Abraham P, Lamba N, Acosta M, Gholmie J, Dawood HY, Vestal M, Huang K, Hulou M, Asgarzadeh M, Zaidi H, Mekary RA, Smith TR (2017) Antibacterial prophylaxis for gram-positive and gram-negative infections in cranial surgery: A meta-analysis. In Journal of Clinical Neuroscience (Vol. 45, pp. 24–32). Churchill Livingstone. https://doi.org/10.1016/j.jocn.2017.07.039
Al-Humaidi JY, Shaaban MM, Rezki N, Aouad MR, Zakaria M, Jaremko M, Hagar M, Elwakil BH (2022) 1,2,3-Triazole-Benzofused Molecular Conjugates as Potential Antiviral Agents against SARS-CoV-2 Virus Variants. Life 12(9). https://doi.org/10.3390/life12091341
Andreeva OV, Garifullin BF, Zarubaev VV, Slita AV, Yesaulkova IL, Saifina LF, Shulaeva MM, Belenok MG, Semenov VE, Kataev VE (2021) Synthesis of 1,2,3-triazolyl nucleoside analogues and their antiviral activity. Mol Diversity 25(1):473–490. https://doi.org/10.1007/s11030-020-10141-y
Ashwini N, Garg M, Mohan CD, Fuchs JE, Rangappa S, Anusha S, Swaroop TR, Rakesh KS, Kanojia D, Madan V, Bender A, Koeffler HP, Basappa, Rangappa KS (2015) Synthesis of 1,2-benzisoxazole tethered 1,2,3-triazoles that exhibit anticancer activity in acute myeloid leukemia cell lines by inhibiting histone deacetylases, and inducing p21 and tubulin acetylation. Bioorg Med Chem 23(18):6157–6165. https://doi.org/10.1016/j.bmc.2015.07.069
Article CAS PubMed Google Scholar
Bachrach U, Abu-Elheiga L, Schnur LF (1983) Leishmania tropica major: Effect of Paromomycin and Pentamidine on Polyamine Levels in the Skin of Normal and Infected Mice’. Exp Parasitol (55)
Bailey S, SMITH K, FAIRLAMB, A. H., HUNTER WN (1993) Substrate interactions between trypanothione reductase and N 1 -glutathionylspermidine disulphide at 0.28‐nm resolution. Eur J Biochem 213(1):67–75. https://doi.org/10.1111/j.1432-1033.1993.tb17734.x
Article CAS PubMed Google Scholar
Baiocco P, Colotti G, Franceschini S, Ilari A (2009) Molecular Basis of Antimony Treatment in Leishmaniasis. J Med Chem 52(8):2603–2612. https://doi.org/10.1021/jm900185q
Article CAS PubMed Google Scholar
Baiocco P, Poce G, Alfonso S, Cocozza M, Porretta GC, Colotti G, Biava M, Moraca F, Botta M, Yardley V, Fiorillo A, Lantella A, Malatesta F, Ilari A (2013) Inhibition of Leishmania infantum Trypanothione Reductase by Azole-Based Compounds: a Comparative Analysis with Its Physiological Substrate by X‐ray Crystallography. ChemMedChem 8(7):1175–1183. https://doi.org/10.1002/cmdc.201300176
Article CAS PubMed Google Scholar
Battista T, Colotti G, Ilari A, Fiorillo A (2020) Targeting Trypanothione Reductase, a Key Enzyme in the Redox Trypanosomatid Metabolism, to Develop New Drugs against Leishmaniasis and Trypanosomiases. Molecules 25(8):1924. https://doi.org/10.3390/molecules250819
Article CAS PubMed PubMed Central Google Scholar
Besson A, Dowdy SF, Roberts JM (2008) CDK inhibitors: cell cycle regulators and beyond. Dev Cell 14(2):159–169
Article CAS PubMed Google Scholar
Bistrović A, Krstulović L, Stolić I, Drenjančević D, Talapko J, Taylor MC, Kelly JM, Bajić M, Raić-Malić S (2018) Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA. J Enzyme Inhib Med Chem 33(1):1323–1334. https://doi.org/10.1080/14756366.2018.1484733
