Multi-Dimensional Perspective of the Gene and Environmental Interaction in Asthma

Delfino RJ (2002) Epidemiologic evidence for asthma and exposure to air toxics: linkages between occupational, indoor, and community air pollution research. Environ Health Perspect 110(Suppl 4):573–589

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guan WC et al (2023) [Analysis on the management of type 2 inflammatory asthma from the guideline of Global Strategy for Asthma Management and Prevention]. Zhonghua Yu Fang Yi Xue Za Zhi 57(12):1964–1971

CAS  PubMed  Google Scholar 

Jiang J, Qi L, Ding S (2026) Trends in asthma and pneumonia-related mortality in the United States: a CDC wonder database analysis (1999–2023). Front Med (Lausanne) 13:1736476

Article  PubMed  PubMed Central  Google Scholar 

Saleem A, Awan T, Akhtar MF (2024) A comprehensive review on endocrine toxicity of gaseous components and particulate matter in smog. Front Endocrinol (Lausanne) 15:1294205

Article  PubMed  PubMed Central  Google Scholar 

Zhu L et al (2023) Endocrine disrupting chemicals in indoor dust: a review of temporal and spatial trends, and human exposure. Sci Total Environ 874:162374

Article  CAS  PubMed  Google Scholar 

Yang J et al (2025) Association of prenatal exposure to phthalates with risks of asthma, wheeze, and allergic diseases during childhood: a systematic review and meta-analysis. J Environ Health Sci Eng 23(2):26

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hatem G et al (2025) Association between exposure to airborne endocrine disrupting chemicals and asthma in children or adolescents: a systematic review and meta-analysis. Environ Pollut 369:125830

Article  CAS  PubMed  Google Scholar 

Nurmatov U et al (2013) Volatile organic compounds and risk of asthma and allergy: a systematic review and meta-analysis of observational and interventional studies. Prim Care Respir J 22(1):PS9–15

Article  PubMed  PubMed Central  Google Scholar 

Pajewska-Szmyt M et al (2025) Association of childhood asthma with the concept of exposomics: a short review. Med Sci Monit 31:e949589

Article  PubMed  PubMed Central  Google Scholar 

Yu Z et al (2025) External exposome and incident asthma across the life course in 14 European cohorts: a prospective analysis within the EXPANSE project. Lancet Reg Health Eur 54:101314

Article  PubMed  PubMed Central  Google Scholar 

Wu CC et al (2023) Environmental risks and sphingolipid signatures in adult asthma and its phenotypic clusters: a multicentre study. Thorax 78(3):225–232

Article  PubMed  Google Scholar 

Liao J et al (2022) Transcriptomic and metabolomic associations with exposures to air pollutants among young adults with childhood asthma history. Environ Pollut 299:118903

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tsai YG et al (2025) Long-term PM(2.5) exposure is associated with asthma prevalence and exhaled nitric oxide levels in children. Pediatr Res 97(1):370–377

Article  CAS  PubMed  Google Scholar 

Hernandez-Pacheco N, Kere M, Melen E (2022) Gene-environment interactions in childhood asthma revisited; expanding the interaction concept. Pediatr Allergy Immunol 33(5):e13780

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chatkin J, Correa L, Santos U (2022) External environmental pollution as a risk factor for asthma. Clin Rev Allergy Immunol 62(1):72–89

Article  PubMed  Google Scholar 

Koppelman GH et al (2025) Genetic and environmental risk factors for asthma: towards prevention. Lancet Respir Med 13(11):1011–1025

Article  CAS  PubMed  Google Scholar 

Lee CL et al (2016) A new grid-scale model simulating the spatiotemporal distribution of PM2.5-PAHs for exposure assessment. J Hazard Mater 314:286–294

Article  CAS  PubMed  Google Scholar 

Hsu SC et al (2020) Differential time-lag effects of ambient PM(2.5) and PM(2.5)-bound PAHs on asthma emergency department visits. Environ Sci Pollut Res Int 27(34):43117–43124

Article  CAS  PubMed  Google Scholar 

Hsu YT et al (2023) BTEX exposure and its body burden pose differential risks for asthma and its phenotypic clusters. Allergy 78(7):2036–2040

Article  PubMed  Google Scholar 

Riahi Y et al (2010) Signaling and cytotoxic functions of 4-hydroxyalkenals. Am J Physiol Endocrinol Metab 299(6):E879–E886

Article  CAS  PubMed  Google Scholar 

Spickett CM (2013) The lipid peroxidation product 4-hydroxy-2-nonenal: advances in chemistry and analysis. Redox Biol 1(1):145–152

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu YT et al (2024) Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters. Respir Res 25(1):139

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu YT et al (2025) Differential risks of exposure to acrylamide in adult asthma clusters. Allergy 80(4):1173–1175

Article  CAS  PubMed  Google Scholar 

Castano-Vinyals G et al (2004) Biomarkers of exposure to polycyclic aromatic hydrocarbons from environmental air pollution. Occup Environ Med 61(4):e12

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hsu YT et al (2024) Longitudinal assessment of oxidative stress markers and their relationship with exposure to PM(2.5) and its bound metals in healthy participants. Int J Hyg Environ Health 258:114348

Article  CAS  PubMed  Google Scholar 

Wang HC et al (2019) Aryl hydrocarbon receptor signaling promotes ORMDL3-dependent generation of sphingosine-1-phosphate by inhibiting sphingosine-1-phosphate lyase. Cell Mol Immunol 16(10):783–790

Article  CAS  PubMed  Google Scholar 

Maceyka M, Spiegel S (2014) Sphingolipid metabolites in inflammatory disease. Nature 510(7503):58–67

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kulinski JM, Munoz-Cano R, Olivera A (2016) Sphingosine-1-phosphate and other lipid mediators generated by mast cells as critical players in allergy and mast cell function. Eur J Pharmacol 778:56–67

Article  CAS  PubMed  Google Scholar 

Worgall TS et al (2013) Impaired sphingolipid synthesis in the respiratory tract induces airway hyperreactivity. Sci Transl Med 5(186):186ra67

Article  PubMed  Google Scholar 

Maguire TJA et al (2023) Sphingosine-1-phosphate induces airway smooth muscle hyperresponsiveness and proliferation. J Allergy Clin Immunol 152(5):1131–1140e6

Article  CAS  PubMed  Google Scholar 

Kuo CH et al (2013) Phthalates suppress type I interferon in human plasmacytoid dendritic cells via epigenetic regulation. Allergy 68(7):870–879

Article  CAS  PubMed  Google Scholar 

Suen JL et al (2013) A common environmental pollutant, 4-nonylphenol, promotes allergic lung inflammation in a murine m

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