Antoniades CG, Berry PA, Wendon JA, Vergani D (2008) The importance of immune dysfunction in determining outcome in acute liver failure. J Hepatol 49(5):845–861
Article CAS PubMed Google Scholar
Arroyo V, Angeli P, Moreau R, Jalan R, Clària J, Trebicka J, Fernández J, Gustot T, Caraceni P, Bernardi M (2021) The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis. J Hepatol 74(3):670–685
Article CAS PubMed Google Scholar
Artyomov MN, Sergushichev A, Schilling JD (2016) Integrating immunometabolism and macrophage diversity. Semin Immunol 28(5):417–424
Article CAS PubMed PubMed Central Google Scholar
Bernard A, Chevrier S, Beltjens F, Dosset M, Viltard E, Lagrange A, Derangère V, Oudot A, Ghiringhelli F, Collin B, Apetoh L, Feron O, Chen S, Arnould L, Végran F, Boidot R (2019) Cleaved caspase-3 transcriptionally regulates angiogenesis-promoting chemotherapy resistance. Cancer Res 79(23):5958–5970
Article CAS PubMed Google Scholar
Fernández J, Bassegoda O, Toapanta D, Bernal W (2024) Acute liver failure: a practical update. JHEP Rep 6(9):101131–101144
Article PubMed PubMed Central Google Scholar
Funes SC, Rios M, Escobar-Vera J, Kalergis AM (2018) Implications of macrophage polarization in autoimmunity. Immunology 154(2):186–195
Article CAS PubMed PubMed Central Google Scholar
Gallo-Oller G, Ordoñez R, Dotor J (2018) A new background subtraction method for Western blot densitometry band quantification through image analysis software. J Immunol Methods 457:1–5
Article CAS PubMed Google Scholar
Guilliams M, Scott CL (2022) Liver macrophages in health and disease. Immunity 55(9):1515–1529
Article CAS PubMed Google Scholar
Hinton JP, Dvorak K, Roberts E, French WJ, Grubbs JC, Cress AE, Tiwari HA, Nagle RB (2019) A method to reuse archived H&e stained histology slides for a multiplex protein biomarker analysis. Methods Protoc 2(4):86–100
Article CAS PubMed PubMed Central Google Scholar
Kolodziejczyk AA, Federici S, Zmora N, Mohapatra G, Dori-Bachash M, Hornstein S, Leshem A, Reuveni D, Zigmond E, Tobar A, Salame TM, Harmelin A, Shlomai A, Shapiro H, Amit I, Elinav E (2020) Acute liver failure is regulated by MYC- and microbiome-dependent programs. Nat Med 26(12):1899–1911
Article CAS PubMed Google Scholar
Li J, Liang X, Jiang J, Yang L, Xin J, Shi D, Lu Y, Li J, Ren K, Hassan HM, Zhang J, Chen P, Yao H, Li J, Wu T, Jin L, Ye P, Li T, Zhang H, Sun S, Guo B, Zhou X, Cai Q, Chen J, Xu X, Huang J, Hao S, He J, Xin S, Wang D, Trebicka J, Chen X, Li J (2022) PBMC transcriptomics identifies immune-metabolism disorder during the development of HBV-ACLF. Gut 71(1):163–175
Article CAS PubMed Google Scholar
Ling S, Jiang G, Que Q, Xu S, Chen J, Xu X (2022) Liver transplantation in patients with liver failure: twenty years of experience from China. Liver Int 42(9):2110–2116
Liu QW, Liu QY, Li JY, Wei L, Ren KK, Zhang XC, Ding T, Xiao L, Zhang WJ, Wu HY, Xin HB (2018) Therapeutic efficiency of human amniotic epithelial stem cell-derived functional hepatocyte-like cells in mice with acute hepatic failure. Stem Cell Res Ther 9(1):321–340
Article CAS PubMed PubMed Central Google Scholar
Maiwall R, Kulkarni AV, Arab JP, Piano S (2024) Acute liver failure. Lancet 404(10454):789–802
Article CAS PubMed Google Scholar
Mathews S, Feng D, Maricic I, Ju C, Kumar V, Gao B (2016) Invariant natural killer T cells contribute to chronic-plus-binge ethanol-mediated liver injury by promoting hepatic neutrophil infiltration. Cell Mol Immunol 13(2):206–216
Article CAS PubMed Google Scholar
McComb S, Chan PK, Guinot A, Hartmannsdottir H, Jenni S, Dobay MP, Bourquin JP, Bornhauser BC (2019) Efficient apoptosis requires feedback amplification of upstream apoptotic signals by effector caspase-3 or -7. Sci Adv 5(7):eaau9433–eaau9443