Article CAS PubMed PubMed Central Google Scholar
Brata Das B, Ganguly A, Majumder KH (2008) DNA Topoisomerases of Leishmania: The Potential Targets for Anti-Leishmanial Therapy. Adv Exp Med Biology, 625, 103115
Caraballo RH, Pociecha J, Reyes G, Espeche A, Galichio S, Fasulo L, Semprino M (2020) Rufinamide as add-on therapy in children with epileptic encephalopathies other than Lennox–Gastaut syndrome: A study of 34 patients. Epilepsy Behav 108. https://doi.org/10.1016/j.yebeh.2020.107074
Das T, Jayasudha R, Chakravarthy SK, Prashanthi GS, Bhargava A, Tyagi M, Rani PK, Pappuru RR, Sharma S, Shivaji S (2021) Alterations in the gut bacterial microbiome in people with type 2 diabetes mellitus and diabetic retinopathy. Sci Rep 11(1):2738. https://doi.org/10.1038/s41598-021-82538-0
Article CAS PubMed PubMed Central Google Scholar
de Souza W, Rodrigues JCF (2009) Sterol Biosynthesis Pathway as Target for Anti-trypanosomatid Drugs. Interdisciplinary Perspectives on Infectious Diseases, 2009, 1–19. https://doi.org/10.1155/2009/642502
Desjeux P (2004) Leishmaniasis: current situation and new perspectives. Comp Immunol Microbiol Infect Dis 27(5):305–318
Article CAS PubMed Google Scholar
Lucht F, Fauche A, Allaert FA (1996) Cefatrizine (8 d) versus penicillin v (10 d) for streptococcal pharyngitis in children. Med Mal Infect 26:557–561
Egan WJ, Merz KM, Baldwin JJ (2000) Prediction of drug absorption using multivariate statistics. J Med Chem 43(21):3867–3877. https://doi.org/10.1021/jm000292e
Article CAS PubMed Google Scholar
Gellis A, Dumètre A, Lanzada G, Hutter S, Ollivier E, Vanelle P, Azas N (2012) Preparation and antiprotozoal evaluation of promising β-carboline alkaloids. Biomed Pharmacotherapy 66(5):339–347. https://doi.org/10.1016/j.biopha.2011.12.006
Ghose AK, Viswanadhan VN, Wendoloski JJ (1999) A knowledge-based approach in designing combinatorial or medicinal chemistry libraries for drug discovery. 1. A qualitative and quantitative characterization of known drug databases. J Comb Chem 1(1):55–68. https://doi.org/10.1021/cc9800071
Article CAS PubMed Google Scholar
Grymel M, Pastuch-Gawołek G, Lalik A, Zawojak M, Boczek S, Krawczyk M, Erfurt K (2020) Glycoconjugation of Betulin Derivatives Using Copper-Catalyzed 1,3-Dipolar Azido-Alkyne Cycloaddition Reaction and a Preliminary Assay of Cytotoxicity of the Obtained Compounds. Molecules 25(24):6019. https://doi.org/10.3390/MOLECULES25246019
Article CAS PubMed PubMed Central Google Scholar
Gupta O, Pradhan T, Bhatia R, Monga V (2021) Recent advancements in anti-leishmanial research: Synthetic strategies and structural activity relationships. Eur J Med Chem 223. https://doi.org/10.1016/j.ejmech.2021.113606. Elsevier Masson s.r.l
Jain V, Jain K (2018) Molecular targets and pathways for the treatment of visceral FIGleishmaniasis. Drug Discovery Today, vol 23. Elsevier Ltd, pp 161–170. 1 https://doi.org/10.1016/j.drudis.2017.09.006
