Zhang Z, Wang T, Wang X, Zhang Y, Song S, Ma C (2022) Improving the ability of CAR-T cells to hit solid tumors: challenges and strategies. Pharmacol Res 175:106036

Article  CAS  PubMed  Google Scholar 

Majzner RG, Heitzeneder S, Mackall CL (2017) Harnessing the immunotherapy revolution for the treatment of childhood cancers. Cancer Cell 31(4):476–485

Article  CAS  PubMed  Google Scholar 

Majzner RG, Mackall CL (2018) Tumor antigen escape from CAR T-cell therapy. Cancer Discov 8(10):1219–1226

Article  CAS  PubMed  Google Scholar 

Li LZ, Sun Q, Fang Y, Yang LJ, Xu ZY, Hu JH, Cao L, Huang JY, Hong M, Li JY, Qian SX (2020) A report on lineage switch at relapse of CD19 CAR-T therapy for Philadelphia chromosome-positive B-precursor acute lymphoblastic leukemia. Chin Med J (Engl) 133(16):2001–2003. https://doi.org/10.1097/CM9.0000000000000962

Article  PubMed  Google Scholar 

Coupland SE, Ott G, Sewell WA et al (2024) Mantle cell lymphoma In: WHO Classification of Tumours Editorial Board. Haematolymphoid tumours. Lyon (France): International Agency for Research on Cancer. (WHO classification of tumours series, 5th ed.; vol. 11).  https://publications.iarc.who.int/637. Accessed 10 Aug 2025

Zhu K, Jamroz A, Huang S, Villa D, Freeman CL, Scott DW, Slack G, Sehn LH, Connors JM, Toze CL, Savage KJ, Gerrie AS (2022) Outcomes of Hodgkin variant Richter transformation in chronic lymphocytic leukaemia and small lymphocytic lymphoma in British Columbia. Br J Haematol 198(4):684–692

Article  CAS  PubMed  Google Scholar 

Ishida T, Sato M, Kamoda Y et al (2022) Transformation of follicular lymphoma to classical Hodgkin lymphoma during observation. J Clin Hematol 63(6):544–549

Google Scholar 

Kramer S et al (2019) Mantle cell lymphoma with Hodgkin and Reed-Sternberg cells: review with illustrative case. Appl Immunohistochem Mol Morphol 27(1):8–14

Article  PubMed  Google Scholar 

Laurent C, Syrykh C, Hamon M, Adélaïde J, Guille A, Escudié F, Jalowicki G, Fina F, Bardet A, Mescam L, Molina TJ, Dartigues P, Parrens M, Sujobert P, Besson C, Birnbaum D, Xerri L (2022) Resistance of B-cell lymphomas to CAR T-cell therapy is associated with genomic tumor changes which can result in transdifferentiation. Am J Surg Pathol 46(6):742–753. https://doi.org/10.1097/PAS.0000000000001834

Article  PubMed  Google Scholar 

Jacoby E, Nguyen SM, Fountaine TJ et al (2016) CD19 CAR immune pressure induces B-precursor acute lymphoblastic leukaemia lineage switch exposing inherent leukaemic plasticity. Nat Commun 7:12320

Article  CAS  PubMed  PubMed Central  Google Scholar 

Evans AG, Rothberg PG, Burack WR et al (2015) Evolution to plasmablastic lymphoma evades CD19-directed chimeric antigen receptor T cells. Br J Haematol 171:205–209

Article  CAS  PubMed  Google Scholar 

Zhang Q, Orlando EJ, Wang HY et al (2020) Transdifferentiation of lymphoma into sarcoma associated with profound reprogramming of the epigenome. Blood 136:1980–1983

Article  PubMed  PubMed Central  Google Scholar 

Schneider S, Crescenzi B, Schneider M, Ascani S, Hartmann S, Hansmann ML, Falini B, Mecucci C, Tiacci E, Küppers R (2014) Subclonal evolution of a classical Hodgkin lymphoma from a germinal center B-cell-derived mantle cell lymphoma. Int J Cancer 134(4):832–843. https://doi.org/10.1002/ijc.28422

Article  CAS  PubMed  Google Scholar 

Negishi S, Girsch JH, Siegler EL, Bezerra ED, Miyao K, Sakemura RL (2024J) Treatment strategies for relapse after CAR T-cell therapy in B cell lymphoma. Front Pediatr 12(11):1305657. https://doi.org/10.3389/fped.2023.1305657

Article  Google Scholar 

Guan H, Xie L, Wirth T, Ushmorov A (2016) Repression of TCF3/E2A contributes to Hodgkin lymphomagenesis. Oncotarget 7(24):36854–36864. https://doi.org/10.18632/oncotarget.9210

Article  PubMed  PubMed Central  Google Scholar 

Ehlers A, Oker E, Bentink S et al (2008) Histone acetylation and DNA demethylation of B cells result in a Hodgkin-like phenotype. Leukemia 22:835–841. https://doi.org/10.1038/leu.2008.12

Article  CAS  PubMed  Google Scholar 

Nadeu F, Martin-Garcia D, Clot G, Diaz-Navarro A, Duran Ferrer M, Navarro A et al (2020) Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes. Blood 136(12):1419–1432

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eskelund CW, Dahl C, Hansen JW, Westman M, Kolstad A, Pedersen LB et al (2017) TP53 mutations identify younger mantle cell lymphoma patients who do not benefit from intensive chemoim munotherapy. Blood 130(17):1903–1910

Article  CAS  PubMed  Google Scholar 

Rodrigues JM, Hassan M, Freiburghaus C, Eskelund CW, Geisler C, Raty R et al (2020) p53 is associated with high-risk and pin points TP53 missense mutations in mantle cell lymphoma. Br J Haematol 191(5):796–805

Article  CAS  PubMed  PubMed Central  Google Scholar 

García R et al (2022) A t(11;14)(q13;q32)/CCND1::IGH carrying progenitor germinal B-cell with subsequent cytogenetic aberrations contributes to the development of classic Hodgkin lymphoma. Cancer Genet 268–269:97–102

Article  PubMed  Google Scholar 

Cai F, Zhang J, Gao H, Shen H (2024) Tumor microenvironment and CAR-T cell immunotherapy in B-cell lymphoma. Eur J Haematol 112(2):223–235. https://doi.org/10.1111/ejh.14103

Article  CAS  PubMed  Google Scholar 

Nguyen DT, Ogando-Rivas E, Liu R et al (2022) CAR T cell locomotion in solid tumor microenvironment. Cell 11:1974. https://doi.org/10.3390/cells11121974

Article  CAS  Google Scholar 

Zhu Y, Xu K, Wang Y (2025) Tumor microenvironment in CAR-T cell therapy for lymphoma. Best Pract Res Clin Haematol 38(2):101635. https://doi.org/10.1016/j.beha.2025.101635

Article  CAS  PubMed  Google Scholar