Design of a metabolically-stable peptide therapeutic with triple-hormone-receptor agonist activity

Lusis AJ, Attie AD, Reue K (2008) Nat Rev Genet 9(11):819

Article  PubMed  PubMed Central  CAS  Google Scholar 

Jamali Z, Ayoobi F, Jalali Z, Bidaki R, Lotfi MA, Esmaeili-Nadimi A, Khalili P (2024) Sci Rep 14(1):3987

Article  PubMed  PubMed Central  CAS  Google Scholar 

DeFronzo RA, Ferrannini E, Groop L, Henry RR, Herman WH, Holst JJ, Hu FB, Kahn CR, Raz I, Shulman GI, Simonson DC, Testa MA, Weiss R (2015) Nat Rev Dis Primers 1(1):15019

Article  PubMed  Google Scholar 

Barnes AS (2011) Tex Heart Inst J 38(2):142

PubMed  PubMed Central  Google Scholar 

Phelps NH, Singleton RK, Zhou B, Heap RA, Ezzati M (2024) The Lancet 403(10431):1027

Article  Google Scholar 

Oh DY, Olefsky JM (2016) Nat Rev Drug Discovery 15(3):161

Article  PubMed  CAS  Google Scholar 

Nauck MA, Quast DR, Wefers J, Pfeiffer AFH (2021) Diabetes Obes Metab 23(S3):5

Article  PubMed  CAS  Google Scholar 

Khoo B, Tan TM-M (2020) J Endocrinol 246(3):R65

Article  PubMed  CAS  Google Scholar 

Holst JJ (2007) Physiol Rev 87(4):1409

Article  PubMed  CAS  Google Scholar 

Chandarana R, D’Souza JS, Coutinho EC (2012) Glucose-dependent insulinotropic polypeptide receptor (GIPR). In: Choi S (ed) Encyclopedia of signaling molecules, New York, NY: Springer New York, pp 773

Seino Y, Fukushima M, Yabe D (2010) J Diabetes Investig 1(1–2):8

Article  PubMed  PubMed Central  CAS  Google Scholar 

Rix I, Nexøe-Larsen C, Bergmann NC, Lund A, Knop FK (2000) Glucagon physiology. MDText.com, Inc., South Dartmouth (MA)

Google Scholar 

Moura FA, Scirica BM, Ruff CT (2022) Nat Med 28(3):450

Article  PubMed  CAS  Google Scholar 

Patel H, Khunti K, Rodbard HW, Bajaj HS, Bray R, Kindracki Z, Rodriguez A (2024) Diabetes Obes Metab 26(2):473

Article  PubMed  CAS  Google Scholar 

Urva S, Coskun T, Loh MT, Du Y, Thomas MK, Gurbuz S, Haupt A, Benson CT, Hernandez-Illas M, D’Alessio DA, Milicevic Z (2022) The Lancet 400(10366):1869

Article  CAS  Google Scholar 

Sanyal AJ, Kaplan LM, Frias JP, Brouwers B, Wu Q, Thomas MK, Harris C, Schloot NC, Du Y, Mather KJ, Haupt A, Hartman ML (2024) Nat Med 30(7):2037

Article  PubMed  PubMed Central  CAS  Google Scholar 

Vishnoi S, Bhattacharya S, Walsh EM, Okoh GI, Thompson D (2023) J Chem Inf Model 63(15):4934

Article  PubMed  PubMed Central  CAS  Google Scholar 

Finan B, Yang B, Ottaway N, Smiley DL, Ma T, Clemmensen C, Chabenne J, Zhang L, Habegger KM, Fischer K, Campbell JE, Sandoval D, Seeley RJ, Bleicher K, Uhles S, Riboulet W, Funk J, Hertel C, Belli S, Sebokova E, Conde-Knape K, Konkar A, Drucker DJ, Gelfanov V, Pfluger PT, Müller TD, Perez-Tilve D, DiMarchi RD, Tschöp MH (2015) Nat Med 21(1):27

