Valenza, C. et al. Circulating tumor DNA clearance as a predictive biomarker of pathologic complete response in patients with solid tumors treated with neoadjuvant immune checkpoint inhibitors: a systematic review and meta-analysis. Ann. Oncol. 36, 726–736 (2025).
Article CAS PubMed Google Scholar
Lam, W. K. J. et al. Achieving control of nasopharyngeal carcinoma: the role of Epstein-Barr virus-based screening and vaccines. Nat. Rev. Clin. Oncol. 23, 7–21 (2026).
Lv, J. et al. Risk-adaptive therapy guided by dynamic ctDNA in nasopharyngeal carcinoma. Nature 652, 731–739 (2026).
Liu, X. et al. Induction-concurrent chemoradiotherapy with or without sintilimab in patients with locoregionally advanced nasopharyngeal carcinoma in China (CONTINUUM): a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial. Lancet 403, 2720–2731 (2024).
Article CAS PubMed Google Scholar
Chen, Y. P. et al. Metronomic capecitabine as adjuvant therapy in locoregionally advanced nasopharyngeal carcinoma: a multicentre, open-label, parallel-group, randomised, controlled, phase 3 trial. Lancet 398, 303–313 (2021).
Article CAS PubMed Google Scholar
Le, Q. T. et al. An international collaboration to harmonize the quantitative plasma Epstein-Barr virus DNA assay for future biomarker-guided trials in nasopharyngeal carcinoma. Clin. Cancer Res. 19, 2208–2215 (2013).
Article CAS PubMed PubMed Central Google Scholar
Chan, A. T. C. et al. Plasma Epstein-Barr virus DNA and residual disease after radiotherapy for undifferentiated nasopharyngeal carcinoma. J. Natl Cancer Inst. 94, 1614–1619 (2002).
Article CAS PubMed Google Scholar
Petit, C. et al. Role of chemotherapy in patients with nasopharynx carcinoma treated with radiotherapy (MAC-NPC): an updated individual patient data network meta-analysis. Lancet Oncol. 24, 611–623 (2023).
Article CAS PubMed Google Scholar
Chan, A. T. C. et al. Analysis of plasma Epstein-Barr virus DNA in nasopharyngeal cancer after chemoradiation to identify high-risk patients for adjuvant chemotherapy: a randomized controlled trial. J. Clin. Oncol. 36, 3091–3100 (2018).
Chan, D. C. T. et al. Improved risk stratification of nasopharyngeal cancer by targeted sequencing of Epstein-Barr virus DNA in post-treatment plasma. Ann. Oncol. 33, 794–803 (2022).
Comments (0)