Ababneh NA, Aldiqs R, Nashwan S, Ismail MA, Barham R, Al Hadidi S, Alrefae A, Alhallaq FK, Abu-Humaidan AH, Saleh T, Awidi A (2025) Distinct anticancer properties of exosomes from induced mesenchymal stem cells vs. bone marrow-derived stem cells in MCF7 and A549 models. Biomed Rep 23(1):116

Article  CAS  PubMed  PubMed Central  Google Scholar 

Adamo A, Fiore D, De Martino F, Roscigno G, Affinito A, Donnarumma E, Puoti I, Ricci Vitiani L, Pallini R, Quintavalle C, Condorelli G (2017) RYK promotes the stemness of glioblastoma cells via the WNT/ β-catenin pathway. Oncotarget 8(8):13476–13487

Article  PubMed  PubMed Central  Google Scholar 

Chu DT, Phuong TNT, Tien NLB, Tran DK, Thanh VV, Quang TL, Truong DT, Pham VH, Ngoc VTN, Chu-Dinh T, Kushekhar K (2020) An update on the progress of isolation, culture, storage, and clinical application of human bone marrow mesenchymal stem/stromal cells. Int J Mol Sci 21(3):708

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cimpean AM, Comsa S, Sturza A, Barb AC, Cosma AA, Fenesan MP, Ionescu C, Ile AM, Sarb S, Chis M (2024) Validation of human bone marrow-derived mesenchymal stem cells and MCF-7 breast cancer cells co-culture using a 3D perfused biomimetic microfluidic platform. Anticancer Res 44(4):1441–1453

Article  PubMed  Google Scholar 

Dai L, Liu Y, Liu J, Wen X, Xu Z, Wang Z, Sun H, Tang S, Maguire AR, Quan J, Zhang H, Ye T (2013) A novel cyclinE/cyclinA-CDK inhibitor targets p27(Kip1) degradation, cell cycle progression and cell survival: implications in cancer therapy. Cancer Lett 333(1):103–112

Article  CAS  PubMed  Google Scholar 

Du T, Gao J, Li P, Wang Y, Qi Q, Liu X, Li J, Wang C, Du L (2021) Pyroptosis, metabolism, and tumor immune microenvironment. Clin Transl Med 11(8):e492

Article  CAS  PubMed  PubMed Central  Google Scholar 

Elhanani O, Ben-Uri R, Keren L (2023) Spatial profiling technologies illuminate the tumor microenvironment. Cancer Cell 41(3):404–420

Article  CAS  PubMed  Google Scholar 

Fan M, Zhang Y, Shi H, Xiang L, Yao H, Lin R (2023) Bone mesenchymal stem cells promote gastric cancer progression through TGF-β1/Smad2 positive feedback loop. Life Sci 323:121657

Article  CAS  PubMed  Google Scholar 

Farahzadi R, Fathi E, Vandghanooni S, Valipour B (2024) Cytokines secreted from bone marrow-derived mesenchymal stem cells promote apoptosis of CD34+ leukemic stem cells as anti-cancer therapy. Regen Ther 26:646–653

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu Y, Chen Y, Huang J, Cai Z, Wang Y (2020) RYK, a receptor of noncanonical Wnt ligand Wnt5a, is positively correlated with gastric cancer tumorigenesis and potential of liver metastasis. Am J Physiol Gastrointest Liver Physiol 318(2):G352–G360

Article  CAS  PubMed  Google Scholar 

Iden CR, Mustafa SM, Øgaard N, Henriksen T, Jensen SØ, Ahlborn LB, Egebjerg K, Baeksgaard L, Garbyal RS, Nedergaard MK, Achiam MP, Andersen CL, Mau-Sørensen M (2025) Circulating tumor DNA predicts recurrence and survival in patients with resectable gastric and gastroesophageal junction cancer. Gastric Cancer 28(1):83–95

Article  CAS  PubMed  Google Scholar 

Jin F, Qu X, Fan Q, Wang L, Tang T, Hao Y, Dai K (2013) Regulation of prostate cancer cell migration toward bone marrow stromal cell-conditioned medium by Wnt5a signaling. Mol Med Rep 8(5):1486–1492

Article  CAS  PubMed  Google Scholar 

Johor A, Mahadiuzzaman ASM, Alqusayer AA, Alkarim SA, Opo FADM (2025) In vivo and in vitro therapeutic evaluation of bone marrow-derived mesenchymal stem cells in liver cancer treatment. Front Cell Dev Biol 13:1521809

Article  PubMed  PubMed Central  Google Scholar 

Kasashima H, Yashiro M, Nakamae H, Masuda G, Kinoshita H, Morisaki T, Fukuoka T, Hasegawa T, Sakurai K, Toyokawa T, Kubo N, Tanaka H, Muguruma K, Ohira M, Nakane T, Hino M (2015Jul 28) Hirakawa K (2015) Bone marrow-derived stromal cells are associated with gastric cancer progression. Br J Cancer 113(3):443–452

