Sammaritano LR (2020) Antiphospholipid syndrome. Best Pract Res Clin Rheumatol 34(1):101463

Article  PubMed  Google Scholar 

Abrahams VM, Chamley LW, Salmon JE (2017) Emerging treatment models in rheumatology: antiphospholipid syndrome and pregnancy: pathogenesis to translation. Arthritis Rheumatol 69(9):1710–1721

Article  PubMed  PubMed Central  Google Scholar 

D’Ippolito S, Barbaro G, Paciullo C, Tersigni C, Scambia G, Di Simone N (2023) Antiphospholipid syndrome in pregnancy: new and old pathogenetic mechanisms. Int J Mol Sci 24(4):3195

Article  PubMed  PubMed Central  Google Scholar 

D’Ippolito S, Meroni PL, Koike T, Veglia M, Scambia G, Di Simone N (2014) Obstetric antiphospholipid syndrome: a recent classification for an old defined disorder. Autoimmun Rev 13(9):901–908

Article  PubMed  Google Scholar 

Abou-Nassar K, Carrier M, Ramsay T, Rodger M (2011) The association between antiphospholipid antibodies and placenta mediated complications: a systematic review and meta-analysis. Thromb Res 128:77–85

Article  CAS  PubMed  Google Scholar 

Tanimura K, Saito S, Tsuda S, Ono Y, Deguchi M, Nagamatsu T, Fujii T, Nakatsuka M, Kobashi G, Arase H, Yamada H (2024) Low-dose aspirin and heparin treatment improves pregnancy outcome in recurrent pregnancy loss women with anti-β2-glycoprotein I/HLA-DR autoantibodies: a prospective, multicenter, observational study. Front Immunol 15:1445852

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khizroeva J, Bitsadze V, Tincani A, Makatsariya A, Arslanbekova M, Babaeva N, Tsibizova V, Shkoda A, Makatsariya N, Tretyakova M, Solopova A, Gadaeva Z, Vorobev A, Khamani I, Aslanova Z, Nakaidze I, Mischenko A, Grigoreva K, Kunesko N, Egorova E, Mashkova T (2022) Hydroxychloroquine in obstetric antiphospholipid syndrome: rationale and results of an observational study of refractory cases. J Matern Fetal Neonatal Med 35(25):6157–6164

Article  CAS  PubMed  Google Scholar 

Arachchillage DJ, Kitchen S (2024) Pleiotropic effects of heparin and its monitoring in the clinical practice. Semin Thromb Hemost 50(8):1153–1162

Article  CAS  PubMed  PubMed Central  Google Scholar 

Burton GJ, Jauniaux E (2018) Pathophysiology of placental-derived fetal growth restriction. Am J Obstet Gynecol 218(2s):S745–s761

Article  CAS  PubMed  Google Scholar 

Kumar S, Pozzi N (2025) Understanding the structure of β2-glycoprotein I: new insights and future paths for antiphospholipid syndrome. Blood Vessels, Thrombosis & Hemostasis 2(2):100041

Article  Google Scholar 

Chighizola CB, Lonati PA, Trespidi L, Meroni PL, Tedesco F (2020) The complement system in the pathophysiology of pregnancy and in systemic autoimmune rheumatic diseases during pregnancy. Front Immunol 11:2084

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dunkelberger JR, Song WC (2010) Complement and its role in innate and adaptive immune responses. Cell Res 20(1):34–50

Article  CAS  PubMed  Google Scholar 

Pierik E, de Jong-Schoots MH, Bulthuis M, Daha MR, van den Born J, Gordijn SJ, Prins JR (2025) Preeclampsia is associated with placental complement C4d deposition. Placenta 171:45–51

Article  CAS  PubMed  Google Scholar 

Varela JC, Tomlinson S (2015) Complement: an overview for the clinician. Hematol Oncol Clin North Am 29(3):409–427

Article  PubMed  PubMed Central  Google Scholar 

Bulla R, Bossi F, Tedesco F (2012) The complement system at the embryo implantation site: friend or foe? Front Immunol 3:55

Article  CAS  PubMed  PubMed Central  Google Scholar 

Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE (2006) Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med 203(9):2165–2175

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giaglis S, Stoikou M, Grimolizzi F, Subramanian BY, van Breda SV, Hoesli I, Lapaire O, Hasler P, Than NG, Hahn S (2016) Neutrophil migration into the placenta: good, bad or deadly? Cell Adhesion & Migration 10(1–2):208–25

