World Health Organization. Accelerating action to stop obesity 2022. [Available from: 1]. Accessed date: November 2025 https://www.who.int/news/item/04-03-2022-world-obesity-day-2022-accelerating-action-to-stop-obesity

Ellulu MS, Patimah I, Khaza’ai H, et al. Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci. 2017;13(4):851–63.

Article  PubMed  CAS  Google Scholar 

Lim Y, Boster J. Obesity and comorbid conditions [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2022. https://www.ncbi.nlm.nih.gov/books/NBK574535/

Mills DW, Woolley DM, Ammori BJ, et al. Changes in serum urate levels after bariatric surgery in patients with obesity: an observational study. Obes Surg. 2024;34(5):1737–41. https://doi.org/10.1007/s11695-024-07191-8.

Article  PubMed  PubMed Central  Google Scholar 

Kawai T, Autieri MV, Scalia R. Adipose tissue inflammation and metabolic dysfunction in obesity. Am J Physiol Cell Physiol. 2021;320(3):C375-91.

Article  PubMed  CAS  Google Scholar 

Shi C, Zhu L, Chen X, et al. IL-6 and TNF-α induced obesity-related inflammatory response through transcriptional regulation of miR-146b. J Interferon Cytokine Res. 2014;34(5):342–8.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lyngdoh T, Marques-Vidal P, Paccaud F, et al. Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based colaus study. Means T, editor. PLoS One. 2011;6(5):e19901.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Tang M, Li Y, Chen Z, et al. Association between visceral adiposity index and hyperuricemia and gout among US adults: a cross-sectional analysis of NHANES 2007–2018. Sci Rep. 2025;15:22196. https://doi.org/10.1038/s41598-025-08138-4.

Article  PubMed  PubMed Central  Google Scholar 

Bashyal S, Qu S, Karki M. Bariatric surgery and its metabolic echo effect on serum uric acid levels. Cureus. 2024. https://doi.org/10.7759/cureus.58103

Kovesdy CP, Furth SL, Zoccali C, World Kidney Day Steering Committee. Obesity and kidney disease: hidden consequences of the epidemic. J Nephrol. 2017;30(1):1–10. https://doi.org/10.1007/s40620-017-0377-y.

Article  PubMed  Google Scholar 

Li K, Zou J, Ye Z, et al. Effects of bariatric surgery on renal function in obese patients: a systematic review and meta-analysis. PLoS One. 2016;11(10):e0163907. https://doi.org/10.1371/journal.pone.0163907.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vafa L, Amini M, Kamran H, et al. The impact of obesity surgery on serum uric acid in people with severe obesity: a retrospective study. Clin Nutr Res. 2023;12(1):21–8.

Article  PubMed  PubMed Central  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. Accessed date: November 2025 For more information, visit: http://www.prisma-statement.org/https://doi.org/10.1136/bmj.n71

Newcastle-Ottawa quality assessment form for cohort studies [Internet]. Accessed date: November 2025 https://www.ncbi.nlm.nih.gov/books/NBK115843/bin/appe-fm3.pdf

Alexandrides TK, Skroubis G, Kalfarentzos F. Resolution of diabetes mellitus and metabolic syndrome following Roux-en-Y gastric bypass and a variant of biliopancreatic diversion in patients with morbid obesity. Obes Surg. 2007;17(2):176–84.

Article  PubMed  Google Scholar 

Chawla N, Kakar A, Khetan M, Mittal T. Does weight loss due to bariatric surgery affect serum uric acid levels? Curr Med Res Pract. 2015;5(5):204–8.

Article  Google Scholar 

Choromańska B, Myśliwiec P, Łuba M, et al. Impact of weight loss on the total antioxidant/oxidant potential in patients with morbid obesity—a longitudinal study. Antioxidants. 2020;9(5):376–6.

Article  PubMed  PubMed Central  Google Scholar 

Davoudi Z, Shokuhi Sabet A, Toreyhi H, et al. Impact of sleeve gastrectomy on uric acid levels in patients with obesity: a comparative study. Obes Surg. 2024;34(7):2704–10.

Article  PubMed  Google Scholar 

Dilimulati D, Du L, Huang X, et al. Serum fibrinogen-like protein 1 levels in obese patients before and after laparoscopic sleeve gastrectomy: a six-month longitudinal study. Diabetes Metab Syndr Obes: Targets Ther. 2022;15:2511–20.

