Taftian A, Abedi N, Zolfi Gol A (2025) Emerging threats: multidrug resistance and clinical challenges of acinetobacter spp. in modern healthcare. Pers Med J. https://doi.org/10.22034/pmj.2025.2058093.1057

Article  Google Scholar 

Sharma R, Lakhanpal D (2025) Acinetobacter baumannii: a comprehensive review of global epidemiology, clinical implications, host interactions, mechanisms of antimicrobial resistance and mitigation strategies. Microb Pathog 204:107605. https://doi.org/10.1016/j.micpath.2025.107605

Article  PubMed  CAS  Google Scholar 

Maitra R, Saxena D, Singh S, A A, Majumder A, Janani S, Dasgupta A, Chopra S (2025) Multidrug-resistant Acinetobacter baumannii: a wily, existential threat to modern healthcare. ACS Infect Dis 11:2951–2978. https://doi.org/10.1021/acsinfecdis.5c00570

Article  PubMed  CAS  Google Scholar 

Zhang S, Di L, Qi Y, Qian X, Wang S (2024) Treatment of infections caused by carbapenem-resistant Acinetobacter baumannii. Front Cell Infect Microbiol 14:1395260. https://doi.org/10.3389/fcimb.2024.1395260

Article  PubMed  PubMed Central  CAS  Google Scholar 

Dubey V, Reza N, Hope W (2025) Drug-resistant Acinetobacter baumannii: mortality, emerging treatments, and future pharmacological targets for a WHO priority pathogen. Clin Microbiol Rev 38:e00279-24. https://doi.org/10.1128/cmr.00279-24

Article  PubMed  PubMed Central  CAS  Google Scholar 

Boutzoukas A, Doi Y (2025) The global epidemiology of carbapenem-resistant Acinetobacter baumannii. JAC-Antimicrob Resist 7:dlaf134. https://doi.org/10.1093/jacamr/dlaf134

Article  PubMed  PubMed Central  Google Scholar 

Zarrilli R, Giannouli M, Tomasone F, Triassi M, Tsakris A (2009) Carbapenem resistance in Acinetobacter baumannii: the molecular epidemic features of an emerging problem in health care facilities. J Infect Dev Ctries 3:335–341. https://doi.org/10.3855/jidc.240

Article  PubMed  CAS  Google Scholar 

Lodise TP, Nguyen ST, Margiotta C, Cai B (2025) Clinical burden of Acinetobacter baumannii, including carbapenem-resistant A. baumannii, in hospitalized adult patients in the USA between 2018 and 2022. BMC Infect Dis 25:549. https://doi.org/10.1186/s12879-025-10749-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Sim HS, Kwon Y-K, Song H, Hwang G-S, Yeom J (2025) Regulation of antibiotic persistence and pathogenesis in Acinetobacter baumannii by glutamate and histidine metabolic pathways. BMC Microbiol 25:74. https://doi.org/10.1186/s12866-024-03654-1

Article  PubMed  PubMed Central  CAS  Google Scholar 

Read BJ, Cadzow AF, Alphey MS, Mitchell JBO, Da Silva RG (2024) Crystal structure, steady-state, and pre-steady-state kinetics of Acinetobacter baumannii ATP phosphoribosyltransferase. Biochemistry 63:230–240. https://doi.org/10.1021/acs.biochem.3c00551

Article  PubMed  CAS  Google Scholar 

Read BJ, Fisher G, Wissett OL, Machado TF, Nicholson J, Mitchell JB, da Silva RG (2021) Allosteric inhibition of Acinetobacter baumannii ATP phosphoribosyltransferase by protein: dipeptide and protein: protein interactions. ACS Infect Dis 8:197–209

Article  PubMed  Google Scholar 

Read BJ, Fisher G, Wissett OLR, Machado TFG, Nicholson J, Mitchell JBO, Da Silva RG (2022) Allosteric inhibition of Acinetobacter baumannii ATP phosphoribosyltransferase by protein:dipeptide and protein:protein interactions. ACS Infect Dis 8:197–209. https://doi.org/10.1021/acsinfecdis.1c00539

Article  PubMed  CAS  Google Scholar 

Arshad N, Azzam W, Zilberberg MD, Shorr AF (2025) Acinetobacter baumannii complex infections: new treatment options in the antibiotic pipeline. Microorganisms 13:356. https://doi.org/10.3390/microorganisms13020356

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ahmad N, Sharma P, Sharma S, Singh TP (2023) Crystal structure of Adenosine triphosphate phosphoribosyltransferase from Acinetobacter baumannii at 2.18 A resolution

Berman HM (2000) The protein data bank. Nucleic Acids Res 28:235–242. https://doi.org/10.1093/nar/28.1.235

Article  PubMed  PubMed Central  CAS  Google Scholar 

Burley SK, Bhatt R, Bhikadiya C, Bi C, Biester A, Biswas P, Bittrich S, Blaumann S, Brown R, Chao H (2025) Updated resources for exploring experimentally-determined PDB structures and computed structure models at the RCSB Protein Data Bank. Nucleic Acids Res 53:D564–D574

Article  PubMed  PubMed Central  CAS  Google Scholar 

DeLano WL (2002) Pymol: an open-source molecular graphics tool. CCP4 Newsl Protein Crystallogr 40:82–92

Google Scholar 

Dallakyan S, Olson AJ (2015) Small-molecule library screening by docking with PyRx. In: Hempel JE, Williams CH, Hong CC (eds) Chemical biology: methods and protocols. Springer, New York, pp 243–250

Chapter  Google Scholar 

Trott O, Olson AJ (2010) AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading. J Comput Chem 31:455–461

Article  PubMed  PubMed Central  CAS  Google Scholar 

O’Boyle NM, Banck M, James CA, Morley C, Vandermeersch T, Hutchison GR (2011) Open Babel: an open chemical toolbox. J Cheminform 3:1–14

Google Scholar 

BIOVIA, Dassault Systèmes (2024) Discovery Studio Visualizer, San Diego

Ahmad N, Singh A, Gupta A, Pant P, Singh TP, Sharma S, Sharma P (2022) Discovery of the lead molecules targeting the first step of the histidine biosynthesis pathway of Acinetobacter baumannii. J Chem Inf Model 62:1744–1759. https://doi.org/10.1021/acs.jcim.1c01421

Article  PubMed  CAS  Google Scholar 

Yang C, Li J, Luo X, Song Z, Zhang J (2026) Therapeutic challenges and emerging strategies against carbapenem-resistant Acinetobacter baumannii. Curr Res Microb Sci 10:100581. https://doi.org/10.1016/j.crmicr.2026.100581

Article  PubMed  PubMed Central  CAS  Google Scholar 

Singh A, Tanwar M, Singh TP, Sharma S, Sharma P (2025) Targeting histidine biosynthesis in Acinetobacter baumannii: structure-based discovery of natural inhibitors of ATP-phosphoribosyltransferase. Mol Divers. https://doi.org/10.1007/s11030-025-11409-x

Article  PubMed  Google Scholar 

Sleijfer S (2001) Bleomycin-induced pneumonitis. Chest 120:617–624. https://doi.org/10.1378/chest.120.2.617

Article  PubMed  CAS  Google Scholar 

Reinert T, Baldotto CSDR, Nunes FAP, Scheliga AADS (2013) Bleomycin-induced lung injury. J Cancer Res 2013:1–9. https://doi.org/10.1155/2013/480608

Article  CAS  Google Scholar