Surgical Determinants of Outcomes in Partial Nephrectomy: a Contemporary Review

Herr HW. A history of partial nephrectomy for renal tumors. J Urol. 2005;173(3):705–8. https://doi.org/10.1097/01.ju.0000146270.65101.1d.

Article  PubMed  Google Scholar 

Cwach K, Kavoussi L. Past, present, and future of laparoscopic renal surgery. Investig Clin Urol. 2016;57(Suppl 2):S110–3. https://doi.org/10.4111/icu.2016.57.S2.S110.

Article  PubMed  PubMed Central  Google Scholar 

Uzzo RG, Novick AC. Nephron sparing surgery for renal tumors: indications, techniques and outcomes. J Urol. 2001;166(1):6–18. https://doi.org/10.1016/S0022-5347(05)66066-1.

Article  CAS  PubMed  Google Scholar 

Van Poppel H, Becker F, Cadeddu JA, Gill IS, Janetschek G, Jewett MAS, et al. Treatment of localised renal cell carcinoma. Eur Urol. 2011;60(4):662–72. https://doi.org/10.1016/j.eururo.2011.06.040.

Article  PubMed  Google Scholar 

Resca S, Frego N, Barletta F, Pissavini A, Mourullo AN, Lambert E, et al. Clampless and sutureless technique for complex robot assisted partial nephrectomy. Urology Video Journal. 2025;25:100317. https://doi.org/10.1016/j.urolvj.2024.100317.

Article  Google Scholar 

Pyrgidis N, Schulz GB, Stief C, Blajan I, Ivanova T, Graser A, et al. Surgical trends and complications in partial and radical nephrectomy: results from the GRAND study. Cancers (Basel). 2023;16(1):97. https://doi.org/10.3390/cancers16010097.

Article  PubMed  PubMed Central  Google Scholar 

Ranganathan S, Riveros C, Xu J, Chang C, Geng M, Satkunasivam R, Laparoscopic, and robotic approach for partial and radical nephrectomy for renal cancer: a real-world study using the national inpatient sample database. PD40-01 Trend in Open J Urol. 2023;209(Supplement 4). https://doi.org/10.1097/JU.0000000000003345.01.

Hadjipavlou M, Khan F, Fowler S, Joyce A, Keeley FX, Sriprasad S. Partial vs radical nephrectomy for T1 renal tumours: an analysis from the British Association of Urological Surgeons Nephrectomy Audit. BJU Int. 2016;117(1):62–71. https://doi.org/10.1111/bju.13114.

Article  PubMed  Google Scholar 

Hevia-Palacios V, Pérez Fentes D, Vilaseca Cabo A, Jalón Monzón A, Rivero Belenchón I, Tolosa Eizaguirre E, et al. Current management of stage T1 renal cell carcinoma in Spain: results of a multicentre national registry. Actas Urol Esp. 2026;50(2):501922. https://doi.org/10.1016/j.acuroe.2026.501922.

Article  CAS  PubMed  Google Scholar 

Hinata N, Fujisawa M. Current status of robotic partial nephrectomy in Japan. Investig Clin Urol. 2016;57(2):121. https://doi.org/10.4111/icu.2016.57.S2.S121.

Article  Google Scholar 

Grimm MO, Bedke J, Nyarangi-Dix J, Khoder W, Foller S, Sommerfeld HJ, et al. Open versus robotic-assisted partial nephrectomy in patients with intermediate/high-complexity kidney tumours: final results of the randomised, controlled, open-label, multicentre trial OpeRa. Ann Oncol. 2025;36(8):988–98. https://doi.org/10.1016/j.annonc.2025.04.005.

Article  PubMed  Google Scholar 

Kubota M, Yamasaki T, Murata S, Abe Y, Tohi Y, Mine Y, et al. Surgical and functional outcomes of robot-assisted versus laparoscopic partial nephrectomy with cortical renorrhaphy omission. Sci Rep. 2022;12(1):13000. https://doi.org/10.1038/s41598-022-17496-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Garg H, Das B, Bansal A, Kaushal R, Desai P, Maheshwari R, et al. Trifecta and pentafecta outcomes in laparoscopic and robotic nephron-sparing surgery for highly complex renal tumors: a propensity score-matched cohort analysis. J Endourol. 2022;36(8):1050–6. https://doi.org/10.1089/END.2021.0830.

Article  PubMed  Google Scholar 

Winfield HN, Donovan JF, Lund GO, Kreder KJ, Stanley KE, Brown BP, et al. Laparoscopic partial nephrectomy: initial experience and comparison to the open surgical approach. J Urol. 1995;153(5):1409–14. https://doi.org/10.1016/s0022-5347(01)67415-9.

Article  CAS  PubMed  Google Scholar 

Kowalewski KF, Neuberger M, Sidoti Abate MA, Kirchner M, Haney CM, Siegel F, et al. Randomized controlled feasibility trial of robot-assisted versus conventional open partial nephrectomy: the ROBOCOP II study. Eur Urol Oncol. 2024;7(1):91–7. https://doi.org/10.1016/j.euo.2023.05.011.