Article  Google Scholar 

Elhag W, El Ansari W. Durability of Cardiometabolic outcomes among adolescents after sleeve gastrectomy: first study with 9-year follow-up. Obes Surg. 2021. https://doi.org/10.1007/s11695-021-05273-4

Hu L, Wang L, Li S, et al. Evaluation study of single-anastomosis duodenal-ileal bypass with sleeve gastrectomy in the treatment of Chinese obese patients based on efficacy and nutrition. Sci Rep. 2024;14(1). https://doi.org/10.1038/s41598-024-63235-5

Li YX, Fang DH, Liu TX. Laparoscopic sleeve gastrectomy combined with single-anastomosis duodenal-jejunal bypass in the treatment of type 2 diabetes mellitus of patients with body mass index higher than 27.5 kg/m2 but lower than 32.5 kg/m2. Med. 2018;97(31):e11537.

Article  Google Scholar 

Kumar R, Lieske JC, Collazo-Clavell ML, et al. Fat malabsorption and increased intestinal oxalate absorption are common after roux-en-Y gastric bypass surgery. Surgery. 2011;149(5):654–61.

Article  PubMed  PubMed Central  Google Scholar 

Li M, Liu Y, Zeng N, et al. Alterations in the serum urate concentrations after bariatric surgery: a short-term prospective observational study. Obes Surg. 2021;31(4):1688–95.

Article  PubMed  Google Scholar 

Liu W, Zhang H, Han X, et al. Uric acid level changes after bariatric surgery in obese subjects with type 2 diabetes mellitus. Ann Transl Med. 2019;7(14):332–42.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Maglio C, Peltonen M, Neovius M, et al. Effects of bariatric surgery on gout incidence in the Swedish obese subjects study: a non-randomised, prospective, controlled intervention trial. Ann Rheum Dis. 2016;76(4):688–93.

Article  PubMed  PubMed Central  Google Scholar 

Malapan K, Goel R, Tai CM, et al. Laparoscopic Roux-en-Y gastric bypass for nonobese type II diabetes mellitus in Asian patients. Surg Obes Relat Dis. 2014;10(5):834–40.

Article  PubMed  Google Scholar 

Menenakos E, Doulami G, Tzanetakou IP, et al. The use of serum uric acid concentration as an indicator of laparoscopic sleeve gastrectomy success. Int Surg. 2015;100(1):173–9.

Article  PubMed  PubMed Central  Google Scholar 

Serpa Neto A, Rossi FM, Guedes L, et al. Relation of uric acid with components of metabolic syndrome before and after Roux-en-Y gastric bypass in morbidly obese subjects. Arq Bras Endocrinol Metabologia. 2011;55(1):38–45.

Article  Google Scholar 

Richette P, Poitou C, Manivet P, et al. Weight loss, xanthine oxidase, and serum urate levels: a prospective longitudinal study of obese patients. Arthritis Care Res. 2016;68(7):1036–42.

Article  CAS  Google Scholar 

Romero-Talamás H, Daigle CR, Aminian A, et al. The effect of bariatric surgery on gout: a comparative study. Surg Obes Relat Dis. 2014;10(6):1161–5.

Article  PubMed  Google Scholar 

Sarzynski MA, Jacobson P, Rankinen T, et al. Changes in uric acid levels following bariatric surgery are not associated with SLC2A9 variants in the Swedish obese subjects study. Kloss-Brandstaetter A, editor. PLoS One. 2012;7(12):e51658.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Shen Y, Zhang B, Hu X, et al. Metabolic surgery results in greater metabolic benefits in patients who achieve healthy weight. Surg Obes Relat Dis. 2024;20(10):925–34.

Article  PubMed  Google Scholar 

Sierżantowicz R, Lewko J, Trochimowicz L, et al. Effectiveness of bariatric procedures based on selected laboratory parameters of patients from rural areas in polish population. Adv Clin Exp Med. 2017;26(4):679–86.

Article  PubMed  Google Scholar 

Silvestre V, Ruano M, Domínguez Y, et al. Morbid obesity and gastric bypass surgery: biochemical profile. Obes Surg. 2004;14(9):1227–32.

Article  PubMed  CAS  Google Scholar 

Song K, He M, Kong X, et al. Benefits of uric acid-lowering medication after bariatric surgery in patients with gout. BMC Surg. 2024;24(1):186.

Article  PubMed  PubMed Central  CAS  Google Scholar 

Toolabi K, Arefanian S, Golzarand M, et al. Effects of laparoscopic Roux-en-Y gastric bypass (LRYGB) on weight loss and biomarker parameters in morbidly obese patients: a 12-month follow-up. Obes Surg. 2011;21(12):1834–42.

Article