Melatonin: A multitasking molecule. (2010). In: progress in brain research Vol 181 Elsevier; . pp. 127–151. https://doi.org/10.1016/S0079-6123(08)81008-4

Ahmad, S. B., Ali, A., Bilal, M., Rashid, S. M., Wani, A. B., Bhat, R. R., et al. (2023). Melatonin and health: Insights of melatonin action, biological functions, and associated disorders. Cellular and Molecular Neurobiology, 43(6), 2437–2458. https://doi.org/10.1007/s10571-023-01324-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hardeland, R. (2012). Neurobiology, pathophysiology, and treatment of melatonin deficiency and dysfunction. The Scientific World Journal, 2012, Article 640389. https://doi.org/10.1100/2012/640389

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xie, W., Chen, S., Tao, X., Zhang, L., Hu, P., Pan, W., et al. (2021). Melatonin: Effects on cartilage homeostasis and therapeutic prospects in cartilage-related diseases. Aging and Disease, 12(1), 297–307. https://doi.org/10.14336/AD.2020.0519

Article  PubMed  PubMed Central  Google Scholar 

Bautista, J., Coral-Riofrio, E. C., Suárez Urresta, S., Palacios-Zavala, D., Echeverría, C. E., Araujo-Abad, S., et al. (2025). Neurodegeneration rewires the tumor microenvironment via the neuro–immune–cancer axis. iScience, 28(10), Article 113550. https://doi.org/10.1016/j.isci.2025.113550

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nguyen, A., Lee, P., Rodriguez, E. K., Chahal, K., Freedman, B. R., & Nazarian, A. (2025). Addressing the growing burden of musculoskeletal diseases in the ageing US population: Challenges and innovations. The Lancet. Healthy Longevity, 6(5), Article 100707. https://doi.org/10.1016/j.lanhl.2025.100707

Article  PubMed  Google Scholar 

Miao, X., Jiang, P., Wang, Z., Kong, W., & Feng, L. (2025). Mitochondrial transplantation: A novel therapeutic approach for treating diseases. MedComm, 6(6), Article e70253. https://doi.org/10.1002/mco2.70253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu, J., Clough, S. J., Hutchinson, A. J., Adamah-Biassi, E. B., Popovska-Gorevski, M., & Dubocovich, M. L. (2016). MT1 and MT2 melatonin receptors: A therapeutic perspective. Annual Review of Pharmacology and Toxicology, 56, 361–383. https://doi.org/10.1146/annurev-pharmtox-010814-124742

Article  CAS  PubMed  Google Scholar 

Proietti, S., Cucina, A., Reiter, R. J., & Bizzarri, M. (2012). Molecular mechanisms of melatonin’s inhibitory actions on breast cancers. Cellular and Molecular Life Sciences: CMLS, 70(12), 2139–2157. https://doi.org/10.1007/s00018-012-1161-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Franceschi, R. T., & Ge, C. (2017). Control of the osteoblast lineage by mitogen-activated protein kinase signaling. Current Molecular Biology Reports, 3(2), 122–132. https://doi.org/10.1007/s40610-017-0059-5

Article  PubMed  PubMed Central  Google Scholar 

Ma, H., Kang, J., Fan, W., He, H., & Huang, F. (2021). ROR: Nuclear receptor for melatonin or not? Molecules, 26(9), 2693. https://doi.org/10.3390/molecules26092693

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ze, Y., Wu, Y., Tan, Z., Li, R., Li, R., Gao, W., et al. (2025). Signaling pathway mechanisms of circadian clock gene Bmal1 regulating bone and cartilage metabolism: A review. Bone Research, 13, Article 19. https://doi.org/10.1038/s41413-025-00403-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kopustinskiene, D. M., & Bernatoniene, J. (2021). Molecular mechanisms of melatonin-mediated cell protection and signaling in health and disease. Pharmaceutics, 13(2), Article 129. https://doi.org/10.3390/pharmaceutics13020129

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kołodziejska, R., Woźniak, A., Bilski, R., Wesołowski, R., Kupczyk, D., Porzych, M., et al. (2025). Melatonin—A powerful antioxidant in neurodegenerative diseases. Antioxidants, 14(7), Article 819. https://doi.org/10.3390/antiox14070819

