Total treatment interval and quality of life of women living with breast cancer in Ethiopia: the mediating role of financial toxicity

Zhang, Y., Ji, Y., Liu, S., Li, J., Wu, J., Jin, Q., Liu, X., Duan, H., Feng, Z., Liu, Y., & Zhang, Y. (2025). Global burden of female breast cancer: New estimates in 2022, temporal trend and future projections up to 2050 based on the latest release from GLOBOCAN. Journal of the National Cancer Center, 5(3), 287–296.

Article  PubMed  PubMed Central  Google Scholar 

Tafese, A. M., Fentie, M. T., Seifu, B. L., Asnake, A. A., Dirbaba, B. D., Jara, A. G., Asare, E. T., & George, B. (2025). Breast cancer survival rates and determinants in Ethiopia: A systematic review and meta-analysis of longitudinal studies. BMC Cancer, 25(1), 1263.

Article  PubMed  PubMed Central  Google Scholar 

Ssentongo, P., Lewcun, J. A., Candela, X., Ssentongo, A. E., Kwon, E. G., Ba, D. M., Oh, J. S., Amponsah-Manu, F., McDonald, A. C., Chinchilli, V. M., & Soybel, D. I. (2019). Regional, racial, gender, and tumor biology disparities in breast cancer survival rates in Africa: A systematic review and meta-analysis. PLoS ONE, 14(11), e0225039.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Francies, F. Z., Hull, R., Khanyile, R., & Dlamini, Z. (2020). Breast cancer in low-middle income countries: Abnormality in splicing and lack of targeted treatment options. American journal of cancer research, 10(5), 1568–1591.

CAS  PubMed  PubMed Central  Google Scholar 

Pruthi, D. S., Ahmad, M., Gupta, M., Bansal, S., Nautiyal, V., & Saini, S. (2018). Assessment of quality of life in resectable gastric cancer patients undergoing chemoradiotherapy as adjuvant treatmentLetter to the Editor. South Asian Journal of Cancer, 7(01), 16–20.

Article  PubMed  PubMed Central  Google Scholar 

Mason, A., Juyal, R., Das, S. C., Shikha, D., Saini, S., & Semwal, J. (2019). Prevalence and correlates of psychological distress among cancer patients in a tertiary care hospital in northern India. International Journal Of Community Medicine And Public Health, 6(5), 2223–2228.

Article  Google Scholar 

Park, J., Rodriguez, J. L., O’Brien, K. M., Nichols, H. B., Hodgson, M. E., Weinberg, C. R., & Sandler, D. P. (2021). Health-related quality of life outcomes among breast cancer survivors. Cancer, 127(7), 1114–1125.

Article  CAS  PubMed  Google Scholar 

Breek, K., Abuhalima, D., Salameh, H., Al-Jabi, S. W., & Zyoud, S. E. H. (2025). Self-reported side effects of breast cancer treatment and its impact on quality of life: A multicenter cross-sectional study in a low-and middle-income country. BMC Cancer, 25(1), 975.

Article  PubMed  PubMed Central  Google Scholar 

Montazeri, A., Milroy, R., Hole, D., McEwen, J., & Gillis, C. R. (2003). How quality of life data contribute to our understanding of cancer patients’ experiences? A study of patients with lung cancer. Quality of Life Research, 12(2), 157–166.

Article  PubMed  Google Scholar 

Montazeri, A. (2008). Health-related quality of life in breast cancer patients: A bibliographic review of the literature from 1974 to 2007. Journal of Experimental & Clinical Cancer Research, 27(1), 32.

Article  Google Scholar 

Franzoi, M. A., Di Meglio, A., Michiels, S., Gillanders, E., Gaudin, C., Martin, A. L., & Vaz-Luis, I. (2024). Patient-reported quality of life 6 years after breast cancer. JAMA Network Open, 7(2), e240688.

Article  PubMed  PubMed Central  Google Scholar 

Paleri, V., Wight, R. G., Silver, C. E., Haigentz, M., Jr., Takes, R. P., Bradley, P. J., Rinaldo, A., Sanabria, A., Bień, S., & Ferlito, A. (2010). Comorbidity in head and neck cancer: A critical appraisal and recommendations for practice. Oral Oncology, 46(10), 712–719.

Article  PubMed  Google Scholar 

Sabir, K., Sajid, J., Butt, N. I., Waris, B., Zahra, A., Shoaib, M., & Butt, N. I. (2025). Clinical profile and outcome of patients with advanced hepatocellular carcinoma (HCC) taking sorafenib or lenvatinib: Real-world experience from a low-middle resource country. Cureus. https://doi.org/10.7759/cureus.83681

Article  PubMed  PubMed Central  Google Scholar 

Zhao, Q., Kuang, Y., Yuan, X., Sun, Y., Zhu, Z., Zhu, J., Gu, H., & Xing, W. (2025). Financial toxicity and quality of life among older adults with cancer: A moderated mediation model of loneliness and social support. Supportive Care in Cancer, 33(8), 680.

Article  PubMed  Google Scholar 

McKenzie, F., Zietsman, A., Galukande, M., Anele, A., Adisa, C., Cubasch, H., Parham, G., Anderson, B. O., Abedi-Ardekani, B., Schuz, J., & dos Santos Silva, I. (2016). African Breast Cancer—Disparities in Outcomes (ABC-DO): Protocol of a multicountry mobile health prospective study of breast cancer survival in sub-Saharan Africa. British Medical Journal Open, 6(8), e011390.