Article  CAS  Google Scholar 

Yang H, Biermann MH, Brauner JM, Liu Y, Zhao Y, Herrmann M (2016) New insights into neutrophil extracellular traps: mechanisms of formation and role in inflammation. Front Immunol 7:302

Article  PubMed  PubMed Central  Google Scholar 

Ostrycharz E, Hukowska-Szematowicz B (2022) New insights into the role of the complement system in human viral diseases. Biomolecules 12(2):226

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang C, Li A, Zhang C, Yang Z, Yang X, Qi W, Liu T, Zhang M, Wang X (2025) Neutrophil extracellular traps aggravate placental injury in OAPS by facilitating activation of BNIP3 mediated mitophagy. Free Radic Biol Med 235:109–123

Article  CAS  PubMed  Google Scholar 

Kelley N, Jeltema D, Duan Y, He Y (2019) The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation. Int J Mol Sci 20(13)

Laplante P, Fuentes R, Salem D, Subang R, Gillis MA, Hachem A, Farhat N, Qureshi S, Fletcher C, Roubey R, Merhi Y, Thorin E, Levine J, Mackman N, Rauch J (2015) Antiphospholipid antibody-mediated effects in an arterial model of thrombosis are dependent on Toll-like receptor 4. Lupus 25:162–176

Article  PubMed  Google Scholar 

Mulla MJ, Myrtolli K, Potter J, Boeras C, Kavathas PB, Sfakianaki AK, Tadesse S, Norwitz ER, Guller S, Abrahams VM (2011) Uric acid induces trophoblast IL-1β production via the inflammasome: implications for the pathogenesis of preeclampsia. Am J Reprod Immunol 65(6):542–548

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mulla MJ, Salmon JE, Chamley LW, Brosens JJ, Boeras CM, Kavathas PB, Abrahams VM (2013) A role for uric acid and the Nalp3 inflammasome in antiphospholipid antibody-induced IL-1β production by human first trimester trophoblast. PLoS One 8(6):e65237

Article  CAS  PubMed  PubMed Central  Google Scholar 

D’Ippolito S, Tersigni C, Marana R, Di Nicuolo F, Gaglione R, Rossi ED, Castellani R, Scambia G, Di Simone N (2016) Inflammosome in the human endometrium: further step in the evaluation of the “maternal side.” Fertil Steril 105(1):111-118. e4

Article  CAS  PubMed  Google Scholar 

Arumugasaamy N, Rock KD, Kuo CY, Bale TL, Fisher JP (2020) Microphysiological systems of the placental barrier. Adv Drug Deliv Rev 161–162 161–175

Deng CL, Ling ST, Liu XQ, Zhao YJ, Lv YF (2015) Decreased expression of matrix metalloproteinase-1 in the maternal umbilical serum, trophoblasts and decidua leads to preeclampsia. Exp Ther Med 9(3):992–998

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Simone N, Di Nicuolo F, D’Ippolito S, Castellani R, Tersigni C, Caruso A, Meroni P, Marana R (2010) Antiphospholipid antibodies affect human endometrial angiogenesis. Biol Reprod 83(2):212–219

Article  CAS  PubMed  Google Scholar 

Di Simone N, D’Ippolito S, Marana R, Di Nicuolo F, Castellani R, Pierangeli SS, Chen P, Tersigni C, Scambia G, Meroni PL (2013) Antiphospholipid antibodies affect human endometrial angiogenesis: protective effect of a synthetic peptide (TIFI) mimicking the phospholipid binding site of β2glycoprotein I. Am J Reprod Immunol 70(4):299–308

Article  CAS  PubMed  Google Scholar 

D’Ippolito S, Di Simone N, Di Nicuolo F, Castellani R, Caruso A (2007) Antiphospholipid antibodies: effects on trophoblast and endothelial cells. Am J Reprod Immunol 58(2):150–158

Article  PubMed  Google Scholar 

D’Ippolito S, Ticconi C, Tersigni C, Garofalo S, Martino C, Lanzone A, Scambia G, Di Simone N (2020) The pathogenic role of autoantibodies in recurrent pregnancy loss. Am J Reprod Immunol 83(1):e13200

Article  PubMed