Deboever, N., Jones, C. M., Yamashita, K., Ajani, J. A., & Hofstetter, W. L. (2024). Advances in diagnosis and management of cancer of the esophagus. BMJ (Clinical Research Ed.), 385, Article e074962. https://doi.org/10.1136/bmj-2023-074962

Article  CAS  PubMed  Google Scholar 

Bray, F., Laversanne, M., Sung, H., Ferlay, J., Siegel, R. L., Soerjomataram, I., & Jemal, A. (2024). Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians, 74(3), 229–263. https://doi.org/10.3322/caac.21834

Article  PubMed  Google Scholar 

Yang, H., Wang, F., Hallemeier, C. L., Lerut, T., & Fu, J. (2024). Oesophageal cancer. The Lancet, 404(10466), 1991–2005. https://doi.org/10.1016/s0140-6736(24)02226-8

Article  Google Scholar 

Eyck, B. M., van Lanschot, J. J. B., Hulshof, M. C., van der Wilk, B. J., Shapiro, J., van Hagen, P., et al. (2021). Ten-year outcome of neoadjuvant chemoradiotherapy plus surgery for esophageal cancer: The randomized controlled cross trial. Journal of Clinical Oncology, 39(18), 1995–2004. https://doi.org/10.1200/JCO.20.03614

Article  CAS  PubMed  Google Scholar 

Gronnier, C., Tréchot, B., Duhamel, A., Mabrut, J.-Y., Bail, J.-P., Carrere, N., et al. (2014). Impact of neoadjuvant chemoradiotherapy on postoperative outcomes after esophageal cancer resection: Results of a European multicenter study. Annals of Surgery, 260(5), 764–771. https://doi.org/10.1097/SLA.0000000000000955

Article  PubMed  Google Scholar 

Liang, Z., Chen, T., Li, W., Lai, H., Li, L., Wu, J., et al. (2024). Efficacy and safety of neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy in locally advanced esophageal cancer: An updated meta-analysis. Medicine (Baltimore), 103(3), Article e36785. https://doi.org/10.1097/md.0000000000036785

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang, X., Wen, D., Feng, H., & Luo, M. (2025). Clinical efficacy of different neoadjuvant therapies for resectable esophageal squamous cell carcinoma. World Journal of Surgical Oncology, 23(1), Article 243. https://doi.org/10.1186/s12957-025-03897-w

Article  PubMed  PubMed Central  Google Scholar 

Ando, N., Kato, H., Igaki, H., Shinoda, M., Ozawa, S., Shimizu, H., et al. (2012). A randomized trial comparing postoperative adjuvant chemotherapy with Cisplatin and 5-Fluorouracil versus preoperative chemotherapy for localized advanced squamous cell carcinoma of the thoracic esophagus (Jcog9907). Annals of Surgical Oncology, 19(1), 68–74. https://doi.org/10.1245/s10434-011-2049-9

Article  PubMed  Google Scholar 

Noordman, B. J., Verdam, M. G. E., Lagarde, S. M., Hulshof, M., van Hagen, P., van Berge Henegouwen, M. I., et al. (2018). Effect of neoadjuvant chemoradiotherapy on health-related quality of life in esophageal or junctional cancer: Results from the randomized cross trial. Journal of Clinical Oncology, 36(3), 268–275. https://doi.org/10.1200/jco.2017.73.7718

Article  CAS  PubMed  Google Scholar 

Zhan, M., Zheng, H., Yang, Y., Xu, T., & Li, Q. (2019). Cost-effectiveness analysis of neoadjuvant chemoradiotherapy followed by surgery versus surgery alone for locally advanced esophageal squamous cell carcinoma based on the Neocrtec5010 Trial. Radiotherapy and Oncology, 141, 27–32. https://doi.org/10.1016/j.radonc.2019.07.031

Article  PubMed  Google Scholar 

Tang, H., Wang, H., Fang, Y., Zhu, J. Y., Yin, J., Shen, Y. X., et al. (2023). Neoadjuvant chemoradiotherapy versus neoadjuvant chemotherapy followed by minimally invasive esophagectomy for locally advanced esophageal squamous cell carcinoma: A prospective multicenter randomized clinical trial. Annals of Oncology, 34(2), 163–172. https://doi.org/10.1016/j.annonc.2022.10.508

Article  CAS  PubMed  Google Scholar 

Reynolds, J. V., Preston, S. R., O’Neill, B., Lowery, M. A., Baeksgaard, L., Crosby, T., et al. (2023). Trimodality therapy versus perioperative chemotherapy in the management of locally advanced adenocarcinoma of the oesophagus and oesophagogastric junction (Neo-Aegis): An open-label, randomised, phase 3 trial. The Lancet. Gastroenterology & Hepatology, 8(11), 1015–1027. https://doi.org/10.1016/s2468-1253(23)00243-1

Article  CAS  Google Scholar 

Bottomley, A. (2002). The cancer patient and quality of life. The Oncologist, 7(2), 120–125. https://doi.org/10.1634/theoncologist.7-2-120

Article  PubMed  Google Scholar 

Zang, Y., Xu, W., Qiu, Y., Gong, D., & Fan, Y. (2025). Baseline functioning scales of quality of life (Eortc Qlq-C30) as a predictor of overall survival in patients with lung cancer: A meta-analysis. Supportive Care in Cancer, 33(5), Article 366. https://doi.org/10.1007/s00520-025-09413-w