Article  CAS  PubMed  PubMed Central  Google Scholar 

Keeble TR, Cooper HM (2006) Ryk: a novel Wnt receptor regulating axon pathfinding. Int J Biochem Cell Biol 38(12):2011–2017

Article  CAS  PubMed  Google Scholar 

Kikuchi H, Yagi H, Hasegawa H, Ishii Y, Okabayashi K, Tsuruta M, Hoshino G, Takayanagi A, Kitagawa Y (2014) Therapeutic potential of transgenic mesenchymal stem cells engineered to mediate anti-high mobility group box 1 activity: targeting of colon cancer. J Surg Res 190(1):134–143

Article  CAS  PubMed  Google Scholar 

Kim HD, Shin J, Hyung J, Lee H, Moon M, Ma J, Park YS, Ryu MH (2025) Survival outcomes of patients with gastric cancer treated with first-line nivolumab plus chemotherapy based on claudin 18.2 expression. Gastric Cancer 28(1):74–82

Article  CAS  PubMed  Google Scholar 

Kim HT, Yin W, Nakamichi Y, Panza P, Grohmann B, Buettner C, Guenther S, Ruppert C, Kobayashi Y, Guenther A, Stainier DYR (2019) WNT/RYK signaling restricts goblet cell differentiation during lung development and repair. Proc Natl Acad Sci U S A 116(51):25697–25706

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kwon JW, Oh JS, Seok SH, An HW, Lee YJ, Lee NY, Ha T, Kim HA, Yoon GM, Kim SE, Oh PR, Lee SH, Voon DC, Kim DY, Park JW (2023) Combined inhibition of Bcl-2 family members and YAP induces synthetic lethality in metastatic gastric cancer with RASA1 and NF2 deficiency. Mol Cancer 22(1):156

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kyriakou CA, Yong KL, Benjamin R, Pizzey A, Dogan A, Singh N, Davidoff AM, Nathwani AC (2006) Human mesenchymal stem cells (hMSCs) expressing truncated soluble vascular endothelial growth factor receptor (tsFlk-1) following lentiviral-mediated gene transfer inhibit growth of Burkitt’s lymphoma in a murine model. J Gene Med 8(3):253–264

Article  CAS  PubMed  Google Scholar 

Li J, Fan H, Liu W, Zhang J, Xiao Y, Peng Y, Yang W, Liu W, He Y, Qin L, Ma X, Li J (2024) Mesenchymal stem cells promote ovarian reconstruction in mice. Stem Cell Res Ther 15(1):115

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li LP, Li HX, Zhou H, Li WY, Wang RL, Zhang YC, Ma Y (2023) Exploring the mechanism of C473D mutation on CDC25B causing weak binding affinity with CDK2/CyclinA by molecular dynamics study. J Biomol Struct Dyn 41(22):12552–12564

Article  CAS  PubMed  Google Scholar 

Liu Z, Wang H, He J, Yuan X, Sun W (2019) Rictor ablation in BMSCs inhibits bone metastasis of TM40D cells by attenuating osteolytic destruction and CAF formation. Int J Biol Sci 15(11):2448–2460

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matsuda R, Yoshikawa M, Kimura H, Ouji Y, Nakase H, Nishimura F, Nonaka JI, Toriumi H, Yamada S, Nishiofuku M, Moriya K, Ishizaka S, Nakamura M, Sakaki T (2009) Cotransplantation of mouse embryonic stem cells and bone marrow stromal cells following spinal cord injury suppresses tumor development. Cell Transplant 18(1):39–54

Article  PubMed  Google Scholar 

Niu P, Zhang F, Ma D, Zhou X, Zhu Y, Luan X, Zhao L, Wang W, Zhang X, Han X, He M, Guan Q, Li Y, Liu Y, Chen Y (2024) Trends of older gastric cancer incidence, mortality, and survival in the highest gastric cancer risk area in China: 2010-2019 and prediction to 2024. BMC Public Health 24(1):2449

Article  PubMed  PubMed Central  Google Scholar 

Ohara S, Suda K, Fujino T, Hamada A, Koga T, Nishino M, Chiba M, Shimoji M, Takemoto T, Soh J, Mitsudomi T (2021) Dose-dependence in acquisition of drug tolerant phenotype and high RYK expression as a mechanism of osimertinib tolerance in lung cancer. Lung Cancer 154:84–91

Article  CAS  PubMed  Google Scholar 

Park EG, Pyo SJ, Cui Y, Yoon SH, Nam JW (2022) Tumor immune microenvironment lncRNAs. Brief Bioinform 23(1):bbab504

Article  PubMed  PubMed Central  Google Scholar 

Qi C, Shi H, Fan M, Chen W, Yao H, Jiang C, Meng L, Pang S, Lin R (2023) Microvesicles from bone marrow-derived mesenchymal stem cells promote Helicobacter pylori-associated gastric cancer progression by transferring thrombospondin-2. Cell Commun Signal 21(1):274