Upper airway muscle activation in obstructive sleep apnea: a brief overview of emerging neuromodulatory and pharmacologic therapies

Punjabi NM. The epidemiology of adult obstructive sleep apnea. Proc Am Thorac Soc. 2008;5:136–43.

Article  PubMed  PubMed Central  Google Scholar 

Benjafield AV, Ayas NT, Eastwood PR, Heinzer R, Ip MSM, Morrell MJ, et al. Estimation of the global prevalence and burden of obstructive sleep apnoea: a literature-based analysis. Lancet Respir Med. 2019;7:687–98.

Article  PubMed  PubMed Central  Google Scholar 

Marin-Oto M, Vicente EE, Marin JM. Long term management of obstructive sleep apnea and its comorbidities. Multidiscip Respir Med. 2019;14:21.

Article  PubMed  PubMed Central  Google Scholar 

Marin JM, Agusti A, Villar I, Forner M, Nieto D, Carrizo SJ, et al. Association between treated and untreated obstructive sleep apnea and risk of hypertension. JAMA. 2012;307:2169–76.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harsch IA, Schahin SP, Radespiel-Tröger M, Weintz O, Jahreiss H, Fuchs FS, et al. Continuous positive airway pressure treatment rapidly improves insulin sensitivity in patients with obstructive sleep apnea syndrome. Am J Respir Crit Care Med. 2004;169:156–62.

Article  PubMed  Google Scholar 

Campos-Rodriguez F, Queipo-Corona C, Carmona-Bernal C, Jurado-Gamez B, Cordero-Guevara J, Reyes-Nuñez N, et al. Continuous positive airway pressure improves quality of life in women with obstructive sleep apnea a randomized controlled trial. Am J Respir Crit Care Med. 2016;194:1286–94.

Article  PubMed  Google Scholar 

Patil SP, Ayappa IA, Caples SM, Kimoff RJ, Patel SR, Harrod CG. Treatment of adult obstructive sleep apnea with positive airway pressure: an American Academy of Sleep Medicine systematic review, meta-analysis, and GRADE assessment. J Clin Sleep Med. 2019;15:301–34.

Article  PubMed  PubMed Central  Google Scholar 

Timkova V, Nagyova I, Reijneveld SA, Tkacova R, van Dijk JP, Bültmann U. Quality of life of obstructive sleep apnoea patients receiving continuous positive airway pressure treatment: a systematic review and meta-analysis. Heart Lung. 2020;49:10–24.

Article  PubMed  Google Scholar 

Tregear S, Reston J, Schoelles K, Phillips B. Continuous positive airway pressure reduces risk of motor vehicle crash among drivers with obstructive sleep apnea: systematic review and meta-analysis. Sleep. 2010;33:1373–80.

Article  PubMed  PubMed Central  Google Scholar 

Bouloukaki I, Giannadaki K, Mermigkis C, Tzanakis N, Mauroudi E, Moniaki V, et al. Intensive versus standard follow-up to improve continuous positive airway pressure compliance. Eur Respir J. 2014;44:1262–74.

Article  PubMed  Google Scholar 

Shapiro GK, Shapiro CM. Factors that influence CPAP adherence: an overview. Sleep Breath. 2010;14:323–35.

Article  PubMed  Google Scholar 

Van Ryswyk E, Anderson CS, Antic NA, Barbe F, Bittencourt L, Freed R, et al. Predictors of long-term adherence to continuous positive airway pressure in patients with obstructive sleep apnea and cardiovascular disease. Sleep. 2019;42(10):zsz152.

Article  PubMed  Google Scholar 

Randerath W, Verbraecken J, de Raaff CAL, Hedner J, Herkenrath S, Hohenhorst W, et al. European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea. Eur Respir Rev. 2021. https://doi.org/10.1183/16000617.0200-2021.

Article  PubMed  PubMed Central  Google Scholar 

Chan ASL, Sutherland K, Cistulli PA. Mandibular advancement splints for the treatment of obstructive sleep apnea. Expert Rev Respir Med. 2020;14:81–8.

Article  CAS  PubMed  Google Scholar 

Edwards BA, Andara C, Landry S, Sands SA, Joosten SA, Owens RL, et al. Upper-airway collapsibility and loop gain predict the response to oral appliance therapy in patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2016;194:1413–22.

Article  PubMed  PubMed Central  Google Scholar 

de Op Beeck S, Dieltjens M, Azarbarzin A, Willemen M, Verbraecken J, Braem MJ, et al. Mandibular advancement device treatment efficacy is associated with polysomnographic endotypes. Ann Am Thorac Soc. 2021;18:511–8.

