Ashok A, Chaudhary S, Wise AS, Rana NA, McDonald D, Kritikos AE, Lindner E, Singh N (2021) Release of iron-loaded ferritin in Sodium Iodate-induced model of Age Related Macular Degeneration: an in-vitro and in-vivo study. Antioxidants. https://doi.org/10.3390/antiox10081253

Article  PubMed  PubMed Central  Google Scholar 

Blader IJ, Saeij JP (2009) Communication between Toxoplasma gondii and its host: impact on parasite growth, development, immune evasion, and virulence. APMIS 117:458–476

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brault C, Lévy P, Duponchel S, Michelet M, Sallé A, Pécheur EI, Plissonnier ML, Parent R, Véricel E, Ivanov AV et al (2016) Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivity. Gut 65:144–154

Article  CAS  PubMed  Google Scholar 

Butler NJ, Furtado JM, Winthrop KL, Smith JR (2013) Ocular toxoplasmosis II: clinical features, pathology and management. Clin Exp Ophthalmol 41:95–108

Article  PubMed  Google Scholar 

Chan CM, Huang DY, Sekar P, Hsu SH, Lin WW (2019) Reactive oxygen species-dependent mitochondrial dynamics and autophagy confer protective effects in retinal pigment epithelial cells against sodium iodate-induced cell death. J Biomed Sci 26:40

Article  PubMed  PubMed Central  Google Scholar 

Choi HG, Gao FF, Zhou W, Sun PR, Yuk JM, Lee YH, Cha GH (2020) The role of PI3K/AKT pathway and NADPH oxidase 4 in host ROS manipulation by Toxoplasma gondii. Korean J Parasitol 58:237–247

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi SH, Park SJ, Cha GH, Quan JH, Chang NS, Ahn MH, Shin DW, Lee YH (2011) Toxoplasma gondii protects against H2O2-induced apoptosis in ARPE-19 cells through the transcriptional regulation of apoptotic elements and downregulation of the p38 MAPK pathway. Acta Ophthalmol 89:e350-356

Article  CAS  PubMed  Google Scholar 

Datta S, Cano M, Ebrahimi K, Wang L, Handa JT (2017) The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD. Prog Retin Eye Res 60:201–218

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Baat A, Meier DT, Fontana A, Böni-Schnetzler M, Donath MY (2023) Cystine/Glutamate antiporter system xc- deficiency impairs macrophage glutathione metabolism and cytokine production. PLoS ONE 18:e0291950

Article  PubMed  PubMed Central  Google Scholar 

de Campos VS, Calaza KC, Adesse D (2020) Implications of TORCH diseases in retinal development-special focus on congenital toxoplasmosis. Front Cell Infect Microbiol 10:585727

Article  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Lemberg KM, Lamprecht MR, Skouta R, Zaitsev EM, Gleason CE, Patel DN, Bauer AJ, Cantley AM, Yang WS et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149:1060–1072

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dixon SJ, Patel DN, Welsch M, Skouta R, Lee ED, Hayano M, Thomas AG, Gleason CE, Tatonetti NP, Slusher BS et al (2014) Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis. Elife 3:e02523

Article  PubMed  PubMed Central  Google Scholar 

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E et al (2014) Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice. Nat Cell Biol 16:1180–1191

Article  CAS  PubMed  PubMed Central  Google Scholar 

Graumann K, Schaumburg F, Reubold TF, Hippe D, Eschenburg S, Lüder CG (2015) Toxoplasma gondii inhibits cytochrome c-induced caspase activation in its host cell by interference with holo-apoptosome assembly. Microb Cell 2:150–162

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gu Y, Niu Z, Lu HH, Li SA, Zhou DH (2025) Inhibition of GPX4 by Toxoplasma gondii promotes ferroptosis and enhances its proliferation in acute and chronic infection. Cells. https://doi.org/10.3390/cells14100756

Article  PubMed  PubMed Central  Google Scholar 

Hakimi MA, Bougdour A (2015) Toxoplasma’s ways of manipulating the host transcriptome via secreted effectors. Curr Opin Microbiol 26:24–31

Article  CAS  PubMed  Google Scholar 

Hanus J, Anderson C, Sarraf D, Ma J, Wang S (2016) Retinal pigment epithelial cell necroptosis in response to sodium iodate. Cell Death Discov 2:16054

Article  CAS  PubMed  PubMed Central  Google Scholar 

Holmes MJ, Shah P, Wek RC, Sullivan WJ Jr. (2019) Simultaneous ribosome profiling of human host cells infected with Toxoplasma gondii. mSphere. https://doi.org/10.1128/mSphere.00292-19

Article  PubMed  PubMed Central  Google Scholar 

Jadeja RN, Martin PM (2021) Oxidative stress and inflammation in retinal degeneration. Antioxidants (Basel). https://doi.org/10.3390/antiox10050790

Article  PubMed  PubMed Central  Google Scholar 

Li LY, Zhou CX, Han B, Elsheikha HM, Qiu HJ, An XD, Zeng T, Liu DA, Yang Q, Zhu XQ et al (2025) Ferroptosis is important for Toxoplasma gondii replication and virulence in vitro and in vivo. Virulence 16:2530164

Article  PubMed  PubMed Central  Google Scholar 

Liu B, Wang W, Shah A, Yu M, Liu Y, He L, Dang J, Yang L, Yan M, Ying Y et al (2021) Sodium iodate induces ferroptosis in human retinal pigment epithelium ARPE-19 cells. Cell Death Dis 12:230

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mammari N, Halabi MA, Yaacoub S, Chlala H, Dardé ML, Courtioux B (2019) Toxoplasma gondii modulates the host cell responses: an overview of apoptosis pathways. Biomed Res Int 2019:6152489

Article  PubMed  PubMed Central  Google Scholar 

Masaldan S, Bush AI, Devos D, Rolland AS, Moreau C (2019) Striking while the iron is hot: iron metabolism and ferroptosis in neurodegeneration. Free Radic Biol Med 133:221–233

Article  CAS  PubMed  Google Scholar 

Mendez OA, Koshy AA (2017) Toxoplasma gondii: entry, association, and physiological influence on the central nervous system. PLoS Pathog 13:e1006351

Article  PubMed  PubMed Central  Google Scholar 

Quan JH, Cha GH, Zhou W, Chu JQ, Nishikawa Y, Lee YH (2013) Involvement of PI 3 kinase/Akt-dependent Bad phosphorylation in Toxoplasma gondii-mediated inhibition of host cell apoptosis. Exp Parasitol 133:462–471

Article  CAS  PubMed  Google Scholar 

Skouta R, Dixon SJ, Wang J, Dunn DE, Orman M, Shimada K, Rosenberg PA, Lo DC, Weinberg JM, Linkermann A et al (2014) Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models. J Am Chem Soc 136:4551–4556

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Z, Ju Y, Dai X, Ni N, Liu Y, Zhang D, Gao H, Sun H, Zhang J, Gu P (2021) HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration. Redox Biol 43:101971

Article  CAS  PubMed  PubMed Central  Google Scholar 

Upadhyay M, Bonilha VL (2024) Regulated cell death pathways in the sodium iodate model: insights and implications for AMD. Exp Eye Res 238:109728

Article  CAS  PubMed  Google Scholar 

Yamada K, Tazaki A, Ushio-Watanabe N, Usui Y, Takeda A, Matsunaga M, Suzumura A, Shimizu H, Zheng H, Ariefta NR et al (2023) Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis. Redox Biol 67:102890