Article  PubMed  Google Scholar 

Aaronson, N. K., Ahmedzai, S., Bergman, B., Bullinger, M., Cull, A., Duez, N. J., et al. (1993). The European organization for research and treatment of cancer Qlq-C30: A quality-of-life instrument for use in international clinical trials in oncology. JNCI Journal of the National Cancer Institute, 85(5), 365–376. https://doi.org/10.1093/jnci/85.5.365

Article  CAS  PubMed  Google Scholar 

Blazeby, J. M., Conroy, T., Hammerlid, E., Fayers, P., Sezer, O., Koller, M., et al. (2003). Clinical and psychometric validation of an EORTC questionnaire module, the EORTC QLQ-OES18, to assess quality of life in patients with oesophageal cancer. European Journal of Cancer, 39(10), 1384–1394. https://doi.org/10.1016/s0959-8049(03)00270-3

Article  CAS  PubMed  Google Scholar 

Darling, G., Eton, D. T., Sulman, J., Casson, A. G., & Celia, D. (2006). Validation of the functional assessment of cancer therapy esophageal cancer subscale. Cancer, 107(4), 854–863. https://doi.org/10.1002/cncr.22055

Article  PubMed  Google Scholar 

Toh, Y., Morita, M., Yamamoto, M., Nakashima, Y., Sugiyama, M., Uehara, H., et al. (2022). Health-related quality of life after esophagectomy in patients with esophageal cancer. Esophagus, 19(1), 47–56. https://doi.org/10.1007/s10388-021-00874-6

Article  PubMed  Google Scholar 

Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., et al. (2021). The Prisma 2020 statement: An updated guideline for reporting systematic reviews. BMJ (Clinical Research Ed.), 372, Article n71. https://doi.org/10.1136/bmj.n71

Article  PubMed  PubMed Central  Google Scholar 

Osoba, D., Rodrigues, G., Myles, J., Zee, B., & Pater, J. (1998). Interpreting the significance of changes in health-related quality-of-life scores. Journal of Clinical Oncology, 16(1), 139–144. https://doi.org/10.1200/jco.1998.16.1.139

Article  CAS  PubMed  Google Scholar 

Alderson, D., Cunningham, D., Nankivell, M., Blazeby, J. M., Griffin, S. M., Crellin, A., et al. (2017). Neoadjuvant Cisplatin and Fluorouracil versus Epirubicin, Cisplatin, and Capecitabine followed by resection in patients with oesophageal adenocarcinoma (UK MRC OE05): An open-label, randomised Phase 3 trial. The Lancet. Oncology, 18(9), 1249–1260. https://doi.org/10.1016/s1470-2045(17)30447-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blazeby, J. M., Sanford, E., Falk, S. J., Alderson, D., & Donovan, J. L. (2005). Health-related quality of life during neoadjuvant treatment and surgery for localized esophageal carcinoma. Cancer, 103(9), 1791–1799. https://doi.org/10.1002/cncr.20980

Article  PubMed  Google Scholar 

Lorenzen, S., Pauligk, C., Homann, N., Schmalenberg, H., Jäger, E., & Al-Batran, S. E. (2013). Feasibility of perioperative chemotherapy with infusional 5-Fu, Leucovorin, and Oxaliplatin with (FLOT) or without (FLO) Docetaxel in elderly patients with locally advanced esophagogastric cancer. British Journal of Cancer, 108(3), 519–526. https://doi.org/10.1038/bjc.2012.588

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shimada, R., Yamasaki, M., Tanaka, K., Makino, T., Doki, Y., & Umeshita, K. (2022). Changes in the quality of life score following preoperative chemotherapy in elderly patients with esophageal cancer. Esophagus, 19(1), 113–119. https://doi.org/10.1007/s10388-021-00862-w

Article  CAS  PubMed  Google Scholar 

Sunde, B., Johnsen, G., Jacobsen, A. B., Glenjen, N. I., Friesland, S., Lindblad, M., et al. (2019). Effects of neoadjuvant chemoradiotherapy vs chemotherapy alone on the relief of dysphagia in esophageal cancer patients: secondary endpoint analysis in a randomized trial. Diseases of the Esophagus. https://doi.org/10.1093/dote/doy069

Article  PubMed  Google Scholar 

Bonnetain, F., Bouché, O., Michel, P., Mariette, C., Conroy, T., Pezet, D., et al. (2006). A comparative longitudinal quality of life study using the Spitzer Quality of Life Index in a randomized multicenter Phase III trial (FFCD 9102): Chemoradiation followed by surgery compared with chemoradiation alone in locally advanced squamous resectable thoracic esophageal cancer. Annals of Oncology, 17(5), 827–834. https://doi.org/10.1093/annonc/mdl033

Article  CAS  PubMed  Google Scholar 

Garant, A., Whitaker, T. J., Spears, G. M., Routman, D. M., Harmsen, W. S., Wilhite, T. J., et al. (2019). A comparison of patient-reported health-related quality of life during proton versus photon chemoradiation therapy for esophageal cancer. Practical Radiation Oncology, 9(6), 410–417. https://doi.org/10.1016/j.prro.2019.07.003

Article