Article  Google Scholar 

Cartwright RD. Effect of sleep position on sleep apnea severity. Sleep. 1984;7:110–4.

Article  CAS  PubMed  Google Scholar 

Schwab RJ, Kim C, Bagchi S, Keenan BT, Comyn FL, Wang S, et al. Understanding the anatomic basis for obstructive sleep apnea syndrome in adolescents. Am J Respir Crit Care Med. 2015;191:1295–309.

Article  PubMed  PubMed Central  Google Scholar 

Jordan AS, McSharry DG, Malhotra A. Adult obstructive sleep apnoea. Lancet. 2014;383:736–47.

Article  PubMed  Google Scholar 

Eckert DJ, White DP, Jordan AS, Malhotra A, Wellman A. Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med. 2013;188:996–1004.

Article  PubMed  PubMed Central  Google Scholar 

Berkovitz BKBHG, Moxham BJ. Chapter 3: regional topography of the mouth and related areas. In: Oral anatomy, histology and embryology. 5th ed. Edinburgh: Elsevier; 2018. p. 70–91.

Google Scholar 

Schwartz AR, Patil SP, Laffan AM, Polotsky V, Schneider H, Smith PL. Obesity and obstructive sleep apnea: pathogenic mechanisms and therapeutic approaches. Proc Am Thorac Soc. 2008;5:185–92.

Article  PubMed  PubMed Central  Google Scholar 

Cori JM, O’Donoghue FJ, Jordan AS. Sleeping tongue: current perspectives of genioglossus control in healthy individuals and patients with obstructive sleep apnea. Nat Sci Sleep. 2018;10:169–79.

Article  PubMed  PubMed Central  Google Scholar 

Eckert DJ, Malhotra A, Lo YL, White DP, Jordan AS. The influence of obstructive sleep apnea and gender on genioglossus activity during rapid eye movement sleep. Chest. 2009;135:957–64.

Article  PubMed  Google Scholar 

Sands SA, Eckert DJ, Jordan AS, Edwards BA, Owens RL, Butler JP, et al. Enhanced upper-airway muscle responsiveness is a distinct feature of overweight/obese individuals without sleep apnea. Am J Respir Crit Care Med. 2014;190:930–7.

Article  PubMed  PubMed Central  Google Scholar 

Chwieśko-Minarowska S, Minarowski Ł, Szewczak WA, Chyczewska E, Kuryliszyn-Moskal A. Efficacy of daytime transcutaneous electrical stimulation of the genioglossus muscle in patients with obstructive sleep apnea syndrome: short report. Eur Arch Otorhinolaryngol. 2016;273:3891–5.

Article  PubMed  Google Scholar 

Lequeux T, Chantrain G, Bonnand M, Chelle AJ, Thill MP. Physiotherapy in obstructive sleep apnea syndrome: preliminary results. Eur Arch Otorhinolaryngol. 2005;262:501–3.

Article  CAS  PubMed  Google Scholar 

Steier J, Seymour J, Rafferty GF, Jolley CJ, Solomon E, Luo Y, et al. Continuous transcutaneous submental electrical stimulation in obstructive sleep apnea: a feasibility study. Chest. 2011;140:998–1007.

Article  PubMed  Google Scholar 

Pengo MF, Xiao S, Ratneswaran C, Reed K, Shah N, Chen T, et al. Randomised sham-controlled trial of transcutaneous electrical stimulation in obstructive sleep apnoea. Thorax. 2016;71:923–31.

Article  PubMed  PubMed Central  Google Scholar 

Ratneswaran D, Cheng M, Nasser E, Madula R, Pengo M, Hope K, et al. Domiciliary transcutaneous electrical stimulation in patients with obstructive sleep apnoea and limited adherence to continuous positive airway pressure therapy: a single-centre, open-label, randomised, controlled phase III trial. EClinicalMedicine. 2023;62:102112.

Article  PubMed  PubMed Central  Google Scholar 

Schwartz AR, Bennett ML, Smith PL, De Backer W, Hedner J, Boudewyns A, et al. Therapeutic electrical stimulation of the hypoglossal nerve in obstructive sleep apnea. Arch Otolaryngol Head Neck Surg. 2001;127:1216–23.

Article  CAS  PubMed  Google Scholar 

Woodson BT, Soose RJ, Gillespie MB, Strohl KP, Maurer JT, de Vries N, et al. Three-year outcomes of cranial nerve stimulation for obstructive sleep apnea: the STAR trial. Otolaryngol Head Neck Surg. 2016;154:181–8.

Article  PubMed 

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