Article  PubMed  CAS  Google Scholar 

Capozzi ME, DiMarchi RD, Tschöp MH, Finan B, Campbell JE (2018) Endocr Rev 39(5):719

Article  PubMed  PubMed Central  Google Scholar 

Weng G, Wang E, Chen F, Sun H, Wang Z, Hou T (2019) Phys Chem Chem Phys 21(19):10135

Article  PubMed  CAS  Google Scholar 

Valdés-Tresanco MS, Valdés-Tresanco ME, Valiente PA, Moreno E (2021) J Chem Theory Comput 17(10):6281

Article  PubMed  Google Scholar 

Panday SK, Alexov E (2022) ACS Omega 7(13):11057

Article  PubMed  PubMed Central  CAS  Google Scholar 

Min J, Rong X, Zhang J, Su R, Wang Y, Qi W (2024) J Chem Theory Comput 20(2):532

Article  PubMed  CAS  Google Scholar 

Peng Y, Li Z, Zhang Y, Ye H, Mei L, Shang S, Zhou P (2025) J Comput Aided Mol Des 39(1):18

Article  PubMed  CAS  Google Scholar 

Wang E, Sun H, Wang J, Wang Z, Liu H, Zhang JZH, Hou T (2019) Chem Rev 119(16):9478

Article  PubMed  CAS  Google Scholar 

Sun H, Duan L, Chen F, Liu H, Wang Z, Pan P, Zhu F, Zhang JZH, Hou T (2018) Phys Chem Chem Phys 20(21):14450

Article  PubMed  CAS  Google Scholar 

Starling S (2022) Nat Rev Endocrinol 18(3):135

PubMed  CAS  Google Scholar 

Zhao F, Zhou Q, Cong Z, Hang K, Zou X, Zhang C, Chen Y, Dai A, Liang A, Ming Q, Wang M, Chen L-N, Xu P, Chang R, Feng W, Xia T, Zhang Y, Wu B, Yang D, Zhao L, Xu HE, Wang M-W (2022) Nat Commun 13(1):1057

Article  PubMed  PubMed Central  CAS  Google Scholar 

Weston C, Lu J, Li N, Barkan K, Richards GO, Roberts DJ, Skerry TM, Poyner D, Pardamwar M, Reynolds CA, Dowell SJ, Willars GB, Ladds G (2015) J Biol Chem 290(38):23009

Article  PubMed  PubMed Central  CAS  Google Scholar 

Graaf Cd, Donnelly D, Wootten D, Lau J, Sexton PM, Miller LJ, Ahn J-M, Liao J, Fletcher MM, Yang D, Brown AJH, Zhou C, Deng J, Wang M-W (2016) Pharmacol Rev 68(4):954

Campbell JE (2021) Mol Metab 46:101139

Article  PubMed  CAS  Google Scholar 

Jang W, Adams CE, Liu H, Zhang C, Levy FO, Andressen KW, Lambert NA (2020) Proc Natl Acad Sci USA 117(48):30755

Article  PubMed  PubMed Central  CAS  Google Scholar 

Portha B, Tourrel-Cuzin C, Movassat J (2011) Exp Diabetes Res 2011:376509

PubMed  PubMed Central  Google Scholar 

Liang YL, Khoshouei M, Glukhova A, Furness SGB, Zhao P, Clydesdale L, Koole C, Truong TT, Thal DM, Lei S, Radjainia M, Danev R, Baumeister W, Wang MW, Miller LJ, Christopoulos A, Sexton PM, Wootten D (2018) Nature 555(7694):121

Article  PubMed  CAS  Google Scholar 

Xie T, Chen M, Zhang QH, Ma Z, Weinstein LS (2007) Proc Natl Acad Sci USA 104(49):19601

Article  PubMed  PubMed Central  CAS  Google Scholar 

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