Percutaneous Endoscopic Lumbar Discectomy With or Without Platelet-Rich Plasma: A Meta-Analysis

“Degenerative Lumbar Spine Disease: Estimating Global Incidence and Worldwide Volume - PMC.” Accessed: Mar. 20, 2025. [Online]. Available: https://pmc.ncbi.nlm.nih.gov/articles/PMC6293435/

Fjeld, O. R., et al. (2019). Complications, reoperations, readmissions, and length of hospital stay in 34 639 surgical cases of lumbar disc herniation. Bone & Joint Journal, 101-B(4), 470–477. https://doi.org/10.1302/0301-620X.101B4.BJJ-2018-1184.R1

Article  CAS  Google Scholar 

Vialle, L. R., Vialle, E. N., Suárez Henao, J. E., & Giraldo, G. (2015). Lumbar disc herniation. Revista Brasileira de Ortopedia, 45(1), 17–22. https://doi.org/10.1016/S2255-4971(15)30211-1

Article  PubMed  PubMed Central  Google Scholar 

Gordon, S. J., Yang, K. H., Mayer, P. J., Mace, A. H., Kish, V. L., & Radin, E. L. (1991). Mechanism of disc rupture. A preliminary report. Spine (Phila Pa 1976), 16(4), 450–456. https://doi.org/10.1097/00007632-199104000-00011

Article  CAS  PubMed  Google Scholar 

Amin, R. M., Andrade, N. S., & Neuman, B. J. (2017). Lumbar disc herniation. Current Reviews in Musculoskeletal Medicine, 10(4), 507–516. https://doi.org/10.1007/s12178-017-9441-4

Article  PubMed  PubMed Central  Google Scholar 

Qaseem, A., et al. (2017). Noninvasive treatments for acute, subacute, and chronic low back pain: A clinical practice guideline from the American College of Physicians. Annals of Internal Medicine, 166(7), 514–530. https://doi.org/10.7326/M16-2367

Article  PubMed  Google Scholar 

Yaman, O., Guchkha, A., Vaishya, S., Zileli, M., Zygourakis, C., & Oertel, J. (2024). The role of conservative treatment in lumbar disc herniations: WFNS spine committee recommendations. World Neurosurgery X, 22, Article 100277. https://doi.org/10.1016/j.wnsx.2024.100277

Article  PubMed  PubMed Central  Google Scholar 

Chou, R., et al. (2015). Epidural corticosteroid injections for radiculopathy and spinal stenosis: A systematic review and meta-analysis. Annals of Internal Medicine, 163(5), 373–381. https://doi.org/10.7326/M15-0934

Article  PubMed  Google Scholar 

Costa, F., Oertel, J., Zileli, M., Restelli, F., Zygourakis, C. C., & Sharif, S. (2024). Role of surgery in primary lumbar disk herniation: WFNS spine committee recommendations. World Neurosurgery X, 22, Article 100276. https://doi.org/10.1016/j.wnsx.2024.100276

Article  PubMed  PubMed Central  Google Scholar 

Chou, R., et al. (2009). Interventional therapies, surgery, and interdisciplinary rehabilitation for low back pain: An evidence-based clinical practice guideline from the American Pain Society. Spine (Phila Pa 1976), 34(10), 1066–1077. https://doi.org/10.1097/BRS.0b013e3181a1390d

Article  PubMed  Google Scholar 

Gadjradj, P. S., et al. (2022). Full endoscopic versus open discectomy for sciatica: Randomised controlled non-inferiority trial. BMJ, 376, Article e065846. https://doi.org/10.1136/bmj-2021-065846

Article  PubMed  PubMed Central  Google Scholar 

Yadav, R. I., Long, L., & Yanming, C. (2019). Comparison of the effectiveness and outcome of microendoscopic and open discectomy in patients suffering from lumbar disc herniation. Medicine (Baltimore), 98(50), Article e16627. https://doi.org/10.1097/MD.0000000000016627

Article  PubMed  PubMed Central  Google Scholar 

Gadjradj, P. S., et al. (2021). Percutaneous transforaminal endoscopic discectomy versus open microdiscectomy for lumbar disc herniation. Spine (Phila Pa 1976), 46(8), 538–549.

Article  PubMed  PubMed Central  Google Scholar 

Le, A. D. K., Enweze, L., DeBaun, M. R., & Dragoo, J. L. (2019). Platelet-rich plasma. Clinics in Sports Medicine, 38(1), 17–44. https://doi.org/10.1016/j.csm.2018.08.001

Article  PubMed  Google Scholar 

Sheean, A. J., Anz, A. W., & Bradley, J. P. (2021). Platelet-rich plasma: Fundamentals and clinical applications. Arthroscopy, 37(9), 2732–2734. https://doi.org/10.1016/j.arthro.2021.07.003

Article  PubMed  Google Scholar 

“Platelet-rich plasma in regenerative medicine | Biomedical Research and Therapy.” Accessed: Mar. 20, 2025. [Online]. Available: https://link.springer.com/article/10.7603/s40730-014-0005-6

Everts, P. A., van Erp, A., DeSimone, A., Cohen, D. S., & Gardner, R. D. (2021). Platelet rich plasma in orthopedic surgical medicine. Platelets, 32(2), 163–174. https://doi.org/10.1080/09537104.2020.1869717

