Ahangar M, Mahjoubi F, Mowla SJ (2024) Bladder cancer biomarkers: current approaches and future directions. Front Oncol 14:1453278. https://doi.org/10.3389/fonc.2024.1453278

Article  CAS  PubMed  PubMed Central  Google Scholar 

Azijli K, Weyhenmeyer B, Peters GJ, de Jong S, Kruyt FA (2013) Non-canonical kinase signaling by the death ligand TRAIL in cancer cells: discord in the death receptor family. Cell Death Differ 20(7):858–868. https://doi.org/10.1038/cdd.2013.28

Article  CAS  PubMed  PubMed Central  Google Scholar 

Babazadeh SM, Zolfaghari MR, Zargar M, Baesi K, Hosseini SY, Ghaemi A (2023) Interleukin-24-mediated antitumor effects against human glioblastoma via upregulation of p38 MAPK and endogenous TRAIL-induced apoptosis and LC3-II activation-dependent autophagy. BMC Cancer 23(1):519. https://doi.org/10.1186/s12885-023-11021-y

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boß M, Newbatt Y, Gupta S, Collins I, Brüne B, Namgaladze D (2016) AMPK-independent inhibition of human macrophage ER stress response by AICAR. Sci Rep 6:32111. https://doi.org/10.1038/srep32111

Article  CAS  PubMed  PubMed Central  Google Scholar 

Byun HS, Zhou W, Park I, Kang K, Lee SR, Piao X, Park JB, Kwon TK, Na M, Hur GM (2018) C-27-carboxylated oleanane triterpenoids up-regulate TRAIL DISC assembly via p38 MAPK and CHOP-mediated DR5 expression in human glioblastoma cells. Biochem Pharmacol 158:243–260. https://doi.org/10.1016/j.bcp.2018.10.019

Article  CAS  PubMed  Google Scholar 

Cao R, Qi W, Huang X, Zheng Y, Zheng R, Ma Y, Zhang H (2025) The dual role of the TRAIL-DR5 signaling axis in cardiovascular disease: From molecular mechanisms to targeted therapies. Biologics 19:613–629. https://doi.org/10.2147/BTT.S538522

Article  CAS  PubMed  PubMed Central  Google Scholar 

CharguiA, Hammami I, Hashem A, Al-Hazzani AA, Abd Allah EF, Belaid A, Marzougui S, Elmay MV, Mograbi B (2025) Cd stabilizes HIF-1α under normoxic conditions via lysine-63-linked ubiquitination and induces ER stress and cell proliferation. Toxicol Res 41(3):221-234. https://doi.org/10.1007/s43188-024-00266-9

Conza D, Mirra P, Calì G, Insabato L, Fiory F, Beguinot F, Ulianich L (2021) Metformin dysregulates the unfolded protein response and the WNT/β-catenin pathway in endometrial cancer cells through an AMPK-independent mechanism. Cells 10(5):1067. https://doi.org/10.3390/cells10051067

Article  CAS  PubMed  PubMed Central  Google Scholar 

Deng Y, Bi R, Guo H, Yang J, Du Y, Wang C, Wei W (2019) Andrographolide enhances TRAIL-induced apoptosis via p53-mediated death receptors up-regulation and suppression of the NF-kB pathway in bladder cancer cells. Int J Biol Sci 15(3):688–700. https://doi.org/10.7150/ijbs.30847

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diaz Arguello OA, Haisma HJ (2021) Apoptosis-inducing TNF superfamily ligands for cancer therapy. Cancers (Basel) 13(7):1543. https://doi.org/10.3390/cancers13071543

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dilshara MG, Jeong JW, Prasad Tharanga Jayasooriya RG, Neelaka Molagoda IM, Lee S, Park SR, Choi YH, Kim GY (2017) Glutamine deprivation sensitizes human breast cancer MDA-MB-231 cells to TRIAL-mediated apoptosis. Biochem Biophys Res Commun 485(2):440–445. https://doi.org/10.1016/j.bbrc.2017.02.059

Article  CAS  PubMed  Google Scholar 

García-García C, Fumarola C, Navaratnam N, Carling D, López-Rivas A (2010) AMPK-independent down-regulation of cFLIP and sensitization to TRAIL-induced apoptosis by AMPK activators. Biochem Pharmacol 79(6):853–863. https://doi.org/10.1016/j.bcp.2009.10.022

Article  CAS  PubMed  Google Scholar 

Glab JA, Cao Z, Puthalakath H (2020) Bcl-2 family proteins, beyond the veil. Int Rev Cell Mol Biol 351:1–22. https://doi.org/10.1016/bs.ircmb.2019.12.001