Kalinin DV, Jana SK, Pfafenrot M, Chakrabarti A, Melesina J, Shaik TB, Lancelot J, Pierce RJ, Sippl W, Romier C, Jung M, Holl R (2020) Structure-Based Design, Synthesis, and Biological Evaluation of Triazole-Based smHDAC8 Inhibitors. ChemMedChem 15(7):571–584. https://doi.org/10.1002/cmdc.201900583
Article CAS PubMed PubMed Central Google Scholar
Lipinski CA, Dominy BW, Feeney PJ (1997) drug delivery reviews Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. In Adv Drug Deliv Rev (23)
Mahender T, Pankaj W, Kumar SP, Ankur V, Kumar SS (2022) Some scaffolds as anti-leishmanial agents: A review. Mini Rev Med Chem 22(5):743–757
Article CAS PubMed Google Scholar
Majoor A, Michel G, Marty P, Boyer L, Pomares C (2025) Leishmaniases: Strategies in treatment development. In Parasite (Vol. 32). EDP Sciences. https://doi.org/10.1051/parasite/2025009
Manda S, Khan SI, Jain SK, Mohammed S, Tekwani BL, Khan IA, Vishwakarma RA, Bharate SB (2014) Synthesis, antileishmanial and antitrypanosomal activities of N-substituted tetrahydro-β-carbolines. Bioorg Med Chem Lett 24(15):3247–3250. https://doi.org/10.1016/j.bmcl.2014.06.030
Article CAS PubMed Google Scholar
McBride A, Walker SL (2018) Diagnostic approach to tropical skin infections. Medicine (United Kingdom), vol 46. Elsevier Ltd, pp 10–15. 1 https://doi.org/10.1016/j.mpmed.2017.10.008
Mohapatra S (2014) Drug resistance in leishmaniasis: Newer developments. Trop Parasitol 4(1):4. https://doi.org/10.4103/2229-5070.129142
Article PubMed PubMed Central Google Scholar
Nare B, Hardy LW, Beverley SM (1997) The roles of pteridine reductase 1 and dihydrofolate reductase- thymidylate synthase in pteridine metabolism in the protozoan parasite Leishmania major. J Biol Chem 272(21):13883–13891. https://doi.org/10.1074/jbc.272.21.13883
Article CAS PubMed Google Scholar
Nguyen C, Kasinathan G, Leal-Cortijo I, Musso-Buendia A, Kaiser M, Brun R, Ruiz-Pérez LM, Johansson NG, González-Pacanowska D, Gilbert IH (2005) Deoxyuridine triphosphate nucleotidohydrolase as a potential antiparasitic drug target. J Med Chem 48(19):5942–5954. https://doi.org/10.1021/jm050111e
Article CAS PubMed Google Scholar
Padmanabhan PK, Mukherjee A, Singh S, Chattopadhyaya S, Gowri VS, Myler PJ, Srinivasan N, Madhubala R (2005) Glyoxalase I from Leishmania donovani: A potential target for anti-parasite drug. Biochem Biophys Res Commun 337(4):1237–1248. https://doi.org/10.1016/j.bbrc.2005.09.179
Article CAS PubMed Google Scholar
Patpi SR, Pulipati L, Yogeeswari P, Sriram D, Jain N, Sridhar B, Murthy R, Devi A, Kalivendi T, S. V., Kantevari S (2012) Design, synthesis, and structure-activity correlations of novel dibenzo[b,d furan, dibenzo[b,d]thiophene, and N-methylcarbazole clubbed 1,2,3-triazoles as potent inhibitors of mycobacterium tuberculosis. J Med Chem 55(8):3911–3922. https://doi.org/10.1021/jm300125e
Article CAS PubMed Google Scholar
Porta EOJ, Ballari MS, Carlucci R, Wilkinson S, Ma G, Tekwani BL, Labadie GR (2023) Systematic study of 1, 2, 3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases. Eur J Med Chem 254:115378
Comments (0)