Article  CAS  PubMed  Google Scholar 

Wang, C., Xu, F., Jia, L., Liu, Y., & Zhang, S. (2024). Lumbar fusion efficacy with local bone grafting and platelet-rich plasma: A clinical investigation in treating degenerative lumbar spinal stenosis in the elderly. International Orthopaedics, 48(11), 2963–2970. https://doi.org/10.1007/s00264-024-06294-2

Article  PubMed  Google Scholar 

Le, V.-T., Bui, D. T. H., & Do, P. T. (2025). Prospective study on a new combination of pulsed radiofrequency and platelet-rich plasma injections for managing grade I lumbosacral spondylolisthesis. Scientific Reports, 15(1), Article 1451. https://doi.org/10.1038/s41598-024-84614-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muthu, S., Viswanathan, V. K., & Gangadaran, P. (2025). Is platelet-rich plasma better than steroids as epidural drug of choice in lumbar disc disease with radiculopathy? Meta-analysis of randomized controlled trials. Experimental Biology and Medicine (Maywood, N.J.), 250, Article 10390. https://doi.org/10.3389/ebm.2025.10390

Article  PubMed  PubMed Central  Google Scholar 

“ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions | The BMJ.” Accessed: Mar. 23, 2025. [Online]. Available: https://www.bmj.com/content/355/bmj.i4919

Boutros, M., et al. (2025). Dual-plating is associated with lower implant removal rates compared with single-plate fixation for midshaft clavicle fractures: A meta-analysis. European Journal of Orthopaedic Surgery & Traumatology, 36(1), Article 22. https://doi.org/10.1007/s00590-025-04572-2

Article  Google Scholar 

Sterne, J. A. C., et al. (2019). RoB 2: A revised tool for assessing risk of bias in randomised trials. BMJ, 366, Article l4898. https://doi.org/10.1136/bmj.l4898

Article  PubMed  Google Scholar 

Boutros, M., et al. (2025). The effect of epinephrine-infused irrigation fluid on visual clarity in arthroscopic shoulder surgery: a meta-analysis. European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie. https://doi.org/10.1007/s00590-025-04605-w

Article  Google Scholar 

H, Q., Z, Z., G, L., Y, H., S, C., & B, L. (2024). Evaluating the impact of platelet-rich plasma injection in spinal endoscopic nucleotomy on MRI Pfirrmann grading and clinical outcomes in lumbar disc herniation. Journal of Orthopaedic Surgery and Research. https://doi.org/10.1186/s13018-024-05153-5

Article  Google Scholar 

T, L., W, D., Z, D., J, L., & Y, D. (2024). Percutaneous endoscopic lumbar discectomy combined with platelet-rich plasma injection for lumbar disc herniation: Analysis of clinical and imaging outcomes. BMC Musculoskeletal Disorders. https://doi.org/10.1186/s12891-024-07444-8

Article  Google Scholar 

T. Li, Y. Ding, Q. Jiang, H. Zhang, and J. Liu, (2024) “Percutaneous transforaminal endoscopic discectomy combined with platelet-rich plasma in treatment of lumbar disc herniation,” 28(15): 2385–2390, https://doi.org/10.12307/2024.401.

Jiang, Y., et al. (2022). Transforaminal endoscopic lumbar discectomy with versus without platelet-rich plasma injection for lumbar disc herniation: A prospective cohort study. Pain Research & Management. https://doi.org/10.1155/2022/6181478

Article  Google Scholar 

Zhang, L., Zhang, C., Song, D., Chen, G., & Liu, L. (2023). Combination of percutaneous endoscopic lumbar discectomy and platelet-rich plasma hydrogel injection for the treatment of lumbar disc herniation. Journal of Orthopaedic Surgery and Research, 18(1), Article 609. https://doi.org/10.1186/s13018-023-04093-w

Article  PubMed  PubMed Central  Google Scholar 

Li, T., Du, W., Ding, Z., Liu, J., & Ding, Y. (2024). Percutaneous endoscopic lumbar discectomy combined with platelet-rich plasma injection for lumbar disc herniation: Analysis of clinical and imaging outcomes. BMC Musculoskeletal Disorders, 25(1), Article 328. https://doi.org/10.1186/s12891-024-07444-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

“Percutaneous transforaminal endoscopic discectomy combined with platelet-rich plasma in treatment of lumbar disc herniation.” Accessed: Mar. 20, 2025. [Online]. Available: https://www.cjter.com/EN/https://doi.org/10.12307/2024.401

Jiang, Y., et al. (2022). Transforaminal endoscopic lumbar discectomy with versus without platelet-rich plasma injection for lumbar disc herniation: A prospective cohort study. Pain Research and Management, 2022, Article 6181478. https://doi.org/10.1155/2022/6181478

Article  PubMed  PubMed Central  Google Scholar 

Qi, H., Zhou, Z., Li, G., Huang, Y., Chen, S., & Liu, B. (2024). Evaluating the impact of platelet-rich plasma injection in spinal endoscopic nucleotomy on MRI Pfirrmann grading and clinical outcomes in lumbar disc herniation. Journal of Orthopaedic Surgery and Research, 19(1), Article 655. https://doi.org/10.1186/s13018-024-05153-5

Article  PubMed  PubMed Central 

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