Article  PubMed  Google Scholar 

Ficarra V, Novara G, Secco S, Macchi V, Porzionato A, De Caro R, et al. Preoperative aspects and dimensions used for an anatomical (PADUA) classification of renal tumours in patients who are candidates for nephron-sparing surgery. Eur Urol. 2009;56(5):786–93. https://doi.org/10.1016/j.eururo.2009.07.040.

Article  PubMed  Google Scholar 

Zhang F, Hu JS, Zhang KY, Liu XH. Perioperative, functional, and oncologic outcomes of laparoscopic partial nephrectomy versus open partial nephrectomy for complex renal tumors: a systematic review and meta-analysis. Front Oncol Front Media SA. 2023. https://doi.org/10.3389/fonc.2023.1283935.

Article  Google Scholar 

Cacciamani GE, Medina LG, Gill TS, Mendelsohn A, Husain F, Bhardwaj L, et al. Impact of Renal Hilar Control on Outcomes of Robotic Partial Nephrectomy: Systematic Review and Cumulative Meta-analysis. European Urology Focus. 2019(4). https://doi.org/10.1016/j.euf.2018.01.012.

Wells S. Successful removal of two solid circum renal tumours. Br Med J. 1884;1(1216):758. https://doi.org/10.1136/bmj.1.1216.758.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vermooten V. Indications for conservative surgery in certain renal tumors. J Urol. 1950;64:200–16.

Article  CAS  PubMed  Google Scholar 

McDougall EM, Clayman RV, Chandhoke PS, Kerbl K, Stone AM, Wick MR, et al. Laparoscopic partial nephrectomy in the pig model. J Urol. 1993;149(6):1633–6. https://doi.org/10.1016/S0022-5347(17)36465-0.

Article  CAS  PubMed  Google Scholar 

Haber GP, Gill IS. Laparoscopic partial nephrectomy: contemporary technique and outcomes. Eur Urol. 2006;49(4):660–5. https://doi.org/10.1016/j.eururo.2006.02.001.

Article  PubMed  Google Scholar 

Scosyrev E, Messing EM, Sylvester R, Campbell S, Van Poppel H. Renal function after nephron-sparing surgery versus radical nephrectomy: results from EORTC randomized trial 30904. Eur Urol. 2014;65(2):372–7. https://doi.org/10.1016/j.eururo.2013.06.044.

Article  PubMed  Google Scholar 

Hakimi K, Campbell SC, Nguyen MV, Rathi N, Wang L, Meagher MF, et al. PADRES: a phase 2 clinical trial of neoadjuvant axitinib for complex partial nephrectomy. BJU Int. 2024;133(4):425–31. https://doi.org/10.1111/BJU.16217.

Article  CAS  PubMed  Google Scholar 

Slawitz M, Dinale F, Patera A, Marco GD, Guarino GG, Bocchialini T, et al. Robotic retroperitoneal partial nephrectomy: rediscovering a proven approach in the era of minimally invasive surgery. J Vis Surg. 2025. https://doi.org/10.21037/jovs-25-14.

Article  Google Scholar 

Amparore D, Pecoraro A, Piramide F, Verri P, Checcucci E, De Cillis S, et al. Three-dimensional imaging reconstruction of the kidney’s anatomy for a tailored minimally invasive partial nephrectomy: a pilot study. Asian J Urol. 2022;9(3):263–71. https://doi.org/10.1016/j.ajur.2022.06.003.

Article  PubMed  PubMed Central  Google Scholar 

Liu P, Chen G, Sang Z, Niu Y. The role of three-dimensional reconstruction in partial nephrectomy for ipsilateral multifocal renal tumors: a multicenter retrospective study. BMC Urology. 2025;25(1):202-. https://doi.org/10.1186/S12894-025-01889-2.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Abdallah N, Rathi N, Heller N, Wood A, Campbell R, Benidir T, et al. A fully automated artificial intelligence-based approach to predict renal function after radical or partial nephrectomy. Urology. 2025;200:97–104. https://doi.org/10.1016/j.urology.2025.01.073.

Article  PubMed  Google Scholar 

Francavilla S, Abern MR, Dobbs RW, Vigneswaran HT, Talamini S, Antonelli A, et al. Single-port robot assisted partial nephrectomy: initial experience and technique with the da Vinci Single-Port platform (IDEAL Phase 1). Minerva Urol Nephrol. 2022;74(2):216–24. https://doi.org/10.23736/S2724-6051.21.03919-9.

Article  PubMed  Google Scholar 

Kutikov A, Uzzo RG. The R.E.N.A.L. nephrometry score: a comprehensive standardized system for quantitating renal tumor size, location and depth. J Urol. 2009;182(3):844–53. https://doi.org/10.1016/j.juro.2009.05.035.

Article  PubMed  Google Scholar 

Rosiello G, Piazza P, Puliatti S, Mazzone E, Amato M, Tames V, et al. Simplified PADUA renal (SPARE) nephrometry score validation and long-term outcomes after robot-assisted partial nephrectomy. Urol Oncol Semin Orig Investig. 2022;40(2):65.e1-65.e9. https://doi.org/10.1016/j.urolonc.2021.09.021.

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