Expert opinion: radiotherapy for basal cell carcinoma

Lang BM, Balermpas P, Bauer A, Blum A, Dirschka T, Follmann M, Frank J, Frerich B, Fritz K, Hauschild A, Heindl LM, Howaldt HP, Ihrler S, Kakkassery V, Klumpp B, Krause-Bergmann A, Löser C, Meissner M, Sachse MM, Schlaak M, Schön MP, Tischendorf L, Tronnier M, Vordermark D, Welzel J, Weichenthal M, Wiegand S, Kaufmann R, Grabbe S (2024) S2k guideline basal cell carcinoma of the skin (update 2023). J Dtsch Dermatol Ges 22(12):1697–1714. https://doi.org/10.1111/ddg.15566

Article  PubMed  PubMed Central  Google Scholar 

Likhacheva A, Awan M, Barker CA, Bhatnagar A, Bradfield L, Brady MS, Buzurovic I, Geiger JL, Parvathaneni U, Zaky S, Devlin PM (2020) Definitive and Postoperative Radiation Therapy for Basal and Squamous Cell Cancers of the Skin: Executive Summary of an American Society for Radiation Oncology Clinical Practice Guideline. Adv Radiat Oncol 10(1):8–20. https://doi.org/10.1016/j.prro.2019.10.014

Article  PubMed  Google Scholar 

Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C, EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E (2023) European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Eur J Cancer 192:113254. https://doi.org/10.1016/j.ejca.2023.113254

Article  PubMed  Google Scholar 

Avril MF, Auperin A, Margulis A, Gerbaulet A, Duvillard P, Benhamou E, Guillaume JC, Chalon R, Petit JY, Sancho-Garnier H, Prade M, Bouzy J, Chassagne D (1997) Basal cell carcinoma of the face: surgery or radiotherapy? Results of a randomized study. Br J Cancer 76(1):100–106. https://doi.org/10.1038/bjc.1997.343

Article  CAS  PubMed  PubMed Central  Google Scholar 

Drucker AM, Adam GP, Rofeberg V, Gazula A, Smith B,Moustafa F, Weinstock MA, Trikalinos TA (2018) Treatments of Primary Basal Cell Carcinoma of the Skin: A Systematic Review and Network Meta-analysis. Ann Intern Med 169(7):456–466. https://doi.org/10.7326/M18-0678

Article  PubMed  Google Scholar 

Frakulli R, Galuppi A, Cammelli S, Macchia G, Cima S, Gambacorta MA et al (2015) Brachytherapy in non melanoma skin cancer of eyelid: a systematic review. J Contemp Brachytherapy 7:497–502. https://doi.org/10.5114/jcb.2015.56465

Article  PubMed  PubMed Central  Google Scholar 

Bussu F, Tagliaferri L, Mattiucci G, Parrilla C, Dinapoli N, Miccichè F et al (2016) Comparison of interstitial brachytherapy and surgery as primary treatments for nasal vestibule carcinomas. Laryngoscope Investig Otolaryngol 126:367–371. https://doi.org/10.1002/lary.25498

Article  PubMed  Google Scholar 

Zaorsky NG, Lee CT, Zhang E, Keith SW, Galloway TJ (2017) Hypofractionated radiation therapy for basal and squamous cell skin cancer: A meta-analysis. Clin Transl Radiat Oncol 125(1):13–20. https://doi.org/10.1016/j.radonc.2017.08.011

Article  PubMed  PubMed Central  Google Scholar 

Benkhaled S, Van Gestel D, Gomes da Silveira Cauduro C, Palumbo S, Del Marmol V, Desmet A (2022) The State of the Art of Radiotherapy for Non-melanoma Skin Cancer: A Review of the Literature. Front Med 9:913269. https://doi.org/10.3389/fmed.2022.913269

Article  PubMed  PubMed Central  Google Scholar 

Safigholi H, Song WY, Meigooni AS (2015) Optimum radiation source for radiation therapy of skin cancer. J Appl Clin Med Phys 16(5):219–227. https://doi.org/10.1120/jacmp.v16i5.5407

Article  PubMed  PubMed Central  Google Scholar 

Guinot JL, Rembielak A, Perez-Calatayud J, Rodríguez-Villalba S, Skowronek J, Tagliaferri L, Guix B, Gonzalez-Perez V, Valentini V, Kovacs G, GEC ESTRO (2018) GEC-ESTRO ACROP recommendations in skin brachytherapy. Clin Transl Radiat Oncol 126(3):377–385. https://doi.org/10.1016/j.radonc.2018.01.013

Article  PubMed  Google Scholar 

Braendstrup ON, Lassen P, Gothelf AB, De Blanck SR, Friborg J, Lonkvist CK, Nielsen AL, Primdahl H, Hanan G, Toure M, Andersen M, Nowicka-Matus K, Kjeldsen R, Eriksen JG (2025) Initial cosmetic outcome six months after kilovoltage therapy of facial basal cell carcinoma: A Danish national prospective study of 932 patients. Sci Rep 15(1):18790. https://doi.org/10.1038/s41598-025-03566-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duinkerken CW, Lohuis PJ, Heemsbergen WD, Zupan-Kajcovski B, Navran A, Hamming-Vrieze O, Klop WM, Balm FJ, Al-Mamgani A (2016) Orthovoltage for basal cell carcinoma of the head and neck: Excellent local control and low toxicity profile. Laryngoscope Investig Otolaryngol 126(8):1796–1802. https://doi.org/10.1002/lary.25865

Article  PubMed  Google Scholar 

Zagrodnik B, Kempf W, Seifert B, Müller B, Burg G, Urosevic M, Dummer R (2003) Superficial radiotherapy for patients with basal cell carcinoma: recurrence rates, histologic subtypes, and expression of p53 and Bcl‑2. Cancer Cytopathol 98(12):2708–2714. https://doi.org/10.1002/cncr.11798

Article  PubMed  Google Scholar 

Lee A, Lum N, Thandi A, Yee K, Seeburruth D, Park M, Chen S, Yeung N, Sibbald C, Liu C (2025) The clinical outcomes, safety profiles, and treatment patterns of electron beam therapy for basal cell carcinoma. JAAD Rev 4:126–128. https://doi.org/10.1016/j.jdrv.2025.03.006

Article  Google Scholar 

Spelman L, Christie D, Kaminski A, Baker C, Supranowicz M, Sinclair R (2022) Radiotherapy, Utilizing Volumetric Modulated Arc Therapy, for Extensive Skin Field Cancerization: A Retrospective Case Series Assessing Efficacy, Safety, and Cosmetic Outcomes at 12 Months After Treatment. Case Rep Dermatol 14(1):31–38. https://doi.org/10.1159/000521067

Article  PubMed  PubMed Central  Google Scholar 

Berridge JK, Morgan DA (1997) A comparison of late cosmetic results following two different radiotherapy techniques for treating basal cell carcinoma. Clin Oncol (R Coll Radiol) 9(6):400–402. https://doi.org/10.1016/s0936-6555(97)80137-9

Article  CAS  PubMed  Google Scholar 

Qin N, Ma J, Lee EH, Barker CA (2023) Quality of Life Before and After Radiation Therapy for Early-Stage Keratinocyte Carcinoma: A Longitudinal Analysis. Adv Radiat Oncol 117(5):1090–1095. https://doi.org/10.1016/j.ijrobp.2023.05.044

Article  PubMed  PubMed Central  Google Scholar 

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