Management and Immunotherapy for Fungal Allergy: Clinical Practice and Unmet Needs

Iliev ID, Brown GD, Bacher P, Gaffen SL, Heitman J, Klein BS et al (2024) Focus on fungi. Cell 187(19):5121–7. https://doi.org/10.1016/j.cell.2024.08.016

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bush RK (2016) Fungal sensitivity: new insights and clinical approaches. J Allergy Clin Immunol Pract 4(3):433–434. https://doi.org/10.1016/j.jaip.2016.02.003

Article  PubMed  Google Scholar 

Simon-Nobbe B, Denk U, Pöll V, Rid R, Breitenbach M (2007) The spectrum of fungal allergy. Int Arch Allergy Immunol 145(1):58–86

Article  PubMed  Google Scholar 

Twaroch TE, Curin M, Valenta R, Swoboda I (2015) Mold allergens in respiratory allergy: from structure to therapy. Allergy Asthma Immunol Res 7(3):205–220. https://doi.org/10.4168/aair.2015.7.3.205

Article  CAS  PubMed  PubMed Central  Google Scholar 

Forkel S, Beutner C, Schröder SS, Bader O, Gupta S, Fuchs T et al (2021) Sensitization against fungi in patients with airway allergies over 20 years in Germany. Int Arch Allergy Immunol 182(6):515–23. https://doi.org/10.1159/000512230

Article  CAS  PubMed  PubMed Central  Google Scholar 

Thacher JD, Gruzieva O, Pershagen G, Melén E, Lorentzen JC, Kull I et al (2016) Mold and dampness exposure and allergic outcomes from birth to adolescence: data from the BAMSE cohort. Allergy 72(6):967–74. https://doi.org/10.1111/all.13102

Article  CAS  PubMed  PubMed Central  Google Scholar 

Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P, Niven RM (2006) The link between fungi and severe asthma: a summary of the evidence. Eur Respir J 27(3):615–626

Article  CAS  PubMed  Google Scholar 

Agarwal R, Muthu V, Sehgal IS (2023) Relationship between Aspergillus and asthma. Allergol Int 72(4):507–520. https://doi.org/10.1016/j.alit.2023.08.004

Article  CAS  PubMed  Google Scholar 

Rhyou H-I, Kim T-B, Yoon S-Y, Kwon J-W, Park H-K, Kim S-R et al (2025) Prevalence and Clinical Characteristics of Severe Asthma With Fungal Sensitization in Korea. Allergy Asthma Immunol Res 17(4):447–59. https://doi.org/10.4168/aair.2025.17.4.447

Article  PubMed  PubMed Central  Google Scholar 

Hughes KM, Price D, Torriero AAJ, Symonds MRE, Suphioglu C (2022) Impact of Fungal Spores on Asthma Prevalence and Hospitalization. Int J Mol Sci. https://doi.org/10.3390/ijms23084313

Article  PubMed  PubMed Central  Google Scholar 

O’Driscoll BR, Hopkinson LC, Denning DW (2005) Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm Med 5:4

Article  PubMed  PubMed Central  Google Scholar 

Fukutomi Y, Taniguchi M (2015) Sensitization to fungal allergens: Resolved and unresolved issues. Allergol Int 64(4):321–331. https://doi.org/10.1016/j.alit.2015.05.007

Article  CAS  PubMed  Google Scholar 

Abel-Fernández E, Fernández-Caldas E (2023) Allergy to fungi: Advances in the understanding of fungal allergens. Mol Immunol 163:216–223. https://doi.org/10.1016/j.molimm.2023.09.017

Article  CAS  PubMed  Google Scholar 

Abel-Fernández E, Martínez MJ, Galán T, Pineda F (2023) Going over Fungal Allergy: Alternaria alternata and Its Allergens. Journal of Fungi. https://doi.org/10.3390/jof9050582

Article  PubMed  PubMed Central  Google Scholar 

Denning DW (2024) Global incidence and mortality of severe fungal disease. Lancet Infect Dis 24(7):e428–e38. https://doi.org/10.1016/S1473-3099(23)00692-8