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reiter, R. J., Mayo, J. C., Tan, D.-X., Sainz, R. M., Alatorre-Jimenez, M., & Qin, L. (2016). Melatonin as an antioxidant: Under promises but over delivers. Journal of Pineal Research, 61(3), 253–278. https://doi.org/10.1111/jpi.12360

Article  CAS  PubMed  Google Scholar 

Marzetti, E., Calvani, R., Cesari, M., Buford, T. W., Lorenzi, M., Behnke, B. J., et al. (2013). Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials. The international journal of biochemistry & cell biology, 45(10), 2288–2301. https://doi.org/10.1016/j.biocel.2013.06.024

Article  CAS  Google Scholar 

Fang, Y., Zhao, C., Xiang, H., Zhao, X., & Zhong, R. (2020). Melatonin inhibits formation of mitochondrial permeability transition pores and improves oxidative phosphorylation of frozen-thawed ram sperm. Frontiers in Endocrinology, 10, 896. https://doi.org/10.3389/fendo.2019.00896

Article  PubMed  PubMed Central  Google Scholar 

Lu, J., Luo, Y., Mei, S., Fang, Y., Zhang, J., & Chen, S. (2021). The effect of melatonin modulation of non-coding RNAs on central nervous system disorders: An updated review. Current Neuropharmacology, 19(1), 3–23. https://doi.org/10.2174/1570159X18666200503024700

Article  CAS  PubMed  PubMed Central  Google Scholar 

Su, C.-M., Tsai, C.-H., Chen, H.-T., Wu, Y.-S., Chang, J.-W., Yang, S.-F., et al. (2023). Melatonin improves muscle injury and differentiation by increasing Pax7 expression. International Journal of Biological Sciences, 19(4), 1049–1062. https://doi.org/10.7150/ijbs.79169

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hambli, R. (2014). Connecting mechanics and bone cell activities in the bone remodeling process: an integrated finite element modeling. Frontiers in Bioengineering and Biotechnology. https://doi.org/10.3389/fbioe.2014.00006

Article  PubMed  PubMed Central  Google Scholar 

Föger-Samwald, U., Dovjak, P., Azizi-Semrad, U., Kerschan-Schindl, K., & Pietschmann, P. (2020). Osteoporosis: Pathophysiology and therapeutic options. EXCLI Journal, 19, 1017–1037. https://doi.org/10.17179/excli2020-2591

Article  PubMed  PubMed Central  Google Scholar 

Lu, X., Yu, S., Chen, G., Zheng, W., Peng, J., Huang, X., et al. (2021). Insight into the roles of melatonin in bone tissue and bone-related diseases (Review). International Journal of Molecular Medicine, 47(5), Article 82. https://doi.org/10.3892/ijmm.2021.4915

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lu, K., Hsieh, Y., Lin, R., Tsai, M., & Yang, S. (2025). Melatonin: A potential therapy for osteoporosis with insights into molecular mechanisms. Journal of Pineal Research, 77(4), Article e70062. https://doi.org/10.1111/jpi.70062

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cadigan, K. M., & Waterman, M. L. (2012). TCF/LEFs and Wnt signaling in the nucleus. Cold Spring Harbor Perspectives in Biology, 4(11), Article a007906. https://doi.org/10.1101/cshperspect.a007906

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, Q., Shou, P., Zheng, C., Jiang, M., Cao, G., Yang, Q., et al. (2016). Fate decision of mesenchymal stem cells: Adipocytes or osteoblasts? Cell Death and Differentiation, 23(7), 1128–1139. https://doi.org/10.1038/cdd.2015.168

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang, T., Xia, C., Chen, X., Hu, Y., Wang, Y., Wu, J., et al. (2019). Melatonin promotes the BMP9-induced osteogenic differentiation of mesenchymal stem cells by activating the AMPK/β-catenin signalling pathway. Stem Cell Research & Therapy, 10, Article 408. https://doi.org/10.1186/s13287-019-1511-7

Article  CAS  Google Scholar