Article  CAS  PubMed  Google Scholar 

Han J, Wu J, Silke J (2020) An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling. F1000Research. https://doi.org/10.12688/f1000research.22092.1

Article  PubMed  PubMed Central  Google Scholar 

Huang CC, Cheng YC, Lin YC, Chou CH, Ho CT, Wang HK, Way TD (2021) CSC-3436 sensitizes triple negative breast cancer cells to TRAIL-induced apoptosis through ROS-mediated p38/CHOP/death receptor 5 signaling pathways. Environ Toxicol 36(12):2578–2588. https://doi.org/10.1002/tox.23372

Article  CAS  PubMed  Google Scholar 

Jan R, Chaudhry GE (2019) Understanding apoptosis and apoptotic pathways targeted cancer therapeutics. Adv Pharm Bull 9(2):205–218. https://doi.org/10.15171/apb.2019.024

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kang KH, Han MH, Jeong JW, Park C, Lee SH, Lee HW, Hong SH, Choi YH, Hong SH (2017) Bufalin sensitizes human bladder carcinoma cells to TRAIL-mediated apoptosis. Oncol Lett 14(1):853–859. https://doi.org/10.3892/ol.2017.6223

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim SY, Hwangbo H, Kim MY, Ji SY, Kim DH, Lee H, Kim GY, Moon SK, Leem SH, Yun SJ, Kim WJ, Cheong J, Park C, Choi YH (2021) Betulinic acid restricts human bladder cancer cell proliferation in vitro by inducing caspase-dependent cell death and cell cycle arrest, and decreasing metastatic potential. Molecules 26(5):1381. https://doi.org/10.3390/molecules26051381

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim JS, Son H, Han J, Cha H, Lee JH, Pack SP, Lee CS (2025) Evaluation of mitochondrial activity via cellular interactions between adrenal and neuronal cells in a microfluidic coculture device. Biotechnol Bioprocess Eng 30(3):502–519. https://doi.org/10.1007/s12257-025-00194-x

Article  CAS  Google Scholar 

Lee J, Park JR, Lee H, Hong SH, Kim WJ, Eickelberg O, Park SM, Ryu S, Cho SJ, Kim SJ, Yang SR (2025) Fludarabine attenuates inflammation and dysregulated autophagy in alveolar macrophages via inhibition of STAT1/IRF1 pathway. Lab Anim Res 41(1):12. https://doi.org/10.1186/s42826-025-00245-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu W, Wang S, Yang Q, Feng X, Yu B, Yu X (2022) 20(s)-ginsenoside Rh2 promotes TRAIL-induced apoptosis by upregulating DR5 in human hepatocellular carcinoma cells. Med Oncol 39(5):70. https://doi.org/10.1007/s12032-022-01663-6

Article  CAS  PubMed  Google Scholar 

Lopez-Beltran A, Blanca A, Downes MR, Cimadamore A, Montironi R, Cheng L (2026) Molecular pathology of bladder cancer. Histopathology 88(1):65–85. https://doi.org/10.1111/his.15555

Article  PubMed  Google Scholar 

Martínez-Limón A, Joaquin M, Caballero M, Posas F, de Nadal E (2020) The p38 pathway: From biology to cancer therapy. Int J Mol Sci 21(6):1913. https://doi.org/10.3390/ijms21061913

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mohanty SS, Warrier S, Rangarajan A (2025) Rethinking AMPK: A reversible switch fortifying cancer cell stress-resilience. Yale J Biol Med 98(1):33–52. https://doi.org/10.59249/JKBB6336

Article  CAS  PubMed  PubMed Central  Google Scholar 

Montinaro A, Walczak H (2023) Harnessing TRAIL-induced cell death for cancer therapy: a long walk with thrilling discoveries. Cell Death Differ 30(2):237–249. https://doi.org/10.1038/s41418-022-01059-z

Article  CAS  PubMed  Google Scholar 

Moyer A, Tanaka K, Cheng EH (2025) Apoptosis in cancer biology and therapy. Annu Rev Pathol 20(1):303–328. https://doi.org/10.1146/annurev-pathmechdis-051222-115023

Article  CAS  PubMed  Google Scholar 

Nguyen D, Osterlund E, Kale J, Andrews DW (2024) The C-terminal sequences of Bcl-2 family proteins mediate interactions that regulate cell death. Biochem J 481(14):903–922. https://doi.org/10.1042/BCJ20210352