Article  PubMed  Google Scholar 

van de Veerdonk FL, Carvalho A, Wauters J, Chamilos G, Verweij PE (2025) Aspergillus fumigatus biology, immunopathogenicity and drug resistance. Nat Rev Microbiol 23(10):652–66. https://doi.org/10.1038/s41579-025-01180-z

Article  CAS  PubMed  Google Scholar 

Hernandez-Ramirez G, Barber D, Tome-Amat J, Garrido-Arandia M, Diaz-Perales A (2021) Alternaria as an Inducer of Allergic Sensitization. Journal of Fungi. https://doi.org/10.3390/jof7100838

Article  PubMed  PubMed Central  Google Scholar 

Meena M, Gupta SK, Swapnil P, Zehra A, Dubey MK, Upadhyay RS (2017) Alternaria Toxins: Potential Virulence Factors and Genes Related to Pathogenesis. Front Microbiol 8:1451. https://doi.org/10.3389/fmicb.2017.01451

Article  PubMed  PubMed Central  Google Scholar 

Jabeen R, Kizhisseri MI, Mayanaik SN, Mohamed MM (2023) Bioaerosol assessment in indoor and outdoor environments: a case study from India. Sci Rep 13(1):18066. https://doi.org/10.1038/s41598-023-44315-z

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reboux G, Rocchi S, Vacheyrou M, Millon L (2019) Identifying indoor air Penicillium species: a challenge for allergic patients. J Med Microbiol 68(5):812–821. https://doi.org/10.1099/jmm.0.000960

Article  CAS  PubMed  Google Scholar 

Sharpe RA, Bearman N, Thornton CR, Husk K, Osborne NJ (2014) Indoor fungal diversity and asthma: a meta-analysis and systematic review of risk factors. J Allergy Clin Immunol 135(1):110–122. https://doi.org/10.1016/j.jaci.2014.07.002

Article  PubMed  Google Scholar 

Pongracic JA, O’Connor GT, Muilenberg ML, Vaughn B, Gold DR, Kattan M et al (2010) Differential effects of outdoor versus indoor fungal spores on asthma morbidity in inner-city children. J Allergy Clin Immunol 125(3):593–9. https://doi.org/10.1016/j.jaci.2009.10.036

Article  PubMed  PubMed Central  Google Scholar 

Neukirch C, Henry C, Leynaert B, Liard R, Bousquet J, Neukirch F (1999) Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study. J Allergy Clin Immunol 103(4):709–711

Article  CAS  PubMed  Google Scholar 

Fernández-Soto R, Navarrete-Rodríguez EM, Del-Rio-Navarro BE, Sienra-Monge JJL, Meneses-Sánchez NA, Saucedo-Ramírez OJ (2018) Fungal allergy: pattern of sensitization over the past 11 years. Allergol Immunopathol (Madr) 46(6):557–64. https://doi.org/10.1016/j.aller.2018.01.005

Article  PubMed  Google Scholar 

Yang L, Li W, Qi S, Jiang Q, Huang N, Yang Y et al (2023) A survey of airborne fungi and their sensitization profile in Wuhan, China. Int Arch Allergy Immunol 184(11):1153–64. https://doi.org/10.1159/000531245

Article  CAS  PubMed  Google Scholar 

Katotomichelakis M, Nikolaidis C, Makris M, Proimos E, Aggelides X, Constantinidis TC et al (2015) Alternaria and Cladosporium calendar of Western Thrace: relationship with allergic rhinitis symptoms. Laryngoscope 126(2):E51–E6. https://doi.org/10.1002/lary.25594

Article  PubMed  Google Scholar 

Anees-Hill S, Douglas P, Pashley CH, Hansell A, Marczylo EL (2021) A systematic review of outdoor airborne fungal spore seasonality across Europe and the implications for health. Sci Total Environ 818:151716. https://doi.org/10.1016/j.scitotenv.2021.151716

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu L, Li X, Sun Y, Li G (2024) Allergen sensitization of parents and children with respiratory allergic diseases. Indian Pediatr 61(8):730–734

Article  PubMed  Google Scholar 

Vitte J, Michel M, Malinovschi A, Caminati M, Odebode A, Annesi-Maesano I et al (2022) Fungal exposome, human health, and unmet needs: a 2022 update with special focus on allergy. Allergy 77(11):3199–216. https://doi.org/10.1111/all.15483

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