Minz RW, Singh P, Rani L, Wani MR, Kumar Y, Anand S (2020) THU328 - tolerogenic dendritic cells modulate pathogenic CD4+ T cells in an ex vivo co-culture system in a concanavalin A-mice model of type-I autoimmune hepatitis. J Hepatol 73:S298–S299
Miyashita T, Nagao K, Krajewski S, Salvesen GS, Reed JC, Inoue T, Yamada M (1998) Investigation of glucocorticoid-induced apoptotic pathway: processing of caspase-6 but not caspase-3. Cell Death Differ 5(12):1034–1041
Article CAS PubMed Google Scholar
Song M, Chen Z, Qiu R, Zhi T, Xie W, Zhou Y, Luo N, Fuqian C, Liu F, Shen C, Lin S, Zhang F, Gao Y, Liu C (2022) Inhibition of NLRP3-mediated crosstalk between hepatocytes and liver macrophages by geniposidic acid alleviates cholestatic liver inflammatory injury. Redox Biol 55:102404–102422
Article PubMed PubMed Central Google Scholar
Sun C, Fujisawa M, Ohara T, Liu Q, Cao C, Yang X, Yoshimura T, Kunkel SL, Matsukawa A (2022) Spred2 controls the severity of concanavalin A-induced liver damage by limiting interferon-gamma production by CD4+ and CD8+ T cells. J Adv Res 35:71–86
Article CAS PubMed Google Scholar
Thuluvath PJ, Alukal JJ, Zhang T (2021) Acute liver failure in Budd-Chiari syndrome and a model to predict mortality. Hepatol Int 15(1):146–154
Tujios S, Stravitz RT, Lee WM (2022) Management of acute liver failure: update 2022. Semin Liver Dis 42(3):362–378
Article PubMed PubMed Central Google Scholar
Vucur M, Ghallab A, Schneider AT, Adili A, Cheng M, Castoldi M, Singer MT, Büttner V, Keysberg LS, Küsgens L, Kohlhepp M, Görg B, Gallage S, Barragan Avila JE, Unger K, Kordes C, Leblond A-L, Albrecht W, Loosen SH, Lohr C, Jördens MS, Babler A, Hayat S, Schumacher D, Koenen MT, Govaere O, Boekschoten MV, Jörs S, Villacorta-Martin C, Mazzaferro V, Llovet JM, Weiskirchen R, Kather JN, Starlinger P, Trauner M, Luedde M, Heij LR, Neumann UP, Keitel V, Bode JG, Schneider RK, Tacke F, Levkau B, Lammers T, Fluegen G, Alexandrov T, Collins AL, Nelson G, Oakley F, Mann DA, Roderburg C, Longerich T, Weber A, Villanueva A, Samson AL, Murphy JM, Kramann R, Geisler F, Costa IG, Hengstler JG, Heikenwalder M, Luedde T (2023) Sublethal necroptosis signaling promotes inflammation and liver cancer. Immunity 56(7):1578–1595
Article CAS PubMed Google Scholar
Wang H, Feng X, Yan W, Tian D (2020) Regulatory T cells in autoimmune hepatitis: unveiling their roles in mouse models and patients. Front Immunol 11:575572–575583
Article CAS PubMed PubMed Central Google Scholar
Wang Y, Zhang H, Chen Q, Jiao F, Shi C, Pei M, Lv J, Zhang H, Wang L, Gong Z (2020) TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury. Cell Prolif 53(6):e12829–e12840
Article CAS PubMed PubMed Central Google Scholar
Wen Z, Lei Z, Yao L, Jiang P, Gu T, Ren F, Liu Y, Gou C, Li X, Wen T (2016) Circulating histones are major mediators of systemic inflammation and cellular injury in patients with acute liver failure. Cell Death Dis 7(9):e2391–e2400
Article CAS PubMed PubMed Central Google Scholar
Wu Z, Han M, Chen T, Yan W, Ning Q (2010) Acute liver failure: mechanisms of immune-mediated liver injury. Liver Int 30(6):782–794
Article CAS PubMed Google Scholar
Yang R, Zou X, Tenhunen J, Tønnessen TI (2017) HMGB1 and extracellular histones significantly contribute to systemic inflammation and multiple organ failure in acute liver failure. Mediators Inflamm 2017:5928078–5928083
Article PubMed PubMed Central Google Scholar
Yatim N, Cullen S, Albert ML (2017) Dying cells actively regulate adaptive immune responses. Nat Rev Immunol 17(4):262–275
Article CAS PubMed Google Scholar
Zheng Y, Cui B, Sun W, Wang S, Huang X, Gao H, Gao F, Cheng Q, Lu L, An Y, Li X, Sun N (2020) Potential crosstalk between liver and extra-liver organs in mouse models of acute liver injury. Int J Biol Sci 16(7):1166–1179
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