Google Scholar 

Williams, F. (2015). Assessment of breast cancer treatment delay impact on prognosis and survival: A look at the evidence from systematic analysis of the literature. Journal of Cancer Biology & Research, 3(4), 1071.

Google Scholar 

Konieczny, M., Cipora, E., Roczniak, W., Babuśka-Roczniak, M., & Wojtaszek, M. (2020). Impact of time to initiation of treatment on the quality of life of women with breast cancer. International Journal of Environmental Research and Public Health, 17(22), 8325. https://doi.org/10.3390/ijerph17228325

Article  PubMed  PubMed Central  Google Scholar 

WHO. (2023). Global breast cancer initiative implementation framework: assessing, strengthening and scaling up of services for the early detection and management of breast cancer: Executive summary. Available from: https://www.who.int/publications/i/item/9789240067134?utm_source=chatgpt.com

Kibret, A. A., Jiang, H., Yang, H., & Liu, C. (2024). Patient journey and timeliness of care for patients with breast cancer in Africa: A scoping review. British Medical Journal Open, 15(8), e098087.

Google Scholar 

Hoveling, L. A., Schuurman, M., Siesling, S., van Asselt, K. M., & Bode, C. (2025). Diagnostic delay in women with cancer: What do we know and which factors contribute? The Breast, 80, 104427. https://doi.org/10.1016/j.breast.2025.104427

Article  PubMed  PubMed Central  Google Scholar 

Ngan, T. T., Van Minh, H., Donnelly, M., & O’Neill, C. (2021). Financial toxicity due to breast cancer treatment in low-and middle-income countries: Evidence from Vietnam. Supportive Care in Cancer, 29(11), 6325–6333.

Article  PubMed  PubMed Central  Google Scholar 

Bhangdia, K., Natarajan, A., Rudolfson, N., Verguet, S., Castro, M. C., Dusengimana, J. M., Shyirambere, C., Schleimer, L. E., Shulman, L. N., Umwizerwa, A., & Kigonya, C. (2025). The association of travel distance and other patient characteristics with breast cancer stage at diagnosis and treatment completion at a rural Rwandan cancer facility. BMC Cancer, 25(1), 146.

Article  PubMed  PubMed Central  Google Scholar 

Jalali, F. S., Seif, M., Jafari, A., Zangouri, V., Keshavarz, K., & Ravangard, R. (2023). Factors affecting the economic burden of breast cancer in southern Iran. BMC Health Services Research, 23(1), 1332.

Article  PubMed  PubMed Central  Google Scholar 

Noronha, V., Tongaonkar, A., Pillai, A., Rao, A. R., Kumar, A., Sehgal, A., Basu, R., Ramaswamy, A., Dhekale, R., Daptardar, A., & Sonkusare, L. (2025). Prevalence and impact of financial toxicity in older patients with cancer: A prospective observational study in India. Supportive Care in Cancer, 33(5), 416.

Article  PubMed  PubMed Central  Google Scholar 

Sakti, V. V., Danaee, M., Yip, C. H., Bustamam, R. S., Saad, M., Gan, G. G., Tan, J., Lim, Y. N., Chong, F. L., Munisamy, M., & Farid, F. M. (2023). Financial toxicity following cancer in a middle-income country with a pluralistic health system: Validation of the COST questionnaire. Cancer Care Research Online, 3(3), e044.

Article  Google Scholar 

Tran, G., & Zafar, S. Y. (2018). Financial toxicity and implications for cancer care in the era of molecular and immune therapies. Annals of Translational Medicine, 6(9), 166.

Article  PubMed  PubMed Central  Google Scholar 

Aaronson, N. K. (1993). The European Organization for Research and Treatment of Cancer QLQ-C30: A quality-of-life instrument for use in international clinical trials in oncology. JNCI Journal of the National Cancer Institute, 85(5), 365–376.

Article  CAS  PubMed  Google Scholar 

Getu, M. A., Chen, C., Wang, P., Kantelhardt, E. J., & Addissie, A. (2022). Quality of life and its influencing factors among breast cancer patients at Tikur Anbessa specialised hospital, Addis Ababa, Ethiopia. BMC Cancer, 22(1), 897.

Article  PubMed  PubMed Central  Google Scholar 

Alem, T., Nigatu, D., Birara, A., Fetene, T., & Giza, M. (2024). Quality of life of breast cancer patients in Amhara region, Ethiopia: A cross-sectional study. PLoS ONE, 19(6), e0305263.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belhaj Haddou, M., Igarramen, T., Khouchani, M., & Elkhoudri, N. (2024). Determinants of health-related quality of life in breast cancer patients: A comprehensive study in Marrakech, Morocco. The Open Public Health Journal, 17(1).

Cserni, G., Chmielik, E., Cserni, B., & Tot, T. (2018). The new TNM-based staging of breast cancer. Virchows Archiv, 472(5), 697–703.

Article  PubMed  Google Scholar 

Van Oostrom, S. H., Picavet, H. S., Van Gelder, B. M., Lemmens, L. C., Hoeymans, N., Van Dijk, C. E., Verheij, R. A., Schellevis, F. G., & Baan, C. A. (2012). Multimorbidity and comorbidity in the Dutch population – Data from general practices. BMC Public Health, 12(1), 715.

Article  PubMed  PubMed Central 

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