro-resolving mediators and NADPH oxidase inhibitors as potential therapeutic strategies. Pharmacol Res 162:105280
Article CAS PubMed Google Scholar
Areti A et al (2014) Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy. Redox Biol 2:289–295
Article CAS PubMed PubMed Central Google Scholar
Alaofi AL (2020) Sinapic acid ameliorates the progression of streptozotocin (STZ)-Induced diabetic nephropathy in rats via NRF2/HO-1 mediated pathways. Front Pharmacol 11:1119
Article CAS PubMed PubMed Central Google Scholar
Pol O (2021) The role of carbon monoxide, Heme Oxygenase 1, and the Nrf2 transcription factor in the modulation of chronic pain and their interactions with opioids and cannabinoids. Med Res Rev 41(1):136–155
Article CAS PubMed Google Scholar
Kansanen E et al (2013) The Keap1-Nrf2 pathway: mechanisms of activation and dysregulation in cancer. Redox Biol 1(1):45–49
Article CAS PubMed PubMed Central Google Scholar
Farkhondeh T et al (2020) The therapeutic effect of resveratrol: focusing on the Nrf2 signaling pathway. Biomed Pharmacother 127:110234
Article CAS PubMed Google Scholar
Everett RD et al (1997) A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein. Embo J 16(7):1519–1530
Article CAS PubMed PubMed Central Google Scholar
Pozhidaeva A, Bezsonova I, USP (2019) Structure, substrate specificity, and Inhibition. DNA Repair (Amst) 7:30–39
Ji L et al (2019) USP7 inhibits Wnt/β-catenin signaling through promoting stabilization of Axin. Nat Commun 10(1):4184
Article PubMed PubMed Central Google Scholar
Fountain MD et al (2019) Pathogenic variants in USP7 cause a neurodevelopmental disorder with speech delays, altered behavior, and neurologic anomalies. Genet Med 21(8):1797–1807
Article PubMed PubMed Central Google Scholar
Zhang XW et al (2022) Neuroinflammation Inhibition by small-molecule targeting USP7 noncatalytic domain for neurodegenerative disease therapy. Sci Adv 8(32):eabo0789
Article CAS PubMed PubMed Central Google Scholar
Yan H et al (2015) Suppression of experimental arthritis through AMP-activated protein kinase activation and autophagy modulation. J Rheum Dis Treat 1(1):5
Article PubMed PubMed Central Google Scholar
Huang Q et al (2024) Eupalinolide B suppresses pancreatic cancer by ROS generation and potential Cuproptosis. iScience 27(8):110496
Article CAS PubMed PubMed Central Google Scholar
Yang L et al (2022) Eupalinolide B attenuates lipopolysaccharide-induced acute lung injury through Inhibition of NF-κB and MAPKs signaling by targeting TAK1 protein. Int Immunopharmacol 111:109148
Article CAS PubMed Google Scholar
Zhang Y et al (2022) Eupalinolide B inhibits hepatic carcinoma by inducing ferroptosis and ROS-ER-JNK pathway. Acta Biochim Biophys Sin (Shanghai) 54(7):974–986
Article CAS PubMed PubMed Central Google Scholar
Decosterd I, Woolf CJ (2000) Spared nerve injury: an animal model of persistent peripheral neuropathic pain. Pain 87(2):149–158
Sanna MD et al (2019) Lavender (Lavandula angustifolia Mill.) essential oil alleviates neuropathic pain in mice with spared nerve injury. Front Pharmacol 10:472
Article CAS PubMed PubMed Central Google Scholar
Hargreaves K et al (1988) A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 32(1):77–88
Article CAS PubMed Google Scholar
Zhang TT et al (2018) Ammoxetine attenuates diabetic neuropathic pain through inhibiting microglial activation and neuroinflammation in the spinal cord. J Neuroinflammation 15(1):176
Article PubMed PubMed Central Google Scholar
De Gregorio D et al (2019) Cannabidiol modulates serotonergic transmission and reverses both allodynia and anxiety-like behavior in a model of neuropathic pain. Pain 160(1):136–150
Zhang J et al (2015) Pharmacokinetics of eupalinolide A, eupalinolide B and Hyperoside from eupatorium lindleyanum in rats by LC/MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 995–996:1–7
Li Y et al (2023) Characterization of the metabolism of eupalinolide A and B by carboxylesterase and cytochrome P450 in human liver microsomes. Front Pharmacol 14:1093696
Article CAS PubMed PubMed Central Google Scholar
Wang C et al (2023) USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats. Neurochem Int 168:105554
Article CAS PubMed Google Scholar
Moalem G, Tracey DJ (2006) Immune and inflammatory mechanisms in neuropathic pain. Brain Res Rev 51(2):240–264
Article CAS PubMed Google Scholar
Kawasaki Y et al (2008) Cytokine mechanisms of central sensitization: distinct and overlapping role of interleukin-1beta, interleukin-6, and tumor necrosis factor-alpha in regulating synaptic and neuronal activity in the superficial spinal cord. J Neurosci 28(20):5189–5194
Article CAS PubMed PubMed Central Google Scholar
Inoue K, Tsuda M (2018) Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential. Nat Rev Neurosci 19(3):138–152
Article CAS PubMed Google Scholar
Kuang W et al (2025) (2020) Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3. MedComm 6(1):e70034
Article CAS PubMed PubMed Central Google Scholar
Gu SL et al (2025) Eupalinolide B alleviates rheumatoid arthritis through the promotion of apoptosis and autophagy via regulating the AMPK/mTOR/ULK-1 signaling axis. Int Immunopharmacol 148:114179
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